KEGG   ENZYME: 3.4.21.94
Entry
EC 3.4.21.94                Enzyme                                 
Name
proprotein convertase 2;
neuroendocrine convertase 2;
PC2
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Release of protein hormones and neuropeptides from their precursors, generally by hydrolysis of -Lys-Arg! bonds
Comment
A Ca2+-dependent enzyme, maximally active at about pH 5.5. Specificity is broader than that of prohormone convertase 1. Substrates include pro-opiomelanocortin, proenkephalin, prodynorphin, proglucagon, proinsulin and proluteinizing-hormone-releasing-hormone. Does not hydrolyse prorenin or prosomatostatin, however. Unusually, processing of prodynorphin occurs at a bond in which P2 is Thr. Present in the regulated secretory pathway of neuroendocrine cells, commonly acting co-operatively with prohormone convertase 1. In peptidase family S8 (subtilisin family)
History
EC 3.4.21.94 created 1996
Orthology
K01360  proprotein convertase subtilisin/kexin type 2
Genes
HSA5126(PCSK2)
PTR458106(PCSK2)
PPS100995237(PCSK2)
GGO101144581(PCSK2)
PON100171744(PCSK2)
NLE100606456(PCSK2)
MCC695730(PCSK2)
MCF102139968(PCSK2)
CSAB103214696(PCSK2)
CATY105582050(PCSK2)
PANU101018120(PCSK2)
TGE112633217(PCSK2)
RRO104676602(PCSK2)
RBB108544396(PCSK2)
TFN117068427(PCSK2)
PTEH111546421(PCSK2)
CJC100410189(PCSK2)
SBQ101032326(PCSK2)
CSYR103256179(PCSK2)
MMUR105868534(PCSK2)
LCAT123622882(PCSK2)
OGA100944687(PCSK2)
MMU18549(Pcsk2)
MCAL110284423(Pcsk2)
MPAH110317783(Pcsk2)
RNO25121(Pcsk2)
MCOC116091050(Pcsk2)
MUN110548494
CGE100771130(Pcsk2)
MAUA106021024(Pcsk2)
PLEU114709434(Pcsk2)
MORG121460161(Pcsk2)
AAMP119815398(Pcsk2)
NGI103747731(Pcsk2)
HGL101710029(Pcsk2)
CPOC100727607(Pcsk2)
CCAN109679472(Pcsk2)
DORD105993720(Pcsk2)
DSP122096086(Pcsk2)
NCAR124970768
OCU100358339(PCSK2)
OPI101517360(PCSK2)
TUP102496906(PCSK2)
CFA485757(PCSK2)
CLUD112673545(PCSK2)
VVP112922736(PCSK2)
VLG121477688(PCSK2)
AML100484456(PCSK2)
UMR103680513(PCSK2)
UAH113258239(PCSK2)
UAR123797738(PCSK2)
ELK111141692
LLV125108857
MPUF101686940(PCSK2)
ORO101380258(PCSK2)
EJU114216413(PCSK2)
ZCA113938351(PCSK2)
MLX118011215(PCSK2)
FCA101098130(PCSK2)
PYU121012516(PCSK2)
PBG122496591(PCSK2)
PTG102951344(PCSK2)
PPAD109274692(PCSK2)
AJU106967042(PCSK2)
HHV120248232(PCSK2)
BTA281968(PCSK2)
BOM102280836(PCSK2)
BIU109568044(PCSK2)
BBUB102415434(PCSK2)
CHX106503927(PCSK2)
OAS114108776 114117573 443027
ODA120868996(PCSK2)
CCAD122448749(PCSK2)
SSC445533(PCSK2)
CFR102511136(PCSK2)
CBAI105083143(PCSK2)
CDK105094118(PCSK2)
VPC102526288(PCSK2)
BACU103012983(PCSK2)
LVE103076654(PCSK2)
OOR101276250(PCSK2)
DLE111184969 111185078
