KEGG   ENZYME: 3.4.21.76
Entry
EC 3.4.21.76                Enzyme                                 
Name
myeloblastin;
leukocyte proteinase 3;
leukocyte proteinase 4;
Wegener's granulomatosis autoantigen;
proteinase PR-3;
proteinase-3;
PMNL proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Hydrolysis of proteins, including elastin, by preferential cleavage: -Ala! > -Val!
Comment
From polymorphonuclear leukocyte granules. In peptidase family S1 (trypsin family). Not inhibited by secretory leukocyte proteinase inhibitor
History
EC 3.4.21.76 created 1993
Orthology
K01350  myeloblastin
Genes
HSA: 5657(PRTN3)
PTR: 749895(PRTN3)
PPS: 103785286(PRTN3)
PON: 100452422(PRTN3)
NLE: 100595573(PRTN3)
MCC: 721131(PRTN3)
MCF: 102135264(PRTN3)
MTHB: 126942981
CSAB: 103233573(PRTN3)
CATY: 105591687(PRTN3)
TGE: 112612319(PRTN3)
RRO: 104671433(PRTN3)
RBB: 108537880(PRTN3)
TFN: 117074505(PRTN3)
PTEH: 111535001(PRTN3)
CJC: 100388897(PRTN3)
SBQ: 101030199(PRTN3)
MMUR: 105860758(PRTN3)
LCAT: 123632356(PRTN3)
OGA: 100964770(PRTN3)
MMU: 19152(Prtn3)
MCAL: 110303978
MPAH: 110326830
RNO: 314615(Prtn3)
MCOC: 116076141
MUN: 110551322
CGE: 100752428
MAUA: 101843355
PLEU: 114684111
MORG: 121459562
MFOT: 126489288
AAMP: 119815522
NGI: 108491030
HGL: 101721935(Prtn3)
DSP: 122122702
TUP: 102487869(PRTN3)
GVR: 103607670(PRTN3) 103609792
BTA: 100298591(PRTN3)
BOM: 102277748(PRTN3)
BBUB: 102412233(PRTN3)
BBIS: 104991958(PRTN3)
CHX: 108636370(PRTN3)
OAS: 101110590(PRTN3)
ODA: 120863727(PRTN3)
SSC: 106509464(PRTN3)
BACU: 103017246(PRTN3)
LVE: 103086930(PRTN3)
OOR: 101278389(PRTN3)
DLE: 111170517(PRTN3)
PCAD: 102978010(PRTN3)
PSIU: 116750551(PRTN3)
ECB: 100147215(PRTN3)
EPZ: 103544820(PRTN3)
EAI: 106834196(PRTN3)
MYB: 102255992(PRTN3)
MYD: 102755748(PRTN3)
MMYO: 118658956(PRTN3)
MLF: 102438046
MNA: 107538547(PRTN3)
PKL: 118711781
HAI: 109390589(PRTN3)
SHON: 118984391(PRTN3)
AJM: 119044599
MMF: 118616223
RFQ: 117037990(PRTN3)
PALE: 102898051
PGIG: 120583674
PVP: 105302268
RAY: 107500902
TOD: 119240358
SARA: 101553450
LAV: 100671715
TMU: 101350723
MDO: 100030473(PRTN3)
GAS: 123232211
SHR: 100933022
PCW: 110196097
XLA: 495841(prtn3.S) 496090(prtn3.L)
BBUF: 120991606(AZU1)
BGAR: 122930791(AZU1)
LCM: 102347764
AGA: AgaP_AGAP006488
AAG: 5570115
AALB: 109414701 115255728
CQU: CpipJ_CPIJ015107
TPRE: 106655397
SOY: 115879767
LDC: 111510371
LSM: 121120191
 » show all
Reference
1  [PMID:1681549]
  Authors
Labbaye C, Musette P, Cayre YE.
  Title
Wegener autoantigen and myeloblastin are encoded by a single mRNA.
  Journal
Proc Natl Acad Sci U S A 88:9253-6 (1991)
DOI:10.1073/pnas.88.20.9253
  Sequence
[hsa:5657]
Reference
2  [PMID:2033050]
  Authors
Rao NV, Wehner NG, Marshall BC, Gray WR, Gray BH, Hoidal JR.
  Title
Characterization of proteinase-3 (PR-3), a neutrophil serine proteinase. Structural and functional properties.
  Journal
J Biol Chem 266:9540-8 (1991)
  Sequence
[hsa:5657]
Reference
3  [PMID:1445363]
  Authors
Brubaker MJ, Groutas WC, Hoidal JR, Rao NV.
  Title
Human neutrophil proteinase 3: mapping of the substrate binding site using peptidyl thiobenzyl esters.
  Journal
Biochem Biophys Res Commun 188:1318-24 (1992)
DOI:10.1016/0006-291X(92)91375-Z
Reference
4  [PMID:1551417]
  Authors
Kam CM, Kerrigan JE, Dolman KM, Goldschmeding R, Von dem Borne AE, Powers JC.
  Title
Substrate and inhibitor studies on proteinase 3.
  Journal
FEBS Lett 297:119-23 (1992)
DOI:10.1016/0014-5793(92)80340-M
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.76
IUBMB Enzyme Nomenclature: 3.4.21.76
ExPASy - ENZYME nomenclature database: 3.4.21.76
BRENDA, the Enzyme Database: 3.4.21.76
CAS: 128028-50-2

  All links  
Gene (100)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (92)   
   RefGene (7)   
Protein sequence (12)   
   UniProt (5)   
   SWISS-PROT (2)   
   RefSeq(pep) (5)   
DNA sequence (10)   
   RefSeq(nuc) (7)   
   GenBank (2)   
   EMBL (1)   
Protein domain (6)   
   InterPro (6)   
All databases (128)   

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