KEGG   ENZYME: 3.4.21.73
Entry
EC 3.4.21.73                Enzyme                                 
Name
u-plasminogen activator;
urokinase;
urinary plasminogen activator;
cellular plasminogen activator;
urokinase-type plasminogen activator;
double-chain urokinase-type plasminogen activator;
two-chain urokinase-type plasminogen activator;
urokinase plasminogen activator;
uPA;
u-PA;
abbokinase;
urinary esterase A
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Specific cleavage of Arg!Val bond in plasminogen to form plasmin
Comment
Formed from the inactive precursor by action of plasmin or plasma kallikrein. Differs in structure from t-plasminogen activator (EC 3.4.21.68), and does not bind to fibrin. In peptidase family S1 (trypsin family). Formerly included in EC 3.4.21.31 and EC 3.4.99.26
History
EC 3.4.21.73 created 1972 as EC 3.4.99.26, transferred 1978 as EC 3.4.21.31, part transferred 1992 to EC 3.4.21.73
Orthology
K01348  urokinase plasminogen activator
Genes
HSA5328(PLAU)
PTR738078(PLAU)
PPS100983615(PLAU)
GGO101137500(PLAU)
PON100171578(PLAU)
NLE100581844(PLAU)
MCC705853(PLAU)
MCF102135886(PLAU)
CSAB103215983(PLAU)
CATY105597347(PLAU)
PANU101018115(PLAU)
TGE112631372(PLAU)
RRO104669975(PLAU)
RBB108516897(PLAU)
TFN117082114(PLAU)
PTEH111537839(PLAU)
CJC100411934(PLAU)
SBQ101045946(PLAU)
CSYR103271491(PLAU)
MMUR105868905(PLAU)
LCAT123650284(PLAU)
OGA100942138(PLAU)
MMU18792(Plau)
MCAL110309656(Plau)
MPAH110325641(Plau)
RNO25619(Plau)
MCOC116085054(Plau)
MUN110552013(Plau)
CGE100759384(Plau)
MAUA101830372(Plau)
PLEU114700209(Plau)
MORG121438633(Plau)
AAMP119800125(Plau)
NGI103736932(Plau)
HGL101717852(Plau)
CPOC100726129(Plau)
CCAN109685905(Plau)
DORD105992685(Plau)
DSP122116568(Plau)
NCAR124984940
OCU100008633(PLAU)
OPI101520813(PLAU)
TUP102472140(PLAU)
CFA403426(PLAU)
CLUD112651515(PLAU)
VVP112924613(PLAU)
VLG121488315(PLAU)
AML100481924(PLAU)
UMR103667835(PLAU)
UAH113259193(PLAU)
UAR123783022(PLAU)
ELK111144976
LLV125084356
MPUF101680648(PLAU)
ORO101369444(PLAU)
EJU114214232(PLAU)
ZCA113923914(PLAU)
MLX118021790(PLAU)
FCA101098338(PLAU)
PYU121036806(PLAU)
PBG122493469(PLAU)
PTG102957275(PLAU)
PPAD109264427(PLAU)
AJU106970985(PLAU)
HHV120233712(PLAU)
BTA281408(PLAU)
BOM102278255(PLAU)
BIU109553885(PLAU)
BBUB102406987(PLAU)
CHX102188193(PLAU)
OAS100302501(PLAU)
ODA120865293(PLAU)
CCAD122446374(PLAU)
SSC396985(PLAU)
CFR102515549(PLAU)
CBAI105075359(PLAU)
CDK105092451(PLAU)
VPC102539887(PLAU)
BACU103005948(PLAU)
LVE103068670(PLAU)
OOR101281249(PLAU)
DLE111183533(PLAU)
PCAD102994257(PLAU)
PSIU116741565(PLAU)
ECB100072886(PLAU)
EPZ103549468(PLAU)
EAI106843544(PLAU)
MYB102249219(PLAU)
MYD102757224(PLAU)
MMYO118670162(PLAU)
MLF102436980(PLAU)
MNA107545793(PLAU)
PKL118719125(PLAU)
HAI109371644(PLAU)
DRO112305567(PLAU)
SHON118993498(PLAU)
AJM119038163(PLAU)
