KEGG   ENZYME: 3.4.21.76
Entry
EC 3.4.21.76                Enzyme                                 
Name
myeloblastin;
leukocyte proteinase 3;
leukocyte proteinase 4;
Wegener's granulomatosis autoantigen;
proteinase PR-3;
proteinase-3;
PMNL proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Hydrolysis of proteins, including elastin, by preferential cleavage: -Ala! > -Val!
Comment
From polymorphonuclear leukocyte granules. In peptidase family S1 (trypsin family). Not inhibited by secretory leukocyte proteinase inhibitor
History
EC 3.4.21.76 created 1993
Orthology
K01350  myeloblastin
Genes
HSA5657(PRTN3)
PTR749895(PRTN3)
PPS103785286(PRTN3)
PON100452422(PRTN3)
NLE100595573(PRTN3)
MCC721131(PRTN3)
MCF102135264(PRTN3)
MTHB126942981
CSAB103233573(PRTN3)
CATY105591687(PRTN3)
TGE112612319(PRTN3)
RRO104671433(PRTN3)
RBB108537880(PRTN3)
TFN117074505(PRTN3)
PTEH111535001(PRTN3)
CJC100388897(PRTN3)
SBQ101030199(PRTN3)
MMUR105860758(PRTN3)
LCAT123632356(PRTN3)
OGA100964770(PRTN3)
MMU19152(Prtn3)
MCAL110303978
MPAH110326830
RNO314615(Prtn3)
MCOC116076141
MUN110551322
CGE100752428
MAUA101843355
PLEU114684111
MORG121459562
MFOT126489288
AAMP119815522
NGI108491030
HGL101721935(Prtn3)
DSP122122702
TUP102487869(PRTN3)
GVR103607670(PRTN3) 103609792
BTA100298591(PRTN3)
BOM102277748(PRTN3)
BBUB102412233(PRTN3)
BBIS104991958(PRTN3)
CHX108636370(PRTN3)
OAS101110590(PRTN3)
ODA120863727(PRTN3)
SSC106509464(PRTN3)
BACU103017246(PRTN3)
LVE103086930(PRTN3)
OOR101278389(PRTN3)
DLE111170517(PRTN3)
PCAD102978010(PRTN3)
PSIU116750551(PRTN3)
ECB100147215(PRTN3)
EPZ103544820(PRTN3)
EAI106834196(PRTN3)
MYB102255992(PRTN3)
MYD102755748(PRTN3)
MMYO118658956(PRTN3)
MLF102438046
MNA107538547(PRTN3)
PKL118711781
HAI109390589(PRTN3)
SHON118984391(PRTN3)
AJM119044599
MMF118616223
RFQ117037990(PRTN3)
PALE102898051
PGIG120583674
PVP105302268
RAY107500902
TOD119240358
SARA101553450
LAV100671715
TMU101350723
MDO100030473(PRTN3)
GAS123232211
SHR100933022
PCW110196097
XLA495841(prtn3.S) 496090(prtn3.L)
BBUF120991606(AZU1)
BGAR122930791(AZU1)
LCM102347764
AGAAgaP_AGAP006488
AAG5570115
AALB109414701 115255728
CQUCpipJ_CPIJ015107
TPRE106655397
SOY115879767
LDC111510371
LSM121120191
 » show all
Reference
1  [PMID:1681549]
  Authors
Labbaye C, Musette P, Cayre YE.
  Title
Wegener autoantigen and myeloblastin are encoded by a single mRNA.
  Journal
Proc Natl Acad Sci U S A 88:9253-6 (1991)
DOI:10.1073/pnas.88.20.9253
  Sequence
[hsa:5657]
Reference
2  [PMID:2033050]
  Authors
Rao NV, Wehner NG, Marshall BC, Gray WR, Gray BH, Hoidal JR.
  Title
Characterization of proteinase-3 (PR-3), a neutrophil serine proteinase. Structural and functional properties.
  Journal
J Biol Chem 266:9540-8 (1991)
  Sequence
[hsa:5657]
Reference
3  [PMID:1445363]
  Authors
Brubaker MJ, Groutas WC, Hoidal JR, Rao NV.
  Title
Human neutrophil proteinase 3: mapping of the substrate binding site using peptidyl thiobenzyl esters.
  Journal
Biochem Biophys Res Commun 188:1318-24 (1992)
DOI:10.1016/0006-291X(92)91375-Z
Reference
4  [PMID:1551417]
  Authors
Kam CM, Kerrigan JE, Dolman KM, Goldschmeding R, Von dem Borne AE, Powers JC.
  Title
Substrate and inhibitor studies on proteinase 3.
  Journal
FEBS Lett 297:119-23 (1992)
DOI:10.1016/0014-5793(92)80340-M
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.76
IUBMB Enzyme Nomenclature: 3.4.21.76
ExPASy - ENZYME nomenclature database: 3.4.21.76
BRENDA, the Enzyme Database: 3.4.21.76
CAS: 128028-50-2

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