KEGG   ENZYME: 3.4.21.71
Entry
EC 3.4.21.71                Enzyme                                 
Name
pancreatic elastase II;
pancreatic elastase 2
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Preferential cleavage: Leu!, Met! and Phe!. Hydrolyses elastin
Comment
A peptidase of family S1 (trypsin family) formed by activation of proelastase II from mammalian pancreas by trypsin. Usually, only one of the pancreatic elastases (see also EC 3.4.21.36) is expressed in a given species; human pancreatic elastase is of type II
History
EC 3.4.21.71 created 1992
Orthology
K01346  pancreatic elastase II
Genes
HSA51032(CELA2B) 63036(CELA2A)
PTR469129 747215(CELA2A)
PPS100992916(CELA2A) 100993275
GGO101130048 101137272
PON100435271 100461933 100462303
NLE100596831 100597738
MCC100426744 106992406 114674066 114674067 114675932 694691
MCF102127568 102135496
CSAB103225552(CELA2B) 103247268 103247269
CATY105579098 105579099 105579109 105593657 105593662 105593663 105599449
PANU101009233 101009565 101023293 101025653 116271819 116274204
TGE112612484(CELA2B)
RRO104667588 104677706 104677707
RBB108515897 108524251
TFN117093254 117093582
PTEH113222475
CJC100395953(CELA2A)
SBQ101051841(CELA2A)
CSYR103260475 103260481
MMUR105870485
OGA100946264
MMU13706(Cela2a)
MPAH110323557
RNO24332(Cela2a)
MCOC116096968
MUN110545075
CGE100753261
PLEU114700898
NGI103725345
HGL101723601(Cela2a)
CPOC100715239 100715518
CCAN109692552(Ctrc)
DORD105989911
DSP122099137
NCAR124966507
OCU100344955(CELA2A)
OPI101526750
TUP102494723(CELA2A)
BTA282687(CELA2A)
BOM102279793(CELA2A)
BIU109570435
BBUB102411682
CHX102174414(CELA2A)
OAS101111210
ODA120879819
CCAD122451729
SSC397197(CELA2A)
CFR102519577
CBAI105070946(CELA2A)
CDK105107055
VPC102537007
BACU103001724(CELA2A)
LVE103078282(CELA2A)
OOR101288479
DLE111187065
PCAD102975160
PSIU116753406
ECB100050670
EPZ103565017(CELA2A)
EAI106828007
MYB102250420(CELA2A)
MYD102759032(CELA2A)
MMYO118674945
MLF102427918
MNA107531541
PKL118724636
HAI109381303
DRO112299499
SHON118986320
AJM119049965
PDIC114497622
PHAS123832341
MMF118626829
RFQ117027312
PALE102878826
PGIG120585784
PVP105294413
RAY107501831
TOD119236048(CELA2A)
SARA101537532
LAV100656878 100657159
TMU101361674 101361929
DNM101432071
MDO100027354(CELA2A) 103094642
GAS123234307 123243103
SHR100922937 100931746(CELA2A)
PCW110197911 110215486
OAA100092350
GGA419486(CELA2A)
PCOC116242535
MGP100542763
CJO107323376
NMEL110408541
APLA101794015
ACYG106040201
AFUL116497749
TGU100224543
LSR116184394
SCAN103820951
PMOA120496764
OTC121343925
PRUF121358455
GFR102039268
FAB101816473
PMAJ107213766
CCAE111938716
ETL114056912 114069649
ZAB102072083
FPG101912600 101922358
FCH102057855
CLV102089151
EGZ104130990 104133141
NNI104009005
ACUN113477290
PADL103916503 103918048 103925859
ACHC115343154
AAM106482438
AROW112970044
NPD112959584
DNE112980578
ASN102386889 112551217
AMJ102575615 109285594
CPOO109314515 109324340
GGN109287308 109293561
PSS102455016 102464019 112545378
CMY102934019 102934278 102939967 102940188
CPIC101944818 101945103 101949408
TST117879757
CABI116824357(CELA2A) 116838985
MRV120387762 120387839 120388015 120409021
ACS103279429 103279433
PVT110072620 110080727
SUND121925880 121936188(CELA2A)
VKO123018203 123034719
PMUA114596795 114602392 114602395
ZVI118087164 118096145
GJA107114248 107124392
XLA108696870 108703379 380555(cela2a.L) 444404(cela2al.L)
XTR100497505 100498609 101734343 116412071 594883(cela2a)
NPR108788616 108797189 108797195
RTEM120909094 120916256 120916257 120916259
BBUF120986821 121004751
BGAR122942421
DRE334304(ela2l) 403061(ela2) 561476(zgc:112285)
SRX107724515 107731135 107731136 107731230 107736286 107744466 107745782 107745828 107749850 107752511
SANH107667984 107668061 107672799 107684136 107690926 107695279