PCAD102978314(PCSK2)
PSIU116740293(PCSK2)
ECB100050755(PCSK2)
EPZ103561885(PCSK2)
EAI106823791(PCSK2)
MYB102239561(PCSK2)
MYD102759435(PCSK2)
MMYO118663794(PCSK2)
MLF102432827(PCSK2)
MNA107536362(PCSK2)
PKL118708055(PCSK2)
HAI109372764(PCSK2)
DRO112304169(PCSK2)
SHON118984882(PCSK2)
AJM119061122(PCSK2)
PDIC114506917(PCSK2)
PHAS123814658(PCSK2)
MMF118619150(PCSK2)
RFQ117016129(PCSK2)
PALE102879445(PCSK2)
PGIG120611881(PCSK2)
PVP105299493(PCSK2)
RAY107520753(PCSK2)
MJV108393766(PCSK2)
TOD119232326(PCSK2) 119242620
SARA101540743(PCSK2)
LAV100659343(PCSK2)
TMU101361430
DNM101416376(PCSK2)
MDO100033262(PCSK2)
GAS123234761(PCSK2)
SHR100925659(PCSK2)
PCW110208376(PCSK2)
OAA100085012(PCSK2)
GGA395136(PCSK2)
PCOC116235280(PCSK2)
MGP100548840(PCSK2)
CJO107310688(PCSK2)
NMEL110396263(PCSK2)
APLA101791329(PCSK2)
ACYG106048665(PCSK2)
AFUL116488002(PCSK2)
TGU100223337(PCSK2)
LSR110484895(PCSK2)
SCAN103822198(PCSK2)
PMOA120506870(PCSK2)
OTC121335864(PCSK2)
PRUF121358756(PCSK2)
GFR102034686(PCSK2)
FAB101808403(PCSK2)
PHI102111890(PCSK2)
PMAJ107202341(PCSK2)
CCAE111926118(PCSK2)
CCW104696571(PCSK2)
CBRC103617205(PCSK2)
ETL114058803(PCSK2)
ZAB102063514(PCSK2)
ACHL103809599(PCSK2)
FPG101924281(PCSK2)
FCH102046561(PCSK2)
CLV102088621(PCSK2)
EGZ104122531(PCSK2)
NNI104022491(PCSK2)
PLET104626782(PCSK2)
PCRI104027279(PCSK2)
ACUN113477999(PCSK2)
TALA104358328(PCSK2)
PADL103920513(PCSK2)
ACHC115344536(PCSK2)
HALD104312650
CCRI104164777(PCSK2)
EHS104513798(PCSK2)
MUI104536743(PCSK2)
FGA104077143(PCSK2)
GSTE104257903(PCSK2)
LDI104354308(PCSK2)
MNB103780818(PCSK2)
OHA104332924(PCSK2)
AAM106496400(PCSK2)
AROW112961092(PCSK2)
NPD112945085(PCSK2)
DNE112989352(PCSK2)
ASN102373017(PCSK2)
AMJ102576051(PCSK2)
CPOO109319520(PCSK2)
GGN109296915(PCSK2)
PSS102463058(PCSK2)
CMY102939591(PCSK2)
CPIC101951129(PCSK2)
TST117874087(PCSK2)
CABI116840008(PCSK2)
MRV120401432(PCSK2)
ACS100564235(pcsk2)
PVT110088789(PCSK2)
SUND121919837(PCSK2)
PBI103053916(PCSK2)
PMUR107283169(PCSK2)
TSR106542372(PCSK2)
PGUT117674425(PCSK2)
VKO123035864(PCSK2)
PMUA114593687(PCSK2)
ZVI118082473(PCSK2)
GJA107116988(PCSK2)
STOW125438196
XLA373675(pcsk2.L) 444586(pcsk2.S)
XTR100036632(pcsk2)
NPR108793310(PCSK2)
RTEM120937785(PCSK2)
BBUF120999305(PCSK2)
BGAR122935639(PCSK2)
DRE100004460(pcsk2)
SRX107719546(pcsk2) 107727889
SANH107699156 107701967
SGH107561970 107573254
CCAR109065357(pcsk2)
CAUA113057406 113113092
PPRM120492369(pcsk2)
MAMB125277521(pcsk2)
IPU108262286(pcsk2)
PHYP113542135(pcsk2)
SMEO124403240(pcsk2)
TFD113655412(pcsk2)
AMEX103033370(pcsk2) 103039520
EEE113585930(pcsk2)
TRU101068590(pcsk2) 101070282
TNGGSTEN00016397G001
LCO104930725(pcsk2)
NCC104955826(pcsk2)
