KEGG ENZYME: 3.4.21.94

ENZYME: 3.4.21.94

Entry

EC 3.4.21.94                Enzyme

Name

proprotein convertase 2;
neuroendocrine convertase 2;
PC2

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases

Reaction(IUBMB)

Release of protein hormones and neuropeptides from their precursors, generally by hydrolysis of -Lys-Arg! bonds

Comment

A Ca2+-dependent enzyme, maximally active at about pH 5.5. Specificity is broader than that of prohormone convertase 1. Substrates include pro-opiomelanocortin, proenkephalin, prodynorphin, proglucagon, proinsulin and proluteinizing-hormone-releasing-hormone. Does not hydrolyse prorenin or prosomatostatin, however. Unusually, processing of prodynorphin occurs at a bond in which P2 is Thr. Present in the regulated secretory pathway of neuroendocrine cells, commonly acting co-operatively with prohormone convertase 1. In peptidase family S8 (subtilisin family)

History

EC 3.4.21.94 created 1996

Orthology

K01360

proprotein convertase subtilisin/kexin type 2

Genes

HSA:	5126(PCSK2)

PTR:	458106(PCSK2)

PPS:	100995237(PCSK2)

GGO:	101144581(PCSK2)

PON:	100171744(PCSK2)

PPYG:

129022012(PCSK2)

NLE:	100606456(PCSK2)

HMH:	116461318(PCSK2)

SSYN:

129474135(PCSK2)

MCC:	695730(PCSK2)

MCF:	102139968(PCSK2)

MTHB:

126929184

MNI:	105486861(PCSK2)

CSAB:

103214696(PCSK2)

CATY:

105582050(PCSK2)

PANU:

101018120(PCSK2)

TGE:	112633217(PCSK2)

MLEU:

105539280(PCSK2)

RRO:	104676602(PCSK2)

RBB:	108544396(PCSK2)

TFN:	117068427(PCSK2)

PTEH:

111546421(PCSK2)

CANG:

105526674(PCSK2)

CJC:	100410189(PCSK2)

SBQ:	101032326(PCSK2)

CIMI:

108292043(PCSK2)

ANAN:

105732617(PCSK2)

CSYR:

103256179(PCSK2)

MMUR:

105868534(PCSK2)

LCAT:

123622882(PCSK2)

PCOQ:

105807145(PCSK2)

OGA:	100944687(PCSK2)

MMU:	18549(Pcsk2)

MCAL:

110284423(Pcsk2)

MPAH:

110317783(Pcsk2)

RNO:	25121(Pcsk2)

MCOC:

116091050(Pcsk2)

ANU:	117704080(Pcsk2)

ASYL:

127684930(Pcsk2)

MUN:	110548494(Pcsk2)

CGE:	100771130(Pcsk2)

MAUA:

106021024(Pcsk2)

PROB:

127221370(Pcsk2)

PLEU:

114709434(Pcsk2)

MORG:

121460161(Pcsk2)

MFOT:

126512047

AAMP:

119815398(Pcsk2)

NGI:	103747731(Pcsk2)

HGL:	101710029(Pcsk2)

CPOC:

100727607(Pcsk2)

CCAN:

109679472(Pcsk2)

DORD:

105993720(Pcsk2)

DSP:	122096086(Pcsk2)

DMER:

138816701(Pcsk2)

PLOP:

125352316(Pcsk2)

NCAR:

124970768

MMMA:

107134363(Pcsk2)

ITI:	101970522(Pcsk2)

OCU:

100358339

OPI:	101517360(PCSK2)

TUP:	102496906(PCSK2)

GVR:	103603908(PCSK2)

CFA:	485757(PCSK2)

CLUD:

112673545(PCSK2)

VVP:	112922736(PCSK2)

VLG:	121477688(PCSK2)

NPO:	129521699(PCSK2)

AML:	100484456(PCSK2)

UMR:	103680513(PCSK2)

UAH:	113258239(PCSK2)

UAR:	123797738(PCSK2)

ELK:

111141692

LLV:

125108857

MPUF:

101686940(PCSK2)

MNP:	132021712(PCSK2)

MLK:	131808137(PCSK2)

NVS:	122916283(PCSK2)

