KEGG   ENZYME: 3.4.21.48
Entry
EC 3.4.21.48                Enzyme                                 
Name
cerevisin;
yeast proteinase B;
proteinase yscB (gene name);
baker's yeast proteinase B;
brewer's yeast proteinase;
peptidase beta
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Hydrolysis of proteins with broad specificity, and of Bz-Arg-OEt Ac-Tyr-OEt. Does not hydrolyse peptide amides
Comment
From Saccharomyces cerevisiae (baker's yeast, brewer's yeast). In peptidase family S8 (subtilisin family), but contains a Cys residue near the active site His, and is inhibited by mercurials. Proteinase ycaB is a similar enzyme from the yeast Candida albicans [3]
History
EC 3.4.21.48 created 1972 as EC 3.4.22.9, transferred 1981 to EC 3.4.21.48
Orthology
K01336  cerevisin
Genes
BFO118411937 118412637
BBEL109468592 109468850
AJC117105741 117105758
SKO100366912 100367213 102803900
PXU106113109 106113139 106119856 106123048
GAE121391443
LAK106151688 106153601 106163865 106164704 106165961 106168269 106177170 106177807
AQU100636066 100641796
QSU111998205 112021837 112024116 112026753 112037725
SCEYEL060C(PRB1) YOR003W(YSP3)
SEUBDI49_1333 DI49_2405
SPAOSPAR_E00150 SPAR_O01500
AGOAGOS_ACR012C
ERCEcym_3018
KLAKLLA0_D00979g
KMXKLMA_80029(PRB1)
LTHKLTH0C11396g
VPOKpol_1032p5 Kpol_1045p75
ZROZYRO0C07942g
CGRCAGL0B03619g CAGL0E02651g CAGL0L13266g
NCSNCAS_0D02630(NCAS0D02630) NCAS_0F00220(NCAS0F00220)
NDINDAI_0I02280(NDAI0I02280) NDAI_0K02880(NDAI0K02880)
TPFTPHA_0M00230(TPHA0M00230)
TBLTBLA_0A07300(TBLA0A07300)
TGBHG536_0H04660
TDLTDEL_0G04550(TDEL0G04550)
KAFKAFR_0B06550(KAFR0B06550) KAFR_0L00360(KAFR0L00360)
KNGKNAG_0E00920(KNAG0E00920) KNAG_0F02970(KNAG0F02970)
ZMKHG535_0G03020
PPAPAS_chr1-1_0226 PAS_chr1-4_0548
DHADEHA2C13882g DEHA2D02816g
PICPICST_4493 PICST_78783(PRB2)
PGUPGUG_05640 PGUG_05905
SPAASPAPADRAFT_60277 SPAPADRAFT_63540 SPAPADRAFT_65953
LELLELG_02417 LELG_05185
CALCAALFM_C206880CA(PRB1) CAALFM_C703860WA(CaO19.7196)
CTPCTRG_01885 CTRG_05182
COTCORT_0C06210 CORT_0G04100
CDUCD36_21180(ScPRB1) CD36_73550
CTENCANTEDRAFT_113719 CANTEDRAFT_123476
YLIYALI0A06435g YALI0A10208g YALI0B16500g YALI0B19316g YALI0B22880g YALI0D02981g YALI0F19646g
CLUCLUG_00086 CLUG_01871
CLUSA9F13_02g04312 A9F13_19g00099
CAURCJI97_004804 CJI97_004900 CJI97_004901
SLBAWJ20_1267(PRB1) AWJ20_3627(PRB1)
PKZC5L36_0B10380
BNNFOA43_003917(PRB1)
