KEGG ENZYME: 3.4.21.9

ENZYME: 3.4.21.9

Entry

EC 3.4.21.9                 Enzyme

Name

enteropeptidase;
enterokinase

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases

Reaction(IUBMB)

Activation of trypsinogen by selective cleavage of Lys6!Ile bond

Comment

Is not inhibited by protein inhibitors of trypsin. In peptidase family S1 (trypsin family).

History

EC 3.4.21.9 created 1961 as EC 3.4.4.8, transferred 1972 to EC 3.4.21.9

Orthology

K01316

enterokinase

Genes

HSA:	5651(TMPRSS15)

PTR:	129135269(TMPRSS15)

PPS:	100992890(TMPRSS15)

GGO:	101151821(TMPRSS15)

PON:	100431479(TMPRSS15)

PPYG:

129022569(TMPRSS15)

NLE:	100580929(TMPRSS15)

HMH:	116481539(TMPRSS15)

SSYN:

129482853(TMPRSS15)

MCC:	100423099(TMPRSS15)

MCF:	102135270(TMPRSS15)

MTHB:

126949617

MNI:	105498551(TMPRSS15)

CSAB:

103218091(TMPRSS15)

CATY:

105571817(TMPRSS15)

PANU:

101015783(TMPRSS15)

TGE:	112621093(TMPRSS15)

MLEU:

105543119(TMPRSS15)

RRO:	104673912(TMPRSS15)

RBB:	108543352(TMPRSS15)

TFN:	117095614(TMPRSS15)

PTEH:

111553001(TMPRSS15)

CANG:

105500836(TMPRSS15)

CJC:	100401965(TMPRSS15)

SBQ:	101053552(TMPRSS15)

CIMI:

108311893(TMPRSS15)

ANAN:

105711852(TMPRSS15)

CSYR:

103257634(TMPRSS15)

MMUR:

105883088(TMPRSS15)

LCAT:

123650155(TMPRSS15)

PCOQ:

105809218(TMPRSS15)

OGA:	100951626(TMPRSS15)

MMU:	19146(Tmprss15)

MCAL:

110311705(Tmprss15)

MPAH:

110329794(Tmprss15)

RNO:	288291(Tmprss15)

MCOC:

116083601(Tmprss15)

ANU:	117717641(Tmprss15)

ASYL:

127666083(Tmprss15)

MUN:	110539510(Tmprss15)

CGE:	100754500(Tmprss15)

MAUA:

101825304(Tmprss15)

PROB:

127227446(Tmprss15)

PLEU:

114701917(Tmprss15)

MORG:

121465316(Tmprss15)

MFOT:

126505702

AAMP:

119825423(Tmprss15)

NGI:	103732242(Tmprss15)

HGL:	101719326(Tmprss15)

CPOC:

100728703(Tmprss15)

CCAN:

109677737(Tmprss15)

DORD:

105996802(Tmprss15)

DSP:	122105659(Tmprss15)

DMER:

138831739(Tmprss15)

PLOP:

125351234(Tmprss15)

NCAR:

124993305

MMMA:

107136237(Tmprss15)

ITI:	101963901(Tmprss15)

OCU:

100350765

OPI:	101534557(TMPRSS15)

TUP:	102474054(TMPRSS15)

CFA:	487700(TMPRSS15)

CLUD:

112661734(TMPRSS15)

VVP:	112917688(TMPRSS15)

VLG:	121479244(TMPRSS15)

NPO:	129502310(TMPRSS15)

AML:	100477756(TMPRSS15)

UMR:	103673186(TMPRSS15)

UAH:	113256976(TMPRSS15)

UAR:	123784394(TMPRSS15)

ELK:

111146811

LLV:

125095353

MPUF:

101683040(TMPRSS15)

MNP:	132010621(TMPRSS15)

MLK:	131825963(TMPRSS15)

NVS:	122910355(TMPRSS15)

ORO:	101363528(TMPRSS15)

EJU:	114217764(TMPRSS15)

ZCA:	113915858(TMPRSS15)

MLX:	118018771(TMPRSS15)

NSU:	110571168(TMPRSS15)

LWW:	102728067(TMPRSS15)

FCA:	101088868(TMPRSS15)

