KEGG   ENZYME: 3.4.21.75
Entry
EC 3.4.21.75                Enzyme                                 
Name
furin;
prohormone convertase;
dibasic processing enzyme;
PACE;
paired basic amino acid cleaving enzyme;
paired basic amino acid converting enzyme;
serine proteinase PACE;
PC1;
SPC3;
proprotein convertase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg! bonds, where Xaa can by any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors
Comment
One of a group of peptidases in peptidase family S8 (subtilisin family) that is structurally and functionally similar to kexin. All are activated by Ca2+, contain Cys near the active site His, and are inhibited by p-mercuribenzoate. At least three related enzymes are recognized in mammals: PC2, PC3 and PC4, which have somewhat different specificities
History
EC 3.4.21.75 created 1993
Orthology
K01349  furin
Genes
HSA5045(FURIN)
PTR453652(FURIN)
PPS100978848(FURIN)
GGO101128325(FURIN)
PON100448725(FURIN)
NLE100591992(FURIN)
MCC715813(FURIN)
MCF102120129(FURIN)
CSAB103231185(FURIN)
CATY105601194(FURIN)
PANU101021519(FURIN)
TGE112629017(FURIN)
RRO104679270(FURIN)
RBB108517214(FURIN)
TFN117070198(FURIN)
PTEH111528632(FURIN)
CJC100396662(FURIN)
SBQ101030569(FURIN)
CSYR103251653(FURIN)
MMUR105870601(FURIN)
LCAT123645109(FURIN)
OGA100958786(FURIN)
MMU18550(Furin)
MCAL110297474(Furin)
MPAH110322269(Furin)
RNO54281(Furin)
MCOC116102464(Furin)
MUN110553377 110553378
CGE100682534(Furin)
MAUA101829993(Furin)
PLEU114696194(Furin)
MORG121446377(Furin)
AAMP119802618(Furin)
NGI103749884(Furin)
HGL101717888(Furin)
CPOC100733158(Furin)
CCAN109695073(Furin)
DORD105982491(Furin)
DSP122099997(Furin)
NCAR124975998
OCU100009442(FURIN)
OPI101523815(FURIN)
TUP102470724(FURIN)
CFA488746(FURIN)
CLUD112653367(FURIN)
VVP112921462(FURIN)
VLG121489653(FURIN)
AML100475645(FURIN)
UMR103660267(FURIN)
UAH113263719(FURIN)
UAR123802412(FURIN)
ELK111152580
LLV125103772
MPUF101673024(FURIN)
ORO101370688(FURIN)
EJU114223280(FURIN)
ZCA113909113(FURIN)
MLX118023076(FURIN)
FCA101100308(FURIN)
PYU121042357(FURIN)
PBG122467535(FURIN)
PTG102959189(FURIN)
PPAD109273473(FURIN)
AJU106965942(FURIN)
HHV120249114(FURIN)
BTA281374(FURIN)
BOM102282121(FURIN)
BIU109575483(FURIN)
BBUB102395744(FURIN)
CHX102187990(FURIN)
OAS780454(FURIN)
ODA120875590(FURIN)
CCAD122455062(FURIN)
SSC100156882(FURIN)
CFR102513312(FURIN)
CBAI105069083(FURIN)
CDK105094698(FURIN)
VPC102540850(FURIN)
BACU103020203(FURIN)
LVE103076349(FURIN)
OOR101273219(FURIN)
DLE111169652(FURIN)
PCAD102996841(FURIN)
PSIU116747533(FURIN)
ECB100068931(FURIN)
EPZ103546212(FURIN)
EAI106832050(FURIN)
MYB102239137(FURIN)
MYD102765324(FURIN)
MMYO118679174(FURIN)
MNA107540400(FURIN)
PKL118706309(FURIN)
HAI109381481(FURIN)
DRO112305946(FURIN)
SHON118991945(FURIN)
AJM119052126(FURIN)
PDIC114488523(FURIN)
PHAS123809612(FURIN)
MMF118640825(FURIN)
RFQ117018737(FURIN)
PALE102887466(FURIN)
PGIG120599247(FURIN)
PVP105302881(FURIN)
RAY107514136(FURIN)
MJV108385790(FURIN)
TOD119244242(FURIN)
SARA101539982(FURIN)
LAV100670249(FURIN)
TMU101356016
DNM101415570(FURIN)
MDO100014434(FURIN)
GAS123238107(FURIN)
SHR100921198(FURIN)
PCW110193651(FURIN)
OAA100681855(FURIN)
GGA395457(FURIN)
