KEGG   ENZYME: 3.4.21.78
Entry
EC 3.4.21.78                Enzyme                                 
Name
granzyme A;
CTLA3;
HuTPS;
T-cell associated protease 1;
cytotoxic T lymphocyte serine protease;
TSP-1;
T-cell derived serine proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: -Arg!, -Lys! >> -Phe! in small molecule substrates
Comment
From cytotoxic T lymphocyte granules. In peptidase family S1 (trypsin family). The human enzyme does not cleave Phe!-
History
EC 3.4.21.78 created 1993
Orthology
K01352  granzyme A
Genes
HSA3001(GZMA)
PTR461873(GZMA)
PPS100984053(GZMA)
GGO101143719(GZMA)
PON100445064(GZMA)
NLE100604986(GZMA)
MCC705712(GZMA)
MCF102143423(GZMA)
MTHB126957167
CSAB103221481(GZMA)
CATY105582706(GZMA)
PANU101022448(GZMA)
TGE112625898(GZMA)
RRO104680493(GZMA)
RBB108530978(GZMA)
TFN117065124(GZMA)
PTEH111541639(GZMA)
CJC100408119(GZMA)
SBQ101036387(GZMA)
CSYR103268229(GZMA)
MMUR105877301(GZMA)
LCAT123647975(GZMA)
OGA100964197(GZMA)
MMU14938(Gzma)
MCAL110307743 110307744 110307745
RNO266708(Gzma)
MCOC116083258(Gzma)
MUN110549641(Gzma) 110549646
CGE100751397 100774711
MAUA101841412 101841676
PLEU114702990 114704161
MORG121455941 121455962
MFOT126507963 126507964
AAMP119809198(Gzma) 119809811
NGI103739933(Gzma) 103739934
HGL101726631(Gzma)
CPOC100726756(Gzma) 100727037
CCAN109685089 109685098
DORD105987406(Gzma)
DSP122117344(Gzma)
NCAR124987589
OCU100346200 100346285
OPI105941740 105941748
TUP102467739(GZMA)
GVR103609933(GZMA)
CFA487207(GZMA)
CLUD112660521(GZMA)
VVP112907700(GZMA)
VLG121497860(GZMA)
AML100476014(GZMA)
UMR103663680(GZMA)
UAH113255334(GZMA)
UAR123790188(GZMA)
ELK111156954
LLV125101038
MPUF101672287(GZMA)
ORO101372849(GZMA)
EJU114221022(GZMA)
ZCA113929389(GZMA)
MLX118016468(GZMA)
NSU110591108(GZMA)
LWW102728618(GZMA)
FCA100113480(GZMA)
PYU121015942(GZMA)
PBG122473642(GZMA)
LRUF124517239
PTG102949286(GZMA)
PPAD109246327(GZMA)
AJU106987310(GZMA)
HHV120239970(GZMA)
BTA407178(gzmA) 539093(GZMA)
BOM102276955 102277241
BIU109574751 109575058(GZMA)
BBUB102410034(GZMA) 102410582
BBIS105001044 105001045
CHX102168390(GZMA) 102184761
OAS101116862(GZMA) 101117107
ODA120879510 120879511
CCAD122454355 122454601(GZMA)
SSC100233183(GZMA) 100526762(GZMA)
CFR102504596 102504859(GZMA)
CBAI105077812 105077814
CDK105087148(GZMA) 105087149
VPC102525452 102525691(GZMA)
BACU103020024 103020307
LVE103079185 103079469
OOR101283420 101283673
DLE111163114 111186706(GZMA)
PCAD102973431 102973708
PSIU116751352(GZMA) 116751440
ECB100062497(GZMA)
EPZ103559058(GZMA)
EAI106843354(GZMA)
MYB102250453(GZMA)
MYD102761771(GZMA)
MMYO118656980(GZMA)
MNA107527151 107527163
PKL118703212(GZMA)
HAI109382131(GZMA)
DRO112315273 112315291
SHON118981689 118981708(GZMA)
AJM119049174(GZMA)
PDIC114507269 114512448
PHAS123819538 123819541
MMF118641958(GZMA)
RFQ117025020(GZMA)
PGIG120608292(GZMA)
PVP105305816(GZMA)
RAY107509610(GZMA)
MJV108392360(GZMA) 108397987
TOD119250650 119260442 119260590 119260713 119260751 119261062