SGH107549241 107555594 107592405 107601431
CCAR109061958 109073568 109100233
CAUA113049896 113107213 113107214 113111679
IPU100528918(ela2l) 108255755(ela3l) 108266055 108271428 108273558(zgc:112285)
PHYP113526964 113527680 113530458 113530463 113542213
SMEO124380292(ela3l) 124385304 124388844(zgc:112285) 124399937 124399938
TFD113638377(ela3l) 113639023(zgc:112285) 113644565 113655917 113655918(ela2l)
AMEX103036513 111191974(ctrc)
EEE113577634 113581091
TRU101064638 101066013 101069212 101069442 101074248 101077973
TNGGSTEN00013062G001 GSTEN00013240G001 GSTEN00016377G001 GSTEN00022509G001 GSTEN00022511G001 GSTEN00023928G001
LCO104920226 104922804 104923424 109137688
NCC104942313 104944188 104946523
CGOB115010820 115010931 115013409 115025765
ELY117247654(zgc:112285) 117252207(ela3l) 117264922 117271048 117271057 117271067
PLEP121944871(ela3l) 121947118 121947119 121947120 121958453(zgc:112285) 121960734
SLUC116040882 116040883 116040884 116054425(ela3l) 116061243(zgc:112285) 116067140
ECRA117936458(zgc:112285) 117944455(ela3l) 117947340 117947341
PFLV114548686 114549505 114555652 114558292 114558293 114558544
GAT120819730(zgc:112285) 120829024 120829026(ela2) 120829027(ela2l) 120830624(ela3l)
PPUG119213113(zgc:112285) 119223259(ela2l) 119223584 119225658(ela3l)
MSAM119891992(ela3l) 119905644(ela2) 119910347 119916600(zgc:112285)
CUD121509293(ela3l) 121517529 121518193 121518194 121528833(zgc:112285)
MZE101473251 101473715 101478012 101478638 101487569
ONL100694176 100695916 100697449 100711807
OAU116309720(ela2) 116313924(ela3l) 116314519 116325983(zgc:112285)
OLA101161025 101165737 101168538 101168781
OML112147967(ela3l) 112153994(zgc:112285) 112159391(ela2) 112159392(ela2l)
XMA102217447 102227844 102236545 102238412
XCO114137160 114143621 114151727 114154755
XHE116712218 116725609 116725616 116726614 116729301
PRET103456554 103467989 103470487 103481623
PFOR103138962 103138963 103138964 103145530 103151173
PLAI106938996 106941809 106958773 106958778 106958779
PMEI106921045 106928039 106928959 106932462 106932463 106932464
GAF122822852(zgc:112285) 122824575 122827985(ela3l) 122836339(ela2) 122836456(ela2l)
CVG107083821 107088856 107090911 107096473
CTUL119776403(ela3l) 119788911 119797039 119797048 119799081(zgc:112285)
GMU124874980 124874986 124875059 124875720 124875738(zgc:112285) 124877741(ela3l)
NFU107382814 107387710 107390707 107393785
KMR108230360 108236447(ela3l) 108236825 108246171(zgc:112285)
ALIM106513350 106516669 106520444 106524183 106524193
NWH119413457(ela3l) 119417672 119417673(ela2l) 119423757(zgc:112285) 119426567
AOCE111567975 111570764 111570887 111570889 111570891
CSEM103377202 103381786 103384941 103384942
POV109629854 109630628 109633857 109641409
SSEN122758991(zgc:112285) 122769132(ela3l) 122777417 122777418
HHIP117753100(zgc:112285) 117753807 117764675 117764676 117764686(ela2) 117767459(ela3l)
LCF108876367 108878661 108881697 108891700 108891702
SDU111219085 111221025 111226691
SLAL111656276 111663913 111670778 111673551
XGL120790200 120794819(zgc:112285) 120803676 120803677 120805316(ela3l)
HCQ109516565 109519497 109525133 109526588
BPEC110164381 110168049 110169836 110170022
MALB109956964 109961491 109967951 109971177
SASA106565388 106572163 106572326 106578915 106580263 106589435
OTW112215640 112215949(ela2) 112215950(ela2l) 112224314(zgc:112285) 112263152(ela3l)
OMY110494144 110498942(zgc:112285) 110532205(ela2) 110532206(ela2l) 110535808(ela3l) 118939489
OGO124031873(ela2) 124031874(ela2l) 124036096(ela3l) 124040071 124047551
ONE115132086 115132087 115143016
SALP111964772 111966384 111966385 111967815 111977398
SNH120025736 120029806 120045340 120058943(ela2l) 120058945 120062690(ela3l)
ELS105013810 105013811 105014497 105026570 114828869
