KEGG   ENZYME: 3.4.21.6
Entry
EC 3.4.21.6                 Enzyme                                 
Name
coagulation factor Xa;
thrombokinase;
prothrombase;
prothrombinase;
activated blood-coagulation factor X;
autoprothrombin C;
thromboplastin;
plasma thromboplastin;
factor Xa;
activated Stuart-Prower factor;
activated factor X
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Selective cleavage of Arg!Thr and then Arg!Ile bonds in prothrombin to form thrombin
Comment
A blood coagulation factor formed from the proenzyme factor X by limited proteolysis. Factor X is a glycoprotein composed of a heavy chain and a light chain, which are generated from a precursor protein by the excision of the tripeptide RKR and held together by one or more disulfide bonds. The activated factor Xa converts prothrombin to thrombin in the presence of factor Va, Ca2+ and phospholipids. Scutelarin (EC 3.4.21.60) has similar specificity, but does not require factor Va.
History
EC 3.4.21.6 created 1972, modified 2011
Orthology
K01314  coagulation factor X
Genes
HSA2159(F10)
PPS100987663(F10)
GGO101135856(F10)
PON100453258(F10)
PPYG129011816(F10)
NLE100607918(F10)
HMH116467580(F10)
SSYN129464132(F10)
MCC714132(F10)
MCF102123736(F10)
MTHB126940830
MNI105485262
CSAB103214832(F10)
CATY105584946(F10)
PANU100137443(F10)
TGE112617328 112617332
MLEU105539247(F10)
RRO104659907(F10)
RBB108521808(F10)
TFN117063476(F10)
PTEH111546374(F10)
CANG105505923(F10)
CJC100408094(F10)
SBQ101048748(F10)
CIMI108285397(F10)
ANAN105729769(F10)
CSYR103250561(F10)
MMUR105871911
LCAT123648814
PCOQ105825137
OGA100948461
MMU14058(F10)
MCAL110300095(F10)
MPAH110336703(F10)
RNO29243(F10)
MCOC116071159(F10)
ANU117721792(F10)
MUN110559730
CGE100758763(F10)
PLEU114701217(F10)
NGI103746284(F10)
HGL101706544(F10)
CPOC100726878(F10)
CCAN109686463(F10) 109686926
DORD105990353(F10)
DSP122122742(F10)
PLOP125349740(F10)
NCAR124985170
MMMA107140885(F10)
OCU100008647(F10)
OPI101524210(F10)
TUP102482452(F10)
GVR103598974(F10)
CFA476993(F10)
CLUD112655836(F10)
VVP112927507(F10)
VLG121477072(F10)
NPO129516309(F10)
AML100471482(F10)
UMR103657616
UAH113247589(F10)
UAR123776735
ELK111146998
LLV125094856
MPUF101692311(F10)
MNP132002995(F10)
MLK131813928(F10)
NVS122907902
ORO101366626(F10)
EJU114196630(F10)
ZCA113919204(F10)
MLX118009111(F10)
NSU110585911
LWW102734285
FCA101098029(F10)
PYU121037685(F10)
PCOO112861207(F10)
PBG122485005
PVIV125161682(F10)
LRUF124517289
PTG102964764(F10)
PPAD109264040(F10)
PUC125933974
AJU106986723
HHV120228329(F10)
BTA280787(F10)
BOM102273533(F10)
BIU109567024(F10)
BBIS104982128(F10)
CHX102174670(F10)
OAS101118624(F10)
BTAX128057787(F10)
ODA120883382(F10)
CCAD122447570(F10)
MBEZ129556647(F10)
SSC733662(F10)
CFR102523467(F10)
CBAI105066914(F10)
CDK105091338(F10)
VPC102529214
BACU103006373
BMUS118884198(F10)
LVE103076225(F10)
OOR101275181(F10)
DLE111176364(F10)
PCAD102976837(F10)
PSIU116743318(F10)
NASI112404626(F10)
ECB100067094(F10)
EPZ103549669(F10)
EAI106839879(F10)
MYB102259886 102260494
MYD102763530(F10)
MMYO118651394 118651396
MLF102420533 102432787(F10)
PKL118729784(F10)
EFUS103288220(F10)
MNA107536945(F10)
DRO112321507(F10)
SHON118984245(F10)
AJM119045870(F10)
PDIC114508715(F10)
PHAS123807380(F10)
MMF118622268(F10)
PPAM129064752(F10)
HAI109383929(F10)
RFQ117021046(F10)
PALE102897100(F10)
PGIG120615621(F10)
PVP105305095(F10)
RAY107514335(F10)
MJV108398703(F10)
TOD119259645(F10)
SARA101546603(F10)
SETR126015567(F10)
LAV100656027(F10)
TMU101347861
ETF101645841(F10)
DNM101443567(F10)
MDO100022394(F10)
GAS123239828(F10)
SHR100916022(F10)
AFZ127553486
PCW110193412(F10) 110194699
TVP118848686(F10)
OAA790961(F10)
GGA395876(F10) 771012
PCOC116242791(F10) 116242792
MGP100549453 100549606