BBRXBRETT_000638
OPAHPODL_03923
SLUDSCDLUD_000951
NCRNCU00673 NCU06949
NTENEUTE1DRAFT118570(NEUTE1DRAFT_118570) NEUTE1DRAFT66622(NEUTE1DRAFT_66622)
SMPSMAC_01351 SMAC_07479
PANPODANSg2023 PODANSg2598
TTTTHITE_2076439
MTMMYCTH_2297779
CTHRCTHT_0008160
MGRMGG_02863 MGG_03670 MGG_07965
PPEIPpBr36_03928 PpBr36_05651 PpBr36_06155 PpBr36_09263
TMNUCRPA7_4894
SSCKSPSK_03204
FGRFGSG_00192 FGSG_03315 FGSG_03331
FPUFPSE_06936 FPSE_07490 FPSE_10439
FVRFVEG_00212 FVEG_08679
FOXFOXG_01284 FOXG_09801
NHENECHADRAFT_51284 NECHADRAFT_61473
TRETRIREDRAFT_121495(prb1) TRIREDRAFT_123244
TRRM419DRAFT_124452 M419DRAFT_24449
MAWMAC_01571 MAC_04385
MAJMAA_02408 MAA_07742 MAA_08718 MAA_10260
CMTCCM_01138 CCM_05422
PLJVFPFJ_06190 VFPFJ_08389
VALVDBG_02202 VDBG_05526
VDAVDAG_02670 VDAG_07176
CFJCFIO01_00799 CFIO01_09770 CFIO01_10447
CLUPCLUP02_00516 CLUP02_08984 CLUP02_09925
CHIGCH63R_00865 CH63R_02862 CH63R_07309 CH63R_07970 CH63R_13070
SAPOSAPIO_CDS3715 SAPIO_CDS9954
ELAUCREL1_7643 UCREL1_7762 UCREL1_8425
PFYPFICI_02849 PFICI_13611
SSLSS1G_03282 SS1G_12605
BFUBCIN_08g02990(Bcser2) BCIN_10g02530(Bcser1)
MBEMBM_03464 MBM_07519
PSCOLY89DRAFT_634549 LY89DRAFT_690190
GLZGLAREA_05270 GLAREA_07864 GLAREA_09085
PCSPc21g14160 Pc21g16970
PDPPDIP_49700
TMFPMAA_079390
TRGTRUGW13939_10665
CIMCIMG_10288 CIMG_13072(CIMG06672)
CPWCPC735_003880 CPC735_031240
UREUREG_01974 UREG_03769
PBLPAAG_00218 PAAG_04168
PBNPADG_07422 PADG_07910
ABEARB_00777 ARB_01495
TVETRV_02781 TRV_07778
AJEHCAG_00635
BGHBDBG_01242
PNOSNOG_13210 SNOG_14851(SNOG_14850) SNOG_16555
PTEPTT_03163 PTT_08980 PTT_12838 PTT_13282
BZECOCCADRAFT_22934 COCCADRAFT_38174 COCCADRAFT_38791 COCCADRAFT_40219 COCCADRAFT_84133
BSCCOCSADRAFT_120979 COCSADRAFT_179893 COCSADRAFT_200777 COCSADRAFT_338540 COCSADRAFT_79601
BORCOCMIDRAFT_29905 COCMIDRAFT_31365 COCMIDRAFT_6343 COCMIDRAFT_69996 COCMIDRAFT_98093
AALTCC77DRAFT_1023931 CC77DRAFT_483913 CC77DRAFT_487559 CC77DRAFT_992049
ZTRMYCGRDRAFT_34374(SPR3) MYCGRDRAFT_70312(MgSPR7)
PFJMYCFIDRAFT_212921 MYCFIDRAFT_71004
FFUCLAFUR5_02055 CLAFUR5_06383 CLAFUR5_13943
BCOMBAUCODRAFT_36171 BAUCODRAFT_55484
NPAUCRNP2_2085 UCRNP2_2853 UCRNP2_3877 UCRNP2_6259 UCRNP2_8713 UCRNP2_9564
TMLGSTUM_00000037001 GSTUM_00001312001 GSTUM_00003125001
SPOSPAC1006.01(psp3) SPAC4A8.04(isp6)
CNECNJ00620
CNBCNBJ2870
CNGCNAG_04625
CGICGB_D9150W
TMSTREMEDRAFT_28113
TASAA1Q1_00800
