KEGG   ENZYME: 3.4.21.74
Entry
EC 3.4.21.74                Enzyme                                 
Name
venombin A;
alpha-fibrinogenase;
habutobin;
zinc metalloproteinase Cbfib1.1;
zinc metalloproteinase Cbfib1.2;
zinc metalloproteinase Cbfib2;
ancrod;
(see also Comments)
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Selective cleavage of Arg! bond in fibrinogen, to form fibrin, and release fibrinopeptide A. The specificity of further degradation of fibrinogen varies with species origin of the enzyme
Comment
A somewhat thrombin-like enzyme from venoms of snakes of the viper/rattlesnake group. Species variants of the enzyme include ancrod from Agkistrodon rhodostoma (Malayan pit viper) (formerly EC 3.4.21.28) [1], batroxobin from Bothrops atrox (South American pit viper) (formerly EC 3.4.21.29) [2,5] and crotalase from Crotalus adamanteus (Eastern diamondback rattlesnake) (formerly EC 3.4.21.30) [3,4]. In peptidase family S1 (trypsin family). Does not require activation by Ca2+.
History
EC 3.4.21.74 created 1992 (EC 3.4.21.28, EC 3.4.21.29 and 3.4.21.30 all created 1978 and incorporated 1992)
Orthology
K20137  venombin A
Reference
1  [PMID:1011992]
  Authors
Nolan C, Hall LS, Barlow GH.
  Title
Ancrod, the coagulating enzyme from Malayan pit viper (Agkistrodon rhodostoma) venom.
  Journal
Methods Enzymol 45:205-13 (1976)
DOI:10.1016/S0076-6879(76)45020-6
Reference
2  [PMID:1011993]
  Authors
Stocker K, Barlow GH
  Title
The coagulant enzyme from Bothrops atrox venom (batroxobin).
  Journal
Methods Enzymol 45:214-23 (1976)
DOI:10.1016/S0076-6879(76)45021-8
Reference
3  [PMID:7043462]
  Authors
Markland FS, Kettner C, Schiffman S, Shaw E, Bajwa SS, Reddy KN, Kirakossian H, Patkos GB, Theodor I, Pirkle H.
  Title
Kallikrein-like activity of crotalase, a snake venom enzyme that clots fibrinogen.
  Journal
Proc Natl Acad Sci U S A 79:1688-92 (1982)
DOI:10.1073/pnas.79.6.1688
Reference
4  [PMID:2934864]
  Authors
Simmons G, Bundalian M, Theodor I, Martinoli J, Pirkle H.
  Title
Action of crotalase, an enzyme with thrombin-like and kallikrein-like specificities, on tripeptide nitroanilide derivatives.
  Journal
Thromb Res 40:555-61 (1985)
DOI:10.1016/0049-3848(85)90292-0
Reference
5  [PMID:3163691]
  Authors
Itoh N, Tanaka N, Funakoshi I, Kawasaki T, Mihashi S, Yamashina I
  Title
Organization of the gene for batroxobin, a thrombin-like snake venom enzyme. Homology with the trypsin/kallikrein gene family.
  Journal
J Biol Chem 263:7628-31 (1988)
  Sequence
[ag:AAA48552]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.74
IUBMB Enzyme Nomenclature: 3.4.21.74
ExPASy - ENZYME nomenclature database: 3.4.21.74
BRENDA, the Enzyme Database: 3.4.21.74
CAS: 146240-35-9

  All links  
Protein sequence (26)   
   UniProt (14)   
   SWISS-PROT (10)   
   PDBSTR (2)   
DNA sequence (9)   
   GenBank (5)   
   EMBL (4)   
3D Structure (2)   
   PDB (2)   
Protein domain (6)   
   InterPro (6)   
All databases (43)   

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