KEGG ENZYME: 3.4.22.16

ENZYME: 3.4.22.16

Entry

EC 3.4.22.16                Enzyme

Name

cathepsin H;
cathepsin B3;
benzoylarginine-naphthylamide (BANA) hydrolase (obsolete);
cathepsin Ba;
aleurain;
N-benzoylarginine-beta-naphthylamide hydrolase

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases

Reaction(IUBMB)

Hydrolysis of proteins, acting as an aminopeptidase (notably, cleaving Arg! bonds) as well as an endopeptidase

Comment

Present in lysosomes of mammalian cells. In peptidase family C1 (papain family)

History

EC 3.4.22.16 created 1981, modified 1989

Orthology

K01366

cathepsin H

Genes

HSA:	1512(CTSH)

PTR:	740462(CTSH)

PPS:	100994578(CTSH)

GGO:	101144312(CTSH)

PON:	100460934(CTSH)

PPYG:

129013580(CTSH)

NLE:	100584322(CTSH)

HMH:	116482262(CTSH)

SSYN:

129482176(CTSH)

MCC:	711437(CTSH)

MCF:	102115935(CTSH)

MTHB:

126960059

MNI:	105493125(CTSH)

CSAB:

103245241(CTSH)

CATY:

105571724(CTSH)

PANU:

101005151(CTSH)

TGE:	112627736(CTSH)

MLEU:

105542261(CTSH)

RRO:	104675185(CTSH)

RBB:	108538647(CTSH)

TFN:	117070311(CTSH)

PTEH:

111527187(CTSH)

CANG:

105509239(CTSH)

CJC:	100413104(CTSH)

SBQ:	101038067(CTSH)

CIMI:

108298612(CTSH)

ANAN:

105732655(CTSH)

CSYR:

103266021(CTSH)

MMUR:

105856543(CTSH)

LCAT:

123644767(CTSH)

PCOQ:

105822761(CTSH)

OGA:	100946905(CTSH)

MMU:	13036(Ctsh)

MCAL:

110302403(Ctsh)

MPAH:

110327865(Ctsh)

RNO:	25425(Ctsh)

MCOC:

116072927(Ctsh)

ANU:	117693791(Ctsh)

ASYL:

127688727(Ctsh)

MUN:	110549493(Ctsh)

CGE:	100756691(Ctsh)

MAUA:

101826391(Ctsh)

PROB:

127238684(Ctsh)

PLEU:

114690943(Ctsh) 114705701

MORG:

121444740(Ctsh)

MFOT:

126510630

AAMP:

119809603(Ctsh)

NGI:	103726016(Ctsh)

HGL:	101700582(Ctsh)

CPOC:

100731416(Ctsh)

CCAN:

109697210(Ctsh)

DORD:

105982452(Ctsh)

DSP:	122123430(Ctsh)

DMER:

138841861(Ctsh)

PLOP:

125338662(Ctsh) 125368313

NCAR:

124977509

MMMA:

107137898(Ctsh)

ITI:	101963076(Ctsh)

OCU:

100101597

OPI:	101520792(CTSH)

TUP:	102483972(CTSH)

GVR:	103606706(CTSH)

CFA:	479065(CTSH)

CLUD:

112653434(CTSH)

VVP:	112920972(CTSH)

VLG:	121490014(CTSH)

NPO:	129510384(CTSH)

AML:	100481013(CTSH)

UMR:	103660296(CTSH)

UAH:	113263792(CTSH)

UAR:	123796880(CTSH)

ELK:

111152563

LLV:

125103910

MPUF:

101674358(CTSH)

MNP:	131998958(CTSH)

MLK:	131835486(CTSH)

NVS:	122893529(CTSH)

ORO:	101362840(CTSH)

EJU:	114201245(CTSH)

ZCA:	113909565(CTSH)

MLX:	118023131(CTSH)

NSU:	110572404(CTSH)

LWW:	102744465(CTSH)

FCA:	101092687(CTSH)

PYU:	121042262(CTSH)

PCOO:

112855339(CTSH)

PBG:	122468169(CTSH)

PVIV:

125158989(CTSH)

LRUF:

124517256

LGF:	123582388(CTSH)

AJU:

106988474

PTG:	102969753(CTSH)

PPAD:

109273576(CTSH)

PUC:

125910846

PLEZ:

122221499(CTSH)

HHV:	120249214(CTSH)

BTA:	510524(CTSH)

BOM:	102281958(CTSH)

BIU:	109575407(CTSH)

BBUB:

102413180(CTSH)

BBIS:

104990903(CTSH)

CHX:	102170638(CTSH)

OAS:	101108427(CTSH)

BTAX:

128066659(CTSH)

CSUM:

138095153(CTSH)

ODA:	120875562(CTSH)

CCAD:

122454810(CTSH)

MREE:

136147211(CTSH)

OVR:	110141664(CTSH)

MBEZ:

129550345(CTSH)

SSC:	396969(CTSH)

CFR:	102524291(CTSH)

CBAI:

105069140(CTSH)

CDK:	105092231(CTSH)

VPC:	102534271(CTSH)

BACU:

103019787(CTSH)

BMUS:

118890614(CTSH)

LVE:	103084230(CTSH)

OOR:	101287575(CTSH)

LALB:

132524777(CTSH)

GMF:	115864578(CTSH)

DDP:	132420663(CTSH)

DLE:	111164745(CTSH)

PCAD:

102974243(CTSH)

PSIU:

116749231(CTSH)

PPHC:

136142765(CTSH)

NASI:

112398272(CTSH)

ECB:	100059835(CTSH) 111775628 111775633

EPZ:	103559011(CTSH)

EAI:	106840814(CTSH)

MYB:	102242799(CTSH)

MYD:	102754763(CTSH)

MMYO:

118679104(CTSH)

MDT:	132222736(CTSH)

MYUM:

138998316(CTSH)

PKL:	118718009(CTSH)

EFUS:

103303838(CTSH)

MNA:	107525553(CTSH)

DRO:	112305948(CTSH)

SHON:

118991857(CTSH)

AJM:	119057245(CTSH)

PDIC:

114488579(CTSH)

PHAS:

123809802(CTSH)

MMF:	118640936(CTSH)

PPAM:

129083088(CTSH)

HAI:	109381379(CTSH)

RFQ:	117018786(CTSH)

PALE:

102897634(CTSH)

PGIG:

120599346(CTSH)

PVP:	105301620(CTSH)

RAY:	107500384(CTSH)

MJV:	108400192(CTSH)

TOD:	119245129(CTSH)

SARA:

101557008(CTSH)

SFUM:

130023630(CTSH)

SETR:

126022697(CTSH)

LAV:	100662496(CTSH)

TMU:

101361718

ETF:	101655316(CTSH)

DNM:	101411932(CTSH)

MDO:	100014210(CTSH)

GAS:	123234217(CTSH)

SHR:	100926518(CTSH)

AFZ:

127551417

PCW:	110193663(CTSH)

TVP:

118829249

PBRV:

138169310(CTSH)

MLAO:

141521456(CTSH)

OAA:	100681064(CTSH)

TACU:

119946157(CTSH)

GGA:	770109(CTSH)

PCOC:

116225511(CTSH)

MGP:	100551376(CTSH)

CJO:	107318952(CTSH)

TPAI:

128075192(CTSH)

LMUT:

125698100(CTSH)

NMEL:

110403678(CTSH)

APLA:

101804912(CTSH)

ACYG:

106048660(CTSH)

CATA:

118259409(CTSH)

AFUL:

116493445(CTSH)

TGU:	115496729(CTSH)

LSR:	110476644(CTSH)

SCAN:

103816275(CTSH)

PMOA:

120509070(CTSH)

OTC:	121343689(CTSH)

PRUF:

121352244(CTSH)

ATRC:

139596678(CTSH)

GFR:	102036092(CTSH)

FAB:	101811077(CTSH)

OMA:	130257559(CTSH)

PHI:	102108387(CTSH)

PMAJ:

107209076(CTSH)

CCAE:

111933844

CCW:	104684052(CTSH)

CBRC:

103619701(CTSH)

ACOE:

138116452(CTSH)

ETL:	114069603(CTSH)

ZAB:	106629985(CTSH)

ZLE:	135452433(CTSH)

ACHL:

103797081(CTSH)

SVG:	106860153(CTSH)

MMEA:

130585606(CTSH)

HRT:	120758984(CTSH)

SATI:

136366873(CTSH)

CCIC:

134049237(CTSH)

FPG:	101922144(CTSH)