TVSTRAVEDRAFT_153966 TRAVEDRAFT_42042
DSQDICSQDRAFT_127445 DICSQDRAFT_183358
PCOPHACADRAFT_260098
SHSSTEHIDRAFT_105089
HIRHETIRDRAFT_153222 HETIRDRAFT_315128 HETIRDRAFT_99563
PSQPUNSTDRAFT_121757
ADLAURDEDRAFT_112072 AURDEDRAFT_115386 AURDEDRAFT_139052 AURDEDRAFT_146669 AURDEDRAFT_159284 AURDEDRAFT_180494 AURDEDRAFT_182320
FMEFOMMEDRAFT_101509
GTRGLOTRDRAFT_93802
LBCLACBIDRAFT_291381 LACBIDRAFT_299797
CCICC1G_04470 CC1G_04562
ABPAGABI1DRAFT112911(AGABI1DRAFT_112911) AGABI1DRAFT130896(AGABI1DRAFT_130896) AGABI1DRAFT130898(AGABI1DRAFT_130898) AGABI1DRAFT130899(AGABI1DRAFT_130899)
ABVAGABI2DRAFT120844(AGABI2DRAFT_120844) AGABI2DRAFT120846(AGABI2DRAFT_120846) AGABI2DRAFT192881(AGABI2DRAFT_192881) AGABI2DRAFT194648(AGABI2DRAFT_194648)
PCUBJR316_0002582
MRRMoror_17908 Moror_4471
MOREE1B28_010297
SCMSCHCO_02630790(SCHCODRAFT_02630790)
CPUTCONPUDRAFT_82713
SLASERLADRAFT_463320
WSEWALSEDRAFT_45712
WICJ056_000638
UMAUMAG_04400
PFPPFL1_05764
MGLMGL_3247
MRTMRET_2448
MSYMMSY001_3319
PGRPGTG_10045 PGTG_12109 PGTG_14692
MLRMELLADRAFT_44205 MELLADRAFT_88167
ECUECU01_1130
EINEint_011060
EHEEHEL_011030
EROEROM_010950
NCENCER_100826
 » show all
Reference
1  [PMID:4961236]
  Authors
Felix F, Brouillet N.
  Title
[Purification and properties of 2 peptidases from baker's yeast]
  Journal
Biochim Biophys Acta 122:127-44 (1966)
Reference
2  [PMID:7028121]
  Authors
Kominami E, Hoffschulte H, Leuschel L, Maier K, Holzer H.
  Title
The substrate specificity of proteinase B from baker's yeast.
  Journal
Biochim Biophys Acta 661:136-41 (1981)
DOI:10.1016/0005-2744(81)90092-9
Reference
3  [PMID:3539100]
  Authors
Farley PC, Shepherd MG, Sullivan PA.
  Title
The purification and properties of yeast proteinase B from Candida albicans.
  Journal
Biochem J 236:177-84 (1986)
DOI:10.1042/bj2360177
Reference
4  [PMID:3325823]
  Authors
Moehle CM, Tizard R, Lemmon SK, Smart J, Jones EW.
  Title
Protease B of the lysosomelike vacuole of the yeast Saccharomyces cerevisiae is homologous to the subtilisin family of serine proteases.
  Journal
Mol Cell Biol 7:4390-9 (1987)
DOI:10.1128/MCB.7.12.4390
  Sequence
[sce:YEL060C]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.48
IUBMB Enzyme Nomenclature: 3.4.21.48
ExPASy - ENZYME nomenclature database: 3.4.21.48
BRENDA, the Enzyme Database: 3.4.21.48
CAS: 37288-81-6

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