KEGG   ENZYME: 3.4.21.6
Entry
EC 3.4.21.6                 Enzyme                                 
Name
coagulation factor Xa;
thrombokinase;
prothrombase;
prothrombinase;
activated blood-coagulation factor X;
autoprothrombin C;
thromboplastin;
plasma thromboplastin;
factor Xa;
activated Stuart-Prower factor;
activated factor X
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Selective cleavage of Arg!Thr and then Arg!Ile bonds in prothrombin to form thrombin
Comment
A blood coagulation factor formed from the proenzyme factor X by limited proteolysis. Factor X is a glycoprotein composed of a heavy chain and a light chain, which are generated from a precursor protein by the excision of the tripeptide RKR and held together by one or more disulfide bonds. The activated factor Xa converts prothrombin to thrombin in the presence of factor Va, Ca2+ and phospholipids. Scutelarin (EC 3.4.21.60) has similar specificity, but does not require factor Va.
History
EC 3.4.21.6 created 1972, modified 2011
Orthology
K01314  coagulation factor X
Genes
HSA2159(F10)
PTR107968009(F10)
PPS100987663(F10)
GGO101135856(F10)
PON100453258(F10)
NLE100607918(F10)
MCC714132(F10)
MCF102123736(F10)
CSAB103214832(F10)
CATY105584946(F10)
PANU100137443(F10)
TGE112617328 112617332
RRO104659907(F10)
RBB108521808(F10)
TFN117063476(F10)
PTEH111546374(F10)
CJC100408094(F10)
SBQ101048748(F10)
CSYR103250561(F10)
MMUR105871911
OGA100948461
MMU14058(F10)
MCAL110300095(F10)
MPAH110336703(F10)
RNO29243(F10)
MCOC116071159(F10)
MUN110559730
CGE100758763(F10)
PLEU114701217(F10)
NGI103746284(F10)
HGL101706544(F10)
CPOC100726878(F10)
CCAN109686463(F10) 109686926
DORD105990353(F10)
DSP122122742(F10)
NCAR124985170
OCU100008647(F10)
OPI101524210(F10)
TUP102482452(F10)
CFA476993(F10)
VVP112927507(F10)
VLG121477072(F10)
AML100471482(F10)
UMR103657616(F10)
UAH113247589(F10)
UAR123776735
ELK111146998
LLV125094856
MPUF101692311(F10)
ORO101366626(F10)
EJU114196630(F10)
ZCA113919204(F10)
MLX118009111(F10)
FCA101098029(F10)
PYU121037685(F10)
PBG122485005
PTG102964764(F10)
PPAD109264040(F10)
AJU106986723(F10)
HHV120228329(F10)
BTA280787(F10)
BOM102273533(F10)
BIU109567024(F10)
CHX102174670(F10)
OAS101118624(F10)
ODA120883382(F10)
CCAD122447570(F10)
SSC733662(F10)
CFR102523467(F10)
CBAI105066914(F10)
CDK105091338(F10)
VPC102529214
BACU103006373
LVE103076225(F10)
OOR101275181(F10)
DLE111176364(F10)
PCAD102976837
PSIU116743318(F10)
ECB100067094(F10)
EPZ103549669(F10)
EAI106839879(F10)
MYB102259886 102260494
MYD102763530(F10)
MMYO118651394 118651396
MLF102420533 102432787(F10)
MNA107536945(F10)
PKL118729784(F10)
HAI109383929(F10)
DRO112321507(F10)
SHON118984245(F10)
AJM119045870(F10)
PDIC114508715(F10)
PHAS123807380(F10)
MMF118622268(F10)
RFQ117021046(F10)
PALE102897100(F10)
PGIG120615621(F10)
PVP105305095(F10)
RAY107514335(F10)
MJV108398703(F10)
TOD119259645(F10)
SARA101546603(F10)
LAV100656027(F10)
TMU101347861
DNM101443567(F10)
MDO100022394(F10)
GAS123239828(F10)
SHR100916022(F10)
PCW110193412(F10) 110194699
OAA790961(F10)
GGA395876(F10) 771012
PCOC116242791(F10) 116242792
MGP100549453 100549606
CJO116652744(F10)
NMEL110407370(F10) 110407388
APLA101795784(F10) 101797246
ACYG106046423(F10) 106046431
AFUL116499897(F10) 116501472
TGU100218905
LSR110478750(F10)
SCAN103812659
PMOA120500075 120508997
OTC121343154 121344169
PRUF121349145
GFR102045057(F10) 106631792
FAB101818023(F10)
PHI102113413
PMAJ107211181(F10)
CCW104686115
ETL114057853
ZAB102067788(F10)
FPG101922977(F10)
FCH102052312(F10)
CLV102094780(F10) 110360871
EGZ104132462(F10)
NNI104019417(F10)
ACUN113481093 113485443(F10)
TALA104359426 104359427(F10)
PADL103918893(F10)
ACHC115334728(F10)
AAM106494078
AROW112960665(F10)
NPD112951590(F10) 112951591
DNE112981387(F10) 112981388
ASN102370854(F10)
AMJ102559264(F10)
CPOO109306297(F10)
GGN109303122(F10)
PSS102463618(F10)
CMY102933056(F10)
CPIC101936955(F10)
TST117870783(F10)
CABI116823351
MRV120390684(F10)
ACS100555331(f10)
PVT110074104(F10) 110075865
SUND121925753
PBI103049058 107326851
PMUR107285510 107290445(F10)
TSR106540894 106543059
PGUT117666375(F10)
