KEGG   ENZYME: 3.4.21.47
Entry
EC 3.4.21.47                Enzyme                                 
Name
alternative-complement-pathway C3/C5 convertase;
complement component C3/C5 convertase (alternative);
proenzyme factor B;
properdin factor B;
C3 proactivator;
glycine-rich beta-glycoprotein;
heat-labile factor;
C3 convertase;
C3b,Bb,CVF,Bb,C5 convertase;
(C3b)n,Bb;
complement C 3(C 5) convertase (amplification);
alternative complement pathway C3(C5) convertase;
C5 convertase;
CVF,Bb;
(CVF)-dependent glycine-rich-beta-glucoprotein;
cobra venom factor-dependent C3 convertase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Cleavage of Arg!Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg! bond in complement component C5 alpha-chain to yield C5a and C5b
Comment
A bimolecular complex of complement fragment Bb with either C3b or cobra venom factor; Bb contains the active site. Bb is formed by cleavage of proenzyme factor B by factor D. Cleavage of complement component C5 requires additional C3b which binds C5 and renders it susceptible to cleavage by C3b,Bb complex. C3b,Bb is stabilized in plasma by factor P. Complement factor B is in peptidase family S1 (trypsin family)
History
EC 3.4.21.47 created 1981
Orthology
K01335  complement factor B
Genes
HSA629(CFB)
PTR494140(CFB)
PPS100990821(CFB)
GGO101141641(CFB)
PON103890868(CFB)
NLE100595765(CFB)
MCC716809(CFB)
MCF102133787(CFB)
CSAB108449896(CFB)
CATY105583239(CFB)
TGE112622244(CFB)
RRO104678121(CFB)
RBB108520262(CFB)
TFN117086976(CFB)
PTEH111523926
CJC100409227(CFB)
SBQ101036079(CFB)
CSYR103271298(CFB)
MMUR105858159(CFB)
OGA100949772(CFB)
MMU14962(Cfb)
MCAL110312388(Cfb)
MPAH110336125(Cfb)
RNO294257(Cfb)
MCOC116075349(Cfb)
MUN110560137(Cfb)
CGE100758781(Cfb)
PLEU114705866(Cfb)
NGI108490121(Cfb)
HGL101725137(Cfb)
CPOC100715616(Cfb)
CCAN109689576(Cfb)
DORD105999873(Cfb)
DSP122111494(Cfb)
NCAR124989525
OCU100355944(CFB)
OPI101536636(CFB)
TUP102480574(CFB)
CFA100688056(CFB)
VVP112913626(CFB)
VLG121500776(CFB)
AML100474759(CFB)
UMR103682288(CFB)
UAH113243739(CFB)
UAR123790973(CFB)
ELK111152198
LLV125101522
MPUF101692539(CFB)
ORO101378817(CFB)
EJU114222131(CFB)
ZCA113927725(CFB)
MLX118027314(CFB)
FCA101093018(CFB)
PYU121022337(CFB)
PBG122478265(CFB)
PTG102969938(CFB)
PPAD109260506(CFB)
AJU106983483(CFB)
HHV120221920(CFB)
BTA514076(CFB)
BOM102267775(CFB)
BIU109576933(CFB)
BBUB102404663(CFB)
CHX102175816(CFB)
OAS101115072(CFB)
ODA120870573(CFB)
CCAD122429827(CFB)
SSC100124383(CFB)
CFR102519366(CFB)
CBAI105074040
CDK105087438(CFB)
VPC102528827(CFB)
BACU103017988(CFB)
LVE103071310(CFB)
OOR101281312(CFB)
DLE111170703(CFB)
PCAD102991673(CFB)
PSIU116762859(CFB)
ECB100051124(CFB)
EPZ103563301(CFB)
EAI106831003(CFB)
MYB102262757(CFB)
MYD102766003(CFB)
MMYO118679565(CFB)
MLF102435318(CFB)
MNA107538978(CFB)
PKL118705365(CFB)
HAI109373064(CFB)
DRO112302049
SHON118979559(CFB)
AJM119053693(CFB)
PDIC114494197(CFB)
PHAS123810444(CFB)
MMF118621310(CFB)
RFQ117020466(CFB)
PALE102877940(CFB)
PGIG120618897(CFB)
PVP105305289(CFB)
RAY107498437(CFB)
MJV108393990(CFB)
TOD119252230(CFB)
SARA101542103
LAV100668025(CFB)
TMU101350698
DNM101435826
MDO107648882(CFB)
GAS123245151(CFB)
PCW110199443(CFB)
PHI106628820(CFB)
AMJ102574048(CFB) 109280870
CPIC101943785 101945361
MRV120403300