SARA101548920
LAV100676692 111749961
TMU101345573 101359638 101359901
ETF101648962(GZMA) 101649280
DNM101410656 101447612
MDO100031794(GZMA)
GAS123251793(GZMA)
SHR100932934(GZMA)
PCW110215570(GZMA)
GGA395108(GZMA)
MGP100549545
CJO107306000 107306002
NMEL110390250
APLA101800784 113840297 113840340
ACYG106035576 106035583
AFUL116501179 116501210
TGU100225754(GZMA)
LSR110472615
SCAN103821031 108962864
PMOA120502456(GZMA)
OTC121346628(GZMA)
PRUF121355398(GZMA)
GFR102045402(GZMA)
FAB101821368(GZMA)
PHI102106832
PMAJ107198458
CCAE111941375
CCW104686670(GZMA)
CBRC103623901(GZMA)
ETL114072712
ZAB102069183
ACHL103803491
FPG101912239(GZMA)
FCH102052542(GZMA)
CLV102093295
EGZ104134695
NNI104008514(GZMA)
PLET104617888
PCRI104024607(GZMA)
PCAO104039811
ACUN113489889(GZMA)
TALA104369356(GZMA)
PADL103919432(GZMA)
AFOR103893404
ACHC115337380(GZMA)
HALD104314979(GZMA)
HLE104839969
AGEN126036358
GCL127027200
CCRI104169400(GZMA)
CSTI104559992
EHS104503492(GZMA)
CMAC104477918(GZMA)
MUI104540055
FGA104075163
GSTE104258207(GZMA)
LDI104355128
MNB103781433
OHA104337787
DPUB104296760
PGUU104458401
ACAR104522925(GZMA)
CPEA104395624(GZMA)
AVIT104267887(GZMA)
CVF104294578
CUCA104054779(GZMA)
TEO104369826
BRHI104498395
AAM106489787 106490945
AROW112964517(GZMA)
NPD112946162(GZMA)
TGT104579117
DNE112995782
SCAM104146849
ASN102381782
AMJ102558867(GZMA)
CPOO109307908
GGN109297822(GZMA)
PSS102462891(GZMA)
CMY102931660(GZMA)
CPIC101935187(GZMA)
TST117879182(GZMA)
CABI116818253(GZMA)
MRV120408238
ACS100557669
PVT110085404 110085407
SUND121920681 121920834
PBI103049382 112541519
PMUR107283810
CTIG120313337 120313343
TSR106546065 106546295 106547751
PGUT117679188(GZMA)
VKO123031294 123031295 123031513
PMUA114606300 114606624 114606652 114606894
ZVI118077149 118077331(GZMA)
GJA107116990 107117064 107120501
STOW125436659 125436964
XLA100036870(XB5962685.L) 108718387(gzmak.L) 379554(gzma.S) 398620(gzmak.S) 494696(gzma.L)
XTR100135014(gzma) 100496550 100497188(gzmak)
NPR108796684 108796688 108801279 108801280 108801281 108801282 108802848 108803471
RTEM120928267 120928270 120928276 120928282 120928288 120928289 120928294 120928297 120928304 120928307 120928310 120928317 120928324 120928325
BBUF120992327 120992328 120992329 120992331
BGAR122936378 122936387 122936392 122936408 122936434
TRU101067058 105416203
TNGGSTEN00029621G001
LCO104923006 104934136
NCC104947021
CGOB115013607
ELY117252909
EFO125890416
PLEP121944665
SLUC116054275 116054277
ECRA117945319
ESP116689767
PFLV114556011 114556031
GAT120831331
PPUG119224448
MSAM119891208 119892071 119917768
CUD121510170
ALAT119020011
MZE101464703 101479592 101479876 101480358 101480646 101480941 106677004 112430045
ONL100690189 100690226 100690494 100695499 100701180 100704488 100708644 100708915 106096443 109194505 109204422 109204553 112848326
OAU116312282 116312284 116312285 116312287 116312306 116312307 116312316 116323274 116325171 116329740 120443045 120443109
OLA101173066