PDIC114497475(PLAU)
PHAS123820826(PLAU)
MMF118632750(PLAU)
RFQ117035764(PLAU)
PALE102880095(PLAU)
PGIG120609551(PLAU)
PVP105288867(PLAU)
RAY107498139(PLAU)
MJV108398766(PLAU)
TOD119234238(PLAU)
SARA101541986(PLAU)
LAV100666634(PLAU)
TMU101350586
DNM101426381(PLAU)
MDO100617123(PLAU)
GAS123236414(PLAU)
SHR100918318(PLAU)
PCW110221495(PLAU)
OAA100079618(PLAU)
GGA396424(PLAU)
PCOC116235082(PLAU)
MGP100541361(PLAU)
CJO107315813(PLAU)
NMEL110400516(PLAU)
APLA101804552(PLAU)
ACYG106033144(PLAU)
AFUL116491404(PLAU)
TGU100228975(PLAU)
LSR110480760(PLAU)
SCAN103813999(PLAU)
PMOA120510965(PLAU)
OTC121336169(PLAU)
PRUF121358165(PLAU)
GFR102037027(PLAU)
FAB101812573(PLAU)
PHI102104449(PLAU)
PMAJ107206512(PLAU)
CCAE111931068(PLAU)
CCW104697483(PLAU)
CBRC103623707(PLAU)
ETL114058134(PLAU)
ZAB102073101(PLAU)
ACHL103797327
FPG101915545(PLAU)
FCH102057824(PLAU)
CLV102086705(PLAU)
EGZ104129010(PLAU)
NNI104020231(PLAU)
PLET104622846(PLAU)
PCRI104035175
ACUN113481574(PLAU)
TALA104359559(PLAU)
PADL103915585(PLAU)
ACHC115348368(PLAU)
HALD104323113
CCRI104161317
CSTI104559520
EHS104504556
CMAC104474685(PLAU)
MUI104548046(PLAU)
FGA104071211(PLAU)
GSTE104252180
LDI104341335(PLAU)
MNB103781076(PLAU)
OHA104335779(PLAU)
AAM106498899(PLAU)
AROW112961025(PLAU)
NPD112951942(PLAU)
DNE112980210(PLAU)
ASN102383006(PLAU)
AMJ102566397(PLAU)
CPOO109324282(PLAU)
GGN109287378(PLAU)
PSS102453835(PLAU)
CMY102933029(PLAU)
CPIC101946783(PLAU)
TST117880753(PLAU)
CABI116831919 116834393
MRV120409092(PLAU)
ACS100552401(plau)
PVT110077791(PLAU)
SUND121927223(PLAU)
PBI103060492
PMUR107287900(PLAU)
TSR106547033(PLAU)
PGUT117676141(PLAU)
VKO123018271(PLAU)
PMUA114597038(PLAU)
ZVI118096475(PLAU)
GJA107113226(PLAU)
STOW125437284(PLAU)
NPR108792944(PLAU)
RTEM120910440(PLAU)
BBUF121005132(PLAU)
DRE100538108(plaub)
SRX107718672 107726940 107743511 107748204
SANH107655433 107659683 107666402 107676428
SGH107595214(plau) 107597759 107601811
CCAR109093886 109100493
CAUA113055804 113055886 113057530 113081403 113112702
PPRM120461960(plaub)
MAMB125255877(plaub)
IPU108262743(plaua)
PHYP113543673(plau)
AMEX103030863 103033735
EEE113582074(plau)
TRU101066245 101068458
TNGGSTEN00030653G001
LCO104929214 104930408
NCC104961344
CGOB115019954(plau) 115024771
ELY117247014(plaub) 117248708(plaua)
EFO125880657(plaub) 125903528(plaua)
PLEP121954773(plaua) 121958918(plaub) 121964012
SLUC116053119(plaua) 116061480(plaub)
ECRA117937087(plaub) 117960235(plaua)
ESP116671705 116705535(plau)
PFLV114548330 114572274(plau)
GAT120819437 120820630
PPUG119213010 119213741(plaua)
MSAM119915402(plaub) 119917749
CUD121511370 121528770(plaub)
ALAT119009318(plaub) 119033661
MZE101473472 101487380(plau)
ONL100693142(plau) 100693623
OAU116322772(plaua) 116328609(plaub)
OLA100529199(plau) 101167229(plau)
OML112153926(plaub) 112162022(plaua)
