limulus clotting factor _overbar_C_;
limulus factor C
Acting on peptide bonds (peptidases);
Selective cleavage of -Arg103!Ser- and -Ile124!Ile- bonds in limulus clotting factor B to form factor _overbar_B_. Cleavage of -Pro-Arg! bonds in synthetic substrates
From the hemocyte granules of the horseshoe crabs Limulus and Tachypleus. Factor C is activated by Gram-negative bacterial lipopolysaccharides and chymotrypsin. Inhibited by antithrombin III. In peptidase family S1 (trypsin family)
Further studies on lipopolysaccharide-sensitive serine protease zymogen (factor C): its isolation from Limulus polyphemus hemocytes and identification as an intracellular zymogen activated by alpha-chymotrypsin, not by trypsin.