CGOB115020186(pcsk2)
ELY117248386(pcsk2)
EFO125903111(pcsk2)
PLEP121954547(pcsk2)
SLUC116055069(pcsk2)
ECRA117960430(pcsk2)
ESP116705553(pcsk2)
PFLV114572158(pcsk2)
GAT120820648(pcsk2)
PPUG119214010(pcsk2)
MSAM119917635(pcsk2)
CUD121510697(pcsk2)
ALAT119033989(pcsk2)
MZE101470601(pcsk2)
ONL100534405(pcsk2)
OAU116333735(pcsk2)
OLA100049241(pcsk2)
OML112161964(pcsk2)
XMA102231965(pcsk2)
XCO114138283(pcsk2)
XHE116713436(pcsk2)
PRET103476807(pcsk2)
PFOR103133516(pcsk2)
PLAI106947443(pcsk2)
PMEI106915462(pcsk2)
GAF122842986(pcsk2)
CVG107089286(pcsk2)
CTUL119790858(pcsk2)
GMU124859577(pcsk2)
NFU107376020(pcsk2)
KMR108245432(pcsk2)
ALIM106513600(pcsk2)
NWH119419217(pcsk2)
AOCE111575540(pcsk2)
MCEP125018824(pcsk2)
CSEM103387697(pcsk2)
POV109629655(pcsk2)
SSEN122781804(pcsk2)
HHIP117775550(pcsk2)
HSP118119407(pcsk2)
LCF108897258(pcsk2)
SDU111235221(pcsk2)
SLAL111670048(pcsk2)
XGL120796104(pcsk2)
HCQ109512729(pcsk2)
BPEC110157135(pcsk2)
MALB109960189(pcsk2)
BSPL114870766(pcsk2)
SASA106576998(pcsk2) 106607177(NEC2)
OTW112253023(pcsk2) 112254478
OMY110502463 110528870(pcsk2)
OGO124038252 124041260(pcsk2)
ONE115113227 115135108
SALP111952031 111977791
SNH120017928(pcsk2) 120045675
CCLU121553379(pcsk2) 121570819
ELS105010665(pcsk2)
SFM108927161(pcsk2) 108933539
PKI111859393(pcsk2)
AANG118217939 118218362(pcsk2)
LOC102684877(pcsk2)
PSPA121316109 121317233
ARUT117403276 117972516
LCM102352855(PCSK2)
CMK103177907(pcsk2)
RTP109916953
BFO118418937
BBEL109477140
CIN100181292(cipc2)
SCLV120327027
SPU579017
APLC110979638
SKO100377458(PCSK2)
DMEDmel_CG6438(amon)
DER6555399
DSE6617074
DSIDsimw501_GD18123(Dsim_GD18123)
DYADyak_GE10618
DAN6501342
DSR110186785
DPO4801332
DPE6588537
DMN108157544
DWI6651467
DGR6564437
DMODmoj_GI24730
DAZ108608635
DNV108659743
DHE111595913
DVI6634920
CCAT101451751
BOD106619189
MDE101898851
SCAC106093803
LCQ111674565
LSQ119602282
HIS119651742
AGAAgaP_AGAP002176
ACOZ120947236
AARA120894120
ASTE118504559
AAG5564601
CQUCpipJ_CPIJ012757
CPII120425703
CNS116338383
BCOO119069360
AME408835
ACER107994313
ALAB122714812
BIM100742794
BBIF117207586
BVK117230983
BVAN117159273
BTER100643887
BPYO122567793
CCAL108627030
OBB114877298
MGEN117224878
NMEA116432650
CGIG122399076
SOC105203804
MPHA105836432
AEC105147744
ACEP105620261
PBAR105426716
VEM105561866
HST105182032
DQU106746237
CFO105257823
FEX115236096
LHU105674509
PGC109855266
OBO105288202
PCF106786031
PFUC122525919
VPS122633063
NVI100116354
CSOL105364830
TPRE106650164
MDL103573332
CGLO123266032
FAS105270270
DAM107036026
AGIF122853164
LHT122498459
CCIN107263285
TCA661336
DPA109535104
SOY115880323
ATD109594697
CSET123307847
AGB108909206
LDC111511946