PCOC116225533(FURIN)
MGP100551066(FURIN)
CJO107318976(FURIN)
NMEL110403724(FURIN)
APLA101790528(FURIN)
ACYG106048640(FURIN)
AFUL116493727(FURIN)
TGU100220259(FURIN)
LSR110476671(FURIN)
SCAN103816136(FURIN)
PMOA120509005(FURIN)
OTC121343676(FURIN)
PRUF121352262(FURIN)
GFR102041810(FURIN)
FAB101807647(FURIN)
PHI102101328(FURIN)
PMAJ107209435(FURIN)
CCAE111933939(FURIN)
CCW104683851(FURIN)
CBRC103618807(FURIN)
ETL114064267(FURIN)
ZAB102070919(FURIN)
FPG101912812(FURIN)
FCH102047991(FURIN)
CLV102090604(FURIN)
EGZ104125996(FURIN)
NNI104017020(FURIN)
ACUN113484039(FURIN)
TALA116958969(FURIN)
PADL103914782(FURIN)
ACHC115341756(FURIN)
AAM106491445(FURIN) 106491446 106498806(DHODH)
AROW112976290(FURIN)
NPD112948343(FURIN)
DNE112994990(FURIN)
ASN102382421(FURIN)
AMJ102566936
CMY102933713(FURIN)
CPIC101931781(FURIN)
TST117883876(FURIN)
CABI116833015(FURIN)
MRV120373498(FURIN)
ACS100551704(furin)
PVT110084442
SUND121933222(FURIN)
PBI103051998(FURIN)
PMUR107289799(FURIN)
TSR106553799(FURIN)
PGUT117676228(FURIN)
VKO123030718(FURIN)
PMUA114584357(FURIN)
ZVI118093217(FURIN)
GJA107109710(FURIN)
STOW125424690(FURIN)
XLA397747(furin.S) 398345(furin.L)
XTR100327238(furin)
NPR108799145(FURIN)
RTEM120931241(FURIN)
BBUF120985900(FURIN)
BGAR122927554(FURIN)
DRE566557(furina) 566591(furinb)
SRX107720773 107733942 107737005 107750721
SANH107662279 107670216 107673235(furin) 107685214
SGH107564611 107578911 107581806 107594731 107600744
CCAR109045813 109051091 109058346
CAUA113051979 113066714 113098354 113105574
PPRM120468220(furinb) 120469859(furina)
MAMB125246722(furinb) 125264432(furina)
IPU108270701(furina) 108274716(furinb)
PHYP113529949 113536428
SMEO124391538(furina) 124392804(furinb)
TFD113653066(furina) 113660005(furinb)
AMEX103024357 103043208
EEE113573922 113588517 113589159
TRU101061571 101078322
TNGGSTEN00017671G001 GSTEN00022836G001
LCO104925266(furin) 104927319
NCC104944022(furin)
CGOB115004588 115009375(furin)
ELY117254385(furina) 117262740(furinb)
EFO125887441(furinb) 125898783(furina)
PLEP121950052(furinb) 121957430(furina)
SLUC116038294(furinb) 116060658(furina)
ECRA117948702(furinb) 117949039(furina)
PFLV114554240 114559648(furin)
GAT120809446(furinb) 120833511(furina)
PPUG119195579(furinb) 119199036(furina)
MSAM119890467(furina) 119893111(furinb)
CUD121510938(furina) 121514668(furinb)
ALAT119017797(furina) 119024920(furinb)
MZE101479014 101482852(furin)
ONL100705046 100709405(furin)
OAU116335380(furinb) 116335756(furina)
OLA100049240 101158353(furin)
OML112152324(furinb) 112161061(furina)
XMA102222459 102231939(furin)
XCO114142600 114155117(furin)
XHE116718381 116733882(furin)
PRET103462559 103466119(furin)
PFOR103133656(furin) 103136585
PLAI106945049(furin) 106948985
PMEI106921969 106927547(furin)
GAF122835572(furinb) 122843218(furina)
CVG107095805 107104466(furin)
CTUL119793084(furinb) 119798957(furina)
GMU124859063(furinb) 124866765(furina)
NFU107381331 107388981(furin)
KMR108228577(furina) 108239969(furinb)
ALIM106515632(furin) 106532108
NWH119415568(furinb) 119422415(furina)
AOCE111563041(furin) 111587677
MCEP125005793(furina) 125014493(furinb)
CSEM103378886 103380512(furin)
POV109624036 109636815(furin)
