KEGG ENZYME: 3.4.21.71

ENZYME: 3.4.21.71

Entry

EC 3.4.21.71 Enzyme

Name

pancreatic elastase II;
pancreatic elastase 2

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases

Reaction(IUBMB)

Preferential cleavage: Leu!, Met! and Phe!. Hydrolyses elastin

Comment

A peptidase of family S1 (trypsin family) formed by activation of proelastase II from mammalian pancreas by trypsin. Usually, only one of the pancreatic elastases (see also EC 3.4.21.36) is expressed in a given species; human pancreatic elastase is of type II

History

EC 3.4.21.71 created 1992

Orthology

K01346

pancreatic elastase II

Genes

HSA:	51032(CELA2B) 63036(CELA2A)

PTR:	469129 747215(CELA2A)

PPS:	100992916(CELA2A) 100993275(CELA2B)

GGO:	101130048 101137272

PON:	100435271 100461933 100462303

NLE:	100596831 100597738

MCC:	100426744 106992406 114674066 114674067 114675932 694691

MCF:	102127568(CELA2A) 102135496(CELA2B) 102139003

CSAB:

103225552(CELA2B) 103247268 103247269

RRO:	104667588 104677706 104677707

RBB:	108515897 108524251

CJC:	100395953(CELA2A)

SBQ:	101051841(CELA2A)

MMU:	13706(Cela2a)

MPAH:

110323557

RNO:	24332(Cela2a)

MUN:

110545075

CGE:

100753261

NGI:

103725345

HGL:	101723601(Cela2a)

CCAN:

109692552(Ctrc)

OCU:	100344955(CELA2A)

TUP:	102494723(CELA2A)

BTA:	282687(CELA2A)

BOM:	102279793(CELA2A)

BIU:

109570435

BBUB:

102411682

CHX:	102174414(CELA2A)

OAS:

101111210

SSC:	397197(CELA2A)

CFR:

102519577

CDK:

105107055

BACU:

103001724(CELA2A)

LVE:	103078282(CELA2A)

OOR:

DLE:

PCAD:

ECB:

EPZ:	103565017(CELA2A)

EAI:

106828007

MYB:	102250420(CELA2A)

MYD:	102759032(CELA2A)

MNA:

HAI:

DRO:

PALE:

RAY:

LAV:	100656878 100657159

TMU:	101361674 101361929

MDO:	100027354(CELA2A) 103094642

SHR:	100922937 100931746(CELA2A)

PCW:	110197911 110215486

OAA:

100092350

GGA:	419486(CELA2A)

MGP:

CJO:

NMEL:

APLA:

ACYG:

TGU:

LSR:

SCAN:

GFR:

FAB:

PMAJ:

CCAE:

ETL:	114056912 114069649

FPG:	101912600 101922358

FCH:

102057855

CLV:

102089151

EGZ:	104130990 104133141

NNI:

104009005

ACUN:

113477290

PADL:

103916503 103918048 103925859

AAM:

106482438

ASN:	102386889 112551217

AMJ:	102575615 109285594

PSS:	102455016 102464019 112545378

CMY:	102934019 102934278 102939967 102940188

CPIC:

101944818 101945103 101949408 101951603

ACS:	103279429 103279433

PVT:	110072620 110080727

PMUA:

114596795 114602392 114602395

GJA:	107114248 107124392

XLA:	108696870 108703379 380555(cela2a.L) 444404

XTR:	100497505 100498609 101734343 116412071 594883(cela2a)

NPR:	108788616 108797189 108797195

DRE:	334304(ela2l) 403061(ela2) 561476(zgc:112285)

SRX:	107724515 107731135 107731136 107731230 107736286 107744466 107745782 107745828 107749850 107752511

SANH:

107667984 107668061 107672799 107684136 107690926 107695279

SGH:	107549241 107555594 107592405 107601431

CCAR:

109061958 109073568 109100233

IPU:	100528918(cel2a) 108255755 108266055 108271428 108273558

PHYP:

113526964 113527680 113530458 113530463 113542213

AMEX:

103036513 111191974(ctrc)

EEE:	113577634 113581091

TRU:	101064638 101066013 101069212 101069442 101074248 101077973

TNG:	GSTEN00013062G001 GSTEN00013240G001 GSTEN00016377G001 GSTEN00022509G001 GSTEN00022511G001 GSTEN00023928G001

LCO:	104920226 104922804 104923424 109137688

NCC:	104942313 104944188 104946523

MZE:	101473251 101473715 101478012 101478638 101487569

ONL:	100694176 100695916 100697449 100711807

OLA:	101161025 101165737 101168538 101168781

XMA:	102217447 102227844 102236545 102238412

XCO:	114137160 114143621 114151727 114154755

PRET:

103456554 103467989 103470487 103481623

CVG:	107083821 107088856 107090911 107096473

NFU:	107382814 107387710 107390707 107393785

KMR:	108230360 108236447(ela3l) 108236825 108246171(zgc:112285)

