EC                Enzyme                                 

cathepsin L;
Aldrichina grahami cysteine proteinase
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Similar to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity towards protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity
A lysosomal enzyme in peptidase family C1 (papain family) that is readily inhibited by the diazomethane inhibitor Z-Phe-Phe-CHN2 or the epoxide inhibitor E-64
EC created 1978 (EC created 1972, incorporated 1981)
K01365  cathepsin L
HSA: 1514(CTSL)
PTR: 473484 737449(CTSL)
PPS: 100987260(CTSL)
GGO: 101143280 101145975 115935969
PON: 100450374(CTSL)
NLE: 100604414(CTSL)
MCC: 694569(CTSL)
MCF: 102116556(CTSL)
CSAB: 103219700(CTSL) 103247618
RRO: 104659397 104673720(CTSL)
RBB: 108521156(CTSL) 108543421
SBQ: 101030077(CTSL) 101051131
MMU: 13039(Ctsl)
RNO: 25697(Ctsl)
HGL: 101717733
CFA: 102156614
AML: 100484313(CTSV)
BTA: 281108(CTSV) 515200(CTSL)
BOM: 102269419 102285097(CTSV)
BIU: 109563231(CTSL)
BBUB: 102394284(CTSV) 102399721(CTSL)
CHX: 102185465(CTSL) 102190225(CTSV)
OAS: 101113725(CTSL) 780510(CTSV)
SSC: 100515919(CTSL) 396926(CTSV)
CFR: 102513187(CTSL) 102515353(CTSV)
CDK: 105084679(CTSV) 105084695(CTSL)
BACU: 103003105(CTSL) 103009986
LVE: 103085310(CTSL) 103089492
OOR: 101285992(CTSL) 101289364
DLE: 111166812 111166814(CTSL)
ECB: 100061234 100061532(CTSL)
EPZ: 103550840(CTSL) 103563220
EAI: 106828084 106844429(CTSV)
MNA: 107543082 107544923(CTSL)
DRO: 112302733(CTSV) 112302874
RAY: 107500189(CTSV) 107502729(CTSL) 107518088
MDO: 100013197
GGA: 420160 427466(CTSV)
MGP: 100546685(CTSL) 100551338
CJO: 107306273(CTSL) 107325555
NMEL: 110388760 110389996(CTSL)
ACYG: 106044971 106045392(CTSL)
TGU: 100226165 100232421(CTSL)
LSR: 110471009(CTSL) 110477893
SCAN: 103822946(CTSL)
GFR: 102031629(CTSL)
FAB: 101814636(CTSL)
PHI: 102099328(CTSL)
PMAJ: 107198348(CTSL)
CCAE: 111941824
CCW: 104692009(CTSL) 104697404
ETL: 114056020(CTSL) 114067895
FPG: 101912292 101914468(CTSL)
FCH: 102046755 102053586(CTSL)
CLV: 102090299(CTSL) 102096675
EGZ: 104124387 104125939(CTSV)
NNI: 104011755(CTSL) 104018797
ACUN: 113489368 113490114(CTSL)
PADL: 103920403(CTSL)
ASN: 102370520 102383850(CTSL)
AMJ: 102560893 102572965(CTSL)
PSS: 102444883(CTSL) 102463027
CPIC: 101930955 101944587(CTSL)
ACS: 100561941(ctsl) 100563896
XLA: 108711337 444163(ctsl.L) 447313(ctsv.L)
XTR: 448179(ctsv)
DRE: 30443(ctslb) 321453(ctsla) 436641(ctsl.1)
LCF: 108875054 108878360(ctsl)
DME: Dmel_CG11459(CG11459) Dmel_CG6692(Cp1)
DSI: Dsimw501_GD10987(Dsim_GD10987) Dsimw501_GD10995(Dsim_GD10995) Dsimw501_GD19566(Dsim_GD19566) Dsimw501_GD19835(Dsim_GD19835) Dsimw501_GD22268(Dsim_GD22268)
AME: 552756
BIM: 100749528
BTER: 100645780
CCAL: 108628348
SOC: 105208238
MPHA: 105838322
AEC: 105153750
ACEP: 105622747
HST: 105191348
DQU: 106746030
OBO: 105277223
PCF: 106792245
MDL: 103568734
BMOR: 693031(Bcp)
BMAN: 114252785
PMAC: 106716166
PRAP: 110999694
HAW: 110372465
PXY: 105382819
API: 100166071(Ctsl) 100167920
DNX: 107173596
ZNE: 110836278
CEL: CELE_T03E6.7(cpl-1)
CBR: CBG22599(Cbr-cpl-1)
BMY: Bm1_20385
TSP: Tsp_11596
CSAT: 104741501
BRP: 103828985
BNA: 106435523
BOE: 106304802
RSZ: 108808349
GRA: 105767701
GHI: 107902406
GAB: 108481537
CAM: 101503214
CANN: 107871500
NTO: 108943964
BDI: 100842032
ATS: 109748138(LOC109748138) 109762805(LOC109762805) 109762807(LOC109762807)
ZMA: 100274134(AY110253)
SITA: 101762122
AOF: 109827744
MNG: MNEG_0471
APRO: F751_4068
SMIN: v1.2.001558.t1(symbB.v1.2.001558.t1) v1.2.008591.t1(symbB.v1.2.008591.t1) v1.2.018196.t1(symbB.v1.2.018196.t1)
 » show all
1  [PMID:7043200]
Barrett AJ, Kirschke H.
Cathepsin B, Cathepsin H, and cathepsin L.
Methods Enzymol 80 Pt C:535-61 (1981)
Barrett, A.J., Buttle, D.J. and Mason, R.W.
Lysosomal cysteine proteinases.
ISI Atlas of Science Biochemistry 1:256-260 (1988)
3  [PMID:2835398]
Joseph LJ, Chang LC, Stamenkovich D, Sukhatme VP.
Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L. An abundant transcript induced by transformation of fibroblasts.
J Clin Invest 81:1621-9 (1988)
[hsa:1514] [mmu:13039]
4  [PMID:3342870]
Kirschke H, Wikstrom P, Shaw E.
Active center differences between cathepsins L and B: the S1 binding region.
FEBS Lett 228:128-30 (1988)
Other DBs
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CAS: 60616-82-2

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