SFM108924888 108934871 108938970 108939027
PKI111848349 111850281 111859142
AANG118208161(ela2) 118208162(ela2l) 118217630(zgc:112285) 118237361(ela3l)
LOC102688573 102693925 107075529 107079261
PSPA121313743 121326226(zgc:112285) 121329402
ARUT117403763 117404100 117418129(zgc:112285)
LCM102347421 102354654 102354909(CTRC) 102355168(CELA2A) 102357388
CMK103181342 103182723(zgc:112285) 103189848 103189849 103189856
RTP109910696 109916043 109916045 109918262
SPU115928534
DPODpse_GA23856 Dpse_GA23857
DPE6601478
DMN108153516 108153517
DWI26528921
DMODmoj_GI26762
DAZ108612310
DNV108650185
DHE111592441
AGAAgaP_AGAP001199 AgaP_AGAP006676 AgaP_AGAP006677
ACOZ120952102 120953076
AARA120901423
AAG5564283 5572507
AALB109409757 109409762 109432156 109432177
CQUCpipJ_CPIJ002142 CpipJ_CPIJ003826
CPII120428405
AEC105152129
DQU106748784
LHU105668026
CSOL105360359 105364424 105365014
TPRE106651993 106658267
DAM107036298
TCA103312384 659100(Ctlp-6e) 661991(H130)
AGB108917979
PPYR116168969 116169276
OTU111426624
BMOR101737732 101740293
BMAN114243670
MSEX115440938
DPLKGM_204361
BANY112043360 112043589 112045195 112047002 112055770 112055771
PMAC106712971
PPOT106106913 106109985 106110048
PXU106118722 106128847
ZCE119839809
HAW110377034 110377042 110382362
TNL113496006
PXY105381831 105381832 105381834 105383918 105385111 105390669 105390670 105390678 105390679 105390680 105390681 105390925 105391007 105391644 105392565 105392566 105392860 105392867 105393240 105397429
CLEC106670539
HHAL106691758
ZNE110830070
DPXDAPPUDRAFT_241413 DAPPUDRAFT_26734 DAPPUDRAFT_302578 DAPPUDRAFT_302655 DAPPUDRAFT_332957 DAPPUDRAFT_33543 DAPPUDRAFT_347750(CHY1B) DAPPUDRAFT_48805 DAPPUDRAFT_49170 DAPPUDRAFT_49378
DMK116920685 116927108 116929460
PJA122262223
PCHN125038669 125044405
PCLA123768845
PTRU123508912 123520699
HAZT108671696
EAF111709850
ISCIscW_ISCW002675 IscW_ISCW007768
DSV119456536
RSAN119377010 119390732 119393119
RMP119164447 119164931 119171374
VDE111254487
VJA111267216
TUT107371020
DFR124496277
SDM118181214
TSPTsp_01067 Tsp_02029a Tsp_09087
HROHELRODRAFT_140768 HELRODRAFT_185617 HELRODRAFT_185618 HELRODRAFT_185620 HELRODRAFT_185899 HELRODRAFT_191905
LGILOTGIDRAFT_108162 LOTGIDRAFT_168364 LOTGIDRAFT_193307 LOTGIDRAFT_196328 LOTGIDRAFT_196330 LOTGIDRAFT_207774 LOTGIDRAFT_95390
BGT106050318 106078970 106079969
GAE121379504 121389078
HRF124125092 124140826
HRJ124265389 124292227
CRG117681655
MYI110442145 110448109 110456806
MMER123558625 123558777
OBI106868563 106873760 106877612 106877618
LAK106175901 112041453
NVE5504681
EPA110234162 110234232 110236062 110242670 110244486 110244502 110253062
ATEN116292337 116294930 116302839 116303098 116305519 116305895
ADF107331797
AMIL114958794 114976349
PDAM113668113 113674922 113676511
SPIS111328514 111328531 111331013 111341804
DGT114529000
HMG100201103 100202420 100209272
PVDCFBP1590__4963
SSUBCP968_01455
STSUB7R87_11780
 » show all
Reference
1  [PMID:3427074]
  Authors
Fletcher TS, Shen WF, Largman C
  Title
Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA.
  Journal
Biochemistry 26:7256-61 (1987)
DOI:10.1021/bi00397a010
  Sequence
[hsa:63036]
Reference
2  [PMID:2834346]
  Authors
Shirasu Y, Yoshida H, Matsuki S, Takemura K, Ikeda N, Shimada Y, Ozawa T, Mikayama T, Iijima H, Ishida A, et al.
  Title
Molecular cloning and expression in Escherichia coli of a cDNA encoding human pancreatic elastase 2.
  Journal
J Biochem (Tokyo) 102:1555-63 (1987)
DOI:10.1093/oxfordjournals.jbchem.a122204
  Sequence
[hsa:63036] [ssc:397197]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.71
IUBMB Enzyme Nomenclature: 3.4.21.71
ExPASy - ENZYME nomenclature database: 3.4.21.71
BRENDA, the Enzyme Database: 3.4.21.71
CAS: 75603-19-9

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