VKO123022731(F10)
PMUA114596454(F10) 114597650
ZVI118084859(F10)
GJA107110911 107123569
STOW125432098(F10)
XLA398778(f10.L)
XTR548445(f10)
NPR108791698(F10) 108792657
RTEM120926383(F10)
BBUF120995774
BGAR122931115 122932922
DRE282670(f10)
SRX107747060 107751061
SANH107654567 107694470
SGH107570070 107572930(f10)
CCAR109064623 109102881
CAUA113044690 113046773 113087161
PPRM120459073(f10)
MAMB125273019 125273020
IPU108258588(f10)
PHYP113537543
SMEO124378650(f10)
TFD113648978(f10)
EEE113577302
TRU101066031 445942(f10)
TNGGSTEN00012558G001 GSTEN00033373G001
LCO104925715 104936794
NCC104947705 104953487
CGOB115005338 115011591
ELY117249788(f10) 117267752(proza)
PLEP121956697(proza) 121962690(f10)
SLUC116059589(proza) 116064658(f10)
ECRA117958475(proza)
PFLV114551519 114569595
GAT120826291 120827250(proza)
PPUG119212654(f10) 119220873(proza)
MSAM119889460(proza) 119905889 119919374
CUD121506040 121529137(proza)
MZE101466292 101466573 101480797
ONL100700322 106096476
OAU116313058(proza) 116325009(f10)
OLA101156578 101163720
OML112146003(proza) 112156778(f10)
XMA102223744 102224360
XCO114140574(f10) 114140599 114160145
XHE116715505 116715693 116735789
PRET103457853 103457956 103469202
PFOR103130088 103130089 103130090 103141599
PLAI106960879 106960881 106960888 106961622
PMEI106906043 106906046 106906052 106929362
GAF122821681(proza) 122827076(f10) 122827093
CVG107092513 107099172 107099177
CTUL119798368(proza)
GMU124861476 124861650 124863370
NFU107376497 107379926(proc) 107384596
KMR108228942(f10) 108239188(proza)
ALIM106511452 106518721
NWH119420986(proza) 119428796(f10)
AOCE111566049 111574984
CSEM103389832 103393035
POV109642632 109645495
SSEN122783461 122785838(proza)
HHIP117772934(f10)
LCF108877175 108886177
SDU111227083 111235522
SLAL111646835 111653421 111667558
XGL120788456(proza)
HCQ109515019 109528275
MALB109971103 109971544 109972727
SASA106575752
OTW112242198(f10)
OMY110495527 110527200
OGO124027850 124028044
ONE115127300
SNH120033707(f10)
ELS105012870 105019752
SFM114912029
PKI111843253 111855790
AANG118213632(f10)
LOC102691106
PSPA121320870 121327782
ARUT117407264(f10) 117417839(proza)
LCM102348987(PROC) 102352858
CMK103185526 103185529 103186822
RTP109917222 109931905 109934416
AARA120894236 120902511
PFUC122514909 122514911 122514919 122515362 122515363 122521790
HAW110383350
LSM121118207 121124682
DSV119461643
RSAN119395758 119405046
RMP119174141
CRG117688412
XEN124444024
 » show all
Reference
1  [PMID:1012041]
  Authors
Fujikawa K, Davie EW.
  Title
Bovine factor X (Stuart factor).
  Journal
Methods Enzymol 45:89-95 (1976)
DOI:10.1016/S0076-6879(76)45013-9
Reference
2  [PMID:1012042]
  Authors
Jesty J, Nemerson Y.
  Title
The activation of bovine coagulation factor X.
  Journal
Methods Enzymol 45:95-107 (1976)
DOI:10.1016/S0076-6879(76)45014-0
Reference
3  [PMID:367103]
  Authors
Davie EW, Fujikawa K, Kurachi K, Kisiel W.
  Title
The role of serine proteases in the blood coagulation cascade.
  Journal
Adv Enzymol Relat Areas Mol Biol 48:277-318 (1979)
DOI:10.1002/9780470122938.ch6
Reference
4  [PMID:6996572]
  Authors
Jackson CM, Nemerson Y.
  Title
Blood coagulation.
  Journal
Annu Rev Biochem 49:765-811 (1980)
DOI:10.1146/annurev.bi.49.070180.004001
Reference
5  [PMID:6871167]
  Authors
McMullen BA, Fujikawa K, Kisiel W, Sasagawa T, Howald WN, Kwa EY, Weinstein B.
  Title
Complete amino acid sequence of the light chain of human blood coagulation factor X: evidence for identification of residue 63 as beta-hydroxyaspartic acid.
  Journal
Biochemistry 22:2875-84 (1983)
DOI:10.1021/bi00281a016
  Sequence
[hsa:2159]
Reference
6  [PMID:6370301]
  Authors
Cho K, Tanaka T, Cook RR, Kisiel W, Fujikawa K, Kurachi K, Powers JC.
  Title
Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates.
  Journal
Biochemistry 23:644-50 (1984)
DOI:10.1021/bi00299a009
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.6
IUBMB Enzyme Nomenclature: 3.4.21.6
ExPASy - ENZYME nomenclature database: 3.4.21.6
BRENDA, the Enzyme Database: 3.4.21.6
CAS: 9002-05-5

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