KEGG   ENZYME: 3.4.21.61
Entry
EC 3.4.21.61                Enzyme                                 
Name
kexin;
yeast KEX2 protease;
proteinase yscF (gene name);
prohormone-processing endoprotease;
paired-basic endopeptidase;
yeast cysteine proteinase F (misleading);
andrenorphin-Gly-generating enzyme;
endoproteinase Kex2p;
gene KEX2 dibasic proteinase;
Kex 2p proteinase;
Kex2 endopeptidase;
Kex2 endoprotease;
Kex2 endoproteinase;
Kex2 protease;
proteinase Kex2p;
Kex2-like precursor protein processing endoprotease;
prohormone-processing KEX2 proteinase;
prohormone-processing proteinase;
proprotein convertase;
protease KEX2;
Kex2 proteinase;
Kex2-like endoproteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Cleavage of -Lys-Arg! and -Arg-Arg! bonds to process yeast alpha-factor pheromone and killer toxin precursors
Comment
A Ca2+-activated peptidase of peptidase family S8, containing Cys near the active site His, and inhibited by p-mercuribenzoate. Similar enzymes occur in mammals.
History
EC 3.4.21.61 created 1989 as EC 3.4.22.23, transferred 1992 to EC 3.4.21.61
Orthology
K01341  kexin
Genes
SCE: YNL238W(KEX2)
SEUB: DI49_4509
SPAO: SPAR_N00900
AGO: AGOS_ABL203W
ERC: Ecym_6486
KLA: KLLA0_D19811g
KMX: KLMA_50628(KEX1)
LTH: KLTH0H00418g
VPO: Kpol_1015p8
ZRO: ZYRO0F15598g
CGR: 2889598(KEX2)
NCS: NCAS_0A00880(NCAS0A00880)
NDI: NDAI_0F03890(NDAI0F03890)
TPF: TPHA_0P01790(TPHA0P01790)
TBL: TBLA_0B00130(TBLA0B00130)
TGB: HG536_0D00240
TDL: TDEL_0E00410(TDEL0E00410)
KAF: KAFR_0A08040(KAFR0A08040)
KNG: KNAG_0F00770(KNAG0F00770)
ZMK: HG535_0D00290
SLUD: SCDLUD_003039
DHA: DEHA2C10296g
PIC: PICST_14973
PGU: PGUG_03723
SPAA: SPAPADRAFT_139715 SPAPADRAFT_153129 SPAPADRAFT_50884
LEL: PVL30_000307(KEX2)
LBG: 92205967(LODBEIA_P07710)
CAL: CAALFM_C108990CA(KEX2)
CTP: CTRG_03249
COT: CORT_0A01670
CDU: CD36_08480
CTEN: 18249061(KEX2)
CLU: CLUG_01869
CLUS: A9F13_02g04334
CAUR: CJI96_0004601
ASAU: 88175797(PUMCH_004737)
PPA: PAS_chr2-1_0304
PKZ: C5L36_0E01280
BNN: FOA43_004608
BBRX: BRETT_001804
OPA: HPODL_03866
YLI: 2907885(YALI2_F00717g)
SLB: AWJ20_2368(KEX2)
NCR: NCU03219
NTE: NEUTE1DRAFT133220(NEUTE1DRAFT_133220)
SMP: 10805897(SMAC4_02938)
PAN: PODANSg09433
PBEL: QC761_101930(KEX2)
PPSD: QC762_101930(KEX2)
PPSP: QC763_101930(KEX2)
PPSA: QC764_101930(KEX2)
TTT: THITE_2120746
MTM: MYCTH_2293998
CTHR: CTHT_0073410
RTHE: 98122787(VTJ83DRAFT_193)
MGR: MGG_15291
PPEI: PpBr36_05578
PGRI: PgNI_00248
TMN: UCRPA7_3661
SSCK: SPSK_03955
FGR: FGSG_09156
FPU: FPSE_06826
FPOA: FPOAC1_012558
FVN: FVRRES_13637
FVR: FVEG_03645
FOX: FOXG_05775
NHE: NECHADRAFT_96635
FFC: NCS54_01229600
FKR: NCS57_01219100
FMU: J7337_003656
TRE: TRIREDRAFT_123561
TRR: M419DRAFT_103000
TATV: 25775714(TrAtP1_006761)
TASP: 36618970(TrAFT101_005981)
MAW: 19247108(KEX2_1)
MAJ: MAA_05263
MBRN: 26237371(KEX1_0)
PCHM: VFPPC_08791 VFPPC_12613 VFPPC_18301
CMT: CCM_04990
AMUS: LMH87_007434
PLJ: 28892292(PLICBS_009959)
PTKZ: JDV02_008870(KEX2)
VAL: VDBG_03817
VDA: VDAG_01043
CFJ: CFIO01_12367
CLUP: CLUP02_13873
CHIG: CH63R_05933
CDET: 87948923(CDEST_12423)
SAPO: SAPIO_CDS6086
ELA: UCREL1_10465
PFY: PFICI_13288
SSL: SS1G_06027
BFU: BCIN_05g03290(Bckex2)
MBE: MBM_03947
PSCO: LY89DRAFT_572892
GLZ: GLAREA_08402
ANI: ANIA_03583
AFM: AFUA_4G12970
ACT: ACLA_051950
NFI: NFIA_103380
AOR: AO090009000291
ANG: An01g08530(kexB)
AFV: AFLA_011068
ALUC: AKAW2_20906A(KEX2)
ACHE: ACHE_10341A(KEX2)
APUU: APUU_60290A(KEX2_1) APUU_60901S(KEX2_2)
PCS: N7525_005913
PDP: PDIP_44570
POU: POX_a01618
TMF: EYB26_005191
TRG: TRUGW13939_02659
CIM: CIMG_00625
CPW: 9691875(KEX2)
URE: UREG_00628
ABE: ARB_00131 ARB_07953
TVE: TRV_04084 TRV_06672
