KEGG   ENZYME: 3.4.21.6
Entry
EC 3.4.21.6                 Enzyme                                 

Name
coagulation factor Xa;
thrombokinase;
prothrombase;
prothrombinase;
activated blood-coagulation factor X;
autoprothrombin C;
thromboplastin;
plasma thromboplastin;
factor Xa;
activated Stuart-Prower factor;
activated factor X
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Selective cleavage of Arg!Thr and then Arg!Ile bonds in prothrombin to form thrombin
Comment
A blood coagulation factor formed from the proenzyme factor X by limited proteolysis. Factor X is a glycoprotein composed of a heavy chain and a light chain, which are generated from a precursor protein by the excision of the tripeptide RKR and held together by one or more disulfide bonds. The activated factor Xa converts prothrombin to thrombin in the presence of factor Va, Ca2+ and phospholipids. Scutelarin (EC 3.4.21.60) has similar specificity, but does not require factor Va.
History
EC 3.4.21.6 created 1972, modified 2011
Orthology
K01314  coagulation factor X
Genes
HSA: 2159(F10)
PTR: 107968009(F10)
PPS: 100987663(F10)
GGO: 101135856(F10)
PON: 100453258(F10)
NLE: 100607918(F10)
MCC: 714132(F10)
MCF: 102123736(F10)
CSAB: 103214832(F10)
RRO: 104659907(F10)
RBB: 108521808(F10)
CJC: 100408094(F10)
SBQ: 101048748(F10)
MMU: 14058(F10)
MCAL: 110300095(F10)
MPAH: 110336703(F10)
RNO: 29243(F10)
MUN: 110559730
CGE: 100758763(F10)
NGI: 103746284(F10)
HGL: 101706544(F10)
CCAN: 109686463(F10) 109686926
OCU: 100008647(F10)
TUP: 102482452(F10)
CFA: 476993
VVP: 112927507(F10)
AML: 100471482(F10)
UMR: 103657616(F10)
UAH: 113247589(F10)
ORO: 101366626(F10)
ELK: 111146998
FCA: 101098029(F10)
PTG: 102964764(F10)
PPAD: 109264040(F10)
AJU: 106986723(F10)
BTA: 280787(F10)
BOM: 102273533(F10)
BIU: 109567024(F10)
BBUB: 102407743(F10)
CHX: 102174670(F10)
OAS: 101118624(F10)
SSC: 733662(F10)
CFR: 102523467(F10)
CDK: 105091338(F10)
BACU: 103006373
LVE: 103076225(F10)
OOR: 101275181(F10)
DLE: 111176364(F10)
PCAD: 102976837
ECB: 100067094(F10)
EPZ: 103549669(F10)
EAI: 106839879(F10)
MYD: 102763530(F10)
MNA: 107536945(F10)
HAI: 109383929(F10)
DRO: 112321507(F10)
PALE: 102897100(F10)
RAY: 107514335(F10)
MJV: 108398703(F10)
LAV: 100656027(F10)
TMU: 101347861
MDO: 100022394(F10)
SHR: 100916022(F10)
PCW: 110193412(F10) 110194699
OAA: 790961(F10)
GGA: 395876(F10) 771012
CJO: 116652744(F10)
NMEL: 110407370(F10) 110407388
APLA: 101795784(F10) 101797246
ACYG: 106046423(F10) 106046431
TGU: 100218905
LSR: 110478750(F10)
SCAN: 103812659
GFR: 102045057(F10) 106631792
FAB: 101818023(F10)
PHI: 102113413
PMAJ: 107211181(F10)
CCW: 104686115
ETL: 114057853
FPG: 101922977(F10)
FCH: 102052312(F10)
CLV: 102094780(F10) 110360871
EGZ: 104132462(F10)
NNI: 104019417(F10)
ACUN: 113481093 113485443(F10)
PADL: 103918893(F10)
AAM: 106494078
ASN: 102370854(F10)
AMJ: 102559264(F10)
PSS: 102463618(F10)
CMY: 102933056(F10)
CPIC: 101936955(F10)
ACS: 100555331(f10)
PVT: 110074104(F10) 110075865
PMUR: 107285510 107290445(F10)
PMUA: 114596454(F10) 114597650
XLA: 398778(f10.L)
XTR: 548445(f10)
NPR: 108791698(F10) 108792657
DRE: 282670(f10)
SGH: 107570070 107572930(f10)
IPU: 108258588(F10)
PHYP: 113537543
EEE: 113577302
TRU: 101066031 445942(f10)
KMR: 108228942(f10) 108239188(proza)
SASA: 106575752
OTW: 112240552
SFM: 114912029
LCM: 102348987(PROC) 102352858
AAG: 5574144
HAW: 110383350
 » show all
Reference
1  [PMID:1012041]
  Authors
Fujikawa K, Davie EW.
  Title
Bovine factor X (Stuart factor).
  Journal
Methods Enzymol 45:89-95 (1976)
DOI:10.1016/S0076-6879(76)45013-9
Reference
2  [PMID:1012042]
  Authors
Jesty J, Nemerson Y.
  Title
The activation of bovine coagulation factor X.
  Journal
Methods Enzymol 45:95-107 (1976)
DOI:10.1016/S0076-6879(76)45014-0
Reference
3  [PMID:367103]
  Authors
Davie EW, Fujikawa K, Kurachi K, Kisiel W.
  Title
The role of serine proteases in the blood coagulation cascade.
  Journal
Adv Enzymol Relat Areas Mol Biol 48:277-318 (1979)
DOI:10.1002/9780470122938.ch6
Reference
4  [PMID:6996572]
  Authors
Jackson CM, Nemerson Y.
  Title
Blood coagulation.
  Journal
Annu Rev Biochem 49:765-811 (1980)
DOI:10.1146/annurev.bi.49.070180.004001
Reference
5  [PMID:6871167]
  Authors
McMullen BA, Fujikawa K, Kisiel W, Sasagawa T, Howald WN, Kwa EY, Weinstein B.
  Title
Complete amino acid sequence of the light chain of human blood coagulation factor X: evidence for identification of residue 63 as beta-hydroxyaspartic acid.
  Journal
Biochemistry 22:2875-84 (1983)
DOI:10.1021/bi00281a016
  Sequence
[hsa:2159]
Reference
6  [PMID:6370301]
  Authors
Cho K, Tanaka T, Cook RR, Kisiel W, Fujikawa K, Kurachi K, Powers JC.
  Title
Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates.
  Journal
Biochemistry 23:644-50 (1984)
DOI:10.1021/bi00299a009
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.6
IUBMB Enzyme Nomenclature: 3.4.21.6
ExPASy - ENZYME nomenclature database: 3.4.21.6
BRENDA, the Enzyme Database: 3.4.21.6
CAS: 9002-05-5

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