SSEN122772274(furina) 122775878(furinb)
HHIP117759251(furina) 117762836(furinb)
HSP118109760(furina) 118110055(furinb)
LCF108875306(furin) 108877754
SDU111221567 111228587(furin)
SLAL111646277 111655357(furin)
XGL120793159(furinb) 120794708(furina)
HCQ109525872 109530490(furin)
BPEC110165934(furin) 110175436
MALB109962881 109968745(furin)
BSPL114852747(furina) 114857048(furinb)
SASA106561302 106562248 106573344 106587394
OTW112218687(furinb) 112249199 112251547 112253271 112253480 112263744
OMY110497223(furinb) 110506586 110522396 110526458 110531970
OGO123989578 123996879 124002179 124033706(furina) 124035603 124035687
ONE115109520 115109771(pcsk4) 115112301 115134149
SALP111952700 111952767(furin) 111962447 111969435 111974070 111975923
SNH120024852 120047639 120054033 120054034 120066383(furinb)
CCLU121532212(furinb) 121548261 121558019 121576850 121577037
ELS105016086 105018383(furin)
SFM108941070 108942037(furin)
PKI111845104 111846807(furin)
AANG118228066(furina)
LOC102698333(furin)
PSPA121304121 121304423 121309276
ARUT117428137 117429744
LCM102359471(FURIN)
CMK103188561
RTP109930441(furin)
BFO118410573
BBEL109462116 109471859
CIN100175968 113474034
SCLV120330211 120330340 120343553
SPU574878
APLC110987280
SKO100366895 100376687
DMEDmel_CG10772(Fur1) Dmel_CG18734(Fur2)
DER6554820
DSE6619724
DSIDsimw501_GD18200(Dsim_GD18200)
DYADyak_GE10700
DAN6500862
DSR110186787
DPO6897901
DPE6594042
DMN108155045
DWI6647595
DGR6563522 6564969
DMODmoj_GI22559
DAZ108621769
DNV108652955
DHE111604800
DVI6629820
CCAT101451553 101460139
BOD106615950 106619388
MDE101893498
SCAC106087875 106090602
LCQ111684383
LSQ119606485 119606835
HIS119654731 119658931
AGAAgaP_AGAP001330
ACOZ120951245
AARA120896454
ASTE118505159 118507665
AAG5578803
CQUCpipJ_CPIJ011701
CPII120418183
CNS116343073 116348720
BCOO119067665 119075946
ACER107994951 108004424
ALAB122715543
BIM100740609
BBIF117208521
BVK117243415
BVAN117165016
BTER100650142
BPYO122574853
CCAL108621912
OBB114871266
MGEN117222962
NMEA116429047
CGIG122396695
SOC105194571
MPHA105835671
AEC105149511
ACEP105626928
PBAR105430658
VEM105569016
HST105188026
DQU106743879
CFO105254895
FEX115236688
LHU105678951
PGC109853364
OBO105278329
PCF106785371
PFUC122524951
VPS122631337
TPRE106648613
MDL103580708
CGLO123259514
FAS105268929
DAM107046152
AGIF122858476
CCIN107267449
TCA661907
DPA109541004
SOY115881411 115887104
ATD109605590
CSET123314742 123322070
AGB108906809 108910006
LDC111509687 111514037
NVL108560582
APLN108739285 108741866
PPYR116163062 116165621
OTU111414549 111421751 111428320
BMOR692448
BMAN114253028
MSEX115446596
DPLKGM_215240
BANY112054240
PMAC106718570
PPOT106110216 106111512
PXU106119396
PRAP111004261
ZCE119839785
HAW110373817
HZE124636758 124637143 124637160
TNL113503415 113503613
SLIU111355157
OFU114362108
PXY105386056
API100166619
DNX107162048
AGS114119617
RMD113551665
BTAB109034866
CLEC106663869
HHAL106690541 106692106
NLU111045632
PHUPhum_PHUM246230
FOC113202058 113209561 113213681 113214041
TPAL117644727 117645278 117645572
ZNE110835312
CSEC111873058
FCD110842575 110861229
DPXDAPPUDRAFT_126713 DAPPUDRAFT_306271
DMK116917232 116925194 116931035
PVM113812833 113817518