ORO:	101380258(PCSK2)

EJU:	114216413(PCSK2)

ZCA:	113938351(PCSK2)

MLX:	118011215(PCSK2)

NSU:	110590033(PCSK2)

LWW:	102736604(PCSK2)

FCA:	101098130(PCSK2)

PYU:	121012516(PCSK2)

PCOO:

112868923(PCSK2)

PBG:	122496591(PCSK2)

PVIV:

125162317(PCSK2)

LRUF:

124504157

LGF:	123580532(PCSK2)

AJU:

106967042

PTG:	102951344(PCSK2)

PPAD:

109274692(PCSK2)

PUC:

125936834

PLEZ:

122215838(PCSK2)

HHV:	120248232(PCSK2)

BTA:	281968(PCSK2)

BOM:	102280836(PCSK2)

BIU:	109568044(PCSK2)

BBUB:

102415434(PCSK2)

BBIS:

105003077(PCSK2)

CHX:	106503927(PCSK2)

OAS:	114117473 443027

BTAX:

128058040 128058509

CSUM:

138091459(PCSK2)

ODA:	120868996(PCSK2)

CCAD:

122448749(PCSK2)

MREE:

136157821(PCSK2)

OVR:	110138011(PCSK2)

MBEZ:

129555341(PCSK2)

SSC:	445533(PCSK2)

CFR:	102511136(PCSK2)

CBAI:

105083143(PCSK2)

CDK:	105094118(PCSK2)

VPC:	102526288(PCSK2)

BACU:

103012983(PCSK2)

BMUS:

118881888(PCSK2)

LVE:	103076654(PCSK2)

OOR:	101276250(PCSK2)

LALB:

132505320(PCSK2)

GMF:	115861635(PCSK2)

DLE:	111184969 111185078

PCAD:

102978314(PCSK2)

PSIU:

116740293(PCSK2)

PPHC:

136134425(PCSK2)

NASI:

112405362(PCSK2)

ECB:	100050755(PCSK2)

EPZ:	103561885(PCSK2)

EAI:	106823791(PCSK2)

MYB:	102239561(PCSK2)

MYD:	102759435(PCSK2)

MMYO:

118663794(PCSK2)

MLF:	102432827(PCSK2)

MDT:	132239333(PCSK2)

MYUM:

139013680(PCSK2)

PKL:	118708055(PCSK2)

EFUS:

103285692(PCSK2)

MNA:	107536362(PCSK2)

DRO:	112304169(PCSK2)

SHON:

118984882(PCSK2)

AJM:	119061122(PCSK2)

PDIC:

114506917(PCSK2)

PHAS:

123814658(PCSK2)

MMF:	118619150(PCSK2)

PPAM:

129070888(PCSK2)

HAI:	109372764(PCSK2)

RFQ:	117016129(PCSK2)

PALE:

102879445(PCSK2)

PGIG:

120611881(PCSK2)

PVP:	105299493(PCSK2)

RAY:	107520753(PCSK2)

MJV:	108393766(PCSK2)

TOD:	119232326(PCSK2) 119242620

SARA:

101540743(PCSK2)

SFUM:

130030147(PCSK2)

SETR:

126010749(PCSK2)

LAV:	100659343(PCSK2)

TMU:

101361430

ETF:	101640004(PCSK2)

DNM:	101416376(PCSK2)

MDO:	100033262(PCSK2)

GAS:	123234761(PCSK2)

SHR:	100925659(PCSK2)

AFZ:

127548466

PCW:	110208376(PCSK2)

TVP:	118843223(PCSK2)

PBRV:

138151891(PCSK2)

MLAO:

141514738(PCSK2)

OAA:	100085012(PCSK2)

TACU:

119932329(PCSK2)

GGA:	395136(PCSK2)

PCOC:

116235280(PCSK2)

MGP:	100548840(PCSK2)

CJO:	107310688(PCSK2)

TPAI:

128077852(PCSK2)

LMUT:

125689022(PCSK2)

NMEL:

110396263(PCSK2)

APLA:

101791329(PCSK2)

ACYG:

106048665(PCSK2)

CATA:

118251151(PCSK2)

AFUL:

116488002(PCSK2)

TGU:	100223337(PCSK2)

