KEGG ENZYME: 3.4.21.69

ENZYME: 3.4.21.69

Entry

EC 3.4.21.69 Enzyme

Name

protein C (activated);
blood-coagulation factor XIVa;
activated blood coagulation factor XIV;
activated protein C;
autoprothrombin II-A;
protein Ca;
APC;
GSAPC

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases

Reaction(IUBMB)

Degradation of blood coagulation factors Va and VIIIa

Comment

A peptidase of family S1 (trypsin family), one of the gamma-carboxyglutamic acid-containing coagulation factors. Formed from protein C, the proenzyme that circulates in plasma, by the action of a complex of thrombin with thrombomodulin, or by serine endopeptidases present in several snake venoms

History

EC 3.4.21.69 created 1992

Orthology

K01344

protein C (activated)

Genes

HSA:	5624(PROC)

PTR:	459593(PROC)

PPS:	100972665(PROC)

GGO:	101151624(PROC)

PON:	100448857(PROC)

NLE:	100602687(PROC)

MCC:	699077(PROC)

MCF:	102136210(PROC)

CSAB:

103216877(PROC)

RRO:	104662428(PROC)

RBB:	108533003(PROC)

CJC:	100400290(PROC)

SBQ:	101036326(PROC)

MMU:	19123(Proc)

MCAL:

110284793(Proc)

MPAH:

110333316(Proc)

RNO:	25268(Proc)

MUN:	110553446(Proc)

CGE:	100772264(Proc)

NGI:	103732131(Proc)

HGL:	101696423(Proc)

CCAN:

109678633(Proc)

OCU:	100009223(PROC)

TUP:	102484495(PROC)

CFA:	476104(PROC)

VVP:	112932724(PROC)

AML:	100474662(PROC)

UMR:	103658613(PROC)

UAH:	113263483(PROC)

ORO:	101367675(PROC)

ELK:

111160850

FCA:	101096161(PROC)

PTG:	102964953(PROC)

PPAD:

109278799(PROC)

AJU:	106966417(PROC)

BTA:	281428(PROC)

BOM:	102273407(PROC)

BIU:	109565294(PROC)

BBUB:

102405790(PROC)

CHX:	102178773(PROC)

OAS:	105601889(PROC)

SSC:	396954(PROC)

CFR:	102512086(PROC)

CDK:	105084499(PROC)

BACU:

103016343(PROC)

LVE:	103082864(PROC)

OOR:	101270550(PROC)

DLE:	111183350(PROC)

PCAD:

102987775(PROC)

ECB:	100051306(PROC)

EPZ:	103562196(PROC)

EAI:	106834091(PROC)

MYB:	102252251(PROC)

MYD:	102753299(PROC)

MNA:	107528567(PROC)

HAI:	109371798(PROC)

DRO:	112312995(PROC)

PALE:

102880670(PROC)

RAY:	107516890(PROC)

MJV:	108400893(PROC)

LAV:	100664853(PROC)

TMU:

101349839

MDO:	100026692(PROC)

SHR:	100916453(PROC)

PCW:	110194676(PROC)

OAA:	100089432(PROC)

GGA:	395085(PROC)

MGP:

100546662

CJO:	107317869(PROC)

NMEL:

110397916

APLA:

101796776(PROC)

ACYG:

106040266

TGU:	100231143(PROC)

LSR:	110478049(PROC)

SCAN:

103815456(PROC)

GFR:	102041709(PROC)

FAB:	101811071(PROC)

PHI:	102100991(PROC)

PMAJ:

107208669(PROC)

CCAE:

111933669(PROC)

CCW:	104683671(PROC)

ETL:	114054841(PROC)

FPG:	101913876(PROC)

FCH:	102047415(PROC)

CLV:	102097119(PROC)

EGZ:	104126888(PROC)

NNI:	104008579(PROC)

ACUN:

113483760

PADL:

103912685(PROC)

AAM:

106484473

ASN:	102372857(PROC)

AMJ:	106737034(PROC)

PSS:	102461421(PROC)

CMY:

102934451

CPIC:

101932392(PROC)

ACS:	100567125(proc)

PVT:	110075800(PROC)

PBI:

103049304

PMUR:

107285529

TSR:	106540892(PROC)

PMUA:

114597651(PROC)

GJA:	107123568(PROC)

XLA:	108716221(proc.L) 380116(proc.S)

XTR:	548476(proc)

NPR:	108792656(PROC)

DRE:	393327(proca)

SRX:	107705314 107737413

SANH:

107653506 107695161

SGH:	107550452 107564253(proc)

CCAR:

109062960 109072401(proc)

IPU:	108280512 108280513 108280516

PHYP:

113546413 113546415 113546416

AMEX:

103027637 103036144(proc)

EEE:	113590121(proc)

TRU:	101069699(proc)

TNG:	GSTEN00003934G001

LCO:

104937173

MZE:	101471449(proc)

ONL:	100704100(proc)

OLA:	101168986(proc)

XMA:	102225133 102234138

XCO:

114146297

PRET:

103460587

CVG:	107101647(proc)

NFU:

107383706

KMR:	108251338(proca)

ALIM:

106531174 106534295

AOCE:

111568598(proc)

CSEM:

103396845(proc)

POV:

109641687

LCF:	108877172 108882451(proc)

SDU:	111233275(proc)

SLAL:

111651344 111651587

HCQ:	109518835(proc)

BPEC:

110165908(proc)

SASA:

106568651(proc)

OTW:	112260140(proc)

SALP:

111956827(proc)

ELS:	105023274(proc)

SFM:	108926808(proc)

PKI:	111836694(proc)

LCM:

102358409

CMK:	103186701(proc)

RTP:

109929299

APLC:

110990439

AGA:	AgaP_AGAP003252(CLIPB6) AgaP_AGAP011040

CQU:	CpipJ_CPIJ016220

AME:

BIM:

BTER:

SOC:

ACEP:

PBAR:

HST:

DQU:

CFO:

PGC:

ATD:

PVM:	113800184 113807408

CSCU:

111638167

» show all

Reference

1 [PMID:3029867]

Authors

Esmon CT.

Title

The regulation of natural anticoagulant pathways.

Journal

Science 235:1348-52 (1987)
DOI:10.1126/science.3029867

Reference

2 [PMID:2538457]

Authors

Esmon CT

Title

The roles of protein C and thrombomodulin in the regulation of blood coagulation.

Journal

J Biol Chem 264:4743-6 (1989)

Other DBs

ExplorEnz - The Enzyme Database:

3.4.21.69

IUBMB Enzyme Nomenclature:

3.4.21.69

ExPASy - ENZYME nomenclature database:

3.4.21.69

BRENDA, the Enzyme Database:

3.4.21.69

CAS:	42617-41-4

DBGET integrated database retrieval system