KEGG   ENZYME: 3.4.21.5
Entry
EC 3.4.21.5                 Enzyme                                 
Name
thrombin;
fibrinogenase;
thrombase;
thrombofort;
topical;
thrombin-C;
tropostasin;
activated blood-coagulation factor II;
blood-coagulation factor IIa;
factor IIa;
E thrombin;
beta-thrombin;
gamma-thrombin
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Selective cleavage of Arg!Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B
Comment
Formed from prothrombin. More selective than trypsin and plasmin. In peptidase family S1 (trypsin family).
History
EC 3.4.21.5 created 1961 as EC 3.4.4.13, transferred 1972 to EC 3.4.21.5
Orthology
K01313  coagulation factor II (thrombin)
Genes
HSA2147(F2)
PTR451158(F2)
PPS100975534(F2)
GGO101149905(F2)
PON100173859(F2)
NLE100595467(F2)
HMH116476292(F2)
MCC712729(F2)
MCF102131020(F2)
MTHB126935772
MNI105471671(F2)
CSAB103236354
CATY105592805(F2)
PANU101003685(F2)
TGE112606320(F2)
MLEU105554807(F2)
RRO104668398(F2)
RBB108521952(F2)
TFN117081636(F2)
PTEH111544903(F2)
CANG105527120(F2)
CJC100386446(F2)
SBQ101049318(F2)
CIMI108304861(F2)
CSYR103267776(F2)
MMUR105885009(F2)
LCAT123642660(F2)
PCOQ105811083(F2)
OGA100959798(F2)
MMU14061(F2)
MCAL110311945(F2)
MPAH110319115(F2)
RNO29251(F2)
MCOC116092238(F2)
ANU117702785(F2)
MUN110549882(F2)
CGE100754947(F2)
MAUA101841138(F2)
PROB127222241(F2)
PLEU114699696(F2)
MORG121437664(F2)
MFOT126489747
AAMP119814487(F2)
NGI103742495(F2)
HGL101720561(F2)
CPOC100725988(F2)
CCAN109681600(F2)
DORD105996039(F2)
DSP122104962(F2)
PLOP125362150(F2)
NCAR124960707
MMMA107135800(F2)
OCU100009146
OPI101528466(F2)
TUP102468231(F2)
GVR103603381(F2)
CFA100856539(F2)
CLUD112663307(F2)
VVP112924085(F2)
VLG121471389(F2)
NPO129501430(F2)
AML100472871(F2)
UMR103672390(F2)
UAH113264978(F2)
UAR123785006(F2)
ELK111149799
LLV125078525
MPUF101682635(F2)
MNP132008217 132008408
MLK131812146(F2)
NVS122912887(F2)
ORO101381460(F2)
EJU114215280(F2)
ZCA113915371(F2)
MLX118015568(F2)
NSU110575764(F2)
LWW102736552 102746346(F2)
FCA101090463(F2)
PYU121043464(F2)
PCOO112865052(F2)
PBG122484430(F2)
LRUF124505518
PTG102950768(F2)
PPAD109245108(F2)
PUC125912698
AJU106978029
HHV120228398(F2)
BTA280685(F2)
BOM102271164(F2)
BIU109569554(F2)
BBUB102415273(F2)
BBIS104990341(F2)
CHX102185018(F2)
OAS100307041(F2)
BTAX128060803(F2)
ODA120876939(F2)
CCAD122449815(F2)
MBEZ129554803(F2)
SSC100144442(F2)
CFR102515763(F2)
CBAI105076458(F2)
CDK105106867(F2)
VPC102534618(F2)
BACU103013731(F2)
LVE103082406(F2)
OOR101289120(F2)
DLE111183976(F2)
PCAD102991552(F2)
PSIU116757330(F2)
NASI112402070(F2)
ECB100057521(F2)
EPZ103566907(F2)
EAI106844001(F2)
MYB102252492(F2)
MYD102752205(F2)
MMYO118650448 118665076(F2)
MLF102428075(F2)
PKL118712792(F2)
EFUS103290842(F2)
MNA107530315(F2)
DRO112303389(F2)
SHON118974544(F2)
AJM119064411(F2)
PDIC114499912(F2)
PHAS123809949(F2)
MMF118628654(F2)
PPAM129081443(F2)
HAI109390173(F2)
RFQ117030063(F2)
PALE102877724(F2)
PGIG120606951(F2)
PVP105290023(F2)
RAY107511857(F2)
MJV108403296(F2)
TOD119254522(F2)
SARA101546501(F2)
LAV100666651(F2)
TMU101347713
ETF101644470(F2)
DNM101420795(F2)
MDO100015821(F2)
