KEGG ENZYME: 3.4.21.6

ENZYME: 3.4.21.6

Entry

EC 3.4.21.6                 Enzyme

Name

coagulation factor Xa;
thrombokinase;
prothrombase;
prothrombinase;
activated blood-coagulation factor X;
autoprothrombin C;
thromboplastin;
plasma thromboplastin;
factor Xa;
activated Stuart-Prower factor;
activated factor X

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases

Reaction(IUBMB)

Selective cleavage of Arg!Thr and then Arg!Ile bonds in prothrombin to form thrombin

Comment

A blood coagulation factor formed from the proenzyme factor X by limited proteolysis. Factor X is a glycoprotein composed of a heavy chain and a light chain, which are generated from a precursor protein by the excision of the tripeptide RKR and held together by one or more disulfide bonds. The activated factor Xa converts prothrombin to thrombin in the presence of factor Va, Ca2+ and phospholipids. Scutelarin (EC 3.4.21.60) has similar specificity, but does not require factor Va.

History

EC 3.4.21.6 created 1972, modified 2011

Orthology

K01314

coagulation factor X

Genes

HSA:

2159(F10)

PTR:	107968009(F10)

PPS:	100987663(F10)

GGO:	101135856(F10)

PON:	100453258(F10)

NLE:	100607918(F10)

HMH:	116467580(F10)

MCC:	714132(F10)

MCF:	102123736(F10)

MTHB:

126940830

MNI:

105485262

CSAB:

103214832(F10)

CATY:

105584946(F10)

PANU:

100137443(F10)

TGE:	112617328 112617332

MLEU:

105539247(F10)

RRO:	104659907(F10)

RBB:	108521808(F10)

TFN:	117063476(F10)

PTEH:

111546374(F10)

CANG:

105505923(F10)

CJC:	100408094(F10)

SBQ:	101048748(F10)

CIMI:

108285397(F10)

CSYR:

103250561(F10)

MMUR:

105871911

LCAT:

123648814

PCOQ:

105825137

OGA:

100948461

MMU:	14058(F10)

MCAL:

110300095(F10)

MPAH:

110336703(F10)

RNO:	29243(F10)

MCOC:

116071159(F10)

ANU:	117721792(F10)

MUN:

110559730

CGE:	100758763(F10)

PLEU:

114701217(F10)

NGI:	103746284(F10)

HGL:	101706544(F10)

CPOC:

100726878(F10)

CCAN:

109686463(F10) 109686926

DORD:

105990353(F10)

DSP:	122122742(F10)

PLOP:

125349740(F10)

NCAR:

124985170

OCU:	100008647(F10)

OPI:	101524210(F10)

TUP:	102482452(F10)

GVR:	103598974(F10)

CFA:	476993(F10)

CLUD:

112655836(F10)

VVP:	112927507(F10)

VLG:	121477072(F10)

NPO:	129516309(F10)

AML:	100471482(F10)

UMR:	103657616(F10)

UAH:	113247589(F10)

UAR:

123776735

ELK:

111146998

LLV:

125094856

MPUF:

101692311(F10)

NVS:

122907902

ORO:	101366626(F10)

EJU:	114196630(F10)

ZCA:	113919204(F10)

MLX:	118009111(F10)

NSU:

110585911

LWW:

102734285

FCA:	101098029(F10)

PYU:	121037685(F10)

PCOO:

112861207(F10)

PBG:

122485005

LRUF:

124517289

PTG:	102964764(F10)

PPAD:

109264040(F10)

PUC:

125933974

AJU:

106986723

HHV:	120228329(F10)

BTA:	280787(F10)

BOM:	102273533(F10)

BIU:	109567024(F10)

BBIS:

104982128(F10)

CHX:	102174670(F10)

OAS:	101118624(F10)

BTAX:

128057787(F10)

ODA:	120883382(F10)

CCAD:

122447570(F10)

SSC:	733662(F10)

CFR:	102523467(F10)

CBAI:

105066914(F10)

CDK:	105091338(F10)

VPC:

102529214

BACU:

103006373

LVE:	103076225(F10)

OOR:	101275181(F10)

DLE:	111176364(F10)

PCAD:

102976837

PSIU:

116743318(F10)

NASI:

112404626(F10)

ECB:	100067094(F10)

EPZ:	103549669(F10)

EAI:	106839879(F10)

MYB:	102259886 102260494

MYD:	102763530(F10)

MMYO:

118651394 118651396

MLF:	102420533 102432787(F10)

MNA:	107536945(F10)

PKL:	118729784(F10)

HAI:	109383929(F10)

DRO:	112321507(F10)

SHON:

118984245(F10)

AJM:	119045870(F10)

PDIC:

114508715(F10)

PHAS:

123807380(F10)

MMF:	118622268(F10)

RFQ:	117021046(F10)

