Entry |
|
Name |
proprotein convertase 2;
neuroendocrine convertase 2;
PC2
|
Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
|
Reaction(IUBMB) |
Release of protein hormones and neuropeptides from their precursors, generally by hydrolysis of -Lys-Arg! bonds
|
Comment |
A Ca2+-dependent enzyme, maximally active at about pH 5.5. Specificity is broader than that of prohormone convertase 1. Substrates include pro-opiomelanocortin, proenkephalin, prodynorphin, proglucagon, proinsulin and proluteinizing-hormone-releasing-hormone. Does not hydrolyse prorenin or prosomatostatin, however. Unusually, processing of prodynorphin occurs at a bond in which P2 is Thr. Present in the regulated secretory pathway of neuroendocrine cells, commonly acting co-operatively with prohormone convertase 1. In peptidase family S8 (subtilisin family)
|
History |
EC 3.4.21.94 created 1996
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Orthology |
K01360 | proprotein convertase subtilisin/kexin type 2 |
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Genes |
» show all
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Reference |
|
Authors |
Seidah NG, Gaspar L, Mion P, Marcinkiewicz M, Mbikay M, Chretien M. |
Title |
cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases. |
Journal |
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Sequence |
|
Reference |
|
Authors |
Smeekens SP, Steiner DF. |
Title |
Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2. |
Journal |
J Biol Chem 265:2997-3000 (1990) |
Sequence |
|
Reference |
|
Authors |
Rouille Y, Westermark G, Martin SK, Steiner DF. |
Title |
Proglucagon is processed to glucagon by prohormone convertase PC2 in alpha TC1-6 cells. |
Journal |
|
Reference |
|
Authors |
Seidah NG, Chretien M. |
Title |
Pro-protein convertases of subtilisin/kexin family. |
Journal |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 3.4.21.94 |
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