KEGG   ENZYME: 3.4.21.93
Entry
EC 3.4.21.93                Enzyme                                 
Name
proprotein convertase 1;
prohormone convertase 3;
neuroendocrine convertase 1;
PC1
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Release of protein hormones, neuropeptides and renin from their precursors, generally by hydrolysis of -Lys-Arg! bonds
Comment
A Ca2+-dependent enzyme, maximally active at about pH 5.5. Substrates include pro-opiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and proinsulin. Unlike prohormone convertase 2, does not hydrolyse proluteinizing-hormone-releasing-hormone. Unusually, processing of prodynorphin occurs at a bond in which P2 is Thr. Present in the regulated secretory pathway of neuroendocrine cells, commonly acting co-operatively with prohormone convertase 2. In peptidase family S8 (subtilisin family)
History
EC 3.4.21.93 created 1996
Orthology
K01359  proprotein convertase subtilisin/kexin type 1
Genes
HSA5122(PCSK1)
PTR461740(PCSK1)
PPS100988619(PCSK1)
GGO101129039(PCSK1)
PON100173253(PCSK1)
NLE100606392(PCSK1)
HMH116470985(PCSK1)
MCC699742(PCSK1)
MCF102142243(PCSK1)
MTHB126957464
MNI105484100(PCSK1)
CSAB103224951(PCSK1)
CATY105599043(PCSK1)
PANU101010467(PCSK1)
TGE112626110(PCSK1)
MLEU105546283(PCSK1)
RRO104654548(PCSK1)
RBB108520341(PCSK1)
TFN117064886(PCSK1)
PTEH111542718(PCSK1)
CANG105513427(PCSK1)
CJC100403507(PCSK1)
SBQ101042932(PCSK1)
CIMI108289441(PCSK1)
CSYR103254025(PCSK1)
MMUR105876203(PCSK1)
LCAT123648637(PCSK1)
PCOQ105805881(PCSK1)
OGA100957267(PCSK1)
MMU18548(Pcsk1)
MCAL110308002(Pcsk1)
MPAH110328930(Pcsk1)
RNO25204(Pcsk1)
MCOC116083517(Pcsk1)
ANU117700596(Pcsk1)
MUN110553616(Pcsk1)
CGE100757402(Pcsk1)
MAUA101841511(Pcsk1)
PROB127220884(Pcsk1)
PLEU114709982(Pcsk1)
MORG121455871(Pcsk1)
MFOT126488611
AAMP119809247(Pcsk1)
NGI103729900(Pcsk1)
HGL101704290(Pcsk1)
CPOC100732445(Pcsk1)
CCAN109684716(Pcsk1)
DORD105989808(Pcsk1)
DSP122117191(Pcsk1)
PLOP125340064(Pcsk1)
NCAR124986507
MMMA107135427(Pcsk1)
OCU100345424
OPI101528795(PCSK1)
TUP102471290(PCSK1)
GVR103587622(PCSK1)
CFA479149(PCSK1)
CLUD112653563(PCSK1)
VVP112915473(PCSK1)
VLG121490174(PCSK1)
NPO129501610(PCSK1)
AML100484463(PCSK1)
UMR103672232(PCSK1)
UAH113255069(PCSK1)
UAR123791580(PCSK1)
ELK111148364
LLV125100905
MPUF101677730(PCSK1)
MNP132028001(PCSK1)
MLK131832482(PCSK1)
NVS122917393(PCSK1)
ORO101371118(PCSK1)
EJU114200059(PCSK1)
ZCA113929954(PCSK1)
MLX118017027(PCSK1)
NSU110588836(PCSK1)
LWW102738182(PCSK1)
FCA101082627(PCSK1)
PYU121012781(PCSK1)
PCOO112860347(PCSK1)
PBG122491394(PCSK1)
PVIV125164483(PCSK1)
LRUF124506660
PTG102971097(PCSK1)
PPAD109254711(PCSK1)
PUC125934319
AJU106969006
HHV120236545(PCSK1)
BTA281967(PCSK1)
BOM102266289(PCSK1)
BIU109562342(PCSK1)
BBUB102409694(PCSK1)
BBIS104982533(PCSK1)
CHX102184429(PCSK1)
OAS443029(PCSK1)
BTAX128051163(PCSK1)
