KEGG   ENZYME: 3.4.21.7Help
Entry
EC 3.4.21.7                 Enzyme                                 

Name
plasmin;
fibrinase;
fibrinolysin;
actase;
serum tryptase;
thrombolysin
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage: Lys! > Arg!; higher selectivity than trypsin. Converts fibrin into soluble products
Comment
Formed from plasminogen by proteolysis which results in multiple forms of the active plasmin. In peptidase family S1 (trypsin family).
History
EC 3.4.21.7 created 1961 as EC 3.4.4.14, transferred 1972 to EC 3.4.21.7
Orthology
K01315  plasminogen
Genes
HSA: 5340(PLG)
PTR: 463117(PLG)
PPS: 100982214(PLG)
PON: 100172984(PLG)
MCC: 703891(PLG)
MCF: 102145643(PLG)
MMU: 18815(Plg)
RNO: 85253(Plg)
CGE: 100761455(Plg)
HGL: 101703481(Plg)
CFA: 403602(PLG)
AML: 100465916(PLG)
FCA: 101095261(PLG)
BTA: 280897(PLG)
BOM: 102279186(PLG)
CHX: 102184723(PLG)
SSC: 733660(PLG)
ECB: 100050531(PLG)
MYB: 102260529(PLG)
MDO: 100028030(PLG)
SHR: 100928828(PLG)
OAA: 100088128
GGA: 421580(PLG) 428593(PLGL)
MGP: 100548534
FAB: 101812892
PHI: 102104141
FPG: 101922752(PLG)
FCH: 102056450(PLG)
CLV: 102089195
ASN: 102377482
ACS: 100554661(plg)
XLA: 108717414
XTR: 100496227(plg)
DRE: 322691(plg)
TRU: 101071971(plg)
MZE: 101468078
XMA: 102220810(plg)
LCM: 102358032(PLG)
CIN: 100182351
SPU: 593482
BBA: Bd0994(splA)
 » show all
Taxonomy
Reference
1  [PMID:138065]
  Authors
Castellino FJ, Sodetz JM.
  Title
Rabbit plasminogen and plasmin isozymes.
  Journal
Methods Enzymol 45:273-86 (1976)
DOI:10.1016/S0076-6879(76)45026-7
Reference
2  [PMID:6210827]
  Authors
Castellino FJ, Powell JR.
  Title
Human plasminogen.
  Journal
Methods Enzymol 80 Pt C:365-78 (1981)
Reference
3  [PMID:6210828]
  Authors
Robbins KC, Summaria L, Wohl RC.
  Title
Human plasmin.
  Journal
Methods Enzymol 80 Pt C:379-87 (1981)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.7
IUBMB Enzyme Nomenclature: 3.4.21.7
ExPASy - ENZYME nomenclature database: 3.4.21.7
BRENDA, the Enzyme Database: 3.4.21.7
CAS: 9001-90-5

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