KEGG   ENZYME: 3.4.21.90
Entry
EC 3.4.21.90                Enzyme                                 
Name
togavirin;
Sindbis virus protease;
Sindbis virus core protein;
NsP2 proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Autocatalytic release of the core protein from the N-terminus of the togavirus structural polyprotein by hydrolysis of a -Trp!Ser- bond
Comment
Known from the Sindbis and Semliki forest togaviruses. Once released, the core protein does not retain catalytic activity. Togavirin is the type example of peptidase family S3 and has a similar tertiary structure to chymotrypsin [3]
History
EC 3.4.21.90 created 1995
Orthology
K25929  Alphavirus capsid protein
Reference
1  [PMID:3052288]
  Authors
Krausslich HG, Wimmer E.
  Title
Viral proteinases.
  Journal
Annu Rev Biochem 57:701-54 (1988)
DOI:10.1146/annurev.bi.57.070188.003413
Reference
2  [PMID:1448929]
  Authors
Strauss EG, De Groot RJ, Levinson R, Strauss JH.
  Title
Identification of the active site residues in the nsP2 proteinase of Sindbis virus.
  Journal
Virology 191:932-40 (1992)
DOI:10.1016/0042-6822(92)90268-t
Reference
3  [PMID:8450538]
  Authors
Tong L, Wengler G, Rossmann MG.
  Title
Refined structure of Sindbis virus core protein and comparison with other chymotrypsin-like serine proteinase structures.
  Journal
J Mol Biol 230:228-47 (1993)
DOI:10.1006/jmbi.1993.1139
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.90
IUBMB Enzyme Nomenclature: 3.4.21.90
ExPASy - ENZYME nomenclature database: 3.4.21.90
BRENDA, the Enzyme Database: 3.4.21.90
CAS: 342882-56-8

  All links  
Protein sequence (636)   
   UniProt (35)   
   SWISS-PROT (35)   
   PDBSTR (566)   
3D Structure (40)   
   PDB (40)   
Protein domain (13)   
   InterPro (13)   
All databases (689)   

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