ODA120864422(PCSK1)
CCAD122439511(PCSK1)
MBEZ129558348(PCSK1)
SSC397103(PCSK1)
CFR102510598(PCSK1)
CBAI105064574(PCSK1)
CDK105100892(PCSK1)
VPC102539848(PCSK1)
BACU103011823(PCSK1)
BMUS118892980(PCSK1)
LVE103072078(PCSK1)
OOR101287435(PCSK1)
DLE111184190(PCSK1)
PCAD102980822(PCSK1)
PSIU116751401(PCSK1)
NASI112394752(PCSK1)
ECB100064886(PCSK1)
EPZ103560422(PCSK1)
EAI106847921(PCSK1)
MYB102259719(PCSK1)
MYD102763458(PCSK1)
MMYO118656885(PCSK1)
MLF102427061(PCSK1)
PKL118703440(PCSK1)
EFUS103288761(PCSK1)
MNA107539604(PCSK1)
DRO112307450(PCSK1)
SHON118977340(PCSK1)
AJM119055604(PCSK1)
PDIC114502355(PCSK1)
PHAS123824850(PCSK1)
MMF118641861(PCSK1)
PPAM129074691(PCSK1)
HAI109390165(PCSK1)
RFQ117025199(PCSK1)
PALE102890971(PCSK1)
PGIG120612559(PCSK1)
PVP105304316(PCSK1)
RAY107518284(PCSK1)
MJV108390924(PCSK1)
TOD119260977(PCSK1)
SARA101548146(PCSK1)
SETR126001933(PCSK1)
LAV100677414(PCSK1)
TMU101353481
ETF101651877(PCSK1)
DNM101438393(PCSK1)
MDO100010673(PCSK1)
GAS123231388(PCSK1)
SHR100925062(PCSK1)
AFZ127559906
PCW110223473(PCSK1)
OAA100081484(PCSK1)
GGA769230(PCSK1)
PCOC116236588(PCSK1)
MGP100547608(PCSK1)
CJO107306483(PCSK1)
TPAI128089788(PCSK1)
LMUT125686616(PCSK1)
NMEL110390176(PCSK1)
APLA101796157(PCSK1)
ACYG106048829(PCSK1)
CATA118258698(PCSK1)
AFUL116500462(PCSK1)
TGU100226064(PCSK1)
LSR110472368(PCSK1)
SCAN103823246(PCSK1)
PMOA120497551(PCSK1)
OTC121331992(PCSK1)
PRUF121352023(PCSK1)
GFR102042035(PCSK1)
FAB101816616(PCSK1)
OMA130265614(PCSK1)
PHI102111185(PCSK1)
PMAJ107198324(PCSK1)
CCAE111940930(PCSK1)
CCW104689825(PCSK1)
CBRC103616413(PCSK1)
ETL114057120(PCSK1)
ZAB102071185(PCSK1)
ZLE135459423(PCSK1)
ACHL103803836(PCSK1)
SVG106857648(PCSK1)
MMEA130579758(PCSK1)
HRT120765664(PCSK1)
FPG101913861(PCSK1)
FCH102048239(PCSK1)
CLV102092106(PCSK1)
EGZ104122051(PCSK1)
NNI104015845(PCSK1) 104019230
PCRI104037707(PCSK1)
PLET104626526(PCSK1)
EHS104510645(PCSK1)
ACUN113490288(PCSK1)
TALA104364106(PCSK1)
PADL103918742(PCSK1)
AFOR103900083(PCSK1)
ACHC115337343(PCSK1)
HALD104321998(PCSK1)
HLE104832533(PCSK1)
AGEN126036342
GCL127027342
CCRI104167556(PCSK1)
CSTI104553579
CMAC104485983(PCSK1)
BREG104639357(PCSK1)
FGA104069084(PCSK1)
GSTE104263626(PCSK1)
LDI104349200(PCSK1)
MNB103771835
OHA104331739(PCSK1)
NNT104399501(PCSK1)
SHAB115601075(PCSK1)
DPUB104305612(PCSK1)
PGUU104461347(PCSK1)
ACAR104524047(PCSK1)
CPEA104394118(PCSK1)
AVIT104279224
CVF104285829(PCSK1)
RTD128903031(PCSK1)
CUCA104061096(PCSK1)
BRHI104496861(PCSK1)
AAM106485770 106488897(PCSK1)
AROW112974490(PCSK1)
NPD112951408(PCSK1)
TGT104566475(PCSK1) 104580040
DNE112980286(PCSK1)
SCAM104150384(PCSK1)
ASN102377633(PCSK1)
AMJ102564458(PCSK1)
CPOO109307699(PCSK1)
GGN109297219(PCSK1)
PSS102461055(PCSK1)
CMY102934087(PCSK1)
CCAY125636839(PCSK1)
DCC119856136(PCSK1)
CPIC101938233(PCSK1)
TST117879548(PCSK1)
CABI116835664(PCSK1)
MRV120408639(PCSK1)