FCH:	102057998(CTSH)

CCRI:

104164564(CTSH)

NNT:	104405276(CTSH)

SHAB:

115612955(CTSH)

ACUN:

113483959(CTSH)

TALA:

104363972(CTSH)

ACHC:

115341996(CTSH)

HALD:

104313835(CTSH)

HLE:	104834643(CTSH)

AGEN:

126044151

HHAR:

128150891(CTSH)

GCL:

127020404

LDI:	104347483(CTSH)

DPUB:

104297403(CTSH)

PPUS:

135183043(CTSH)

AVIT:

104276160(CTSH)

BRHI:

104498362(CTSH)

EGZ:	104122478(CTSH)

NNI:	104017190(CTSH)

PCRI:

104033100(CTSH)

PCAO:

104052832(CTSH)

PADL:

103914793(CTSH)

AFOR:

103899903(CTSH)

FGA:	104079240(CTSH)

GSTE:

104255707(CTSH)

CBOY:

140655346(CTSH)

CLV:	102087477(CTSH)

CNIC:

135992705(CTSH)

MUI:	104545144(CTSH)

PGUU:

104464671(CTSH)

PLET:

104618666(CTSH)

CMAC:

104479155(CTSH)

CUCA:

104056437(CTSH)

TEO:	104378620(CTSH)

BREG:

104629162(CTSH)

ACAR:

104528744

CPEA:

104393357(CTSH)

CVF:	104283015(CTSH)

RTD:	128915158(CTSH)

CRID:

134520992(CTSH)

AAM:	106487037(CTSH)

AROW:

112963599(CTSH)

NPD:	112948249(CTSH)

DNE:	112987928(CTSH)

SCAM:

104151508(CTSH)

ASN:	102384797(CTSH)

AMJ:	102564481(CTSH)

CPOO:

109309243(CTSH)

GGN:	109288388(CTSH)

PSS:	102458148(CTSH)

CMY:	102938471(CTSH)

CCAY:

125643794(CTSH)

DCC:	119862069(CTSH)

CPIC:

101936196(CTSH)

TST:	117884141(CTSH)

CABI:

116833068(CTSH)

MRV:	120373479(CTSH)

ACS:	100561600(ctsh)

ASAO:

132762444(CTSH)

PVT:	110091401(CTSH)

SUND:

121933119(CTSH)

PBI:

103061128

PMUR:

107283909(CTSH)

CTIG:

120316446(CTSH)

PGUT:

117676211(CTSH)

PCAE:

139324021(CTSH)

APRI:

131184589(CTSH)

PTEX:

113442050(CTSH)

NSS:	113423342(CTSH)

VKO:	123030736(CTSH)

PMUA:

114584529(CTSH)

PRAF:

128401656(CTSH)

ZVI:	118093178(CTSH)

HCG:	128334904(CTSH)

GJA:	107125357(CTSH)

STOW:

125425625(CTSH)

EMC:	129345664(CTSH)

PWL:	138284324(CTSH)

MUO:	115459969(CTSH)

GSH:	117348571(CTSH)

DRE:	324818(ctsh)

SRX:	107715232(ctsh)

SANH:

107690365 107691125 107691144

SGH:	107551467(ctsh) 107556249

CCAR:

109056799 109076347

CAUA:

113061626 113091663

CGIB:

127933788 127977650

PTET:

122322981(ctsh)

LROH:

127180335(ctsh)

GRF:	141345458(ctsh) 141345526

OMC:	131524537(ctsh)

PPRM:

120487745(ctsh)

RKG:	130089331(ctsh)

MAMB:

125254127(ctsh)

CIDE:

127499510

CERY:

137023418(ctsh)

MASI:

127455705

TROS:

130562877(ctsh)

TDW:	130435519(ctsh)

MANU:

129419440(ctsh)

PDAB:

135773505(ctsh)

IPU:	100305012(ctsh)

IFU:	128602094(ctsh)

PHYP:

113537355(ctsh)

SMEO:

124378189(ctsh)

TFD:	113663684(ctsh)

TVC:	132839189(ctsh)

CGAR:

128506838(ctsh)

NGRA:

132866328(ctsh)

AMEX:

103043563(ctsh)

CMAO:

118801415(ctsh)

EEE:	113573981(ctsh)

SPIL:

134093411(ctsh) 134096020

TRU:	101078766(ctsh)

