KEGG   ENZYME: 3.4.21.79
Entry
EC 3.4.21.79                Enzyme                                 
Name
granzyme B;
CTLA1;
CCPII;
cytotoxic cell proteinase-1;
granzyme G;
granzyme H;
CCP1 proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Preferential cleavage: -Asp! >> -Asn! > -Met!, -Ser!
Comment
From cytotoxic T lymphocyte granules. In peptidase family S1 (trypsin family)
History
EC 3.4.21.79 created 1993
Orthology
K01353  granzyme B
Genes
HSA3002(GZMB)
PTR452825(GZMB)
PPS100987153(GZMB)
GGO101133374
PON100432682
NLE100604300(GZMB)
MCC716518(GZMB)
MCF102130260(GZMB)
MTHB126959475
CSAB103228744(GZMB)
CATY105600215(GZMB)
PANU101000503
TGE112628753
RRO104662660(GZMB)
RBB108515190(GZMB)
TFN117069888(GZMB)
PTEH111552883(GZMB)
CJC100389206(GZMB)
SBQ101039443(GZMB)
MMUR105864427 105864431 105864432 105864434 105864436 105864583
LCAT123650592
OGA100957079 100957388 100957699 100959107 100961499
MMU14939(Gzmb)
MCAL110309193 110309364 110309408
MPAH110325528 110325544 110325862
RNO171528(Gzmb)
MCOC116084385 116084470 116084677
MUN110559569 110559571 110565882
CGE100751926 100754015 100754310 100754595 100754885 100755174 100755462 100765811
MAUA101844297 101844567
PLEU114683786 114683802 114683803 114683804 114689300 114689301 114692456 114708739 114708759 114708762 114708763
MORG121435007 121435008 121435012
MFOT126492597 126492601 126492609 126496582
AAMP119799953 119800102 119800130 119800145
NGI103732523 103739490 103744106 103751171
HGL101702156(Gzmb)
CPOC100715008 100715856 100718836 100719110 100719669 100720219 100724690 100726326 100728774 100733665 100733943 100734223 100734504 100735067 100735344 100735618
CCAN109676124 109679265 109679269 109679271 109679272 109679273 109679320 109680646
DORD105992458 105992478 105992489
DSP122113471 122113474
NCAR124977087 124977147
OCU100101600 103351183
OPI101518542
TUP102472210 102473071 102491528 102492779
CFA490630(GZMB)
CLUD112657189
VVP112926569
VLG121493507
AML100464420
UMR103679303
UAH113245994
UAR123795665 123795689
ELK111139675 111161254
LLV125104493 125104667
MPUF101693455
ORO101370515 101383301
EJU114217855 114217878
ZCA113909272 113910204
MLX118003297 118003491
NSU110585238 110585494
FCA100127106(GZMB) 101099215
PYU121031586 121031587
PBG122468966 122468967
LRUF124508204 124508205
PTG102957957(GZMB) 102967670
PPAD109254955 109254957
AJU106987852 106987873
HHV120246996 120246997
BTA281731(GZMB) 505326 508646 508858 786126
BOM102285196 102285463(GZMB) 102286892 102287464
BIU109575204 109575279 109575715 109575716 109575719 109575720 109575773
BBUB102397582 102410930 102411756 112580795 112580796 112580797 112580884
CHX102168343 102175759 102176598 102176878 102177285 102190602 108633178 108638461 108638467
OAS101108034 101113279 101122059 114108608 114109111 443429(MCP-3) 443546(MCP1)
ODA120859906 120860133 120860134 120861046 120861047 120875326
CCAD122419670 122419671 122455089 122455090 122455092 122455194 122455234 122455266
SSC100233184(GZMB) 100739080
CFR102518273 116664195 116664198
CBAI105068826 105075274
CDK105094200 116153371 116153492
VPC102532683 102535495 102545567
BACU103000247 103010961(GZMB)
LVE103087729(GZMB) 103088275
OOR101287187
DLE111164169 111164234
PCAD102996600 102996887
PSIU116748601 116749064
ECB100033978(GZMB) 100049805 100050711 100052229 100052638 100052689 100052901 100052951 100053001 100053327 100055651 111767413 111768663 111768988 111768996 111771745
EPZ103541286 103542062 103542179 103543772 103544143 103544373 103544385 103544452 103545105 103545302 103545376 103545654 103545732 103545905 103546012 103561061 103561488 103564648 103564650
EAI106828029 106828030 106830400 106830406 106830409 106830410 106830417 106848556 106848588 106848589 106848592 106848611 106848613 123275657 123283066