ACS100565158(pcsk1)
ASAO132767163(PCSK1)
PVT110078772(PCSK1)
SUND121920967(PCSK1)
PBI103055161(PCSK1)
PMUR107302787(PCSK1)
CTIG120306718(PCSK1)
TSR106542108(PCSK1)
PGUT117679081(PCSK1)
APRI131192439(PCSK1)
PTEX113448531(PCSK1)
NSS113415254(PCSK1)
VKO123031580(PCSK1)
PMUA114606645(PCSK1)
PRAF128423369(PCSK1)
ZVI118076775(PCSK1)
HCG128346760(PCSK1)
GJA107119975(PCSK1)
STOW125436439(PCSK1)
EMC129334590(PCSK1)
XLA108707229(pcsk1.S)
XTR100496933(pcsk1)
NPR108790052(PCSK1)
MUO115462310(PCSK1)
GSH117352619(PCSK1)
DRE100005716(pcsk1)
SRX107739678 107754628
SANH107661910 107665244
SGH107584544(pcsk1) 107600928
CCAR109045223 109074034
CAUA113038837(pcsk1) 113063922
CGIB127941323 127986629
PTET122326897(pcsk1)
LROH127152493(pcsk1)
OMC131529376(pcsk1)
PPRM120490799(pcsk1)
RKG130090791(pcsk1)
MAMB125253063(pcsk1)
CIDE127504133 127525348
MASI127429212 127431248
TROS130570602(pcsk1)
TDW130408462(pcsk1)
MANU129424488(pcsk1)
IPU108279303
IFU128622601(pcsk1)
PHYP113535469(pcsk1)
SMEO124398413(pcsk1)
TFD113646394(pcsk1)
TVC132860272(pcsk1)
TRN134330490(pcsk1)
AMEX103035459(pcsk1)
CMAO118797500 118820256(pcsk1)
EEE113573749(pcsk1)
CHAR105902475(pcsk1)
TRU101067633(pcsk1)
TFS130524202(pcsk1) 130533158
TNGGSTEN00020152G001
LCO104923770 104928927(pcsk1)
NCC104957061(pcsk1)
TBEN117475445(pcsk1) 117480740
CGOB115008554(pcsk1) 115021661
PGEO117446970(pcsk1)
GACU117555251 117561867(pcsk1)
EMAC134862067 134882272(pcsk1)
ELY117257436(pcsk1) 117266197
EFO125887391(pcsk1) 125893281
PLEP121946024 121949891(pcsk1)
SLUC116034811(pcsk1) 116066554
ECRA117944094(pcsk1) 117945770
ESP116688116(pcsk1) 116690692
PFLV114554546(pcsk1) 114557388
GAT120810024 120834701(pcsk1)
PPUG119193893(pcsk1) 119197399
AFB129105992(pcsk1) 129109234
CLUM117727952 117731044(pcsk1)
PSWI130208301(pcsk1) 130213296
MSAM119886831(pcsk1) 119898035
SCHU122864174(pcsk1) 122882240
CUD121506991(pcsk1) 121513486
ALAT119005929 119021957(pcsk1)
MZE101467660(pcsk1)
ONL100534403(pcsk1)
OAU116326485(pcsk1)
OLA101161187 101174018(pcsk1)
OML112143846 112145446(pcsk1)
CSAI133440587 133448878(pcsk1)
XMA102231210(pcsk1) 106699876
XCO114135174(pcsk1) 114144237
XHE116710597(pcsk1) 116716835
PRET103464990(pcsk1)
PFOR103139591(pcsk1) 103151010
PLAI106949162(pcsk1) 106950884
PMEI106927188(pcsk1)
GAF122831727 122834414(pcsk1)
PPRL129358273(pcsk1) 129367733
CVG107088562 107091393(pcsk1)
CTUL119778565(pcsk1) 119795641
GMU124856155(pcsk1) 124865699
NFU107385468(pcsk1)
KMR108234188 108239887(pcsk1)
ALIM106523578(pcsk1) 106528261
NWH119410401 119412205(pcsk1)
AOCE111564532 111581198(pcsk1)
MCEP125007069(pcsk1) 125015863
CSEM103386425(pcsk1)
POV109628877(pcsk1) 109632018
SSEN122768375(pcsk1) 122774677
HHIP117761679(pcsk1) 117777394
HSP118105491(pcsk1) 118114289
PPLT128448803(pcsk1) 128450082
SMAU118299900 118309975(pcsk1)
LCF108887327 108899706
SDU111221841(pcsk1)
SLAL111671003(pcsk1)
