EC                Enzyme                                 

t-plasminogen activator;
tissue plasminogen activator;
plasminogen activator, tissue-type;
tissue-type plasminogen activator;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Specific cleavage of Arg!Val bond in plasminogen to form plasmin
A peptidase of family S1 (trypsin family) from a wide variety of mammalian tissues, especially endothelial cells. Secreted as a single chain precursor which is cleaved to a two-chain form by plasmin. Activity is considerably enhanced by fibrin. Formerly included in EC and EC
EC created 1972 as EC, transferred 1978 as EC, part transferred 1992 to EC
K01343  tissue plasminogen activator
HSA: 5327(PLAT)
PTR: 472748(PLAT)
PPS: 100991098(PLAT)
PON: 100173068(PLAT)
NLE: 100586515(PLAT)
MCC: 704475(PLAT)
MCF: 102145462(PLAT)
CSAB: 103215685(PLAT)
RRO: 104668281(PLAT)
RBB: 108540718(PLAT)
CJC: 100391990(PLAT)
SBQ: 101046492(PLAT)
MMU: 18791(Plat)
MCAL: 110300159(Plat)
MPAH: 110336411(Plat)
RNO: 25692(Plat)
MUN: 110556621(Plat)
CGE: 100750775(Plat)
NGI: 103749408(Plat)
HGL: 101713266(Plat)
CCAN: 109683543(Plat)
OCU: 100009556(PLAT)
TUP: 102468654(PLAT)
CFA: 482840(PLAT)
VVP: 112916154(PLAT)
AML: 100471928(PLAT)
UMR: 103677060(PLAT)
UAH: 113245571(PLAT)
ORO: 101377749(PLAT)
ELK: 111144489
FCA: 101100299(PLAT)
PTG: 102964598(PLAT)
PPAD: 109262266(PLAT)
AJU: 106990011(PLAT)
BTA: 281407(PLAT)
BOM: 102281728(PLAT)
BIU: 109553480(PLAT)
BBUB: 102398577(PLAT)
CHX: 102187371(PLAT)
OAS: 101118332(PLAT)
SSC: 397121(PLAT)
CFR: 102507711(PLAT)
CDK: 105086430(PLAT)
BACU: 103012605(PLAT)
LVE: 103088899(PLAT)
OOR: 101285324(PLAT)
DLE: 111173550(PLAT)
PCAD: 102976916(PLAT)
ECB: 100050239(PLAT)
EPZ: 103562905(PLAT)
EAI: 106828955(PLAT)
MYB: 102261113(PLAT)
MYD: 102775541(PLAT)
MNA: 107523945(PLAT)
HAI: 109386253(PLAT)
DRO: 112321404(PLAT)
PALE: 102893511(PLAT)
RAY: 107501341(PLAT)
MJV: 108406900(PLAT)
LAV: 100657644(PLAT)
TMU: 101350991
MDO: 100033029(PLAT)
SHR: 100928675(PLAT)
PCW: 110196405(PLAT)
OAA: 100078960(PLAT)
GGA: 426791(PLAT)
MGP: 100542402(PLAT)
CJO: 107323741(PLAT)
NMEL: 110387185(PLAT)
APLA: 101790558(PLAT)
ACYG: 106044399(PLAT)
TGU: 100227960(PLAT)
LSR: 110473407(PLAT)
SCAN: 103822680(PLAT)
GFR: 102034369(PLAT)
FAB: 101819512(PLAT)
PHI: 102108905(PLAT)
PMAJ: 107213913(PLAT)
CCAE: 111938865(PLAT)
CCW: 104694864(PLAT)
ETL: 114066443(PLAT)
FPG: 106112248(PLAT)
FCH: 106631098(PLAT)
CLV: 102093040(PLAT)
EGZ: 104135301(PLAT)
NNI: 104016029(PLAT)
ACUN: 113488113(PLAT)
PADL: 103920542(PLAT)
AAM: 106487785(PLAT)
ASN: 102369638(PLAT)
AMJ: 102560959(PLAT)
PSS: 102450593(PLAT)
CMY: 102932303(PLAT)
CPIC: 101945243(PLAT)
ACS: 100568270(plat)
PVT: 110072150(PLAT)
PBI: 103047961(PLAT)
PMUR: 107287961(PLAT)
TSR: 106550871(PLAT)
PMUA: 114602841(PLAT)
GJA: 107107821(PLAT)
XLA: 399010(plat.L)
XTR: 594962(plat)
NPR: 108791447(PLAT)
DRE: 100320028(plat)
SRX: 107754398
SGH: 107559562(plat) 107560034
CCAR: 109095149
IPU: 108265556(plat)
PHYP: 113533570(plat)
AMEX: 103040332(plat)
EEE: 113584931(plat)
TRU: 101062205(plat)
LCO: 104921663(plat)
NCC: 104956683(plat)
MZE: 101472111(plat)
ONL: 100697807(plat)
OLA: 100049466(plat)
XMA: 102223519(plat)
XCO: 114155004(plat)
PRET: 103470022(plat)
CVG: 107089642(plat)
NFU: 107394261(plat)
KMR: 108233564(plat)
ALIM: 106519922(plat)
AOCE: 111577274(plat)
CSEM: 103397764(plat)
POV: 109636963(plat)
LCF: 108881585(plat)
SDU: 111236537(plat)
SLAL: 111665985(plat)
HCQ: 109527086(plat)
BPEC: 110153526(plat)
MALB: 109956492(plat)
ELS: 105014297(plat)
SFM: 108920189(plat)
PKI: 111854365(plat)
LCM: 102346134(PLAT)
CMK: 103181893(plau)
RTP: 109911332(plat)
BBT: BBta_1433
 » show all
1  [PMID:6337343]
Pennica D, Holmes WE, Kohr WJ, Harkins RN, Vehar GA, Ward CA, Bennett WF, Yelverton E, Seeburg PH, Heyneker HL, Goeddel DV, Collen D.
Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli.
Nature 301:214-21 (1983)
2  [PMID:3148826]
Loskutoff DJ, Schleef RR.
Plasminogen activators and their inhibitors.
Methods Enzymol 163:293-302 (1988)
3  [PMID:2962643]
Petersen LC, Johannessen M, Foster D, Kumar A, Mulvihill E.
The effect of polymerised fibrin on the catalytic activities of one-chain tissue-type plasminogen activator as revealed by an analogue resistant to plasmin cleavage.
Biochim Biophys Acta 952:245-54 (1988)
4  [PMID:3148827]
Verheijen JH.
Tissue-type plasminogen activator and fast-acting plasminogen activator inhibitor in plasma.
Methods Enzymol 163:302-9 (1988)
5  [PMID:2496643]
Gerard RD, Meidell RS.
Regulation of tissue plasminogen activator expression.
Annu Rev Physiol 51:245-62 (1989)
Collen, D., Lijnen, H. R. and Verstraete, M.
The fibrinolytic system and its disorders.
In: Handin, R.I., Lux, S.E. and Stossel, J.P. (Eds.), Blood: Principles and Practice of Hematology, 2nd ed., J.B.Lippincott Company, Philadelphia, 1990.
Other DBs
ExplorEnz - The Enzyme Database:
IUBMB Enzyme Nomenclature:
ExPASy - ENZYME nomenclature database:
BRENDA, the Enzyme Database:
CAS: 139639-23-9

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