LSR:	110484895(PCSK2)

SCAN:

103822198(PCSK2)

PMOA:

120506870(PCSK2)

OTC:	121335864(PCSK2)

PRUF:

121358756(PCSK2)

ATRC:

139589110(PCSK2)

GFR:	102034686(PCSK2)

FAB:	101808403(PCSK2)

OMA:	130251508(PCSK2)

PHI:	102111890(PCSK2)

PMAJ:

107202341(PCSK2)

CCAE:

111926118(PCSK2)

CCW:	104696571(PCSK2)

CBRC:

103617205(PCSK2)

ACOE:

138107611(PCSK2)

ETL:	114058803(PCSK2)

ZAB:	102063514(PCSK2)

ZLE:	135445944(PCSK2)

ACHL:

103809599(PCSK2)

SVG:	106863229(PCSK2)

MMEA:

130575246(PCSK2)

HRT:	120750420(PCSK2)

SATI:

136359662(PCSK2)

CCIC:

134042278(PCSK2)

FPG:	101924281(PCSK2)

FCH:	102046561(PCSK2)

CCRI:

104164777(PCSK2)

NNT:	104411689(PCSK2)

SHAB:

115609680(PCSK2)

ACUN:

113477999(PCSK2)

TALA:

104358328(PCSK2)

ACHC:

115344536(PCSK2)

HALD:

104312650

HLE:	104836443(PCSK2)

AGEN:

126038426

HHAR:

128140433(PCSK2)

GCL:

127014213

LDI:	104354308(PCSK2)

MNB:	103780818(PCSK2)

DPUB:

104305994(PCSK2)

PPUS:

135176804(PCSK2)

AVIT:

104275039(PCSK2)

BRHI:

104499218(PCSK2)

EGZ:	104122531(PCSK2)

NNI:	104022491(PCSK2)

PCRI:

104027279(PCSK2)

PCAO:

104047597(PCSK2)

PADL:

103920513(PCSK2)

AFOR:

103901650(PCSK2)

FGA:	104077143(PCSK2)

GSTE:

104257903(PCSK2)

CBOY:

140650359(PCSK2)

CLV:	102088621(PCSK2)

CNIC:

135987750(PCSK2)

MUI:	104536743(PCSK2)

PGUU:

104463966(PCSK2)

PLET:

104626782(PCSK2)

EHS:	104513798(PCSK2)

CUCA:

104055448(PCSK2)

BREG:

104632403(PCSK2)

OHA:	104332924(PCSK2)

ACAR:

104532040(PCSK2)

CPEA:

104390984(PCSK2)

CVF:	104283269(PCSK2)

RTD:	128907412(PCSK2)

CRID:

134512489(PCSK2)

AAM:	106496400(PCSK2)

AROW:

112961092(PCSK2)

NPD:	112945085(PCSK2)

TGT:	104564754(PCSK2)

DNE:	112989352(PCSK2)

SCAM:

104143481(PCSK2)

ASN:	102373017(PCSK2)

AMJ:	102576051(PCSK2)

CPOO:

109319520(PCSK2)

GGN:	109296915(PCSK2)

PSS:	102463058(PCSK2)

CMY:	102939591(PCSK2)

CCAY:

125633454(PCSK2)

DCC:	119853688(PCSK2)

CPIC:

101951129(PCSK2)

TST:	117874087(PCSK2)

CABI:

116840008(PCSK2)

MRV:	120401432(PCSK2)

ACS:	100564235(pcsk2)

ASAO:

132780445(PCSK2)

PVT:	110088789(PCSK2)

SUND:

121919837(PCSK2)

PBI:	103053916(PCSK2)

PMUR:

107283169(PCSK2)

CTIG:

120310661

TSR:	106542372(PCSK2)

PGUT:

117674425(PCSK2)

PCAE:

139326429(PCSK2)

APRI:

131197647(PCSK2)

PTEX:

113444230(PCSK2)

NSS:	113412708(PCSK2)

VKO:	123035864(PCSK2)

PMUA:

114593687(PCSK2)

PRAF:

128409983(PCSK2)

ZVI:	118082473(PCSK2)

HCG:	128339967(PCSK2)