XGL120784663 120807348(pcsk1)
HCQ109522656(pcsk1)
SSCV125977840
SBIA133507997(pcsk1)
PEE133408535(pcsk1)
PTAO133484038(pcsk1)
BPEC110166707(pcsk1)
MALB109956208(pcsk1) 109964548
BSPL114843405 114855241(pcsk1)
SJO128356279(pcsk1) 128366865
SASA106565194 106581764 106583415
STRU115150203 115177405 115208259
OTW112233763 112254937(pcsk1)
OMY110493995 110504035 110528459(pcsk1)
OGO124003492 124027572(pcsk1)
ONE115114274 115143329 115143598
OKI109891631 109892371
OKE118379244(pcsk1) 118389026
SALP111962632 111970427
SNH120026237 120064634(pcsk1)
CCLU121543941 121575510 121578046(pcsk1)
ELS105008684 105016778(pcsk1)
SFM108928574(pcsk1) 108937256
PKI111843765(pcsk1)
AANG118213112(pcsk1) 118237356
LOC102685299(pcsk1) 107078452
PSPA121305806 121313229 121316242
ARUT117402762 117403513 117973454
PSEX120525368 120532903(pcsk1)
LCM102356617(PCSK1)
CMK103178388(pcsk1)
CPLA122550661 122559736(pcsk1)
HOC132816742 132825846(pcsk1)
LERI129695881(pcsk1) 129697375 129698179
PMRN116953638
LRJ133355061(PCSK4)
BFO118409753
BBEL109462268 109482637 109484828
SCLV120346276
LPIC129258750
APLC110983302 110988880
AJC117100115 117122554
ECOE129942790
HIS119658457
AME410438
ALAB122716064
ADR102675390
AFLR100871573
BIM100740253
BTER100648653
FVI122535693
CCAL108632970
OBB114872734
OLG117603559
SOC105194699
MPHA105832146
AEC105151284
ACEP105618631
PBAR105422178
VEM105562269
HST105186252
DQU106744203
CFO105256335
FEX115235749
LHU105675912
PGC109854544
OBO105287489
PCF106790738
PFUC122517846
VPS122637643
VCRB124423104
VVE124957899
NVI100115928
CSOL105365254
TPRE106660601
LHT122505100
LBD127285344
MDL103577201
CGLO123261175
FAS105270428
AGIF122854046
CINS118069353
VCAN122415965
CCIN107269531
DSM124413630
NPT124221884
NFB124185040
NLO107223046
NVG124307938
AROA105693339
TCA661661
DPA109543176
SOY115888807
AGRG126740932
ATD109609666
CSET123315146
AGB108915560
LDC111510090
DVV126880496
NVL108559489 108564649
APLN108734297
PPYR116164260
OTU111413712
BMOR101741624
BMAN114240289
MSEX115448317
DPLKGM_215392
NIQ126773485
VCD124534771
MCIX123659254
PMAC106711372
PPOT106111529
PXU106119256
PRAP111003596
PBX123707344
PNAP125050633
ZCE119839762
CCRC123698679
LSIN126975494
AAGE121734422
HAW110376925
HZE124636801
TNL113503398
SLIU111355206
OFU114360672
ATRA106143291
PGW126370665
LGLY125234174
API100161992 100166094
DNX107168153
AGS114121160 114121161
RMD113556361 113557255
ACOO126846510 126846575
DVT126893713 126894017
BTAB109043119 109043175
DCI103505210 103512963 103513453
CLEC106667998
HHAL106683322
NLU120356274
HVI124365882
MQU128982096 128987228 129002668 129004034
PHUPhum_PHUM246240
FOC113206906
TPAL117645894
ZNE110838089
CSEC111870149
SGRE126281373
BROR134527325
IEL124166751
FCD110863089
DPXDAPPUDRAFT_43136 DAPPUDRAFT_59868
DMK116931038
DPZ124349263
PVM113829446
PJA122265272
PCHN125047912
PMOO119595243
HAME121855724
PCLA123762676