CJO116652744(F10)
TPAI128071574 128092245(F10)
LMUT125700083(F10) 125700539
NMEL110407370(F10) 110407388
APLA101795784 101797246 119716512
ACYG106046423(F10) 106046431
CATA118257489(F10) 118257492
AFUL116499897(F10) 116501472
TGU100218905
LSR110478750(F10)
SCAN103812659
PMOA120500075 120508997
OTC121343154 121344169
PRUF121349145
GFR102045057(F10) 106631792
FAB101818023(F10)
OMA130249673 130249679
PHI102113413
PMAJ107211181(F10)
CCW104686115
CBRC103617617
ETL114057853
ZAB102067788(F10)
ZLE135446045(F10) 135446931
SVG106858460
MMEA130585574 130589260
HRT120748691 120748991
FPG101922977(F10)
FCH102052312(F10)
CLV102094780(F10) 110360871
EGZ104132462(F10)
NNI104019417(F10)
PCRI104030191
PLET104616019 104616140
EHS104510997 104511079
PCAO104049031(F10)
ACUN113481093 113485443(F10)
TALA104359426 104359427(F10)
PADL103918893(F10)
AFOR103896306 103896307
ACHC115334728(F10)
HALD104323803(F10)
HLE104836960(F10)
AGEN126052941
GCL127027456
CCRI104164465 104164466
CSTI104552440(F10)
CMAC104477926
MUI104536859
BREG104632867 104632868
FGA104083151
GSTE104259482 104263947(F10)
LDI104349364
OHA104332935 104333042
NNT104404527(F10)
SHAB115604012
DPUB104298626(F10)
ACAR104531059(F10)
CPEA104389021 104389023
AVIT104272534 104272536
CVF104292737(F10)
RTD128904265(F10) 128904301
CUCA104056614 104056666
TEO104371435
BRHI104496829(F10)
AAM106494078
AROW112960665(F10)
NPD112951590(F10) 112951591
TGT104576723 104577827
DNE112981387(F10) 112981388
SCAM104138072(F10)
ASN102370854(F10)
AMJ102559264(F10)
CPOO109306297(F10)
GGN109303122(F10)
PSS102463618(F10)
CMY102933056(F10)
CCAY125639140(F10)
DCC119859117(F10)
CPIC101936955(F10)
TST117870783(F10)
CABI116823351
MRV120390684(F10)
ACS100555331(f10)
ASAO132771515
PVT110074104(F10) 110075865
SUND121925753
PBI103049058 107326851
PMUR107285510 107290445(F10)
CTIG120315425
TSR106540894 106543059
PGUT117666375(F10)
APRI131200249(F10)
PTEX113440795(F10)
NSS113428979 113428980 113428994
VKO123022731(F10)
PMUA114596454(F10) 114597650
PRAF128412405(F10)
ZVI118084859(F10)
HCG128352127(F10)
GJA107110911 107123569
STOW125432098(F10)
EMC129326471(F10)
XLA398778(f10.L)
XTR548445(f10)
NPR108791698(F10)
RTEM120926383(F10)
BBUF120995774
BGAR122931115 122932922
MUO115469160(F10)
GSH117363133(F10)
DRE282670(f10)
SRX107747060 107751061
SANH107654567 107694470
SGH107570070 107572930(f10)
CCAR109064623 109102881
CAUA113044690 113046773 113087161
CGIB127948899 128014997
PTET122346666(f10)
LROH127156824(f10)
OMC131541962(f10)
PPRM120459073(f10)
MAMB125273019 125273020
CIDE127508893
MASI127443441
TROS130552643(f10)
TDW130438576(f10)
MANU129445167(f10)
IPU108258588(f10)
IFU128601878(f10)
PHYP113537543
SMEO124378650(f10)
TFD113648978(f10)
TVC132839316(f10)
TRN134329265(f10)
CMAO118798124(f10)
EEE113577302
CHAR105896532(f10)
TRU101066031 445942(f10)
TFS130514816(proza)
TNGGSTEN00012558G001 GSTEN00033373G001
LCO104925715 104936794
NCC104947705 104953487
TBEN117469711 117492883(proza)
CGOB115005338 115011591
PGEO117443646(f10) 117443653(prozb) 117451403(proza)
GACU117545181(f10) 117545201(prozb) 117548831(proza)
EMAC134861141(f10) 134861162 134878779(proza)
ELY117249788(f10) 117267752(proza)
EFO125879804(proza)
PLEP121956697(proza) 121962690(f10)
SLUC116059589(proza) 116064658(f10)
ECRA117958475(proza)
ESP116702978
PFLV114551519 114569595
GAT120826291 120827250(proza)
PPUG119212654(f10) 119220873(proza)
AFB129098810(proza) 129111639(f10) 129111670
CLUM117735000(proza) 117745447(f10)
PSWI130188428(proza) 130204478 130204480(f10)
MSAM119889460(proza) 119905889 119919374
SCHU122869113(proza) 122871942(f10)
CUD121506040 121529137(proza)
ALAT119014261(proza) 119015130(f10)
MZE101466292 101466573 101480797
ONL100700322 106096476
OAU116313058(proza) 116325009(f10)