GAS123253047(F2)
SHR100915186(F2)
AFZ127540431
PCW110223959(F2)
OAA100081028(F2)
GGA395306(F2)
PCOC116229164(F2)
MGP100549057(F2)
CJO107314808(F2)
TPAI128086314(F2)
LMUT125695225(F2)
NMEL110400969(F2)
APLA101792756(F2)
ACYG106043598(F2)
CATA118244272(F2)
AFUL116490058(F2)
TGU100220988(F2)
LSR110472069(F2)
SCAN103826687(F2)
PMOA120500525(F2)
OTC121332682(F2)
PRUF121349589(F2)
GFR102034334(F2)
FAB101811384(F2)
OMA130253752(F2)
PHI102114657(F2)
PMAJ107205921(F2)
CCAE111930178(F2)
CCW104697991(F2)
CBRC103620744(F2)
ETL114058944(F2)
ZAB102068190(F2)
ACHL103812105(F2)
SVG106856489(F2)
MMEA130572935(F2)
HRT120754366(F2)
FPG101912106(F2)
FCH102047000(F2)
CLV102087936(F2)
EGZ104134075(F2)
NNI104020379(F2)
PCRI104037943(F2)
PLET104624282(F2)
EHS104510680(F2)
PCAO104049155(F2)
ACUN113480877(F2)
TALA104365891(F2)
PADL103921711(F2)
AFOR103897480(F2)
ACHC115336537(F2)
HALD104323769(F2)
HLE104839691(F2)
AGEN126049385
GCL127017067
CCRI104166558(F2)
CSTI104554499(F2)
CMAC104477891(F2)
MUI104546438(F2)
BREG104637160(F2)
FGA104073761(F2)
GSTE104259590(F2)
LDI104348979(F2)
MNB103777712(F2)
OHA104328094(F2)
NNT104413789(F2)
SHAB115606033(F2)
DPUB104297436(F2)
PGUU104457993(F2)
ACAR104528263(F2)
CPEA104390414(F2)
AVIT104267874(F2)
CVF104295858(F2)
RTD128908224(F2)
CUCA104067295(F2)
TEO104375980(F2)
BRHI104501080(F2)
AAM106498225(F2)
AROW112973932(F2)
NPD112943815(F2)
TGT104578858(F2)
DNE112979203(F2)
SCAM104149233(F2)
ASN102370968(F2)
AMJ102568064(F2)
CPOO109321079(F2)
GGN109298901(F2)
PSS102449827(F2)
CMY102937607(F2)
CCAY125638166(F2)
DCC119857601(F2)
CPIC101938037(F2)
TST117876933(F2)
CABI116821699(F2)
MRV120405074(F2)
ACS100566916(f2)
ASAO132768094(F2)
PVT110081895(F2)
SUND121919932(F2)
PBI103065535(F2)
PMUR107294859(F2)
CTIG120314788
TSR106554431
PGUT117665523(F2)
APRI131187470(F2)
PTEX113441034(F2)
NSS113414351(F2)
PMUA114595904(F2)
PRAF128413097
ZVI118084964(F2)
HCG128336170(F2)
GJA107106779(F2)
STOW125427507(F2)
EMC129324126(F2)
XLA443652(f2.L) 446352(f2.S)
XTR548514(f2)
NPR108791599(F2)
RTEM120917137(F2)
BBUF120980221(F2)
BGAR122920581 122920976 122921050
MUO115468837(F2)
GSH117352401(F2)
DRE325881(f2)
SRX107742559
SANH107677184 107703282
SGH107554629 107560109
CCAR109055202 109081883
CAUA113051457 113106097
CGIB127962215 128016815
PTET122348035(f2)
LROH127168348(f2)
OMC131544543(f2)
PPRM120492080(f2)
RKG130069732(f2)
MAMB125265013(f2)
CIDE127516001
MASI127443075 127452373
TROS130552920(f2)
TDW130424323(f2)
MANU129445329(f2)
IPU108259272
IFU128602575(f2)
PHYP113546761(f2)
SMEO124380054(f2)
TFD113634222(f2)
TVC132838547(f2)
AMEX103039180(f2)
CMAO118817367(f2)
EEE113592322(f2)
CHAR105889157(f2)
TRU446073(f2)
TFS130523021(f2)
TNGGSTEN00012553G001
LCO104936791(f2)
NCC104959957(f2)
CGOB115004947 115004955
EMAC134861107(f2)
ELY117250030(f2)
EFO125885041(f2) 125894740
PLEP121963005
SLUC116064661(f2)
ECRA117940849(f2)
PFLV114550683(f2)
GAT120817458(f2)
PPUG119212629(f2)
AFB129111698(f2)
CLUM117746509(f2)
PSWI130204479(f2)
MSAM119899034(f2)
SCHU122871930(f2)
CUD121506518(f2)
ALAT119015121(f2)
MZE101463683 101477799
ONL100702313
OAU116325006(f2) 116325008
OLA101170246
OML112156760(f2)