CQD128693866
PTRU123506832
ESN126983070
MNZ135209278 135212773
HAZT108664938
EAF111705271
LSM121118452
TCF131879452
PPOI119100268
DSV119449826
RSAN119382798
RMP119169333
TUT107362087
DPTE113791235
DFR124493883
CSCU111616523 111619886
PTEP107452277
ABRU129956177 129985133
UDV129225309 129232147
SDM118185696
LPOL106473941
PMEO129586529 129600864 129602351
HROHELRODRAFT_193616 HELRODRAFT_74170
LGILOTGIDRAFT_102960
PVUL126809519 126817679
PCAN112554321
BGT106078663
GAE121371772 121379630
HRF124114087 124115669
HRJ124254254 124257971
CRG105344671
CVN111103856 111128901
CANU128176473
OED125649115 125677735
MYI110462830
PMAX117334159
MCAF127734383
MMER123523001 123541536 123547153 123552686
RPHI132745223 132747204 132758737 132759675
DPOL127843859 127845818 127877737 127881056
OBI106874530 106875064
OSN115222333
LJP135474085
LAK106155046 106160625 106173102
SMMSmp_149400
LLON135487775 135500227
NVE5504528 5512606 5519937
EPA110239568 110248170 110248187 110251909
ATEN116288300 116290691 116290698 116301779 116304938
ADF107351431 107358341
AMIL114961986 114965472 114965473 114970251
PDAM113668359 113670666 113675011 113678927
SPIS111325458 111338335
DGT114521600 114522474 114537130 114537656 114537804 114540550
XEN124436810 124443035 124446506 124459460
HMG100201910 100202929 100205483
HSY130613855 130639822 130642775 130644785 130655201
TADTRIADDRAFT_22925
 » show all
Reference
1  [PMID:2169760]
  Authors
Seidah NG, Gaspar L, Mion P, Marcinkiewicz M, Mbikay M, Chretien M.
  Title
cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases.
  Journal
DNA Cell Biol 9:415-24 (1990)
DOI:10.1089/dna.1990.9.415
  Sequence
[mmu:18548]
Reference
2  [PMID:1988934]
  Authors
Smeekens SP, Avruch AS, LaMendola J, Chan SJ, Steiner DF
  Title
Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans.
  Journal
Proc Natl Acad Sci U S A 88:340-4 (1991)
DOI:10.1073/pnas.88.2.340
  Sequence
Reference
3  [PMID:1429684]
  Authors
Steiner DF, Smeekens SP, Ohagi S, Chan SJ.
  Title
The new enzymology of precursor processing endoproteases.
  Journal
J Biol Chem 267:23435-8 (1992)
Reference
4  [PMID:7845206]
  Authors
Seidah NG, Chretien M.
  Title
Pro-protein convertases of subtilisin/kexin family.
  Journal
Methods Enzymol 244:175-88 (1994)
DOI:10.1016/0076-6879(94)44015-8
Reference
5  [PMID:7741698]
  Authors
Jean F, Basak A, DiMaio J, Seidah NG, Lazure C.
  Title
An internally quenched fluorogenic substrate of prohormone convertase 1 and furin leads to a potent prohormone convertase inhibitor.
  Journal
Biochem J 307 ( Pt 3):689-95 (1995)
DOI:10.1042/bj3070689
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.93
IUBMB Enzyme Nomenclature: 3.4.21.93
ExPASy - ENZYME nomenclature database: 3.4.21.93
BRENDA, the Enzyme Database: 3.4.21.93
CAS: 99676-46-7

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