Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy

Autocatalytic release of the core protein from the N-terminus of the togavirus structural polyprotein by hydrolysis of a -Trp!Ser- bond

Known from the Sindbis and Semliki forest togaviruses. Once released, the core protein does not retain catalytic activity. Togavirin is the type example of peptidase family S3 and has a similar tertiary structure to chymotrypsin [3]

EC 3.4.21.90 created 1995

1  [PMID:3052288]

Krausslich HG, Wimmer E.

Viral proteinases.

Annu Rev Biochem 57:701-54 (1988)
DOI:10.1146/annurev.bi.57.070188.003413

2  [PMID:1448929]

Strauss EG, De Groot RJ, Levinson R, Strauss JH.

Identification of the active site residues in the nsP2 proteinase of Sindbis virus.

Virology 191:932-40 (1992)
DOI:10.1016/0042-6822(92)90268-t

3  [PMID:8450538]

Tong L, Wengler G, Rossmann MG.

Refined structure of Sindbis virus core protein and comparison with other chymotrypsin-like serine proteinase structures.

J Mol Biol 230:228-47 (1993)
DOI:10.1006/jmbi.1993.1139