KEGG   ENZYME: 3.4.21.6Help
Entry
EC 3.4.21.6                 Enzyme                                 

Name
coagulation factor Xa;
thrombokinase;
prothrombase;
prothrombinase;
activated blood-coagulation factor X;
autoprothrombin C;
thromboplastin;
plasma thromboplastin;
factor Xa;
activated Stuart-Prower factor;
activated factor X
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Selective cleavage of Arg!Thr and then Arg!Ile bonds in prothrombin to form thrombin
Comment
A blood coagulation factor formed from the proenzyme factor X by limited proteolysis. Factor X is a glycoprotein composed of a heavy chain and a light chain, which are generated from a precursor protein by the excision of the tripeptide RKR and held together by one or more disulfide bonds. The activated factor Xa converts prothrombin to thrombin in the presence of factor Va, Ca2+ and phospholipids. Scutelarin (EC 3.4.21.60) has similar specificity, but does not require factor Va.
History
EC 3.4.21.6 created 1972, modified 2011
Orthology
K01314  coagulation factor X
Genes
HSA: 2159(F10)
PTR: 107968009(F10)
PPS: 100987663(F10)
GGO: 101135856(F10)
PON: 100453258(F10)
NLE: 100607918(F10)
MCC: 714132(F10)
MCF: 102123736(F10)
CSAB: 103214832(F10)
RRO: 104659907(F10)
RBB: 108521808(F10)
CJC: 100408094(F10)
SBQ: 101048748(F10)
MMU: 14058(F10)
MCAL: 110300095(F10)
MPAH: 110336703(F10)
RNO: 29243(F10)
MUN: 110559730
CGE: 100758763(F10)
NGI: 103746284(F10)
HGL: 101706544(F10)
CCAN: 109686463(F10) 109686926
OCU: 100008647(F10)
TUP: 102482452(F10)
CFA: 476993
VVP: 112927507(F10)
AML: 100471482(F10)
UMR: 103657616(F10)
UAH: 113247589(F10)
ORO: 101366626(F10)
FCA: 101098029(F10)
PTG: 102964764(F10)
PPAD: 109264040(F10)
AJU: 106986723(F10)
BTA: 280787(F10)
BOM: 102273533(F10)
BIU: 109567024(F10)
BBUB: 102407743(F10)
CHX: 102174670(F10)
OAS: 101118624(F10)
SSC: 733662(F10)
CFR: 102523467(F10)
CDK: 105091338(F10)
BACU: 103006373
LVE: 103076225(F10)
OOR: 101275181(F10)
DLE: 111176364(F10)
PCAD: 102976837
ECB: 100067094(F10)
EPZ: 103549669(F10)
EAI: 106839879(F10)
MNA: 107536945(F10)
HAI: 109383929(F10)
DRO: 112321507(F10)
PALE: 102897100(F10)
RAY: 107514335(F10)
MJV: 108398703(F10)
LAV: 100656027(F10)
TMU: 101347861
MDO: 100022394(F10)
SHR: 100916022(F10)
PCW: 110193412(F10)
OAA: 790961(F10)
GGA: 395876(F10)
MGP: 100549606(F10)
NMEL: 110407370(F10) 110407388
APLA: 101795784(F10) 101797246
ACYG: 106046423(F10) 106046431
TGU: 100218905
LSR: 110478750(F10)
SCAN: 103812659
GFR: 102045057(F10) 106631792
FAB: 101818023(F10) 101819399
PHI: 102113413
PMAJ: 107211181(F10)
CCW: 104686115(F10)
ETL: 114057853
FPG: 101922977(F10)
FCH: 102052312(F10)
CLV: 102094780(F10) 110360871
EGZ: 104132462(F10)
NNI: 104019417(F10)
ACUN: 113481093 113485443(F10)
PADL: 103918892 103918893(F10)
ASN: 102370854(F10)
AMJ: 102559264(F10)
PSS: 102463618(F10)
CMY: 102933056(F10)
CPIC: 101933935 101936955(F10)
ACS: 100555331(f10)
PVT: 110075865
PBI: 107326851
PMUR: 107285510 107290445(F10)
PMUA: 114596454(F10)
XLA: 398778(f10.L)
XTR: 108644439 548445(f10)
NPR: 108791698(F10)
DRE: 282670(f10)
IPU: 108258588(F10) 108277713
TRU: 445942(f10)
LCO: 104936794
NCC: 104953487
ONL: 106096476
OLA: 101163720
XCO: 114140574(f10) 114140599
KMR: 108228942
CSEM: 103389832
SASA: 100380442(fa9) 106575752
SALP: 111949682
LCM: 102348987(PROC) 102352858
 » show all
Taxonomy
Reference
1  [PMID:1012041]
  Authors
Fujikawa K, Davie EW.
  Title
Bovine factor X (Stuart factor).
  Journal
Methods Enzymol 45:89-95 (1976)
DOI:10.1016/S0076-6879(76)45013-9
Reference
2  [PMID:1012042]
  Authors
Jesty J, Nemerson Y.
  Title
The activation of bovine coagulation factor X.
  Journal
Methods Enzymol 45:95-107 (1976)
DOI:10.1016/S0076-6879(76)45014-0
Reference
3  [PMID:367103]
  Authors
Davie EW, Fujikawa K, Kurachi K, Kisiel W.
  Title
The role of serine proteases in the blood coagulation cascade.
  Journal
Adv Enzymol Relat Areas Mol Biol 48:277-318 (1979)
Reference
4  [PMID:6996572]
  Authors
Jackson CM, Nemerson Y.
  Title
Blood coagulation.
  Journal
Annu Rev Biochem 49:765-811 (1980)
DOI:10.1146/annurev.bi.49.070180.004001
Reference
5  [PMID:6871167]
  Authors
McMullen BA, Fujikawa K, Kisiel W, Sasagawa T, Howald WN, Kwa EY, Weinstein B.
  Title
Complete amino acid sequence of the light chain of human blood coagulation factor X: evidence for identification of residue 63 as beta-hydroxyaspartic acid.
  Journal
Biochemistry 22:2875-84 (1983)
  Sequence
[hsa:2159]
Reference
6  [PMID:6370301]
  Authors
Cho K, Tanaka T, Cook RR, Kisiel W, Fujikawa K, Kurachi K, Powers JC.
  Title
Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates.
  Journal
Biochemistry 23:644-50 (1984)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.6
IUBMB Enzyme Nomenclature: 3.4.21.6
ExPASy - ENZYME nomenclature database: 3.4.21.6
BRENDA, the Enzyme Database: 3.4.21.6
CAS: 9002-05-5

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