KEGG   ENZYME: 3.4.21.5Help
Entry
EC 3.4.21.5                 Enzyme                                 

Name
thrombin;
fibrinogenase;
thrombase;
thrombofort;
topical;
thrombin-C;
tropostasin;
activated blood-coagulation factor II;
blood-coagulation factor IIa;
factor IIa;
E thrombin;
beta-thrombin;
gamma-thrombin
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Selective cleavage of Arg!Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B
Comment
Formed from prothrombin. More selective than trypsin and plasmin. In peptidase family S1 (trypsin family).
History
EC 3.4.21.5 created 1961 as EC 3.4.4.13, transferred 1972 to EC 3.4.21.5
Orthology
K01313  coagulation factor II (thrombin)
Genes
HSA: 2147(F2)
PTR: 451158(F2)
PPS: 100975534(F2)
GGO: 101149905(F2)
PON: 100173859(F2)
NLE: 100595467(F2)
MCC: 712729(F2)
MCF: 102131020(F2)
CSAB: 103236354
RRO: 104668398(F2)
RBB: 108521952(F2)
CJC: 100386446(F2)
SBQ: 101049318(F2)
MMU: 14061(F2)
RNO: 29251(F2)
CGE: 100754947(F2)
NGI: 103742495(F2)
HGL: 101720561(F2)
CCAN: 109681600(F2)
OCU: 100009146(F2)
TUP: 102468231(F2)
CFA: 100856539(F2)
AML: 100472871(F2)
UMR: 103672390(F2)
ORO: 101381460(F2)
FCA: 101090463(F2)
PTG: 102950768(F2)
AJU: 106978029(F2)
BTA: 280685(F2)
BOM: 102271164(F2)
BIU: 109569554(F2)
PHD: 102321823(F2)
CHX: 102185018(F2)
OAS: 100307041(F2)
SSC: 100144442(F2)
CFR: 102515763(F2)
CDK: 105106867(F2)
BACU: 103013731(F2)
LVE: 103082406(F2)
OOR: 101289120(F2)
ECB: 100057521(F2)
EPZ: 103566907(F2)
EAI: 106844001(F2)
MYB: 102252492(F2)
MYD: 102752205(F2)
HAI: 109390173(F2)
RSS: 109453694(F2)
PALE: 102877724(F2)
LAV: 100666651(F2)
TMU: 101347713
MDO: 100015821(F2)
SHR: 100915186(F2)
OAA: 100081028(F2)
GGA: 395306(F2)
MGP: 100549057(F2)
CJO: 107314808(F2)
APLA: 101792756(F2)
ACYG: 106043598(F2)
TGU: 100220988(F2)
GFR: 102034334(F2)
FAB: 101811384(F2)
PHI: 102114657(F2)
PMAJ: 107205921(F2)
CCW: 104697991(F2)
FPG: 101912106(F2)
FCH: 102047000(F2)
CLV: 102087936(F2)
EGZ: 104134075(F2)
AAM: 106498225(F2)
ASN: 102370968(F2)
AMJ: 102568064(F2)
PSS: 102449827(F2)
CMY: 102937607(F2)
CPIC: 101938037(F2)
ACS: 100566916(f2)
PVT: 110081895(F2)
PBI: 103065535(F2)
GJA: 107106779(F2)
XLA: 443652(f2.L) 446352(f2.S)
XTR: 548514(f2)
NPR: 108791599(F2)
DRE: 325881(f2)
SRX: 107742559
IPU: 108259272(f2)
AMEX: 103039180(f2)
TRU: 446073(f2)
LCO: 104936791(f2)
NCC: 104959957(f2)
OLA: 101170246
XMA: 102217884(f2)
PRET: 103480906(f2)
NFU: 107384579(f2)
CSEM: 103389837(f2)
HCQ: 109510409(f2)
BPEC: 110172075(f2)
ELS: 105017464(f2)
SFM: 108940837(f2)
LCM: 102347036(F2)
CMK: 103186030(f2)
APLC: 110974931
SKO: 100377746
CRG: 105327809
OBI: 106884382
EPA: 110232337
ADF: 107333270
 » show all
Taxonomy
Reference
1
  Authors
Baughman, D.J.
  Title
Thrombin assay.
  Journal
Methods Enzymol 19:145-157 (1970)
Reference
2
  Authors
Magnusson, S.
  Title
Bovine prothrombin and thrombin.
  Journal
Methods Enzymol 19:157-184 (1970)
Reference
3
  Authors
Miller, K.D.
  Title
Horse prothrombin.
  Journal
Methods Enzymol 19:140-145 (1970)
Reference
4  [PMID:1011989]
  Authors
Lundblad RL, Kingdon HS, Mann KG.
  Title
Thrombin.
  Journal
Methods Enzymol 45:156-76 (1976)
DOI:10.1016/S0076-6879(76)45017-6
Reference
5  [PMID:1011988]
  Authors
Mann KG.
  Title
Prothrombin.
  Journal
Methods Enzymol 45:123-56 (1976)
DOI:10.1016/S0076-6879(76)45016-4
Reference
6  [PMID:367103]
  Authors
Davie EW, Fujikawa K, Kurachi K, Kisiel W.
  Title
The role of serine proteases in the blood coagulation cascade.
  Journal
Adv Enzymol Relat Areas Mol Biol 48:277-318 (1979)
Reference
7  [PMID:6370301]
  Authors
Cho K, Tanaka T, Cook RR, Kisiel W, Fujikawa K, Kurachi K, Powers JC.
  Title
Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates.
  Journal
Biochemistry 23:644-50 (1984)
Reference
8  [PMID:6326805]
  Authors
MacGillivray RT, Davie EW.
  Title
Characterization of bovine prothrombin mRNA and its translation product.
  Journal
Biochemistry 23:1626-34 (1984)
  Sequence
[bta:280685]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.5
IUBMB Enzyme Nomenclature: 3.4.21.5
ExPASy - ENZYME nomenclature database: 3.4.21.5
BRENDA, the Enzyme Database: 3.4.21.5
CAS: 9002-04-4

DBGET integrated database retrieval system