EC                Enzyme                                 

proprotein convertase 2;
neuroendocrine convertase 2;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Release of protein hormones and neuropeptides from their precursors, generally by hydrolysis of -Lys-Arg! bonds
A Ca2+-dependent enzyme, maximally active at about pH 5.5. Specificity is broader than that of prohormone convertase 1. Substrates include pro-opiomelanocortin, proenkephalin, prodynorphin, proglucagon, proinsulin and proluteinizing-hormone-releasing-hormone. Does not hydrolyse prorenin or prosomatostatin, however. Unusually, processing of prodynorphin occurs at a bond in which P2 is Thr. Present in the regulated secretory pathway of neuroendocrine cells, commonly acting co-operatively with prohormone convertase 1. In peptidase family S8 (subtilisin family)
EC created 1996
K01360  proprotein convertase subtilisin/kexin type 2
HSA: 5126(PCSK2)
PTR: 458106(PCSK2)
PPS: 100995237(PCSK2)
GGO: 101144581(PCSK2)
PON: 100171744(PCSK2)
NLE: 100606456(PCSK2)
MCC: 695730(PCSK2)
MCF: 102139968(PCSK2)
CSAB: 103214696(PCSK2)
RRO: 104676602(PCSK2)
RBB: 108544396(PCSK2)
CJC: 100410189(PCSK2)
SBQ: 101032326(PCSK2)
MMU: 18549(Pcsk2)
MCAL: 110284423(Pcsk2)
MPAH: 110317783(Pcsk2)
RNO: 25121(Pcsk2)
MUN: 110548494
CGE: 100771130(Pcsk2)
NGI: 103747731(Pcsk2)
HGL: 101710029(Pcsk2)
CCAN: 109679472(Pcsk2)
OCU: 100358339(PCSK2)
TUP: 102496906(PCSK2)
CFA: 485757(PCSK2)
VVP: 112922736(PCSK2)
AML: 100484456(PCSK2)
UMR: 103680513(PCSK2)
UAH: 113258239(PCSK2)
ORO: 101380258(PCSK2)
ELK: 111141692
FCA: 101098130(PCSK2)
PTG: 102951344(PCSK2)
PPAD: 109274692(PCSK2)
AJU: 106967042(PCSK2)
BTA: 281968(PCSK2)
BOM: 102280836(PCSK2)
BIU: 109568044(PCSK2)
BBUB: 102415434(PCSK2)
CHX: 106503927(PCSK2)
SSC: 445533(PCSK2)
CFR: 102511136(PCSK2)
CDK: 105094118(PCSK2)
BACU: 103012983(PCSK2)
LVE: 103076654(PCSK2)
OOR: 101276250(PCSK2)
PCAD: 102978314(PCSK2)
ECB: 100050755(PCSK2)
EPZ: 103561885(PCSK2)
EAI: 106841498
MYB: 102239561(PCSK2)
MYD: 102759435(PCSK2)
MNA: 107536362(PCSK2)
HAI: 109372764(PCSK2)
DRO: 112304169(PCSK2)
PALE: 102879445(PCSK2)
RAY: 107520753(PCSK2)
MJV: 108393766(PCSK2)
LAV: 100659343(PCSK2)
TMU: 101361430
MDO: 100033262(PCSK2)
SHR: 100925659(PCSK2)
PCW: 110208376(PCSK2)
OAA: 100085012(PCSK2)
GGA: 395136(PCSK2)
MGP: 100548840(PCSK2)
CJO: 107310688(PCSK2)
NMEL: 110396263(PCSK2)
APLA: 101791329(PCSK2)
ACYG: 106048665(PCSK2)
TGU: 100223337(PCSK2)
LSR: 110484895(PCSK2)
SCAN: 103822198(PCSK2)
GFR: 102034686(PCSK2)
FAB: 101808403(PCSK2)
PHI: 102111890(PCSK2)
PMAJ: 107202341(PCSK2)
CCAE: 111926118(PCSK2)
CCW: 104696571(PCSK2)
ETL: 114058803(PCSK2)
FPG: 101924281(PCSK2)
FCH: 102046561(PCSK2)
CLV: 102088621(PCSK2)
EGZ: 104122531(PCSK2)
NNI: 104022491(PCSK2)
ACUN: 113477999(PCSK2)
PADL: 103920513(PCSK2)
AAM: 106496400(PCSK2)
ASN: 102373017(PCSK2)
AMJ: 102576051(PCSK2)
PSS: 102463058(PCSK2)
CMY: 102939591(PCSK2)
CPIC: 101951129(PCSK2)
ACS: 100564235(pcsk2)
PVT: 110088789(PCSK2)
PBI: 103053916(PCSK2)
PMUR: 107283169(PCSK2)
TSR: 106542372(PCSK2)
PMUA: 114593687(PCSK2)