MYB102254077 102254375 102255120 102255724(GZMH) 102256937 102261579
MYD102759056 102764944 102767665 102769778 102770101 102772954 102773232(GZMH) 102774777
MMYO118678479 118678489 118678492 118678504
MLF102434869 102435171 102435479 102440283 102440598 102441463 102441778 102442096 111823008
MNA107544835 107544836
PKL118726101 118726108 118726126 118726137
HAI109378494 109378533 109378535 109378555 109378558 109378669 109378715 109378716
DRO112296490 112296591
SHON118980823 118980881
AJM119037278
PDIC114492846 114492848 114492886 114492957
PHAS123820443 123820457
MMF118631374 118631379
RFQ117022812 117022813
PALE102881520 102881776
PGIG120608540 120608541
PVP105302752 105302756
RAY107513516 107513518
MJV108392608
TOD119238086 119238241 119238975 119239511
SARA101537026 101537294 101537553 101537826 101551388 101551660 101555084 101555357
LAV100653795 100654077 100655496 100659417 100676656 100677226 100677506 100677788 104847000
TMU101349286 101350051 105756280
DNM101419645 101422721 101426115
MDO100015759(GZMB)
GAS123235914
SHR100913913 100920867 111718797
PCW110220292
OAA100079691 100082304 791103(GZMB)
TGU100222370
LSR110475783
PMOA120498103
OTC121335949
CCAE111940364
ZAB102072614
ACHL103803938
FPG101923715
FCH102052058
ACUN113489397
AFOR103893205
LDI104343676
PGUU104470428
ACAR104519444
CVF104290401
ASN102367834 102387989
AMJ102574848(GZMB)
CPOO109315268
PSS102444467 102453822 102454335 102454843 102454985 102455097 102455167 102455354 102455484 102458389 102459172 102459655 102460125 102461598 102461984 102462471 102462771 102462794 102462956 102463197 102463497 106732480 112547190
CMY102930074 102930674 102937901 114022418 119563637 119567824
CPIC101932313 101932579 101932860 101935057 101935532 101936431 101939070 101941268 101941749 101945280 101947007 101947844 101948578 101951420 103306959
TST117885532 117885536 117885765 117885767 117885769 117885802 117885803 117885896 117885904 117886163 117886164 117886291 117886292 117886300
CABI116820456 116821554 116821556 116830410 116830780 116830784 116830786 116830790 116830793 116833091 116833092 116833094
MRV120379867 120380056 120380332 120380333 120380334 120380335 120380379 120380382 120380383 120380384 120380617 120380679 120381064 120381065 120381066 120381069 120381127
XLA108704981
NPR108788431
RTEM120924898
DRE100000986(gzm3) 100001065(si:ch211-165b19.5) 100001138(gzm3.3) 100001210(gzm3.4)
SRX107719817 107719818 107719819 107731739 107731741 107752546
SANH107659882 107659883 107659902 107690624
SGH107554811 107569997 107570004 107586450 107595882 107595883
CCAR109059914 109078458 109086216 109095997
CAUA113040055 113040081 113053141 113053744 113053745 113064916 113064918 113072704 113074374 113079831 113081496 113093745 113093748 113098278 113108044 113109329
PPRM120467250 120467251
MAMB125270379 125270382 125270384
IPU100304651 108267045(gzm3.3) 108267046
PHYP113526084 113526166 113526278
TFD113664041 113664042 113664048 125141417 125141418 125141442 125141443
AMEX103022973 107197919
EEE113587565 113587566
TRU101065337
LCO104918775 104927628 109137337 109137338
NCC104950606 104950607
CGOB115007259 115007335 115025954
ELY117249061 117254294 117254325
EFO125895474 125895475 125896251 125899676
PLEP121941392 121941393 121950664
SLUC116037709 116063369 116063370 116063492 118492925 118496212
ECRA117950354 117950355 117952653
ESP116695028 116698057
PFLV114561849 114561850 114561851 114561852 114561853 114563677 114564560
GAT120823382 120823386 120833862
PPUG119217246 119217247 119228558
MSAM119900919 119900920 119900921 119901366 119903901
CUD121511918 121512395 121512396 121512570 121522266
ALAT119025549 119025550 119025551 119028702 119028793
MZE101463843 101464142 101464418 101473742 101480778 101483052 101487603 101487852 101488124