CSAI133425380(f2)
XMA102217884(f2)
XCO114140554(f2)
XHE116715665(f2)
PRET103480906(f2)
PFOR103130081(f2)
PLAI106960877(f2)
PMEI106906062(f2)
GAF122827062(f2)
PPRL129354727
CVG107099194(f2)
CTUL119795312(f2)
GMU124861454(f2)
NFU107384579(f2)
KMR108228250(f2)
ALIM106531261(f2)
NWH119428832(f2)
AOCE111587274(f2)
MCEP125000649(f2)
CSEM103389837(f2)
POV109648054(f2)
SSEN122765100(f2)
HHIP117777517(f2)
HSP118103503(f2)
SMAU118316743(f2)
LCF108873916 108877193
SDU111235568(f2)
SLAL111646879(f2)
XGL120797943(f2)
HCQ109510409(f2)
SSCV125988048
SBIA133510202(f2)
PEE133411321(f2)
PTAO133484684(f2)
BPEC110172075(f2)
MALB109971101(f2)
BSPL114845787(f2)
SJO128354259(f2)
SASA106561958 106587117
STRU115167517 115202882
OTW112232253 112249021(f2)
OMY100136077 100136616(f2)
OGO124033913 124035881
ONE115112078 115113496
OKI109885619 109895524
OKE118358092 118393693
SALP111969223 111974010
SNH120025261 120045869(f2)
CCLU121573310(f2)
ELS105017464(f2)
SFM108940837(f2)
PKI111858234(f2)
AANG118215655(f2)
LOC102695044 102698385
PSPA121329605
ARUT117432060 117434678
PSEX120530275(f2)
LCM102347036(F2)
CMK103186030(f2)
RTP109918716(f2)
CPLA122558109(f2)
HOC132824537(f2)
LERI129705875(f2)
PMRN116945671(F2)
LRJ133351367(F2)
BBEL109470513
SPU100890082 115924790 580206 752081
APLC110974931
MJU123877027
LSM121124704
RMP119186596
VDE111246622
VJA111270994
SDM118182941
GAE121391255
HRF124117379
HRJ124270845 124270852
CRG105337626
PMAX117330388
RPHI132730096
OBI106884382
NVE5515513
HMG100204772
 » show all
Reference
1
  Authors
Baughman, D.J.
  Title
Thrombin assay.
  Journal
Methods Enzymol 19:145-157 (1970)
Reference
2
  Authors
Magnusson, S.
  Title
Bovine prothrombin and thrombin.
  Journal
Methods Enzymol 19:157-184 (1970)
Reference
3
  Authors
Miller, K.D.
  Title
Horse prothrombin.
  Journal
Methods Enzymol 19:140-145 (1970)
Reference
4  [PMID:1011989]
  Authors
Lundblad RL, Kingdon HS, Mann KG.
  Title
Thrombin.
  Journal
Methods Enzymol 45:156-76 (1976)
DOI:10.1016/S0076-6879(76)45017-6
Reference
5  [PMID:1011988]
  Authors
Mann KG.
  Title
Prothrombin.
  Journal
Methods Enzymol 45:123-56 (1976)
DOI:10.1016/S0076-6879(76)45016-4
Reference
6  [PMID:367103]
  Authors
Davie EW, Fujikawa K, Kurachi K, Kisiel W.
  Title
The role of serine proteases in the blood coagulation cascade.
  Journal
Adv Enzymol Relat Areas Mol Biol 48:277-318 (1979)
DOI:10.1002/9780470122938.ch6
Reference
7  [PMID:6370301]
  Authors
Cho K, Tanaka T, Cook RR, Kisiel W, Fujikawa K, Kurachi K, Powers JC.
  Title
Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates.
  Journal
Biochemistry 23:644-50 (1984)
DOI:10.1021/bi00299a009
Reference
8  [PMID:6326805]
  Authors
MacGillivray RT, Davie EW
  Title
Characterization of bovine prothrombin mRNA and its translation product.
  Journal
Biochemistry 23:1626-34 (1984)
DOI:10.1021/bi00303a007
  Sequence
[bta:280685]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.5
IUBMB Enzyme Nomenclature: 3.4.21.5
ExPASy - ENZYME nomenclature database: 3.4.21.5
BRENDA, the Enzyme Database: 3.4.21.5
CAS: 9002-04-4

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