PYU:	121036479(TMPRSS15)

PCOO:

112849799(TMPRSS15)

PBG:	122491282(TMPRSS15)

PVIV:

125174404(TMPRSS15)

LRUF:

124527283

LGF:	123610687(TMPRSS15)

AJU:

106973146

PTG:	102969357(TMPRSS15)

PPAD:

109277847(TMPRSS15)

PUC:

125921735

PLEZ:

122230231(TMPRSS15)

HHV:	120246295(TMPRSS15)

BTA:	282009(TMPRSS15)

BOM:	102265063(TMPRSS15)

BIU:	109559391(TMPRSS15)

BBUB:

102402700(TMPRSS15)

BBIS:

104997982(TMPRSS15)

CHX:	102180152(TMPRSS15)

OAS:	101115497(TMPRSS15)

BTAX:

128055198(TMPRSS15)

CSUM:

138087155(TMPRSS15)

ODA:	120853539(TMPRSS15)

CCAD:

122428915(TMPRSS15)

MREE:

136152459(TMPRSS15)

OVR:	110145200(TMPRSS15)

MBEZ:

129550252(TMPRSS15)

SSC:	397152(TMPRSS15)

CFR:	102520122(TMPRSS15)

CBAI:

105072992(TMPRSS15)

CDK:	105086815(TMPRSS15)

VPC:	102525419(TMPRSS15)

BACU:

103001216(TMPRSS15)

BMUS:

118894440(TMPRSS15)

LVE:	103081000(TMPRSS15)

OOR:	101289210(TMPRSS15)

LALB:

132520677(TMPRSS15)

GMF:	115864263(TMPRSS15)

DDP:	132424003(TMPRSS15)

DLE:	111175153(TMPRSS15)

PCAD:

102987176(TMPRSS15)

PSIU:

116753095(TMPRSS15)

PPHC:

136122932(TMPRSS15)

NASI:

112390941(TMPRSS15)

ECB:	100067591(TMPRSS15)

EPZ:	103550998(TMPRSS15)

EAI:	106846583(TMPRSS15)

MYB:	102249267(TMPRSS15)

MYD:	102770624(TMPRSS15)

MMYO:

118677405(TMPRSS15)

MLF:	102429319(TMPRSS15)

MDT:	132230014(TMPRSS15)

MYUM:

139004182(TMPRSS15)

PKL:	118724376(TMPRSS15)

EFUS:

103289745(TMPRSS15)

MNA:	107544677(TMPRSS15)

DRO:	112304515(TMPRSS15)

SHON:

118993293(TMPRSS15)

AJM:	119038634(TMPRSS15)

PDIC:

114491040(TMPRSS15)

PHAS:

123827286(TMPRSS15)

MMF:	118617200(TMPRSS15)

PPAM:

129072988(TMPRSS15)

HAI:	109391711(TMPRSS15)

RFQ:	117013799(TMPRSS15)

PALE:

102893141(TMPRSS15)

PGIG:

120598512(TMPRSS15)

PVP:	105290837(TMPRSS15)

RAY:	107512688(TMPRSS15)

MJV:	108394355(TMPRSS15)

TOD:	119257124(TMPRSS15)

SARA:

101540291(TMPRSS15)

SFUM:

130018640(TMPRSS15)

SETR:

126026020(TMPRSS15)

LAV:	100655543(TMPRSS15)

TMU:

101357439

ETF:	101655904(TMPRSS15)

DNM:	101422145(TMPRSS15)

MDO:	100020597(TMPRSS15)

GAS:	123239626(TMPRSS15)

SHR:	100928791(TMPRSS15)

AFZ:

127557153

PCW:	110214906(TMPRSS15)

TVP:	118839265(TMPRSS15)

PBRV:

138151309(TMPRSS15)

MLAO:

141504970(TMPRSS15)

OAA:	100079480(TMPRSS15)

TACU:

119945144(TMPRSS15)

GGA:	427967(TMPRSS15)

PCOC:

116242068(TMPRSS15)

MGP:	100547096(TMPRSS15)

CJO:	107322530(TMPRSS15)

TPAI:

128072753(TMPRSS15)

LMUT:

125696421(TMPRSS15)

NMEL:

110401927(TMPRSS15)

APLA:

101801915(TMPRSS15)

ACYG:

106036979(TMPRSS15)

CATA:

118247788(TMPRSS15)

AFUL:

116494033(TMPRSS15)

TGU:	100220466(TMPRSS15)

LSR:	110471651(TMPRSS15)

SCAN:

103818409(TMPRSS15)

PMOA:

120504044(TMPRSS15)

OTC:	121341342(TMPRSS15)

PRUF:

121354546(TMPRSS15)

ATRC:

139593242(TMPRSS15)

GFR:	102042374(TMPRSS15)

FAB:	101817773(TMPRSS15)

OMA:	130251202(TMPRSS15)

PHI:	102106374(TMPRSS15)

PMAJ:

107212126(TMPRSS15)

CCAE:

111940884(TMPRSS15)

CCW:	104689447(TMPRSS15)

CBRC:

103613745(TMPRSS15)

ACOE:

138117495(TMPRSS15)

ETL:	114058557(TMPRSS15)

ZAB:	102073361(TMPRSS15)

ZLE:	135442260(TMPRSS15)

ACHL:

103797326(TMPRSS15)

SVG:	106857499(TMPRSS15)

MMEA:

130575003(TMPRSS15)

HRT:	120748934(TMPRSS15)

SATI:

136373260(TMPRSS15)

CCIC:

134054797(TMPRSS15)

FPG:	101922858(TMPRSS15)

FCH:	102047221(TMPRSS15)

NNT:	104413399(TMPRSS15)

SHAB:

115604185(TMPRSS15)

ACUN:

113481103(TMPRSS15)

TALA:

104365714(TMPRSS15)

ACHC:

115343949(TMPRSS15)

HLE:	104831807(TMPRSS15)

AGEN:

126048815

HHAR:

128145130(TMPRSS15)

GCL:

127026038

LDI:	104344503(TMPRSS15)

MNB:	103779185(TMPRSS15)

DPUB:

104301506(TMPRSS15)

PPUS:

135179975(TMPRSS15)

AVIT:

104273674(TMPRSS15)

BRHI:

104492455(TMPRSS15)

EGZ:	104128144(TMPRSS15)

NNI:	104023355(TMPRSS15)

PCRI:

104033603(TMPRSS15)

PCAO:

104044661(TMPRSS15)

PADL:

103920211(TMPRSS15)

AFOR:

103902054(TMPRSS15)

GSTE:

104254476(TMPRSS15)

CBOY:

140647783(TMPRSS15)

CLV:	102094803(TMPRSS15)

CNIC:

135992666(TMPRSS15)

MUI:	104547889(TMPRSS15)

PLET:

104621902(TMPRSS15)

EHS:	104514719(TMPRSS15)

CMAC:

104477387(TMPRSS15)

CUCA:

104068808(TMPRSS15)

TEO:	104372957(TMPRSS15)

OHA:	104331723(TMPRSS15)

ACAR:

104526389(TMPRSS15)

CPEA:

104387728(TMPRSS15)

CVF:	104285409(TMPRSS15)

RTD:	128905401(TMPRSS15)

CRID:

134518219(TMPRSS15)

AAM:	106494880(TMPRSS15)

AROW:

112969651(TMPRSS15)

NPD:	112942846(TMPRSS15)

TGT:	104572373(TMPRSS15)

DNE:	112987899(TMPRSS15)

SCAM:

104139651(TMPRSS15)

ASN:	102380816(TMPRSS15)

AMJ:	102561133(TMPRSS15)

CPOO:

109305714(TMPRSS15)

GGN:	109302335(TMPRSS15)

PSS:	102446226(TMPRSS15)

CMY:	102940846(TMPRSS15)

CCAY:

125631500(TMPRSS15)

DCC:	119842454(TMPRSS15)

CPIC:

101946023(TMPRSS15)

TST:	117877038(TMPRSS15)

CABI:

116828034(TMPRSS15)

MRV:	120407874(TMPRSS15)

ACS:	100554809(tmprss15)

ASAO:

132770250(TMPRSS15)

PVT:	110074808(TMPRSS15)

SUND:

121925801(TMPRSS15)

PBI:	103048043(TMPRSS15)

