Entry
Name
coagulation factor Xa;
thrombokinase;
prothrombase;
prothrombinase;
activated blood-coagulation factor X;
autoprothrombin C;
thromboplastin;
plasma thromboplastin;
factor Xa;
activated Stuart-Prower factor;
activated factor X
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Selective cleavage of Arg!Thr and then Arg!Ile bonds in prothrombin to form thrombin
Comment
A blood coagulation factor formed from the proenzyme factor X by limited proteolysis. Factor X is a glycoprotein composed of a heavy chain and a light chain, which are generated from a precursor protein by the excision of the tripeptide RKR and held together by one or more disulfide bonds. The activated factor Xa converts prothrombin to thrombin in the presence of factor Va, Ca2+ and phospholipids. Scutelarin (EC
3.4.21.60 ) has similar specificity, but does not require factor Va.
History
EC 3.4.21.6 created 1972, modified 2011
Orthology
Genes
CCAN : 109686463(F10) 109686926
MMYO : 118651394 118651396
MLF : 102420533 102432787(F10)
PCW : 110193412(F10) 110194699
PCOC : 116242791(F10) 116242792
TPAI : 128071574 128092245(F10)
NMEL : 110407370(F10) 110407388
APLA : 101795784(F10) 101797246
ACYG : 106046423(F10) 106046431
AFUL : 116499897(F10) 116501472
PMOA : 120500075 120508997
GFR : 102045057(F10) 106631792
CLV : 102094780(F10) 110360871
PLET : 104616019 104616140
ACUN : 113481093 113485443(F10)
TALA : 104359426 104359427(F10)
AFOR : 103896306 103896307
CCRI : 104164465 104164466
BREG : 104632867 104632868
GSTE : 104259482 104263947(F10)
CPEA : 104389021 104389023
AVIT : 104272534 104272536
CUCA : 104056614 104056666
NPD : 112951590(F10) 112951591
DNE : 112981387(F10) 112981388
PVT : 110074104(F10) 110075865
PMUR : 107285510 107290445(F10)
NSS : 113428979 113428980 113428994
PMUA : 114596454(F10) 114597650
NPR : 108791698(F10) 108792657
BGAR : 122931115 122932922
SANH : 107654567 107694470
SGH : 107570070 107572930(f10)
CCAR : 109064623 109102881
CAUA : 113044690 113046773 113087161
CGIB : 127948899 128014997
MAMB : 125273019 125273020
TRU : 101066031 445942(f10)
TNG : GSTEN00012558G001 GSTEN00033373G001
CGOB : 115005338 115011591
ELY : 117249788(f10) 117267752(proza)
PLEP : 121956697(proza) 121962690(f10)
SLUC : 116059589(proza) 116064658(f10)
PFLV : 114551519 114569595
GAT : 120826291 120827250(proza)
PPUG : 119212654(f10) 119220873(proza)
MSAM : 119889460(proza) 119905889 119919374
SCHU : 122869113(proza) 122871942(f10)
CUD : 121506040 121529137(proza)
ALAT : 119014261(proza) 119015130(f10)
MZE : 101466292 101466573 101480797
OAU : 116313058(proza) 116325009(f10)
OML : 112146003(proza) 112156778(f10)
XCO : 114140574(f10) 114140599 114160145
XHE : 116715505 116715693 116735789
PRET : 103457853 103457956 103469202
PFOR : 103130088 103130089 103130090 103141599
PLAI : 106960879 106960881 106960888 106961622
PMEI : 106906043 106906046 106906052 106929362
GAF : 122821681(proza) 122827076(f10) 122827093
CVG : 107092513 107099172 107099177
GMU : 124861476 124861650 124863370
NFU : 107376497 107379926(proc) 107384596
KMR : 108228942(f10) 108239188(proza)
ALIM : 106511452 106518721
NWH : 119420986(proza) 119428796(f10)
AOCE : 111566049 111574984
MCEP : 124998007(proza) 125000658 125000659
CSEM : 103389832 103393035
SSEN : 122783461 122785838(proza)
HSP : 118103656 118123776(proza)
LCF : 108877175(f10) 108886177(proza)
SLAL : 111646835 111653421 111667558
MALB : 109971103 109971544 109972727
BSPL : 114850175 114851169(f10) 114859923(proza)
CCLU : 121547782 121547783 121547784 123488968
PSPA : 121320870 121327782
ARUT : 117407264(f10) 117417839(proza)
PSEX : 120523373(f10) 120523374(prozb)
LCM : 102348987(PROC) 102352858
CMK : 103185526 103185529 103186822
RTP : 109917222 109931905 109934416
AARA : 120894236 120902511
ASTE : 118507263 118509749
PFUC : 122514909 122514911 122514919 122515362 122515363 122521790
RSAN : 119395758 119405046
» show all
Taxonomy
Reference
Authors
Fujikawa K, Davie EW.
Title
Bovine factor X (Stuart factor).
Journal
Reference
Authors
Jesty J, Nemerson Y.
Title
The activation of bovine coagulation factor X.
Journal
Reference
Authors
Davie EW, Fujikawa K, Kurachi K, Kisiel W.
Title
The role of serine proteases in the blood coagulation cascade.
Journal
Reference
Authors
Jackson CM, Nemerson Y.
Title
Blood coagulation.
Journal
Reference
Authors
McMullen BA, Fujikawa K, Kisiel W, Sasagawa T, Howald WN, Kwa EY, Weinstein B.
Title
Complete amino acid sequence of the light chain of human blood coagulation factor X: evidence for identification of residue 63 as beta-hydroxyaspartic acid.
Journal
Sequence
Reference
Authors
Cho K, Tanaka T, Cook RR, Kisiel W, Fujikawa K, Kurachi K, Powers JC.
Title
Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.6
ExPASy - ENZYME nomenclature database: 3.4.21.6