KEGG ENZYME: 3.4.21.76

ENZYME: 3.4.21.76

Entry

EC 3.4.21.76                Enzyme

Name

myeloblastin;
leukocyte proteinase 3;
leukocyte proteinase 4;
Wegener's granulomatosis autoantigen;
proteinase PR-3;
proteinase-3;
PMNL proteinase

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases

Reaction(IUBMB)

Hydrolysis of proteins, including elastin, by preferential cleavage: -Ala! > -Val!

Comment

From polymorphonuclear leukocyte granules. In peptidase family S1 (trypsin family). Not inhibited by secretory leukocyte proteinase inhibitor

History

EC 3.4.21.76 created 1993

Orthology

K01350

myeloblastin

Genes

HSA:	5657(PRTN3)

PTR:	749895(PRTN3)

PPS:	103785286(PRTN3)

GGO:	129528801(PRTN3)

PON:	100452422(PRTN3)

PPYG:

129026100(PRTN3)

NLE:	100595573(PRTN3)

HMH:	116482907(PRTN3)

SSYN:

129466491(PRTN3)

MCC:	721131(PRTN3)

MCF:	102135264(PRTN3)

MTHB:

126942981

MNI:	105486449(PRTN3)

CSAB:

103233573(PRTN3)

CATY:

105591687(PRTN3)

TGE:	112612319(PRTN3)

MLEU:

105532877(PRTN3)

RRO:	104671433(PRTN3)

RBB:	108537880(PRTN3)

TFN:	117074505(PRTN3)

PTEH:

111535001(PRTN3)

CJC:	100388897(PRTN3)

SBQ:	101030199(PRTN3)

CIMI:

108293191(PRTN3)

MMUR:

105860758(PRTN3)

LCAT:

123632356(PRTN3)

OGA:	100964770(PRTN3)

MMU:	19152(Prtn3)

MCAL:

110303978

MPAH:

110326830

RNO:	314615(Prtn3)

MCOC:

116076141

ANU:

117696368

ASYL:

127671164

MUN:

110551322

CGE:

100752428

MAUA:

101843355

PROB:

127216656

PLEU:

114684111

MORG:

121459562

MFOT:

126489288

AAMP:

119815522

NGI:

108491030

HGL:	101721935(Prtn3)

DSP:

122122702

DMER:

138817606

PLOP:

125347626

TUP:	102487869(PRTN3)

GVR:	103607670(PRTN3) 103609792

BTA:	100298591(PRTN3)

BOM:

102277748

BBUB:

102412233(PRTN3)

BBIS:

104991958(PRTN3)

CHX:	108636370(PRTN3)

OAS:	101110590(PRTN3)

BTAX:

128051782(PRTN3)

CSUM:

138086281(PRTN3)

ODA:	120863727(PRTN3)

MREE:

136158137(PRTN3)

OVR:	110135342(PRTN3)

MBEZ:

129559244(PRTN3)

SSC:	106509464(PRTN3)

BACU:

103017246(PRTN3)

BMUS:

118892656(PRTN3)

LVE:	103086930(PRTN3)

OOR:

101278389

LALB:

132517928

DDP:	132421646(PRTN3)

DLE:	111170517(PRTN3)

PCAD:

102978010(PRTN3)

PSIU:

116750551(PRTN3)

PPHC:

136120470

NASI:

112396313

ECB:	100147215(PRTN3)

EPZ:	103544820(PRTN3)

EAI:	106834196(PRTN3)

MYB:	102255992(PRTN3)

MYD:	102755748(PRTN3)

MMYO:

118658956(PRTN3)

MLF:

102438046

MDT:	132235301(PRTN3)

MYUM:

139009751

PKL:

118711781

EFUS:

103294437(PRTN3)

MNA:	107538547(PRTN3)

SHON:

118984391(PRTN3)

AJM:	119044599(PRTN3)

MMF:

118616223

PPAM:

129080094

HAI:	109390589(PRTN3)

RFQ:	117037990(PRTN3)

PALE:

102898051

PGIG:

120583674

PVP:

105302268

RAY:

107500902

TOD:

119240358

SARA:

101553450

SFUM:

130022229(PRTN3)

SETR:

126030030(PRTN3)

LAV:

100671715

TMU:

101350723

MDO:	100030473(PRTN3)

GAS:

123232211

SHR:

100933022

AFZ:

127545083

PCW:

110196097

TVP:	118834808(PRTN3)

PBRV:

138172248

MLAO:

141497522

XLA:	495841(prtn3.S) 496090(prtn3.L)

XTR:	448597(prtn3)

NPR:	108798701(AZU1)

ACAT:

141104404

BBUF:

120991606(AZU1)

BGAR:

122930791(AZU1)

DTC:

141048057

PWL:

138268050

MUO:

115479506

GSH:

117365828

LCM:

102347764

AGA:

5667298

AMRS:

128715549

AAG:

5570115

AALB:

109414701 115255728

ASUA:

134212982

CQU:	CpipJ_CPIJ015107

TPRE:

106655397

VCAN:

122409180

LDC:

111510371

CCRN:

123290441 123290509

LSM:

121120191

» show all

Reference

1 [PMID:1681549]

Authors

Labbaye C, Musette P, Cayre YE.

Title

Wegener autoantigen and myeloblastin are encoded by a single mRNA.

Journal

Proc Natl Acad Sci U S A 88:9253-6 (1991)
DOI:10.1073/pnas.88.20.9253

Sequence

[hsa:5657]

Reference

2 [PMID:2033050]

Authors

Rao NV, Wehner NG, Marshall BC, Gray WR, Gray BH, Hoidal JR.

Title

Characterization of proteinase-3 (PR-3), a neutrophil serine proteinase. Structural and functional properties.

Journal

J Biol Chem 266:9540-8 (1991)

Sequence

[hsa:5657]

Reference

3 [PMID:1445363]

Authors

Brubaker MJ, Groutas WC, Hoidal JR, Rao NV.

Title

Human neutrophil proteinase 3: mapping of the substrate binding site using peptidyl thiobenzyl esters.

Journal

Biochem Biophys Res Commun 188:1318-24 (1992)
DOI:10.1016/0006-291X(92)91375-Z

Reference

4 [PMID:1551417]

Authors

Kam CM, Kerrigan JE, Dolman KM, Goldschmeding R, Von dem Borne AE, Powers JC.

Title

Substrate and inhibitor studies on proteinase 3.

Journal

FEBS Lett 297:119-23 (1992)
DOI:10.1016/0014-5793(92)80340-M

Other DBs

ExplorEnz - The Enzyme Database:

3.4.21.76

IUBMB Enzyme Nomenclature:

3.4.21.76

ExPASy - ENZYME nomenclature database:

3.4.21.76

BRENDA, the Enzyme Database:

3.4.21.76

CAS:	128028-50-2

All links

Gene (7)   
   RefGene (7)   
Protein sequence (12)   
   UniProt (5)   
   SWISS-PROT (2)   
   RefSeq(pep) (5)   
DNA sequence (10)   
   RefSeq(nuc) (7)   
   GenBank (2)   
   EMBL (1)   
Protein domain (7)   
   InterPro (7)   
All databases (36)   

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