GJA: 107116988(PCSK2)
XLA: 373675(pcsk2.L) 444586(pcsk2.S)
XTR: 100036632(pcsk2)
NPR: 108793310(PCSK2)
DRE: 100004460(pcsk2)
SRX: 107719546(pcsk2) 107727889
CCAR: 109065357(pcsk2)
IPU: 108262286(pcsk2)
PHYP: 113542135(pcsk2)
AMEX: 103033370(pcsk2) 103039520
EEE: 113585930(pcsk2)
TRU: 101068590(pcsk2) 101070282
LCO: 104930725(pcsk2)
NCC: 104955826(pcsk2)
MZE: 101470601(pcsk2)
ONL: 100534405(pcsk2)
OLA: 100049241(pcsk2)
XMA: 102231965(pcsk2)
XCO: 114138283(pcsk2)
PRET: 103476807(pcsk2)
CVG: 107089286(pcsk2)
NFU: 107376020(pcsk2)
KMR: 108245432(pcsk2)
ALIM: 106513600(pcsk2)
AOCE: 111575540(pcsk2)
CSEM: 103387697(pcsk2)
POV: 109629655(pcsk2)
LCF: 108897258(pcsk2)
SDU: 111235221(pcsk2)
SLAL: 111670048(pcsk2)
HCQ: 109512729(pcsk2)
BPEC: 110157135(pcsk2)
MALB: 109960189(pcsk2)
SASA: 106576998(pcsk2) 106607177(NEC2)
OTW: 112253023(pcsk2) 112254478
ELS: 105010665(pcsk2)
SFM: 108927161(pcsk2) 108933539
PKI: 111859393(pcsk2)
LCM: 102352855(PCSK2)
CMK: 103177907(pcsk2)
RTP: 109916953
BFO: 118418937
CIN: 100181292(cipc2)
SPU: 579017
APLC: 110979638
SKO: 100377458(PCSK2)
DME: Dmel_CG6438(amon)
DER: 6555399
DSE: 6617074
DSI: Dsimw501_GD18123(Dsim_GD18123)
DAN: 6501342
DSR: 110186785
DPE: 6588537
DMN: 108157544
DWI: 6651467
DAZ: 108608635
DNV: 108659743
DHE: 111595913
DVI: 6634920
MDE: 101898851
LCQ: 111674565
AAG: 5564601
AME: 408835
BIM: 100742794
BTER: 100643887
CCAL: 108627030
OBB: 114877298
SOC: 105203804
MPHA: 105836432
AEC: 105147744
ACEP: 105620261
PBAR: 105426716
VEM: 105561866
HST: 105182032
DQU: 106746237
CFO: 105257823
LHU: 105674509
PGC: 109855266
OBO: 105288202
PCF: 106786031
NVI: 100116354
CSOL: 105364830
MDL: 103573332
TCA: 661336
DPA: 109535104
ATD: 109594697
NVL: 108562637
BMOR: 101740216
BMAN: 114246427
PRAP: 110994302
HAW: 110377468
TNL: 113498528
PXY: 105390833
API: 100167562
AGS: 114119692
RMD: 113555949
BTAB: 109043545
CLEC: 112126413
ZNE: 110830089
FCD: 110843872
PVM: 113827760
TUT: 107370069
DPTE: 113795626
CSCU: 111627047
PTEP: 107452671
CEL: CELE_C51E3.7(egl-3)
CBR: CBG09536(Cbr-egl-3)
BMY: Bm1_52415
PCAN: 112570448
CRG: 105340113
MYI: 110462057
OBI: 106876825
LAK: 106180256
SHX: MS3_05446
EGL: EGR_08746
LMIR: NCTC12852_01159(prcA_4)
LBF: LBF_3168
 » show all
1  [PMID:2169760]
Seidah NG, Gaspar L, Mion P, Marcinkiewicz M, Mbikay M, Chretien M.
cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases.
DNA Cell Biol 9:415-24 (1990)
2  [PMID:2154467]
Smeekens SP, Steiner DF.
Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2.
J Biol Chem 265:2997-3000 (1990)
3  [PMID:8159732]
Rouille Y, Westermark G, Martin SK, Steiner DF.
Proglucagon is processed to glucagon by prohormone convertase PC2 in alpha TC1-6 cells.
Proc Natl Acad Sci U S A 91:3242-6 (1994)
4  [PMID:7845206]
Seidah NG, Chretien M.
Pro-protein convertases of subtilisin/kexin family.
Methods Enzymol 244:175-88 (1994)
Other DBs
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IUBMB Enzyme Nomenclature:
ExPASy - ENZYME nomenclature database:
BRENDA, the Enzyme Database:
CAS: 388092-42-0

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