KEGG   ENZYME: 3.4.21.59
Entry
EC 3.4.21.59                Enzyme                                 
Name
tryptase;
mast cell tryptase;
mast cell protease II;
skin tryptase;
lung tryptase;
pituitary tryptase;
mast cell neutral proteinase;
mast cell tryptase;
mast cell neutral proteinase;
mast cell serine proteinase II;
mast cell proteinase II;
mast cell serine proteinase tryptase;
rat mast cell protease II;
tryptase M
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Preferential cleavage: Arg!, Lys!, but with more restricted specificity than trypsin
Comment
Occurs as a tetrameric molecule with high affinity for heparin, in mast cell granules. In peptidase family S1 (trypsin family). Not inhibited by alpha1-proteinase inhibitor or alpha2-macroglobulin
History
EC 3.4.21.59 created 1992
Orthology
K01340  tryptase
Genes
HSA23430(TPSD1) 64499(TPSB2) 7177(TPSAB1)
PTR100614054 454333(TPSB2) 468084
PPS100978423(TPSB2) 100983216 100983474 117978660 117978661(TPSD1)
GGO101141984 101143084
PON100294628 100448573(TPSD1)
NLE100586612
MCC100425930 699599
MCF102139613 102140229
CSAB103225829 103225859
CATY105574008 105574098
PANU101010225 110741984
TGE112613876 112613877
RRO104681498 104681499
TFN117097868 117097870
PTEH111535552
CJC100409652
SBQ101042059
CSYR103254059 103255338
MMUR105859603(TPSAB1) 105859609
OGA100947777 100948098
MMU100503895(Tpsab1) 17229(Tpsb2)
MCAL110284076 110284206
MPAH110338270 110338502
RNO29268(Tpsb2) 54271(Tpsab1)
MCOC116077537 116077731
MUN110548711
CGE118239120
PLEU114681232 114681248
HGL101712997
DORD105981925
DSP122123737
CFA100049001
VVP112909106
VLG121487580
AML100477216
UMR103668756
UAH113245122
UAR123783776
ELK111156014
LLV125090219
MPUF106005611
ORO101378934
EJU114215748
ZCA113933006
MLX118021920
HHV120241568
BTA281545(TPSB2) 786948
BOM102276593
BIU109578813 109578824
BBUB102415161 112581768
CHX102177855 102178129
OAS100144429 443433(TPSB2)
ODA120859362 120859384 120882273
CCAD122432925 122433089
SSC110255206 397389(MCT7)
CBAI105062365 105064891 105064937
VPC102531374 116278558 116284114
OOR101285596
DLE111184995 111184996
PSIU116740244 116740299
ECB100033966(RET)
EPZ103542236
EAI106836196(TPSB2)
MYB102258917(TPSAB1)
MMYO118652902 118652903
MLF102419094 102419400 102437182
MNA107533340 107533342
PKL118731552 118731553 118731556
DRO112298273 112298274
SHON118978859
AJM119058218 119058238(TPSB2)
PDIC114503298 114508660
PHAS123825553 123825586
MMF118641912
RFQ117019668 117019883 117019884
PALE102890577(TPSB2)
PGIG120620210 120620543
PVP105303290
RAY107506027 107506028
SARA101547756
DNM101428717
MDO100022090
GAS123230922 123248737 123256465 123256483
SHR100920443
OAA100087741
LOC102685043
TPRE106650697
SOY115881038
DMK116920722
DSV119461781
BGT106061971
MMER123533887 123535369
APUUAPUU_31283S
 » show all
Reference
1  [PMID:6358206]
  Authors
Tanaka T, McRae BJ, Cho K, Cook R, Fraki JE, Johnson DA, Powers JC.
  Title
Mammalian tissue trypsin-like enzymes. Comparative reactivities of human skin tryptase, human lung tryptase, and bovine trypsin with peptide 4-nitroanilide and thioester substrates.
  Journal
J Biol Chem 258:13552-7 (1983)
Reference
2  [PMID:3890754]
  Authors
Kido H, Fukusen N, Katunuma N.
  Title
Chymotrypsin- and trypsin-type serine proteases in rat mast cells: properties and functions.
  Journal
Arch Biochem Biophys 239:436-43 (1985)
DOI:10.1016/0003-9861(85)90709-X
Reference
3  [PMID:3543004]
  Authors
Cromlish JA, Seidah NG, Marcinkiewicz M, Hamelin J, Johnson DA, Chretien M.
  Title
Human pituitary tryptase: molecular forms, NH2-terminal sequence, immunocytochemical localization, and specificity with prohormone and fluorogenic substrates.
  Journal
J Biol Chem 262:1363-73 (1987)
  Sequence
[hsa:7177]
Reference
4  [PMID:3140898]
  Authors
Harvima IT, Schechter NM, Harvima RJ, Fraki JE.
  Title
Human skin tryptase: purification, partial characterization and comparison with human lung tryptase.
  Journal
Biochim Biophys Acta 957:71-80 (1988)
DOI:10.1016/0167-4838(88)90158-6
Reference
5  [PMID:2187193]
  Authors
Vanderslice P, Ballinger SM, Tam EK, Goldstein SM, Craik CS, Caughey GH.
  Title
Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family.
  Journal
Proc Natl Acad Sci U S A 87:3811-5 (1990)
DOI:10.1073/pnas.87.10.3811
  Sequence
[hsa:7177 64499]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.59
IUBMB Enzyme Nomenclature: 3.4.21.59
ExPASy - ENZYME nomenclature database: 3.4.21.59
BRENDA, the Enzyme Database: 3.4.21.59
CAS: 97501-93-4

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