| Entry |
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| Name |
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
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| Reaction(IUBMB) |
Cleavage of the Leu!Leu bond in synthetic tetradecapeptide renin substrate (horse), to produce angiotensin I, but not active on natural angiotensinogen, unlike renin (EC 3.4.23.15). Also hydrolyses Bz-Arg-p-nitroanilide
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| Comment |
A member of the tissue kallikrein family, from submandibular glands of male mice. In peptidase family S1 (trypsin family)
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| History |
EC 3.4.21.54 created 1986
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| Orthology |
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| Genes |
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| Reference |
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| Authors |
Poe M, Wu JK, Florance JR, Rodkey JA, Bennett CD, Hoogsteen K. |
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| Title |
Purification and properties of renin and gamma-renin from the mouse submaxillary gland. |
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| Journal |
J Biol Chem 258:2209-16 (1983) |
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| Sequence |
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| Reference |
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| Authors |
Drinkwater CC, Evans BA, Richards RI |
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| Title |
Sequence and expression of mouse gamma-renin. |
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| Journal |
J Biol Chem 263:8565-8 (1988) |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 3.4.21.54 |
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