KEGG   ENZYME: 3.4.21.71
Entry
EC 3.4.21.71                Enzyme                                 

Name
pancreatic elastase II;
pancreatic elastase 2
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Preferential cleavage: Leu!, Met! and Phe!. Hydrolyses elastin
Comment
A peptidase of family S1 (trypsin family) formed by activation of proelastase II from mammalian pancreas by trypsin. Usually, only one of the pancreatic elastases (see also EC 3.4.21.36) is expressed in a given species; human pancreatic elastase is of type II
History
EC 3.4.21.71 created 1992
Orthology
K01346  pancreatic elastase II
Genes
HSA: 51032(CELA2B) 63036(CELA2A)
PTR: 469129 747215(CELA2A)
PPS: 100992916(CELA2A) 100993275(CELA2B)
GGO: 101130048 101137272
PON: 100435271 100461933 100462303
NLE: 100596831 100597738
MCC: 100426744 106992406 114674066 114674067 114675932 694691
MCF: 102127568(CELA2A) 102135496(CELA2B) 102139003
CSAB: 103225552(CELA2B) 103247268 103247269
RRO: 104667588 104677706 104677707
CJC: 100395953(CELA2A)
SBQ: 101051841(CELA2A)
MMU: 13706(Cela2a)
MPAH: 110323557
RNO: 24332(Cela2a)
MUN: 110545075
CGE: 100753261
NGI: 103725345
HGL: 101723601(Cela2a)
CCAN: 109692552(Ctrc)
OCU: 100344955(CELA2A)
TUP: 102494723(CELA2A)
BTA: 282687(CELA2A)
BOM: 102279793(CELA2A)
BIU: 109570435
BBUB: 102411682
CHX: 102174414(CELA2A)
OAS: 101111210
SSC: 397197(CELA2A)
CFR: 102519577
CDK: 105107055
BACU: 103001724(CELA2A)
LVE: 103078282(CELA2A)
OOR: 101288479
DLE: 111187065
PCAD: 102975160
ECB: 100050670
EPZ: 103565017(CELA2A)
EAI: 106828007
MYB: 102250420(CELA2A)
MYD: 102759032(CELA2A)
MNA: 107531541
HAI: 109381303
DRO: 112299499
PALE: 102878826
RAY: 107501831
MDO: 100027354(CELA2A) 103094642
SHR: 100922937 100931746(CELA2A)
OAA: 100092350
GGA: 419486(CELA2A)
MGP: 100542763
CJO: 107323376
NMEL: 110408541
APLA: 101794015
ACYG: 106040201
TGU: 100224543
LSR: 116184394
SCAN: 103820951
GFR: 102039268
FAB: 101816473
PMAJ: 107213766
CCAE: 111938716
FCH: 102057855
CLV: 102089151
NNI: 104009005
ACUN: 113477290
AAM: 106482438
DRE: 334304(ela2l) 403061(ela2) 561476(zgc:112285)
AMEX: 103036513 111191974(ctrc)
KMR: 108230360 108236447(ela3l) 108236825 108246171(zgc:112285)
SPU: 115928534
DPE: 6601478
DWI: 26528921
DAZ: 108612310
DNV: 108650185
DHE: 111592441
AEC: 105152129
DQU: 106748784
LHU: 105668026
TCA: 103312384 657370(H116) 659100(Ctlp-6e) 661991(H130)
NVL: 108560204
PMAC: 106712971
TNL: 113496006
CLEC: 106670539
ZNE: 110830070
TUT: 107371020
CRG: 105317979
NVE: 5504681
ADF: 107331797
DGT: 114529000
 » show all
Reference
1  [PMID:3427074]
  Authors
Fletcher TS, Shen WF, Largman C
  Title
Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA.
  Journal
Biochemistry 26:7256-61 (1987)
DOI:10.1021/bi00397a010
  Sequence
[hsa:63036]
Reference
2  [PMID:2834346]
  Authors
Shirasu Y, Yoshida H, Matsuki S, Takemura K, Ikeda N, Shimada Y, Ozawa T, Mikayama T, Iijima H, Ishida A, et al.
  Title
Molecular cloning and expression in Escherichia coli of a cDNA encoding human pancreatic elastase 2.
  Journal
J Biochem (Tokyo) 102:1555-63 (1987)
DOI:10.1093/oxfordjournals.jbchem.a122204
  Sequence
[hsa:63036] [ssc:397197]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.71
IUBMB Enzyme Nomenclature: 3.4.21.71
ExPASy - ENZYME nomenclature database: 3.4.21.71
BRENDA, the Enzyme Database: 3.4.21.71
CAS: 75603-19-9

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