PALE:

102897100(F10)

PGIG:

120615621(F10)

PVP:	105305095(F10)

RAY:	107514335(F10)

MJV:	108398703(F10)

TOD:	119259645(F10)

SARA:

101546603(F10)

LAV:	100656027(F10)

TMU:

101347861

ETF:	101645841(F10)

DNM:	101443567(F10)

MDO:	100022394(F10)

GAS:	123239828(F10)

SHR:	100916022(F10)

AFZ:

127553486

PCW:	110193412(F10) 110194699

OAA:	790961(F10)

GGA:	395876(F10) 771012

PCOC:

116242791(F10) 116242792

MGP:	100549453 100549606

CJO:	116652744(F10)

TPAI:

128071574 128092245(F10)

NMEL:

110407370(F10) 110407388

APLA:

101795784(F10) 101797246

ACYG:

106046423(F10) 106046431

AFUL:

116499897(F10) 116501472

TGU:

100218905

LSR:	110478750(F10)

SCAN:

103812659

PMOA:

120500075 120508997

OTC:	121343154 121344169

PRUF:

121349145

GFR:	102045057(F10) 106631792

FAB:	101818023(F10)

PHI:

102113413

PMAJ:

107211181(F10)

CCW:

104686115

CBRC:

103617617

ETL:

114057853

ZAB:	102067788(F10)

SVG:

106858460

FPG:	101922977(F10)

FCH:	102052312(F10)

CLV:	102094780(F10) 110360871

EGZ:	104132462(F10)

NNI:	104019417(F10)

PLET:

104616019 104616140

PCRI:

104030191

PCAO:

104049031(F10)

ACUN:

113481093 113485443(F10)

TALA:

104359426 104359427(F10)

PADL:

103918893(F10)

AFOR:

103896306 103896307

ACHC:

115334728(F10)

HALD:

104323803(F10)

HLE:	104836960(F10)

AGEN:

126052941

GCL:

127027456

CCRI:

104164465 104164466

CSTI:

104552440(F10)

EHS:	104510997 104511079

CMAC:

104477926

MUI:

104536859

BREG:

104632867 104632868

FGA:

104083151

GSTE:

104259482 104263947(F10)

LDI:

104349364

OHA:	104332935 104333042

NNT:	104404527(F10)

SHAB:

115604012

DPUB:

104298626(F10)

ACAR:

104531059(F10)

CPEA:

104389021 104389023

AVIT:

104272534 104272536

CVF:	104292737(F10)

CUCA:

104056614 104056666

TEO:

104371435

BRHI:

104496829(F10)

AAM:

106494078

AROW:

112960665(F10)

NPD:	112951590(F10) 112951591

TGT:	104576723 104577827

DNE:	112981387(F10) 112981388

SCAM:

104138072(F10)

ASN:	102370854(F10)

AMJ:	102559264(F10)

CPOO:

109306297(F10)

GGN:	109303122(F10)

PSS:	102463618(F10)

CMY:	102933056(F10)

CPIC:

101936955(F10)

TST:	117870783(F10)

CABI:

116823351

MRV:	120390684(F10)

ACS:	100555331(f10)

PVT:	110074104(F10) 110075865

SUND:

121925753

PBI:	103049058 107326851

PMUR:

107285510 107290445(F10)

CTIG:

120315425

TSR:	106540894 106543059

PGUT:

117666375(F10)

PTEX:

113440795(F10)

NSS:	113428979 113428980 113428994

VKO:	123022731(F10)

PMUA:

114596454(F10) 114597650

ZVI:	118084859(F10)

HCG:	128352127(F10)

GJA:	107110911 107123569

STOW:

125432098(F10)

XLA:	398778(f10.L)

XTR:	548445(f10)

NPR:	108791698(F10) 108792657

RTEM:

120926383(F10)

BBUF:

120995774

BGAR:

122931115 122932922

DRE:	282670(f10)

SRX:	107747060 107751061

SANH:

107654567 107694470

SGH:	107570070 107572930(f10)

CCAR:

109064623 109102881

CAUA:

113044690 113046773 113087161

CGIB:

127948899 128014997

PTET:

122346666(f10)

LROH:

127156824(f10)

PPRM:

120459073(f10)

MAMB:

125273019 125273020

CIDE:

127508893

MASI:

127443441

IPU:	108258588(f10)

PHYP:

113537543

SMEO:

124378650(f10)

TFD:	113648978(f10)

CMAO:

118798124(f10)

EEE:

113577302

TRU:	101066031 445942(f10)

TNG:	GSTEN00012558G001 GSTEN00033373G001

LCO:	104925715 104936794

NCC:	104947705 104953487

CGOB:

115005338 115011591

ELY:	117249788(f10) 117267752(proza)

EFO:	125879804(proza)

PLEP:

121956697(proza) 121962690(f10)