ONL100691703 100692241 100692510 100692779 100692889 100693053 100693152 100693160 100693634 102082461
OAU116314994 116314995 116316539 116316557 116323265 116323266 116327923 116327934 116327936 116327949 116327950
OLA101157849 101158094 101161875
OML112137028(si:ch211-212d10.1) 112155175 112155393 112155394
XMA102216992 102217322 102217574 102229982 102230245 106699834
XCO114148697 114148872 114148875 114150444 114151627 114151628
XHE116723013 116723014 116723502 116725209 116725274 116725302
PRET103460710 103460719 103463688 103463689 103463690
PFOR103150441 103150442(prtn3) 103150443 103150641 103150644 103150645
PLAI106954192 106954194 106954195 106959625
PMEI106925477 106925480 106925481 106929665 106929667 106929670
GAF122838480(si:ch211-212d10.1) 122838990 122838991 122839590 122839591 122839594
CVG107095300 107095469 107095470 107095471 107103707 107103712
CTUL119776828 119776846 119776849 119780647 119780654 119780655 119780670 119790059
GMU124870782 124870783 124870785 124874224(si:ch211-212d10.1) 124874273 124874275 124874430
NFU107390210 107393329
KMR108230697 108230705 108230706 108230707 108230710 108230712 108230715 108238504 112450232
ALIM106514965 106514995 106523141 106523346
NWH119407457 119407968 119419048 119419049
AOCE111571834
MCEP125008925 125008926 125009487(si:ch211-212d10.1) 125017759 125018283
CSEM103392320 103399906
POV109631307
SSEN122758519 122758530 122758540 122780475(si:ch211-212d10.1)
HHIP117754422 117754423
HSP118119869 118119870
LCF108877279 108877301 108877302 108877303 108877304 108877306 108886885 108886987 108893013 108893014 108893015 108893016 108895425
SDU111218882 111232006 111232190 111232191 111232207 111239168
SLAL111657487 111657488 111657489 111657490 111668761
XGL120790938 120790950 120801418
HCQ109523326
BPEC110156126
MALB109957168 109962015 109962083 109962084 109966997 109966998
BSPL114847116 114847117 114854662 114854663
SASA106573599 106586879 106586880 106614002
STRU115151806 115158213 115160566 115160567 115161404 115161424
OTW112251797(si:ch211-212d10.1)
OMY110520645 110520647 110520655 110524258(si:ch211-212d10.1)
OGO123997614 124043027 124044293 124044478
ONE115107389 115116173 115136727 115136728
SALP111952707 111975283 112071056 112076133 112076426
SNH120054453(si:ch211-212d10.1) 120058552
CCLU121533561 121536361 121536365 121536366 121577300
ELS105011524
SFM108920035 108920043 108937451
PKI111852681 111852716
AANG118223847 118223971
LOC102684423 102686644 102686851 102687051 102687250 102698655
PSPA121300661 121300968 121301544 121321086 121328063
ARUT117401433 117406489 117428840 117428865 117428982 117966147 117966222
AARA120895735
CNS116336805
CGLO123263581
DAM107037603 107047325
AGB108907325
PPYR116179834
FOC113216394
PJA122249479 122264717 122267455
VDE111255088
MMER123534496
OSN115228274
SVS117861067
 » show all
Reference
1  [PMID:2953813]
  Authors
Schmid J, Weissmann C.
  Title
Induction of mRNA for a serine protease and a beta-thromboglobulin-like protein in mitogen-stimulated human leukocytes.
  Journal
J Immunol 139:250-6 (1987)
  Sequence
[hsa:3002]
Reference
2  [PMID:1998680]
  Authors
Odake S, Kam CM, Narasimhan L, Poe M, Blake JT, Krahenbuhl O, Tschopp J, Powers JC.
  Title
Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins.
  Journal
Biochemistry 30:2217-27 (1991)
DOI:10.1021/bi00222a027
Reference
3  [PMID:1985927]
  Authors
Poe M, Blake JT, Boulton DA, Gammon M, Sigal NH, Wu JK, Zweerink HJ.
  Title
Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity.
  Journal
J Biol Chem 266:98-103 (1991)
  Sequence
[hsa:3002]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.79
IUBMB Enzyme Nomenclature: 3.4.21.79
ExPASy - ENZYME nomenclature database: 3.4.21.79
BRENDA, the Enzyme Database: 3.4.21.79
CAS: 143180-74-9

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