NVL108562637
APLN108736387
PPYR116172692
OTU111418869
BMOR101740216
BMAN114246427
MSEX115453010 115455278
BANY112058357
PMAC106719619 106721647
PPOT106110445
PXU106119922
PRAP110994302
ZCE119828501
HAW110377468
HZE124639980
TNL113498528
SLIU111350287
OFU114362794
PXY105390833
API100167562
DNX107161769 107161799
AGS114119692
RMD113555949
BTAB109043545
DCI103511271
CLEC112126413
HHAL106685325
NLU111057277 111062474
PHUPhum_PHUM354430
FOC113203115
TPAL117650796
ZNE110830089
CSEC111865371
FCD110843872
DPXDAPPUDRAFT_193075
DMK116931096
PVM113827760
PJA122251134
PCHN125025999
HAME121875763
PCLA123765084
PTRU123518529
HAZT108671730
EAF111706660
LSM121122294
PPOI119093727
ISCIscW_ISCW020499
DSV119453738 119464287
RSAN119401392
RMP119164045
VDE111247174
VJA111259967
TUT107370069
DPTE113795626
DFR124499025
CSCU111627047
PTEP107452671
SDM118180923
CELCELE_C51E3.7(egl-3)
CBRCBG_09536(Cbr-egl-3)
BMYBM_BM2886(Bma-egl-3)
LOALOAG_16369
NAINECAME_01697 NECAME_12953
TSPTsp_03058 Tsp_03058a
HROHELRODRAFT_96355
LGILOTGIDRAFT_212426
PCAN112570448
BGT106073932
GAE121370855
HRF124141952
HRJ124287366
CRG105337074 105340113
MYI110462057
PMAX117323912 117328224
MMER123536670 123540803 123546319 123546595 123547405 123547542 123547565 123548691 123550436
OBI106876825
OSN115229259
LAK106180256
SMMSmp_077980
SHXMS3_0013605
OVIT265_05982
EGLEGR_08746
TVATVAG_103310 TVAG_184220 TVAG_187410 TVAG_369830
LMIRNCTC12852_01159(prcA_4)
LBILEPBI_I3281
LBFLBF_3168
 » show all
Reference
1  [PMID:2169760]
  Authors
Seidah NG, Gaspar L, Mion P, Marcinkiewicz M, Mbikay M, Chretien M.
  Title
cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases.
  Journal
DNA Cell Biol 9:415-24 (1990)
DOI:10.1089/dna.1990.9.415
  Sequence
[mmu:18549]
Reference
2  [PMID:2154467]
  Authors
Smeekens SP, Steiner DF.
  Title
Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2.
  Journal
J Biol Chem 265:2997-3000 (1990)
  Sequence
[hsa:5126]
Reference
3  [PMID:8159732]
  Authors
Rouille Y, Westermark G, Martin SK, Steiner DF.
  Title
Proglucagon is processed to glucagon by prohormone convertase PC2 in alpha TC1-6 cells.
  Journal
Proc Natl Acad Sci U S A 91:3242-6 (1994)
DOI:10.1073/pnas.91.8.3242
Reference
4  [PMID:7845206]
  Authors
Seidah NG, Chretien M.
  Title
Pro-protein convertases of subtilisin/kexin family.
  Journal
Methods Enzymol 244:175-88 (1994)
DOI:10.1016/0076-6879(94)44015-8
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.94
IUBMB Enzyme Nomenclature: 3.4.21.94
ExPASy - ENZYME nomenclature database: 3.4.21.94
BRENDA, the Enzyme Database: 3.4.21.94
CAS: 388092-42-0

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