KEGG   ENZYME: 3.4.21.79
Entry
EC 3.4.21.79                Enzyme                                 

Name
granzyme B;
CTLA1;
CCPII;
cytotoxic cell proteinase-1;
granzyme G;
granzyme H;
CCP1 proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Preferential cleavage: -Asp! >> -Asn! > -Met!, -Ser!
Comment
From cytotoxic T lymphocyte granules. In peptidase family S1 (trypsin family)
History
EC 3.4.21.79 created 1993
Orthology
K01353  granzyme B
Genes
HSA: 3002(GZMB)
PTR: 452825(GZMB)
PPS: 100987153(GZMB)
GGO: 101133374
PON: 100432682
NLE: 100604300(GZMB)
MCC: 716518(GZMB)
MCF: 102130260(GZMB)
CSAB: 103228744(GZMB)
RRO: 104662660(GZMB)
RBB: 108515190(GZMB)
CJC: 100389206(GZMB)
SBQ: 101039443(GZMB)
MMU: 14939(Gzmb)
RNO: 100361468(Gzmbl2) 171528(Gzmb)
HGL: 101702156(Gzmb)
CFA: 490630
VVP: 112926569
AML: 100464420
UMR: 103679303
UAH: 113245994
FCA: 100127106(GZMB) 101099215
PTG: 102957957(GZMB) 102967670
SSC: 100233184(GZMB) 100739080
BACU: 103000247 103010961(GZMB)
LVE: 103087729(GZMB) 103088275
OOR: 101287187
MJV: 108392608
MDO: 100015759(GZMB)
PCW: 110220292
CJO: 107325410
TGU: 100222370
LSR: 110475783
CCAE: 111940364
FPG: 101923715
FCH: 102052058
EGZ: 104124381
NNI: 104016272
ACUN: 113489397
AMJ: 102574848(GZMB)
XLA: 108704981
NPR: 108788431
DRE: 100000986(gzm3) 100001065(si:ch211-165b19.5) 100001138(gzm3.3) 100001210(gzm3.4)
IPU: 100304651(Gzmf) 108267046
TRU: 101065337
AOCE: 111571834
POV: 109631307
HCQ: 109523326
BPEC: 110156126
OTW: 112251797
ELS: 105011524
 » show all
Reference
1  [PMID:2953813]
  Authors
Schmid J, Weissmann C.
  Title
Induction of mRNA for a serine protease and a beta-thromboglobulin-like protein in mitogen-stimulated human leukocytes.
  Journal
J Immunol 139:250-6 (1987)
  Sequence
[hsa:3002]
Reference
2  [PMID:1998680]
  Authors
Odake S, Kam CM, Narasimhan L, Poe M, Blake JT, Krahenbuhl O, Tschopp J, Powers JC.
  Title
Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins.
  Journal
Biochemistry 30:2217-27 (1991)
DOI:10.1021/bi00222a027
Reference
3  [PMID:1985927]
  Authors
Poe M, Blake JT, Boulton DA, Gammon M, Sigal NH, Wu JK, Zweerink HJ.
  Title
Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity.
  Journal
J Biol Chem 266:98-103 (1991)
  Sequence
[hsa:3002]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.79
IUBMB Enzyme Nomenclature: 3.4.21.79
ExPASy - ENZYME nomenclature database: 3.4.21.79
BRENDA, the Enzyme Database: 3.4.21.79
CAS: 143180-74-9

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