KEGG   ENZYME: 3.4.21.80Help
Entry
EC 3.4.21.80                Enzyme                                 

Name
streptogrisin A;
Streptomyces griseus protease A;
protease A;
proteinase A;
Streptomyces griseus proteinase A;
Streptomyces griseus serine proteinase 3;
Streptomyces griseus serine proteinase A
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of proteins with specificity similar to chymotrypsin
Comment
From Streptomyces griseus. A component of Pronase, in family S1 (trypsin family). Not inhibited by Tos-Phe-CH2Cl or ovomucoid
History
EC 3.4.21.80 created 1993
Orthology
K18544  streptogrisin A
Genes
SGR: SGR_370(sprA)
SSX: SACTE_5330
SFA: Sfla_1153
SALB: XNR_0210
STRP: F750_5687
SFI: SFUL_6948
Taxonomy
Reference
1  [PMID:5575653]
  Authors
Johnson P, Smillie LB.
  Title
The disulfide bridge sequences of a serine protease of wide specificity from Streptomyces griseus.
  Journal
Can J Biochem 49:548-62 (1971)
Reference
2  [PMID:119870]
  Authors
Sielecki AR, Hendrickson WA, Broughton CG, Delbaere LT, Brayer GD, James MN.
  Title
Protein structure refinement: Streptomyces griseus serine protease A at 1.8 A resolution.
  Journal
J Mol Biol 134:781-804 (1979)
DOI:10.1016/0022-2836(79)90486-8
  Sequence
[sgr:SGR_370]
Reference
3  [PMID:6783761]
  Authors
James MN, Sielecki AR, Brayer GD, Delbaere LT, Bauer CA.
  Title
Structures of product and inhibitor complexes of Streptomyces griseus protease A at 1.8 A resolution. A model for serine protease catalysis.
  Journal
J Mol Biol 144:43-88 (1980)
DOI:10.1016/0022-2836(80)90214-4
Reference
4  [PMID:3892018]
  Authors
Delbaere LT, Brayer GD.
  Title
The 1.8 A structure of the complex between chymostatin and Streptomyces griseus protease A. A model for serine protease catalytic tetrahedral intermediates.
  Journal
J Mol Biol 183:89-103 (1985)
DOI:10.1016/0022-2836(85)90283-9
Reference
5  [PMID:3112129]
  Authors
Henderson G, Krygsman P, Liu CJ, Davey CC, Malek LT.
  Title
Characterization and structure of genes for proteases A and B from Streptomyces griseus.
  Journal
J Bacteriol 169:3778-84 (1987)
DOI:10.1128/JB.169.8.3778-3784.1987
  Sequence
[sgr:SGR_370]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.80
IUBMB Enzyme Nomenclature: 3.4.21.80
ExPASy - ENZYME nomenclature database: 3.4.21.80
BRENDA, the Enzyme Database: 3.4.21.80
CAS: 55326-50-6

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