limulus clotting enzyme;
Acting on peptide bonds (peptidases);
Selective cleavage of -Arg18! and -Arg47! bonds in coagulogen to form coagulin and fragments
From the hemocyte granules of horseshoe crabs Limulus and Tachypleus. Proclotting enzyme is activated by limulus clotting factor . In peptidase family S1 (trypsin family)
EC 22.214.171.124 created 1993
K20753 limulus clotting enzyme
Muta T, Hashimoto R, Miyata T, Nishimura H, Toh Y, Iwanaga S
Proclotting enzyme from horseshoe crab hemocytes. cDNA cloning, disulfide locations, and subcellular localization.
J Biol Chem 265:22426-33 (1990)
Tokunaga F, Nakajima H, Iwanaga S.
Further studies on lipopolysaccharide-sensitive serine protease zymogen (factor C): its isolation from Limulus polyphemus hemocytes and identification as an intracellular zymogen activated by alpha-chymotrypsin, not by trypsin.
ExPASy - ENZYME nomenclature database: 126.96.36.199