PMUR:

107285869(TMPRSS15)

CTIG:

120310679(TMPRSS15)

TSR:	106550916(TMPRSS15)

PGUT:

117666163(TMPRSS15)

PCAE:

139316791(TMPRSS15)

APRI:

131199918(TMPRSS15)

PTEX:

113436418(TMPRSS15)

NSS:	113409750(TMPRSS15)

VKO:	123029135(TMPRSS15)

PMUA:

114596003(TMPRSS15)

PRAF:

128412934(TMPRSS15)

ZVI:	118084896(TMPRSS15)

HCG:	128350492(TMPRSS15)

GJA:	107113039(TMPRSS15)

STOW:

125431302(TMPRSS15)

EMC:	129326257(TMPRSS15)

XLA:

108709213

XTR:	100490249(tmprss15)

NPR:	108787208(TMPRSS15)

RTEM:

120927855(TMPRSS15)

ACAT:

141129199(TMPRSS15)

BGAR:

122931846(TMPRSS15)

DTC:	141097373(TMPRSS15)

PWL:	138249894(TMPRSS15)

MUO:	115471347(TMPRSS15)

GSH:	117359688(TMPRSS15)

DRE:	100148042(tmprss15)

SRX:	107757854(tmprss15)

SANH:

107668446(tmprss15)

SGH:	107603215(tmprss15)

CCAR:

109050978(tmprss15)

CAUA:

113063807 113063808

CGIB:

127941332

PTET:

122326480(tmprss15)

LROH:

127152100(tmprss15)

GRF:	141292725(tmprss15)

OMC:

131528188

PPRM:

120483194(tmprss15)

RKG:	130095504(tmprss15)

MAMB:

125253313(tmprss15)

CIDE:

127503545

CERY:

137013286(tmprss15)

MASI:

127429025 127431042

TROS:

130570607(tmprss15)

TDW:	130408078(tmprss15)

MANU:

129423055(tmprss15)

PDAB:

135776534(tmprss15)

IPU:	108278517(tmprss15)

IFU:	128622685(tmprss15)

PHYP:

113524594(tmprss15)

SMEO:

124397922(tmprss15)

TFD:	113650174(tmprss15)

TVC:	132860232(tmprss15)

CGAR:

128507124 128507712(tmprss15)

NGRA:

132895764(tmprss15)

TRN:	134330257(tmprss15)

CMAO:

118820473(tmprss15)

EEE:	113567777(tmprss15)

CHAR:

105892411(tmprss15)

SPIL:

134093467(tmprss15)

TRU:	101079914(tmprss15)

TFS:	130537403(tmprss15)

TNG:	GSTEN00014573G001

LCO:	104919454(tmprss15)

TBEN:

117490689(tmprss15)

CGOB:

115005667 115005672

GACU:

117558951(tmprss15)

EMAC:

134871704(tmprss15)

ELY:	117262609(tmprss15)

EFO:	125898209(tmprss15)

SLUC:

116062361(tmprss15)

ECRA:

117956052

ESP:	116678413(tmprss15)

PFLV:

114566305(tmprss15)

GAT:	120822981(tmprss15)

PPUG:

119215881(tmprss15)

AFB:	129113795(tmprss15)

CLUM:

117742756(tmprss15)

PSWI:

130210115(tmprss15)

CANA:

137788064(tmprss15)

CVE:	137871488(tmprss15)

MSAM:

119895248(tmprss15)

SCHU:

122888271(tmprss15)

CUD:	121518603(tmprss15)

SPUL:

138599142(tmprss15)

LMIX:

132988387(tmprss15)

ALAT:

119031663(tmprss15)

ASTR:

137605919(tmprss15)

MZE:	101483978(tmprss15)

ONL:	100710011(tmprss15)

OAU:	116331675(tmprss15)

OLA:	100125450(tmprss15)

OML:	112142496(tmprss15)

CSAI:

133460014(tmprss15)

XMA:	102229238(tmprss15)

XCO:	114152657(tmprss15)

XHE:	116728032(tmprss15)

PRET:

103459937(tmprss15)

PFOR:

103141088

PLAI:

106948544

PMEI:

106918539(tmprss15)

GAF:	122844820(tmprss15)