SLUC:

116059589(proza) 116064658(f10)

ECRA:

117958475(proza)

ESP:

116702978

PFLV:

114551519 114569595

GAT:	120826291 120827250(proza)

PPUG:

119212654(f10) 119220873(proza)

MSAM:

119889460(proza) 119905889 119919374

SCHU:

122869113(proza) 122871942(f10)

CUD:	121506040 121529137(proza)

ALAT:

119014261(proza) 119015130(f10)

MZE:	101466292 101466573 101480797

ONL:	100700322 106096476

OAU:	116313058(proza) 116325009(f10)

OLA:	101156578 101163720

OML:	112146003(proza) 112156778(f10)

XMA:	102223744 102224360

XCO:	114140574(f10) 114140599 114160145

XHE:	116715505 116715693 116735789

PRET:

103457853 103457956 103469202

PFOR:

103130088 103130089 103130090 103141599

PLAI:

106960879 106960881 106960888 106961622

PMEI:

106906043 106906046 106906052 106929362

GAF:	122821681(proza) 122827076(f10) 122827093

CVG:	107092513 107099172 107099177

CTUL:

119798368(proza)

GMU:	124861476 124861650 124863370

NFU:	107376497 107379926(proc) 107384596

KMR:	108228942(f10) 108239188(proza)

ALIM:

106511452 106518721

NWH:	119420986(proza) 119428796(f10)

AOCE:

111566049 111574984

MCEP:

124998007(proza) 125000658 125000659

CSEM:

103389832 103393035

POV:	109642632 109645495

SSEN:

122783461 122785838(proza)

HHIP:

117772934(f10)

HSP:	118103656 118123776(proza)

LCF:	108877175(f10) 108886177(proza)

SDU:	111227083 111235522

SLAL:

111646835 111653421 111667558

XGL:	120788456(proza)

HCQ:	109515019 109528275

SSCV:

125983737

MALB:

109971103 109971544 109972727

BSPL:

114850175 114851169(f10) 114859923(proza)

SASA:

106575752

STRU:

115179127

OTW:	112242198(f10)

OMY:	110495527 110527200

OGO:	124027850 124028044

ONE:

115127300

SNH:	120033707(f10)

CCLU:

121547782 121547783 121547784 123488968

ELS:	105012870 105019752

SFM:

114912029

PKI:

111855790

AANG:

118213632(f10)

LOC:

102691106

PSPA:

121320870 121327782

ARUT:

117407264(f10) 117417839(proza)

PSEX:

120523373(f10) 120523374(prozb)

LCM:	102348987(PROC) 102352858

CMK:	103185526 103185529 103186822

RTP:	109917222 109931905 109934416

CPLA:

122554899

AARA:

120894236 120902511

ASTE:

118507263 118509749

PFUC:

122514909 122514911 122514919 122515362 122515363 122521790

LSM:

121124682

DSV:

119461643

RSAN:

119395758 119405046

RMP:

119174141

CRG:

117688412

XEN:

124444024

» show all

Reference

1 [PMID:1012041]

Authors

Fujikawa K, Davie EW.

Title

Bovine factor X (Stuart factor).

Journal

Methods Enzymol 45:89-95 (1976)
DOI:10.1016/S0076-6879(76)45013-9

Reference

2 [PMID:1012042]

Authors

Jesty J, Nemerson Y.

Title

The activation of bovine coagulation factor X.

Journal

Methods Enzymol 45:95-107 (1976)
DOI:10.1016/S0076-6879(76)45014-0

Reference

3 [PMID:367103]

Authors

Davie EW, Fujikawa K, Kurachi K, Kisiel W.

Title

The role of serine proteases in the blood coagulation cascade.

Journal

Adv Enzymol Relat Areas Mol Biol 48:277-318 (1979)
DOI:10.1002/9780470122938.ch6

Reference

4 [PMID:6996572]

Authors

Jackson CM, Nemerson Y.

Title

Blood coagulation.

Journal

Annu Rev Biochem 49:765-811 (1980)
DOI:10.1146/annurev.bi.49.070180.004001

Reference

5 [PMID:6871167]

Authors

McMullen BA, Fujikawa K, Kisiel W, Sasagawa T, Howald WN, Kwa EY, Weinstein B.

Title

Complete amino acid sequence of the light chain of human blood coagulation factor X: evidence for identification of residue 63 as beta-hydroxyaspartic acid.

Journal

Biochemistry 22:2875-84 (1983)
DOI:10.1021/bi00281a016

Sequence

[hsa:2159]

Reference

6 [PMID:6370301]

Authors

Cho K, Tanaka T, Cook RR, Kisiel W, Fujikawa K, Kurachi K, Powers JC.

Title

Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates.

Journal

Biochemistry 23:644-50 (1984)
DOI:10.1021/bi00299a009