Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy

Selective hydrolysis of -Xaa-Xaa!Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala

Known from classical flaviviruses (yellow fever, dengue fever). The functional viral peptidase is part of the NS2B protein. Catalytic His, Asp and Ser residues are arranged as in chymotrypsin, but flavivrin is the type example of peptidase family S7.

EC 3.4.21.91 created 1995

1  [PMID:2174669]

Chambers TJ, Hahn CS, Galler R, Rice CM.

Flavivirus genome organization, expression, and replication.

Annu Rev Microbiol 44:649-88 (1990)
DOI:10.1146/annurev.mi.44.100190.003245

2  [PMID:1531368]

Cahour A, Falgout B, Lai CJ.

Cleavage of the dengue virus polyprotein at the NS3/NS4A and NS4B/NS5 junctions is mediated by viral protease NS2B-NS3, whereas NS4A/NS4B may be processed by a cellular protease.

J Virol 66:1535-42 (1992)
DOI:10.1128/JVI.66.3.1535-1542.1992

3  [PMID:8445732]

Lin C, Amberg SM, Chambers TJ, Rice CM.

Cleavage at a novel site in the NS4A region by the yellow fever virus NS2B-3 proteinase is a prerequisite for processing at the downstream 4A/4B signalase site.

J Virol 67:2327-35 (1993)
DOI:10.1128/JVI.67.4.2327-2335.1993

[vg:1502173]