ALIM:

106513350 106516669 106520444 106524183 106524193

AOCE:

111567975 111570764 111570887 111570889 111570891

CSEM:

103377202 103381786 103384941 103384942

POV:	109629854 109630628 109633857 109641409

LCF:	108876367 108878661 108881697 108891700 108891702

SDU:	111219085 111221025 111226691

SLAL:

111656276 111663913 111670778 111673551

HCQ:	109516565 109519497 109525133 109526588

BPEC:

110164381 110168049 110169836 110170022

MALB:

109956964 109961491 109967951 109971177

SASA:

106565388 106572163 106572326 106578915 106580263 106589435

OTW:	112215640 112215949 112215950 112224314 112263152

SALP:

111964772 111966384 111966385 111967815 111977398

ELS:	105013810 105013811 105014497 105026570 114828869

SFM:	108924888 108934871 108938970 108939027

PKI:	111848349 111850281 111859142

LCM:	102347421 102354654 102354909(CTRC) 102355168(CELA2A) 102357388

CMK:	103181342 103182723 103189848 103189849 103189856

RTP:	109910696 109916043 109916045 109918262

SPU:

115928534

DPO:	Dpse_GA23856 Dpse_GA23857

DPE:

6601478

DMN:	108153516 108153517

DWI:

26528921

DGR:	Dgri_GH15024

DMO:	Dmoj_GI26762

DAZ:

108612310

DNV:

108650185

DHE:

111592441

AGA:	AgaP_AGAP001199 AgaP_AGAP006676 AgaP_AGAP006677

AAG:	5564283 5572507

AALB:

109409757 109409762 109432156 109432177

CQU:	CpipJ_CPIJ002142 CpipJ_CPIJ003826

AEC:

105152129

DQU:

106748784

LHU:

105668026

CSOL:

105360105 105360359 105364424 105365014

TCA:	103312384 657370(H116) 659100(Ctlp-6e) 661991(H130)

NVL:

108560204

BMOR:

101737732 101740293

BMAN:

114243670 114246039

DPL:	KGM_204361

PMAC:

106712971

PRAP:

110992777 110992778 110996588 111000016

HAW:	110377034 110377042 110382362

TNL:

113496006

CLEC:

106670539

ZNE:

110830070

DPX:	DAPPUDRAFT_241413 DAPPUDRAFT_26734 DAPPUDRAFT_302578 DAPPUDRAFT_302655 DAPPUDRAFT_332957 DAPPUDRAFT_33543 DAPPUDRAFT_347750(CHY1B) DAPPUDRAFT_48805 DAPPUDRAFT_49170 DAPPUDRAFT_49378

ISC:	IscW_ISCW002675 IscW_ISCW007768

TUT:

107371020

TSP:	Tsp_01067 Tsp_02029a Tsp_09087

HRO:	HELRODRAFT_140768 HELRODRAFT_185617 HELRODRAFT_185618 HELRODRAFT_185620 HELRODRAFT_185899 HELRODRAFT_191905

LGI:	LOTGIDRAFT_108162 LOTGIDRAFT_168364 LOTGIDRAFT_193307 LOTGIDRAFT_196328 LOTGIDRAFT_196330 LOTGIDRAFT_207774 LOTGIDRAFT_95390

CRG:

105317979

MYI:	110442145 110448109 110456806

OBI:	106868563 106873760 106877612 106877618

LAK:	106175901 112041453

NVE:

5504681

EPA:	110234162 110234232 110236062 110242670 110244486 110244502 110253062

ADF:

107331797

AMIL:

114958794 114976349

PDAM:

113668113 113674922 113676511

SPIS:

111328514 111328531 111331013 111341804

DGT:

114529000

HMG:	100201103 100202420 100209272

PVD:	CFBP1590__4963

SSUB:

CP968_01455

» show all

Reference

1 [PMID:3427074]

Authors

Fletcher TS, Shen WF, Largman C

Title

Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA.

Journal

Biochemistry 26:7256-61 (1987)
DOI:10.1021/bi00397a010

Sequence

[hsa:63036]

Reference

2 [PMID:2834346]

Authors

Shirasu Y, Yoshida H, Matsuki S, Takemura K, Ikeda N, Shimada Y, Ozawa T, Mikayama T, Iijima H, Ishida A, et al.

Title

Molecular cloning and expression in Escherichia coli of a cDNA encoding human pancreatic elastase 2.

Journal

J Biochem (Tokyo) 102:1555-63 (1987)
DOI:10.1093/oxfordjournals.jbchem.a122204

Sequence

[hsa:63036] [ssc:397197]

Other DBs

ExplorEnz - The Enzyme Database:

3.4.21.71

IUBMB Enzyme Nomenclature:

3.4.21.71

ExPASy - ENZYME nomenclature database:

3.4.21.71

BRENDA, the Enzyme Database:

3.4.21.71

CAS:	75603-19-9

DBGET integrated database retrieval system