GJA:	107116988(PCSK2)

STOW:

125438196

EMC:	129343477(PCSK2)

XLA:	373675(pcsk2.L) 444586(pcsk2.S)

XTR:	100036632(pcsk2)

NPR:	108793310(PCSK2)

RTEM:

120937785(PCSK2)

ACAT:

141140761(PCSK2)

BBUF:

120999305(PCSK2)

BGAR:

122935639(PCSK2)

DTC:	141057268(PCSK2)

PWL:	138295658(PCSK2)

MUO:	115465689(PCSK2)

GSH:	117358024(PCSK2)

DRE:	100004460(pcsk2)

SRX:	107719546(pcsk2) 107727889

SANH:

107699156 107701967

SGH:	107561970 107573254

CCAR:

109065357 109100431

CAUA:

113057406 113113092

CGIB:

127969646 128026550

PTET:

122335481 122335483(pcsk2)

LROH:

127174793(pcsk2)

GRF:	141326500(pcsk2)

OMC:	131552783(pcsk2)

PPRM:

120492369(pcsk2)

RKG:	130103842(pcsk2)

MAMB:

125277521(pcsk2)

CIDE:

127525198

CERY:

137020210(pcsk2)

MASI:

127412310 127413928

TROS:

130559111(pcsk2)

TDW:	130432213(pcsk2)

MANU:

129416255(pcsk2)

PDAB:

135731775(pcsk2)

IPU:

108262286

IFU:	128605267(pcsk2)

PHYP:

113542135(pcsk2)

SMEO:

124403240(pcsk2)

TFD:	113655412(pcsk2)

TVC:	132847004(pcsk2)

CGAR:

128528459(pcsk2)

NGRA:

132888574(pcsk2)

TRN:	134314452(pcsk2)

AMEX:

103033370(pcsk2)

CMAO:

118810137(pcsk2)

EEE:	113585930(pcsk2)

CHAR:

105892728(pcsk2)

SPIL:

134064216(pcsk2)

TRU:	101068590(pcsk2) 101070282

TFS:	130534025(pcsk2)

TNG:	GSTEN00016397G001

LCO:	104930725(pcsk2)

NCC:	104955826(pcsk2)

TBEN:

117499911(pcsk2)

CGOB:

115020186(pcsk2)

PGEO:

117459288(pcsk2)

GACU:

117560906(pcsk2)

EMAC:

134858378(pcsk2)

ELY:	117248386(pcsk2)

EFO:	125903111(pcsk2)

PLEP:

121954547(pcsk2)

SLUC:

116055069(pcsk2)

ECRA:

117960430(pcsk2)

ESP:	116705553(pcsk2)

PFLV:

114572158(pcsk2)

GAT:	120820648(pcsk2)

PPUG:

119214010(pcsk2)

AFB:	129092246(pcsk2)

CLUM:

117744078(pcsk2)

PSWI:

130207080(pcsk2)

CANA:

137779680(pcsk2)

CVE:	137880142(pcsk2)

MSAM:

119917635(pcsk2)

SCHU:

122884577(pcsk2)

CUD:	121510697(pcsk2)

SPUL:

138588826(pcsk2)

LMIX:

132975383(pcsk2)

ALAT:

119033989(pcsk2)

ASTR:

137603657(pcsk2)

MZE:	101470601(pcsk2)

ONL:	100534405(pcsk2)

OAU:	116333735(pcsk2)

OLA:	100049241(pcsk2)

OML:	112161964(pcsk2)

CSAI:

133464056(pcsk2)

XMA:	102231965(pcsk2)

XCO:	114138283(pcsk2)

XHE:	116713436(pcsk2)

PRET:

103476807(pcsk2)

PFOR:

103133516(pcsk2)

PLAI:

106947443(pcsk2)

PMEI:

106915462(pcsk2)

GAF:	122842986(pcsk2)

PPRL:

129360133(pcsk2)

CVG:	107089286(pcsk2)

CTUL:

119790858(pcsk2)

GMU:	124859577(pcsk2)

NFU:	107376020(pcsk2)

KMR:	108245432(pcsk2)

ALIM:

106513600(pcsk2)

NWH:	119419217(pcsk2)

AOCE:

111575540(pcsk2)