PBL: PAAG_07022
PBN: PADG_01553
AJE: HCAG_07015
BGH: BDBG_02235
PNO: SNOG_04420
PTE: PTT_12023
PTRR: 6346230(PtrM4_136850)
BZE: COCCADRAFT_34558
BSC: COCSADRAFT_340340
BOR: COCMIDRAFT_98148
AALT: CC77DRAFT_1019478
ADAC: 96086937(ACET3X_006615)
ARAB: EKO05_0001920
ZTR: MYCGRDRAFT_10819(MgSPR2)
PFJ: MYCFIDRAFT_156783
FFU: CLAFUR5_08204
CBET: CB0940_04355
BCOM: BAUCODRAFT_532569
NPA: UCRNP2_4501
TML: GSTUM_00008707001
SPO: 2542576(krp1)
SOM: SOMG_03462(krp1)
CNE: CNH01120
CNB: CNBL1060
CNG: CNAG_05446
CGI: CGB_L1170W
CDEU: CNBG_4411
CDEP: 91086598(L203_102386)
KMG: 30165350(I203_101484)
KNE: 92179764(IAR55_002506)
TMS: TREMEDRAFT_70081
TASA: A1Q1_02903
CCAC: CcaHIS019_0603220(KEX2)
DSQ: DICSQDRAFT_165877
SHS: STEHIDRAFT_145445
HIR: HETIRDRAFT_457632
PSQ: PUNSTDRAFT_53587 PUNSTDRAFT_70782
ADL: AURDEDRAFT_110900 AURDEDRAFT_142208
FME: FOMMEDRAFT_110361 FOMMEDRAFT_124597
GTR: GLOTRDRAFT_36402
RSX: RhiXN_02310
LBC: LACBIDRAFT_248825 LACBIDRAFT_322240
CCI: CC1G_01625 CC1G_02379 CC1G_12012
ABP: AGABI1DRAFT52884(AGABI1DRAFT_52884)
ABV: AGABI2DRAFT199236(AGABI2DRAFT_199236)
PCUB: JR316_0003406 JR316_0008359
MRR: Moror_4888 Moror_8398
MORE: E1B28_009092 E1B28_009100
SCM: SCHCO_02607864(SCHCODRAFT_02607864)
WSE: WALSEDRAFT_30910
WIC: J056_002134
UMA: UMAG_02843
PFP: PFL1_01903
SGRA: EX895_001835
MGL: MGL_3817
MRT: MRET_0618
MSYM: MSY001_1822
PGR: PGTG_08683
PTRC: PtA15_7A657
PSTR: Pst134EA_013699
MLR: MELLADRAFT_34111
RIE: OCT59_022929
FCY: FRACYDRAFT_179604
EHX: EMIHUDRAFT_108768
DAF: Desaf_1407
 » show all
Reference
1  [PMID:6430565]
  Authors
Julius D, Brake A, Blair L, Kunisawa R, Thorner J.
  Title
Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-alpha-factor.
  Journal
Cell 37:1075-89 (1984)
DOI:10.1016/0092-8674(84)90442-2
Reference
2  [PMID:3894003]
  Authors
Achstetter T, Wolf DH.
  Title
Hormone processing and membrane-bound proteinases in yeast.
  Journal
EMBO J 4:173-7 (1985)
DOI:10.1002/j.1460-2075.1985.tb02333.x
Reference
3  [PMID:2845974]
  Authors
Mizuno K, Nakamura T, Ohshima T, Tanaka S, Matsuo H
  Title
Yeast KEX2 genes encodes an endopeptidase homologous to subtilisin-like serine proteases.
  Journal
Biochem Biophys Res Commun 156:246-54 (1988)
DOI:10.1016/S0006-291X(88)80832-5
  Sequence
[sce:YNL238W]
Reference
4  [PMID:2646633]
  Authors
Fuller RS, Brake A, Thorner J.
  Title
Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine protease.
  Journal
Proc Natl Acad Sci U S A 86:1434-8 (1989)
DOI:10.1073/pnas.86.5.1434
  Sequence
[sce:YNL238W]
Reference
5  [PMID:2647083]
  Authors
Mizuno K, Nakamura T, Ohshima T, Tanaka S, Matsuo H
  Title
Characterization of KEX2-encoded endopeptidase from yeast Saccharomyces cerevisiae.
  Journal
Biochem Biophys Res Commun 159:305-11 (1989)
DOI:10.1016/0006-291X(89)92438-8
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.61
IUBMB Enzyme Nomenclature: 3.4.21.61
ExPASy - ENZYME nomenclature database: 3.4.21.61
BRENDA, the Enzyme Database: 3.4.21.61
CAS: 99676-46-7

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Gene (321)   
   MGENES (112)   
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Protein sequence (173)   
   UniProt (89)   
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   RefSeq(pep) (61)   
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DNA sequence (160)   
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   GenBank (34)   
   EMBL (32)   
3D Structure (5)   
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Protein domain (10)   
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All databases (669)   

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