PJA122248384 122254218 122262593 122267606
PCHN125037293 125043103 125047190 125048037
HAME121857898 121868704 121873204 121876390
PCLA123765522 123768377 123770315
PTRU123507880 123512313 123515370 123515847
HAZT108671426 108676954
EAF111698254 111700110 111700479 111708112
LSM121116754 121119030 121119337 121126132 121129007
PPOI119100534 119100535 119100859
ISCIscW_ISCW006048
DSV119442214 119442370
RSAN119387287 119387718
RMP119159553
VDE111251054
VJA111264558
TUT107364419 107367020
DPTE113791404
DFR124493877
CSCU111619913 111638182
PTEP107454912
SDM118184093 118185709 118188184
CELCELE_F11A6.1(kpc-1)
CBRCBG_15803(Cbr-kpc-1)
BMYBM_BM3293(Bma-kpc-1)
LOALOAG_03049 LOAG_04307
NAINECAME_01389
TSPTsp_12023
HROHELRODRAFT_105284 HELRODRAFT_107946 HELRODRAFT_170307 HELRODRAFT_72480 HELRODRAFT_82350 HELRODRAFT_82977 HELRODRAFT_84740
LGILOTGIDRAFT_112524
PCAN112554120
BGT106059132 106070600
GAE121383612
HRF124143748
HRJ124291131
CRG105320244 105323116 105337580 105346909 117690912 117691566
MYI110447249
PMAX117334865
MMER123524785 123528967 123533308 123534165 123534595 123535155 123545805 123547519 123548687 123560080 123563904 123563905 123566363
OBI106882877
OSN115210771
LAK106154677 106156258 106159649 106170020 106173945
SMMSmp_160240
SHXMS3_0018849
OVIT265_09434
EGLEGR_00543
NVE5510456
EPA110248172
ATEN116290699
AMIL114954185 114954192 114977448
PDAM113670141 113678907
SPIS111330827 111331019 111335101 111335105 111342661 111346486
XEN124436935 124443327
HMG100202203 100206357
AQU105312851
MBRMONBRDRAFT_30798
ACANACA1_234230
 » show all
Reference
1  [PMID:2094803]
  Authors
van de Ven WJ, Voorberg J, Fontijn R, Pannekoek H, van den Ouweland AM, van Duijnhoven HL, Roebroek AJ, Siezen RJ.
  Title
Furin is a subtilisin-like proprotein processing enzyme in higher eukaryotes.
  Journal
Mol Biol Rep 14:265-75 (1990)
DOI:10.1007/bf00429896
Reference
2  [PMID:1843280]
  Authors
Van de Ven WJ, Creemers JW, Roebroek AJ.
  Title
Furin: the prototype mammalian subtilisin-like proprotein-processing enzyme. Endoproteolytic cleavage at paired basic residues of proproteins of the eukaryotic secretory pathway.
  Journal
Enzyme 45:257-70 (1991)
DOI:10.1159/000468900
Reference
3  [PMID:1587790]
  Authors
Hatsuzawa K, Murakami K, Nakayama K.
  Title
Molecular and enzymatic properties of furin, a Kex2-like endoprotease involved in precursor cleavage at Arg-X-Lys/Arg-Arg sites.
  Journal
J Biochem (Tokyo) 111:296-301 (1992)
DOI:10.1093/oxfordjournals.jbchem.a123753
Reference
4  [PMID:18407092]
  Authors
Seidah NG, Chretien M
  Title
Proprotein and prohormone convertases of the subtilisin family Recent developments and future perspectives.
  Journal
Trends Endocrinol Metab 3:133-40 (1992)
DOI:10.1016/1043-2760(92)90102-7
Reference
5  [PMID:1429684]
  Authors
Steiner DF, Smeekens SP, Ohagi S, Chan SJ.
  Title
The new enzymology of precursor processing endoproteases.
  Journal
J Biol Chem 267:23435-8 (1992)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.75
IUBMB Enzyme Nomenclature: 3.4.21.75
ExPASy - ENZYME nomenclature database: 3.4.21.75
BRENDA, the Enzyme Database: 3.4.21.75
CAS: 141760-45-4

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