Entry |
|
Name |
togavirin;
Sindbis virus protease;
Sindbis virus core protein;
NsP2 proteinase
|
Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
|
Reaction(IUBMB) |
Autocatalytic release of the core protein from the N-terminus of the togavirus structural polyprotein by hydrolysis of a -Trp!Ser- bond
|
Comment |
Known from the Sindbis and Semliki forest togaviruses. Once released, the core protein does not retain catalytic activity. Togavirin is the type example of peptidase family S3 and has a similar tertiary structure to chymotrypsin [3]
|
History |
EC 3.4.21.90 created 1995
|
Orthology |
K19288 | Alphavirus structral polyprotein |
|
Reference |
|
Authors |
Krausslich HG, Wimmer E. |
Title |
Viral proteinases. |
Journal |
|
Reference |
|
Authors |
Strauss EG, De Groot RJ, Levinson R, Strauss JH. |
Title |
Identification of the active site residues in the nsP2 proteinase of Sindbis virus. |
Journal |
|
Reference |
|
Authors |
Tong L, Wengler G, Rossmann MG. |
Title |
Refined structure of Sindbis virus core protein and comparison with other chymotrypsin-like serine proteinase structures. |
Journal |
|
Other DBs |
ExPASy - ENZYME nomenclature database: | 3.4.21.90 |
|