ACS100555786 100555981(cfb)
PVT110088690(CFB)
SUND121922134
PBI103054626
PMUR107287873 107300231 107302884
TSR106539402 106544271
PGUT117667853
PMUA114590977(CFB)
GJA107105481(CFB)
XLA108698939 373577(cfb.S) 397725(cfb.L)
XTR100491419(cfb)
NPR108786506
RTEM120913256
BBUF120977484 120977492 120977496 120978194 120978195 120978196
BGAR122919722 122946120 122946787 122946788 122946789
DRE30604(cfb) 792472(cfbl)
SRX107715263 107715390 107715393 107723846 107756066 107756181
SANH107669352 107669354 107693811 107693822
SGH107568309 107572119 107574087 107574090
CCAR109052426 109052431
CAUA113038495 113038496 113063652 113064084 113064085 113064160 113071732 113078027
IPU100862742
PHYP113541515 113541657
SMEO124397805 124398258
TFD113662099 113662100
AMEX103039688 103040831
EEE113568769 113585998
TRU101069540 101069998
TNGGSTEN00018968G001
LCO104929932
NCC104964654
CGOB115018874 115018985
ELY117272009
PLEP121952156
SLUC116064868
ECRA117955159
PFLV114566514
GAT120821357
PPUG119215742
MSAM119895101
CUD121518408
MZE101486732
ONL100707990
OAU116317731 116336174
OLA100049430(bf/c2)
OML112142732 112142733
XMA102216506 102235456
XCO114153817
XHE116727817
PRET103475468
PFOR103141081
PLAI106956137
PMEI106921330
GAF122844416 122844417
CVG107098502 107098503
CTUL119775850(bfb) 119775881
GMU124876043 124876048
NFU107379288 107379289 107386372
KMR108237014
ALIM106514073
NWH119420895
AOCE111580649
CSEM103395154
POV109628349
SSEN122779130
HHIP117774178
LCF108893578
SDU111234364
SLAL111666299
XGL120802806
HCQ109517895
BPEC110158573
MALB109959265
SASA106563698 106569366 106602980
OTW112228943 112231175(cfbl) 112260753
OMY100136605(cfbl) 100653464 110534129(cfb)
OGO124006256 124007468 124010056
ONE115101442 115114668 115135507
SALP111956628 111964346
SNH120021442(cfbl) 120056081 120057316
ELS105030044 105030049
SFM108934440(cfb) 108938433
PKI111839196 111860092
AANG118234983(cfbl)
PSPA121299068(cfbl)
ARUT117398282 117430318 117434000 117434001 117964868 117964901 117964906
LCM102360252 102360987(CFB)
RTP109921430
BBEL109471260
CIN497244(bf-3)
SCLV120329807 120344514 120344863 120344889 120345032 120345064
SPU373308(bf)
APLC110989106 110989117
SKO100373330
RSAN119395859
RMP119173521
CSCU111622536 111622553
PTEP107454561
SDM118189532 118204855
MMER123548468 123548952 123552382
ATEN116300929
PDAM113673827
SPIS111333045
DGT114533679 114533680
XEN124438971 124439145
 » show all
Reference
1  [PMID:7043188]
  Authors
Kerr MA.
  Title
Human factor B.
  Journal
Methods Enzymol 80 Pt C:102-12 (1981)
DOI:10.1016/s0076-6879(81)80010-9
Reference
2  [PMID:6323161]
  Authors
Morley BJ, Campbell RD.
  Title
Internal homologies of the Ba fragment from human complement component Factor B, a class III MHC antigen.
  Journal
EMBO J 3:153-7 (1984)
DOI:10.1002/j.1460-2075.1984.tb01776.x
  Sequence
[hsa:629]
Reference
3  [PMID:3052276]
  Authors
Muller-Eberhard HJ.
  Title
Molecular organization and function of the complement system.
  Journal
Annu Rev Biochem 57:321-47 (1988)
DOI:10.1146/annurev.bi.57.070188.001541
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.47
IUBMB Enzyme Nomenclature: 3.4.21.47
ExPASy - ENZYME nomenclature database: 3.4.21.47
BRENDA, the Enzyme Database: 3.4.21.47
CAS: 80295-67-6

DBGET integrated database retrieval system