XMA102224115 102225828(plau)
XCO114137431(plau) 114152362
XHE116712564(plau) 116727622
PRET103476977 103481601
PFOR103134048 103150898
PLAI106935138 106944819(plau)
PMEI106915154 106917278
GAF122822892(plaub) 122842305
CVG107086593(plau) 107101847
CTUL119775919(plaub) 119790671(plaua)
GMU124858719(plaua) 124875389(plaub)
NFU107375597(plau)
KMR108234023 108248995(plaub)
ALIM106522009 106527119(plau)
NWH119426767
AOCE111571761 111581413(plau)
MCEP125018981(plaua) 125022591
CSEM103382392 103387402
POV109631675 109642514
SSEN122759412(plaub) 122781554(plaua)
HHIP117753133(plaub) 117775989(plaua)
HSP118100651(plaub) 118118678(plaua)
LCF108891091 108891981
SDU111220056 111234617(plau)
SLAL111658190(plau) 111664325
XGL120794434(plaub) 120796073
HCQ109516284(plau) 109518538
BPEC110157185(plau) 110160428
MALB109961193 109962715
BSPL114841773(plaua)
SASA106589884(plau)
OTW112236268(plaub)
OMY110499464(plaub)
OGO124039385(plaub)
ONE115144458(plau)
SALP111968170(plau)
SNH120029718(plaub)
CCLU121548044 121568285
ELS105010681 105027399
SFM108942714(plau)
PKI111836766(plau) 111850383
AANG118218073 118221410
LOC102691540(plau)
PSPA121321543 121326039
ARUT117415187 117417693
LCM102366984(PLAU)
NVI103317625
FOC113203387
TPAL117650759
LSM121117979
PPOI119113947
 » show all
Reference
1  [PMID:6210826]
  Authors
Lottenberg R, Christensen U, Jackson CM, Coleman PL.
  Title
Assay of coagulation proteases using peptide chromogenic and fluorogenic substrates.
  Journal
Methods Enzymol 80 Pt C:341-61 (1981)
DOI:10.1016/s0076-6879(81)80030-4
Reference
2  [PMID:3148826]
  Authors
Loskutoff DJ, Schleef RR.
  Title
Plasminogen activators and their inhibitors.
  Journal
Methods Enzymol 163:293-302 (1988)
DOI:10.1016/0076-6879(88)63028-x
Reference
3  [PMID:3143380]
  Authors
Saksela O, Rifkin DB.
  Title
Cell-associated plasminogen activation: regulation and physiological functions.
  Journal
Annu Rev Cell Biol 4:93-126 (1988)
DOI:10.1146/annurev.cb.04.110188.000521
Reference
4
  Authors
Collen, D., Lijnen, H. R. and Verstraete, M.
  Title
The fibrinolytic system and its disorders.
  Journal
In: Handin, R.I., Lux, S.E. and Stossel, J.P. (Eds.), Blood: Principles and Practice of Hematology, 2nd ed., J.B.Lippincott Company, Philadelphia, 1990
Reference
5  [PMID:1969415]
  Authors
Lijnen HR, Van Hoef B, Nelles L, Collen D.
  Title
Plasminogen activation with single-chain urokinase-type plasminogen activator (scu-PA). Studies with active site mutagenized plasminogen (Ser740----Ala) and plasmin-resistant scu-PA (Lys158----Glu).
  Journal
J Biol Chem 265:5232-6 (1990)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.73
IUBMB Enzyme Nomenclature: 3.4.21.73
ExPASy - ENZYME nomenclature database: 3.4.21.73
BRENDA, the Enzyme Database: 3.4.21.73
CAS: 9039-53-6

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