activated protein C (thrombin-activated peptidase);
blood-coagulation factor XIVa;
activated blood coagulation factor XIV;
activated protein C;
autoprothrombin II-A;
protein Ca;
APC;
GSAPC;
protein C (activated)
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Degradation of blood coagulation factors Va and VIIIa
Comment
A peptidase of family S1 (trypsin family), one of the gamma-carboxyglutamic acid-containing coagulation factors. The enzyme plays an important role in regulating anticoagulation, inflammation, and cell death by proteolytically inactivating the blood coagulation factors factor Va and factor VIIIa. Formed from protein C, the proenzyme that circulates in plasma, by the action of a complex of thrombin with thrombomodulin. Protein C can also be activated by serine endopeptidases present in several snake venoms.