EJA:	138192492(pcsk2)

BFRE:

138617626(pcsk2)

MCEP:

125018824(pcsk2)

CSEM:

103387697(pcsk2)

POV:	109629655(pcsk2)

SSEN:

122781804(pcsk2)

SSOE:

131474417(pcsk2)

HHIP:

117775550(pcsk2)

HSP:	118119407(pcsk2)

PPLT:

128453592(pcsk2)

SMAU:

118284093(pcsk2)

LCF:

108897258

SDU:	111235221(pcsk2)

SLAL:

111670048(pcsk2)

XGL:	120796104(pcsk2)

HCQ:	109512729(pcsk2)

SSCV:

125978557(pcsk2)

SBIA:

133510256(pcsk2)

PEE:	133409613(pcsk2)

PTAO:

133485983(pcsk2)

BPEC:

110157135(pcsk2)

ENY:	140351575(pcsk2)

MALB:

109960189(pcsk2)

BSPL:

114870766(pcsk2)

SJO:	128373131(pcsk2)

SSCO:

133991820(pcsk2)

GMH:	115560303(pcsk2)

SASA:

106576998(pcsk2) 106607177(NEC2)

STRU:

115153213 115193769

OTW:	112253023(pcsk2) 112254478

OMY:	110502463 110528870(pcsk2)

OGO:	124038252 124041260(pcsk2)

ONE:	115113227 115135108

OKI:	109889940(pcsk2) 109899106

OKE:	118369712(pcsk2) 118400241

OMM:	135511021(pcsk2) 135512328

OCLA:

139381940 139411608

SALP:

111952031 111977791

SNH:	120017928(pcsk2) 120045675

CCLU:

121553379(pcsk2) 121570819

ELS:	105010665(pcsk2)

OEP:	134022771(pcsk2)

SFM:	108927161(pcsk2) 108933539

PKI:	111859393(pcsk2)

AANG:

118217939 118218362(pcsk2)

AROT:

135244439(pcsk2) 135244664

CCOG:

133121803(pcsk2)

LOC:	102684877(pcsk2)

PSPA:

121316109 121317233

ARUT:

117403276 117972516

PSEX:

120516353(pcsk2)

LCM:	102352855(PCSK2)

CMK:	103177907(pcsk2)

RTP:	109916953(pcsk2)

CPLA:

122553106(pcsk2)

HOC:	132819532(pcsk2)

LERI:

129695066(pcsk2)

HAKA:

140730590(pcsk2)

PMRN:

116939757(PCSK2)

LRJ:	133347050(PCSK2)

BFO:

118418937

BBEL:

109477140

CIN:	100181292(cipc2)

SCLV:

120327027

SPU:

579017

LPIC:

129265223

AJJ:

139970988

APLC:

110979638

ARUN:

117288504

AAMU:

139934035

AFIL:

140153122

AJC:

117105634

SKO:	100377458(PCSK2)

PFLL:

139149034

DME:	Dmel_CG6438(amon)

DER:

6555399

DSE:

6617074

DSI:	Dsimw501_GD18123(Dsim_GD18123)

DYA:	Dyak_GE10618

DAN:

6501342

DSR:

110186785

DPO:

4801332

DPE:

6588537

DMN:

108157544

DWI:

6651467

DGR:

6564437

DMO:	Dmoj_GI24730

DAZ:

108608635

DNV:

108659743

DHE:

111595913

DVI:	6634920(amon)

CCAT:

101451751

BOD:

106619189

BDR:

105227005

RZE:	108354669 108358306

AOQ:

129235498

ALUD:

128855084

TDA:

119676081

MDE:

101898851

SCAC:

106093803

LCQ:

111674565

LSQ:

119602282

CVJ:	135949597(amon)

GFS:

119641728

ECOE:

129942097

CLON:

129611764

HIS:

119651742

AGA:

1269379

ACOZ:

120947236

AARA:

120894120

AMER:

121603559

ASTE:

118504559

AMAP:

126557373

AFUN:

125765923

AMOU:

128309905

AMRS:

128710042

AALI:

118456826

ACOS:

131261466

AAG:

5564601

ASUA:

134205299

CQU:	CpipJ_CPIJ012757

CPII:

120425703

CBRI:

134833440

CNS:

116338383

BCOO:

119069360

LLL:

129787173

PPAP:

129799714

AME:

408835

ACER:

107994313

ALAB:

122714812

ADR:

102671853

AFLR:

100866084

BIM:

100742794

BBIF:

117207586

BVK:

117230983

BVAN:

117159273

BHUN:

126872036

BTER:

100643887

BAFF:

126921960

BPYO:

122567793

BPAS:

132912777

FVI:

122537275

CCAL:

108627030

OBB:

114877298

OLG:

117602708

MGEN:

117224878

NMEA:

116432650

CGIG:

122399076

SOC:

105203804

MPHA:

105836432

AEC:

105147744

ACEP:

105620261

ACOC:

108692590

MZT:	108727247(amon)

PBAR:

105426716

VEM:

105561866

COBS:

139105873(Amon)

TLN:	139822543(Amon)

HST:

105182032

DQU:

106746237

CFO:

105257823

FEX:

115236096

PMEC:

138941049(Amon)

LHU:	105674509(amon)

PGC:

109855266

OBO:

105288202

PCF:

106786031

PFUC:

122525919

VPS:

122633063

VCRB:

124427840

VVE:

124952820

NVI:

100116354

CSOL:

105364830

TPRE:

106650164

LHT:

122498459

LBD:

127280500

MDL:

103573332

CGLO:

123266032

CTYP:

141530689(Amon)

FAS:

105270270

DAM:

107036026

AGIF:

122853164

CINS:

118067914

VCAN:

122410143

CCIN:

107263285

DSM:

124408242

NPT:	124217896(amon)

NFB:

124181299

NLO:

107225795

NVG:

124303838

AROA:

105692395

TCA:

661336

TMOL:

138123084(amon)

DPA:

109535104

ESIM:

136408713(amon)

EFOR:

136341544(amon)

SOY:

115880323

AGRG:

126735256

ATD:

109594697

CSET:

123307847

HAXR:

123682466

AGB:

108909206

LDC:

111511946

DVV:

114330885

NVL:

108562637

DCOR:

135798894(amon)

APLN:

108736387

PPYR:

116172692

OTU:

111418869

BMOR:

101740216

BMAN:

114246427

MSEX:

115453010 115455278

BANY:

112058357

MJU:

123874843

NIQ:

126775961

VCD:

124538251

MCIX:

123662200

PMAC:

106719619 106721647

PPOT:

106110445

PXU:

106119922

BPHI:

137920054(amon)

PRAP:

110994302

PBX:

123716616

PNAP:

125059948

ZCE:

119828501

CCRC:

123699680

LSIN:

126966140

AAGE:

121726121

HAW:

110377468

HZE:

124639980

TNL:

113498528

SLIU:

111350287

OFU:

114362794

ONU:

135080895

ATRA:

106143350

GMW:

116413009

PXY:

105390833

PGW:

126375128

LGLY:

125232347

CSTB:

134748245

CFUM:

141432798(amon)

CFEL:

113375187

CCRN:

123292934

API:

100167562

DNX:	107161769 107161799

AGS:

114119692

RMD:

113555949

ACOO:

126844167

DVT:

126900007

BTAB:

109043545

DCI:

103511271

CLEC:

112126413

HHAL:

106685325

NLU:	111057277 111062474

HVI:

124371878

MQU:

128985528

PHU:	Phum_PHUM354430

FOC:	113203115 127749951

TPAL:

117650796

ZNE:

110830089

CSEC:

111865371

PAME:

138692926(amon)

SGRE:

126266626

BROR:

134538304

IEL:

124167752

HAMR:

139698650(amon)

FCD:

110843872

DPX:	DAPPUDRAFT_193075

DMK:

116931096

DPZ:

124327055

AFRA:

136029425

PVM:	113827760(amon)

PJA:

122251134

PCHN:

125025999

PMOO:

119576977

HAME:

121875763

PCLA:

123765084(amon)

CQD:	128703341(amon)

PTRU:

123518529

ESN:

126987833

MNZ:

135208751

MRJ:	136845842(amon)

PORN:

139760507(amon)

HAZT:

108671730

EAF:

111706660

LSM:	121122294(amon)

TCF:

131884160

PPOI:

119093727

ISC:

8034786

DSV:	119453738 119464287

RSAN:

119401392

RMP:

119164045

VDE:

111247174

VJA:

111259967

GOE:

100906556

TUT:

107370069

DPTE:

113795626

DFR:

124499025

CSCU:

111627047

CVS:

136969304

PTEP:

107452671

ABRU:

129956628

UDV:

129224015

SDM:

118180923

LPOL:

106459205

PMEO:

129584982

CEL:	CELE_C51E3.7(egl-3)

CBR:	CBG_09536(Cbr-egl-3)

CRQ:	GCK72_017605

NAI:	NECAME_01697 NECAME_12953

BMY:	BM_BM2886(Bma-egl-3)

LOA:	LOAG_16369

TSP:	Tsp_03058 Tsp_03058a

HRO:	HELRODRAFT_96355

LGI:	LOTGIDRAFT_212426

PCAN:

112570448

LSAX:

138952393

BGT:

106073932

GAE:

121370855

HRF:

124141952

HRJ:

124287366

HASI:

137294422

HCRA:

139442108

CRG:

105340113

CANU:

128157396 128175454 128185202 128186002

CVN:	111125728 111125730 111130394

OED:

125649577

MYI:

110462057

PMAX:

117323912 117328224

AIRR:

138319214 138329358

MCAF:

127698734

MMER:

123536670 123550436

RPHI:

132725002 132725003 132731113 132734671 132737329 132745221 132745222 132755075

DPOL:

127843860 127873116

MAEA:

128208261 128216501 128228786 128228796 128228806 128234937 128237515 128243021 128243565 128246621

OBI:

106876825

OSN:

115229259

LJP:	135463056 135466772

LAK:

106180256

SMM:	Smp_077980

SHX:	MS3_00006538(PCSK2)

OVI:	T265_05982

EGL:

EGR_08746

LLON:

135485607

TVA:	4727949(TVAGG3_0621280) 4764663(TVAGG3_0931330) 4768456(TVAGG3_0221310) 75663497(TVAGG3_0621030)

LMIR:

NCTC12852_01159(prcA_4)

LBI:	LEPBI_I3281

LBF:

LBF_3168

» show all

Reference

1 [PMID:2169760]

Authors

Seidah NG, Gaspar L, Mion P, Marcinkiewicz M, Mbikay M, Chretien M.

Title

cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases.

Journal

DNA Cell Biol 9:415-24 (1990)
DOI:10.1089/dna.1990.9.415

Sequence

[mmu:18549]

Reference

2 [PMID:2154467]

Authors

Smeekens SP, Steiner DF.

Title

Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2.

Journal

J Biol Chem 265:2997-3000 (1990)

Sequence

[hsa:5126]

Reference

3 [PMID:8159732]

Authors

Rouille Y, Westermark G, Martin SK, Steiner DF.

Title

Proglucagon is processed to glucagon by prohormone convertase PC2 in alpha TC1-6 cells.

Journal

Proc Natl Acad Sci U S A 91:3242-6 (1994)
DOI:10.1073/pnas.91.8.3242

Reference

4 [PMID:7845206]

Authors

Seidah NG, Chretien M.

Title

Pro-protein convertases of subtilisin/kexin family.

Journal

Methods Enzymol 244:175-88 (1994)
DOI:10.1016/0076-6879(94)44015-8

Other DBs

ExplorEnz - The Enzyme Database:

3.4.21.94

IUBMB Enzyme Nomenclature:

3.4.21.94

ExPASy - ENZYME nomenclature database:

3.4.21.94

BRENDA, the Enzyme Database:

3.4.21.94

CAS:	388092-42-0

All links

Gene (3140)   
   MGENES (512)   
   RefGene (2628)   
Protein sequence (1805)   
   UniProt (1772)   
   SWISS-PROT (8)   
   RefSeq(pep) (21)   
   PMD (4)   
DNA sequence (56)   
   RefSeq(nuc) (25)   
   GenBank (18)   
   EMBL (13)   
Protein domain (11)   
   InterPro (11)   
All databases (5012)   

Download RDF

DBGET integrated database retrieval system