| Entry |
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| Name |
coagulation factor Xa;
thrombokinase;
prothrombase;
prothrombinase;
activated blood-coagulation factor X;
autoprothrombin C;
thromboplastin;
plasma thromboplastin;
factor Xa;
activated Stuart-Prower factor;
activated factor X
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
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| Reaction(IUBMB) |
Selective cleavage of Arg!Thr and then Arg!Ile bonds in prothrombin to form thrombin
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| Comment |
A blood coagulation factor formed from the proenzyme factor X by limited proteolysis. Factor X is a glycoprotein composed of a heavy chain and a light chain, which are generated from a precursor protein by the excision of the tripeptide RKR and held together by one or more disulfide bonds. The activated factor Xa converts prothrombin to thrombin in the presence of factor Va, Ca2+ and phospholipids. Scutelarin (EC 3.4.21.60) has similar specificity, but does not require factor Va.
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| History |
EC 3.4.21.6 created 1972, modified 2011
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| Orthology |
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| Genes |
» show all
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| Reference |
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| Authors |
Fujikawa K, Davie EW. |
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| Title |
Bovine factor X (Stuart factor). |
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| Journal |
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| Reference |
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| Authors |
Jesty J, Nemerson Y. |
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| Title |
The activation of bovine coagulation factor X. |
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| Journal |
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| Reference |
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| Authors |
Davie EW, Fujikawa K, Kurachi K, Kisiel W. |
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| Title |
The role of serine proteases in the blood coagulation cascade. |
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| Journal |
Adv Enzymol Relat Areas Mol Biol 48:277-318 (1979) |
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| Reference |
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| Authors |
Jackson CM, Nemerson Y. |
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| Title |
Blood coagulation. |
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| Journal |
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| Reference |
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| Authors |
McMullen BA, Fujikawa K, Kisiel W, Sasagawa T, Howald WN, Kwa EY, Weinstein B. |
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| Title |
Complete amino acid sequence of the light chain of human blood coagulation factor X: evidence for identification of residue 63 as beta-hydroxyaspartic acid. |
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| Journal |
Biochemistry 22:2875-84 (1983) |
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| Sequence |
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| Reference |
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| Authors |
Cho K, Tanaka T, Cook RR, Kisiel W, Fujikawa K, Kurachi K, Powers JC. |
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| Title |
Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates. |
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| Journal |
Biochemistry 23:644-50 (1984) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.4.21.6 |
| ExPASy - ENZYME nomenclature database: | 3.4.21.6 |
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