| Entry |
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| Name |
proprotein convertase 1;
prohormone convertase 3;
neuroendocrine convertase 1;
PC1
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
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| Reaction(IUBMB) |
Release of protein hormones, neuropeptides and renin from their precursors, generally by hydrolysis of -Lys-Arg! bonds
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| Comment |
A Ca2+-dependent enzyme, maximally active at about pH 5.5. Substrates include pro-opiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and proinsulin. Unlike prohormone convertase 2, does not hydrolyse proluteinizing-hormone-releasing-hormone. Unusually, processing of prodynorphin occurs at a bond in which P2 is Thr. Present in the regulated secretory pathway of neuroendocrine cells, commonly acting co-operatively with prohormone convertase 2. In peptidase family S8 (subtilisin family)
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| History |
EC 3.4.21.93 created 1996
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| Orthology |
| K01359 | proprotein convertase subtilisin/kexin type 1 |
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| Genes |
» show all
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| Reference |
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| Authors |
Seidah NG, Gaspar L, Mion P, Marcinkiewicz M, Mbikay M, Chretien M. |
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| Title |
cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Smeekens SP, Avruch AS, LaMendola J, Chan SJ, Steiner DF |
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| Title |
Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Steiner DF, Smeekens SP, Ohagi S, Chan SJ. |
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| Title |
The new enzymology of precursor processing endoproteases. |
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| Journal |
J Biol Chem 267:23435-8 (1992) |
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| Reference |
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| Authors |
Seidah NG, Chretien M. |
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| Title |
Pro-protein convertases of subtilisin/kexin family. |
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| Journal |
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| Reference |
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| Authors |
Jean F, Basak A, DiMaio J, Seidah NG, Lazure C. |
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| Title |
An internally quenched fluorogenic substrate of prohormone convertase 1 and furin leads to a potent prohormone convertase inhibitor. |
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| Journal |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 3.4.21.93 |
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