OML112148640
XMA102227155 102227673 102236487 111610261
XCO114154036 114154051 114154052 114154877
XHE116729217 116729218 116729275 116730113
PRET103469978 103469980 103470643 108166573
PFOR103132859 103132885 103142037 103142041 103142042 103142063
PLAI106957580 106962022 106962031 106962033 106962034
PMEI106912553 106912554 106912555 106925774 106925784 106926009 106926017
GAF122828006 122828705
CVG107085297 107085303 107085306
CTUL119778187 119778188 119778189
GMU124878189 124878190 124878308
NFU107377780
KMR108233660 108233661 108233662 108233663 108235366
ALIM106519866 106519867
NWH119413867 119413868 119413869 119413870
AOCE111580749 111580754
MCEP125011737 125012742 125012743 125012744 125012745 125012747 125012748
CSEM103397912
POV109637074
SSEN122768999
HHIP117767366 117767367 117767368 117767369 117767370
HSP118124770 124851060 124851954 124851968 124852391 124852413 124852414 124852415 124852416
LCF108881328
SDU111236503
SLAL111654932
XGL120805272
HCQ109527364 109527376 109527384
BPEC110165459
MALB109956500
SASA100196008(graa) 106570903(GRAA)
STRU115200611(gzma)
OTW112263954
OMY110536463 118965065
OGO124035320 124035321
ONE115140619 115140620
SALP112070973 112070975
SNH120037341 120062827 120062828 120062829 120062830 120062961
CCLU121530706 121547230
ELS105008251 105008252 105008253 105009266 105014507 105014707 105029171 114840681
SFM108938441 108938512
PKI111839252 111839253
AANG118237433
LOC102684904 107075377
PSPA121301993 121303987 121315213 121327189 121327196 121330635
ARUT117409167 117420520 117420525 117433356
PSEX120527184 120527185 120527187 120527188 120527189 120527190 120527191 120527192 120528526 120528551 120528552 120528553 120528556 120528557
LCM102345118 102346386 102346637
CMK103177826 103177828
FAS105267611 105269340
MSEX115440926
 » show all
Reference
1  [PMID:3545816]
  Authors
Simon MM, Hoschutzky H, Fruth U, Simon HG, Kramer MD.
  Title
Purification and characterization of a T cell specific serine proteinase (TSP-1) from cloned cytolytic T lymphocytes.
  Journal
EMBO J 5:3267-74 (1986)
DOI:10.1002/j.1460-2075.1986.tb04638.x
Reference
2  [PMID:3257574]
  Authors
Gershenfeld HK, Hershberger RJ, Shows TB, Weissman IL.
  Title
Cloning and chromosomal assignment of a human cDNA encoding a T cell- and natural killer cell-specific trypsin-like serine protease.
  Journal
Proc Natl Acad Sci U S A 85:1184-8 (1988)
DOI:10.1073/pnas.85.4.1184
  Sequence
[hsa:3001]
Reference
3  [PMID:1998680]
  Authors
Odake S, Kam CM, Narasimhan L, Poe M, Blake JT, Krahenbuhl O, Tschopp J, Powers JC.
  Title
Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins.
  Journal
Biochemistry 30:2217-27 (1991)
DOI:10.1021/bi00222a027
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.78
IUBMB Enzyme Nomenclature: 3.4.21.78
ExPASy - ENZYME nomenclature database: 3.4.21.78
BRENDA, the Enzyme Database: 3.4.21.78
CAS: 143180-73-8

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