PPRL:

129370749(tmprss15)

CVG:	107102286(tmprss15)

CTUL:

119785592(tmprss15)

GMU:	124875954(tmprss15)

NFU:	107387187(tmprss15)

KMR:	108228482(tmprss15)

ALIM:

106536089(tmprss15)

NWH:	119420745(tmprss15)

AOCE:

111575727 129350516

EJA:	138213614 138213617

BFRE:

138634847 138634862

MCEP:

125021393(tmprss15)

CSEM:

103395735(tmprss15)

POV:	109642208(tmprss15)

SSEN:

122780186(tmprss15)

SSOE:

131458616(tmprss15)

HHIP:

117759006 117759018

HSP:	118122374(tmprss15)

PPLT:

128457278(tmprss15)

SMAU:

118300840(tmprss15)

LCF:

108873644

SDU:	111239500(tmprss15)

SLAL:

111671152(tmprss15)

XGL:	120802716(tmprss15)

HCQ:	109528878(tmprss15)

SSCV:

125981965(tmprss15)

SBIA:

133491363(tmprss15)

PEE:	133416395(tmprss15)

PTAO:

133467037(tmprss15)

BPEC:

110174990(tmprss15)

ENY:	140372543(tmprss15)

MALB:

109955105(tmprss15)

BSPL:

114870013(tmprss15)

SJO:	128371685(tmprss15)

SSCO:

133993635(tmprss15)

GMH:	115547974(tmprss15)

SASA:

106603180(tmprss15)

STRU:

115154775(tmprss15)

OTW:	112228897(tmprss15)

OMY:	110534073(tmprss15)

OGO:	124006809(tmprss15)

ONE:	115135556(tmprss15)

OKI:	109872715(tmprss15)

OKE:	118390443(tmprss15)

OMM:	135550344(tmprss15)

OCLA:

139419252

SALP:

111950203(tmprss15)

SNH:	120057579(tmprss15)

CCLU:

121580244(tmprss15)

ELS:	105027690 114828757

OEP:	134013555(tmprss15)

SFM:	108923738(tmprss15)

PKI:	111857254(tmprss15)

AANG:

118235531(tmprss15)

AROT:

135263120(tmprss15)

CCOG:

133133238(tmprss15)

LOC:	107076776(tmprss15)

PSPA:

121321272 121327799

ARUT:

117407202(tmprss15)

PSEX:

120524439(tmprss15)

LCM:	102345914(TMPRSS15)

CMK:	103189792(tmprss15)

CPLA:

122554852(tmprss15)

HOC:	132820631(tmprss15)

LERI:

129702497(tmprss15)

HAKA:

140727482(tmprss15)

PMRN:

116955838 116955839

LRJ:	133358477(TMPRSS15)

BFO:	118406284 118407219

BBEL:

109480386

SPU:	105439626 105441667 105444528 753320

AJJ:

139984315

APLC:

110981891

AFIL:

140154602

SKO:

100372484

OTU:

111425419

MSEX:

115445432

BANY:

112043038

PXU:

106124714

PRAP:

110994394

SLIU:

111353040

OFU:

114365766

TPAL:

117643675

DMK:	116921727 123466273

HAZT:

108670741

PPOI:

119089378 119101496

RMP:

119173869

VDE:

111250398

DFR:

124495271

CRG:

105321499

MYI:

110457836

PMAX:

117333542

NVE:

5511246

ADF:	107329153 107340983 107345036 107358384

AMIL:

114961447 114971824 114974377 122950750

DGT:

114520451

XEN:

124444622

TAD:	TRIADDRAFT_53232

» show all

Reference

1 [PMID:2658218]

Authors

Light A, Janska H.

Title

Enterokinase (enteropeptidase): comparative aspects.

Journal

Trends Biochem Sci 14:110-2 (1989)
DOI:10.1016/0968-0004(89)90133-3

Other DBs

ExplorEnz - The Enzyme Database:

3.4.21.9

IUBMB Enzyme Nomenclature:

3.4.21.9

ExPASy - ENZYME nomenclature database:

3.4.21.9

BRENDA, the Enzyme Database:

3.4.21.9

CAS:

9014-74-8

DBGET integrated database retrieval system