| Entry |
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| Name |
oryzin;
Aspergillus alkaline proteinase;
aspergillopeptidase B;
API 21;
aspergillopepsin B;
aspergillopepsin F;
Aspergillus candidus alkaline proteinase;
Aspergillus flavus alkaline proteinase;
Aspergillus melleus semi-alkaline proteinase;
Aspergillus oryzae alkaline proteinase;
Aspergillus parasiticus alkaline proteinase;
Aspergillus serine proteinase;
Aspergillus sydowi alkaline proteinase;
Aspergillus soya alkaline proteinase;
Aspergillus melleus alkaline proteinase;
Aspergillus sulphureus alkaline proteinase;
prozyme;
P 5380;
kyorinase;
seaprose S;
semi-alkaline protease;
sumizyme MP;
prozyme 10;
onoprose;
onoprose SA;
protease P;
promelase
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
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| Reaction(IUBMB) |
Hydrolysis of proteins with broad specificity, and of Bz-Arg-OEt > Ac-Tyr-OEt. Does not hydrolyse peptide amides
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| Comment |
A peptidase of family S8 (subtilisin family), not containing cysteine, that is the predominant extracellular alkaline endopeptidase of the mold Aspergillus oryzae. Identical or closely related enzymes are produced by A. flavus and A. sojae [2,3,4]
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| History |
EC 3.4.21.63 created 1992 (EC 3.4.21.14 created 1961 as EC 3.4.4.16, transferred 1972 to EC 3.4.21.14, modified 1986, part incorporated 1992)
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| Orthology |
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| Genes |
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| Reference |
1 |
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| Authors |
Nakagawa, Y. |
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| Title |
Alkaline proteinases from Aspergillus. |
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| Journal |
Methods Enzymol 19:581-591 (1970) |
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| Reference |
2 |
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| Authors |
Hayashi, K. and Terada, M. |
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| Title |
Some characteristics of hydrolysis of synthetic substrates and proteins by the alkaline proteases from Aspergillus sojae. |
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| Journal |
Agric Biol Chem 36:1755-1765 (1972) |
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| Reference |
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| Authors |
Turkova J, Mikes O, Hayashi K, Danno G, Polgar L. |
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| Title |
Alkaline proteinases of the genus Aspergillus. |
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| Journal |
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| Reference |
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| Authors |
Morihara K, Oka T, Tsuzuki H. |
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| Title |
Comparative study of various serine alkaline proteinases from microorganisms. Esterase activity against N-acylated peptide ester substrates. |
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| Journal |
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| Reference |
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| Authors |
Spadari S, Subramanian AR, Kalnitsky G. |
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| Title |
Highly restricted specificity of the serine proteinase aspergillopeptidase B. |
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| Journal |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 3.4.21.63 |
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