Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy

Selective cleavage of Arg! bond in fibrinogen, to form fibrin, and release fibrinopeptide A. The specificity of further degradation of fibrinogen varies with species origin of the enzyme

A somewhat thrombin-like enzyme from venoms of snakes of the viper/rattlesnake group. Species variants of the enzyme include ancrod from Agkistrodon rhodostoma (Malayan pit viper) (formerly EC 3.4.21.28) [1], batroxobin from Bothrops atrox (South American pit viper) (formerly EC 3.4.21.29) [2,5] and crotalase from Crotalus adamanteus (Eastern diamondback rattlesnake) (formerly EC 3.4.21.30) [3,4]. In peptidase family S1 (trypsin family). Does not require activation by Ca2+

EC 3.4.21.74 created 1992 (EC 3.4.21.28, EC 3.4.21.29 and 3.4.21.30 all created 1978 and incorporated 1992)

1  [PMID:1011992]

Nolan C, Hall LS, Barlow GH.

Ancrod, the coagulating enzyme from Malayan pit viper (Agkistrodon rhodostoma) venom.

Methods Enzymol 45:205-13 (1976)
DOI:10.1016/S0076-6879(76)45020-6

2  [PMID:1011993]

Stocker K, Barlow GH

The coagulant enzyme from Bothrops atrox venom (batroxobin).

Methods Enzymol 45:214-23 (1976)
DOI:10.1016/S0076-6879(76)45021-8

3  [PMID:7043462]

Markland FS, Kettner C, Schiffman S, Shaw E, Bajwa SS, Reddy KN, Kirakossian H, Patkos GB, Theodor I, Pirkle H.

Kallikrein-like activity of crotalase, a snake venom enzyme that clots fibrinogen.

Proc Natl Acad Sci U S A 79:1688-92 (1982)
DOI:10.1073/pnas.79.6.1688

4  [PMID:2934864]

Simmons G, Bundalian M, Theodor I, Martinoli J, Pirkle H.

Action of crotalase, an enzyme with thrombin-like and kallikrein-like specificities, on tripeptide nitroanilide derivatives.

Thromb Res 40:555-61 (1985)
DOI:10.1016/0049-3848(85)90292-0

5  [PMID:3163691]

Itoh N, Tanaka N, Funakoshi I, Kawasaki T, Mihashi S, Yamashina I

Organization of the gene for batroxobin, a thrombin-like snake venom enzyme. Homology with the trypsin/kallikrein gene family.

J Biol Chem 263:7628-31 (1988)

[ag:AAA48552]