OLA101156578 101163720
OML112146003(proza) 112156778(f10)
CSAI133422312(proza) 133425381(f10)
XMA102223744 102224360
XCO114140574(f10) 114140599 114160145
XHE116715505 116715693 116735789
PRET103457853 103457956 103469202
PFOR103130088 103130089 103130090 103141599
PLAI106960879 106960881 106960888 106961622
PMEI106906043 106906046 106906052 106929362
GAF122821681(proza) 122827076(f10) 122827093
PPRL129354697 129354732(prozb) 129354806 129363887(proza)
CVG107092513 107099172 107099177
CTUL119798368(proza)
GMU124861476 124861650 124863370
NFU107376497 107379926(proc) 107384596
KMR108228942(f10) 108239188(proza)
ALIM106511452 106518721
NWH119420986(proza) 119428796(f10)
AOCE111566049 111574984
MCEP124998007(proza) 125000658 125000659
CSEM103389832 103393035
POV109642632 109645495
SSEN122783461 122785838(proza)
HHIP117772934(f10)
HSP118103656 118123776(proza)
PPLT128431309 128458407(proza)
SMAU118289250(proza) 118308402
LCF108877175(f10) 108886177(proza)
SDU111227083 111235522
SLAL111646835 111653421 111667558
XGL120788456(proza)
HCQ109515019 109528275
SSCV125983737
SBIA133507422(f10) 133514863(proza)
PEE133406169(f10) 133415258(proza)
PTAO133466234(proza) 133481061(f10)
MALB109971103 109971544 109972727
BSPL114850175 114851169(f10) 114859923(proza)
SJO128354592 128378488(proza)
SASA106575752
STRU115179127
OTW112242198(f10)
OMY110495527 110527200
OGO124027850 124028044
ONE115127300
OKI109887402 116369900
OKE118380227(f10)
SNH120033707(f10)
CCLU121547782 121547783 121547784 123488968
ELS105019752
SFM114912029
PKI111855790
AANG118213632(f10)
LOC102691106
PSPA121320870 121327782
ARUT117407264(f10)
PSEX120523373(f10) 120523374(prozb)
LCM102348987(PROC) 102352858
CMK103185526 103185529 103186822
RTP109917222 109931905 109934416
CPLA122554899
HOC132820887
LERI129702275(f9a) 129702476 129702765
PMRN116952517 116956258 116956259
LRJ133347935 133353873 133357162 133357163 133357397
ASTE118509749
PFUC122514909 122514911 122514919 122515362 122515363 122521790
LSM121124682
DSV119461643
RSAN119395758
RMP119174141
XEN124444024
 » show all
Reference
1  [PMID:1012041]
  Authors
Fujikawa K, Davie EW.
  Title
Bovine factor X (Stuart factor).
  Journal
Methods Enzymol 45:89-95 (1976)
DOI:10.1016/S0076-6879(76)45013-9
Reference
2  [PMID:1012042]
  Authors
Jesty J, Nemerson Y.
  Title
The activation of bovine coagulation factor X.
  Journal
Methods Enzymol 45:95-107 (1976)
DOI:10.1016/S0076-6879(76)45014-0
Reference
3  [PMID:367103]
  Authors
Davie EW, Fujikawa K, Kurachi K, Kisiel W.
  Title
The role of serine proteases in the blood coagulation cascade.
  Journal
Adv Enzymol Relat Areas Mol Biol 48:277-318 (1979)
DOI:10.1002/9780470122938.ch6
Reference
4  [PMID:6996572]
  Authors
Jackson CM, Nemerson Y.
  Title
Blood coagulation.
  Journal
Annu Rev Biochem 49:765-811 (1980)
DOI:10.1146/annurev.bi.49.070180.004001
Reference
5  [PMID:6871167]
  Authors
McMullen BA, Fujikawa K, Kisiel W, Sasagawa T, Howald WN, Kwa EY, Weinstein B.
  Title
Complete amino acid sequence of the light chain of human blood coagulation factor X: evidence for identification of residue 63 as beta-hydroxyaspartic acid.
  Journal
Biochemistry 22:2875-84 (1983)
DOI:10.1021/bi00281a016
  Sequence
[hsa:2159]
Reference
6  [PMID:6370301]
  Authors
Cho K, Tanaka T, Cook RR, Kisiel W, Fujikawa K, Kurachi K, Powers JC.
  Title
Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates.
  Journal
Biochemistry 23:644-50 (1984)
DOI:10.1021/bi00299a009
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.6
IUBMB Enzyme Nomenclature: 3.4.21.6
ExPASy - ENZYME nomenclature database: 3.4.21.6
BRENDA, the Enzyme Database: 3.4.21.6
CAS: 9002-05-5

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