TFS:	130536688(ctsh)

TNG:	GSTEN00035643G001

LCO:	104917829(ctsh) 104940230

NCC:	104951771 104964027

TBEN:

117471203 117491363(ctsh)

CGOB:

115009720 115025119

PGEO:

117448148(ctsh) 117461038

GACU:

117533014 117557664(ctsh)

EMAC:

134863320 134882397(ctsh)

ELY:	117255654 117262553(ctsh)

EFO:	125888044(ctsh) 125906114

PLEP:

121943753 121950050(ctsh)

SLUC:

116038479(ctsh) 116060462

ECRA:

117943849 117948573(ctsh)

ESP:	116690568 116694176

PFLV:

114560026(ctsh) 114573889

GAT:	120831228(ctsh)

PPUG:

119227596(ctsh)

AFB:	129104763 129107893

CLUM:

117728662(ctsh)

CANA:

137800919 137803999(ctsh)

CVE:	137881725(ctsh) 137887350

MSAM:

119890554 119894208(ctsh)

SCHU:

122874366(ctsh) 122877551

CUD:	121514231 121515145(ctsh)

SPUL:

138590907 138612856(ctsh)

LMIX:

132972470(ctsh) 132975774

ALAT:

119017778 119024705(ctsh)

MZE:	101468200(ctsh) 101475779

ONL:	100702144 100708413(ctsh)

OAU:	116314697 116326248(ctsh)

OLA:	111947539(ctsh)

OML:	112152656(ctsh)

CSAI:

133444247(ctsh)

XMA:	102227764(ctsh)

XCO:	114159939(ctsh)

XHE:	116732858(ctsh)

PRET:

103466621(ctsh)

PFOR:

103147844(ctsh)

PLAI:

106946134(ctsh)

PMEI:

106921434(ctsh)

GAF:	122835462(ctsh)

PPRL:

129359743(ctsh)

CVG:	107099914(ctsh)

CTUL:

119772364(ctsh)

GMU:	124856929(ctsh)

NFU:	107388794(ctsh)

KMR:	108230028(ctsh) 108237393

ALIM:

106514343(ctsh) 106518967

NWH:	119415727(ctsh) 119430108

AOCE:

111580156(ctsh) 111587586

EJA:	138206618(ctsh) 138212864

BFRE:

138616307 138626822(ctsh)

MCEP:

125005757 125014320(ctsH)

CSEM:

103379443(ctsh)

SSEN:

122775464(ctsh)

SSOE:

131470233(ctsh)

HHIP:

117754538(ctsh)

HSP:	118108131(ctsh)

PPLT:

128428755(ctsh)

SMAU:

118315004(ctsh)

LCF:	108875435(ctsh) 108877025

SDU:	111220923 111228545

SLAL:

111659106 111666932

XGL:	120792665(ctsh)

SBIA:

133497759(ctsh)

PEE:	133415492(ctsh)

PTAO:

133474248(ctsh)

MALB:

109967274(ctsh)

BSPL:

114857358(ctsh)

SJO:	128356599 128358692

SSCO:

133979737 133981841(ctsh)

GMH:	115559025(ctsh)

SASA:

106561173(CATH) 106562440(CATH)

STRU:

115196734 115203334

OTW:	112218593(ctsh) 112247294 112247472

OMY:	110495904(ctsh) 110506772

OGO:	124035003 124036427(ctsh)

ONE:	115113802 115134231

OKI:	109867538 109881088 109882252

OKE:	118360888 118396737(ctsh)

OMM:	135509331(ctsh) 135551537 135556808

OCLA:

139372326 139384871

SALP:

111962429

SNH:	120024924 120066687(ctsh)

CCLU:

121531924(ctsh) 121560399 121577450

ELS:	105025674(ctsh)

OEP:	134021119(ctsh) 134028004

SFM:	108931675(ctsh)

PKI:	111843502(ctsh)

AANG:

118215419(ctsh)

AROT:

135241603(ctsh)

CCOG:

133112092(ctsh)

LOC:	102699078(ctsh)

PSPA:

121294562 121299342(ctsh)

ARUT:

117427928 117429312

PSEX:

120541458(ctsh)

LCM:	102358878(CTSH)

CMK:	103186362(ctsh)

RTP:	109934550(ctsh)

CPLA:

122540879(ctsh)

HOC:	132834158(ctsh)

LERI:

129712712(ctsh)

HAKA:

140718667(ctsh)

BFO:

118410484

BBEL:

109480828

CIN:

100184721

SCLV:

120334255

AJC:

117123420

SKO:

100370397

PFLL:

139121544 139121572

SOY:

115878643

VCD:

124530977

PPOT:

106099478

BPHI:

137922534

PRAP:

111004481

ZCE:

119837137

GMW:

128202385

PGW:

126370667

LGLY:

125224891 125226953

CSTB:

134743309

CFUM:

141426181

DCI:	103517125 103518578

DMK:	116919996 116919998 116932915

TCF:	131877454 131891409 131891754 131892094

VDE:

111248979

VJA:

111263297

DFR:	124494675 124496119

AQU:	100636464 100636590

ATH:	AT3G45310 AT5G60360(ALP)

ALY:	9302454 9313468

CRB:	17876993 17887285

CSAT:

104710996 104726627 104737757 104756683 104762144 104790787

EUS:	EUTSA_v10002588mg EUTSA_v10013934mg

BRP:	103837111 103845456 103851512 103856563 103856569

BNA:	106364017 106371600 106385145 106385833 106386886 106401153 106419550 106419694 106431716

BOE:	106319139 106327677 106329729

RSZ:	108818372 108820664 108846542 108846647 130502195 130508428

THJ:

104814838

CPAP:

110817702

CIT:

102578016

CIC:	CICLE_v10008748mg

PVY:	116126364 116132552

MINC:

123194768 123200041

TCC:

18588277

GRA:	105768892 105772929 105782653

GHI:	107893361 107901061 107907097 107951073 107958837 121212573

GAB:	108463952 108465689 108473592

HSYR:

120117644 120147630 120166319 120166320 120169344 120192438

DZI:	111285718 111299188 111303055

EGR:	104436411 104436414 104436415 104439005 120291616 120291617 120291618

RARG:

115740954 125312440

GMX:	100170694 100787165 547734

GSJ:	114367678 114387650 114393883

PVU:	137807168 137820094

VRA:	106762644 106769487

VAR:	108330571 108337148

VUN:	114163167 114179052

VUM:	124834179 124843666

CCAJ:

109808138 109815285

APRC:

113846206 113862658

MTR:	120577892 25494167

TPRA:

123907340

CAM:

101510518

PSAT:

127138683

VVO:

131629808

LJA:

130710074

ADU:	107457839 107479122

AIP:	107630460 107643670

AHF:	112696530 112738342 112790519

LANG:

109347727 109356310

PCIN:

129320296

QSA:	O6P43_002662 O6P43_022494

FVE:

101297079

AANS:

126794503

RCN:

112188415

PPER:

18770752

PMUM:

103340590

PAVI:

110749196

PDUL:

117634136

MDM:	103400937 103451125

MSYL:

126604718 126607040

PXB:	103929718 103950268

PCOX:

137718395 137748385

ZJU:

107423924

MNT:

21410015

CSAV:

115706674

CSV:

101209045

CMO:

103492370

BHJ:

120071800

MCHA:

111016585

CMAX:

111467145 111485029

CMOS:

111440035 111461492

CPEP:

111780306 111793834

RCU:

8281173

MEAN:

126667942

JCU:

105637967

HBR:	110631569 110635086

MESC:

110603794 110612147

POP:

18100334

PEU:

105140741

PALZ:

118048080

PNZ:

133687875

JRE:

109008520

CILL:

122304279

CAVE:

132166352

AGLU:

133857103

QLO:

115968365

TWL:	119996375 120005633

VVI:

100244107

VRI:

117925012

SLY:	101252200 101252505(Cyp-3)

SPEN:

107024548 107026034

SOT:	102578939 102579266 107059966

SSTN:

125876799 125876800

SDUL:

129893196

CANN:

107877862

LBB:	132616737 132640917

NTA:	107775429 107779938 107784768(NTCP-23) 107818105 107823208(CYS)

NSY:	104224819 104246478

NTO:	104089405 104107336

NAU:	109225599 109225621

INI:

109193112

ITR:	116013982 116020733

SIND:

105161928 105173682

OEU:	111368619 111385176

EGT:	105968067 105971000

SSPL:

121747527 121796246 121799996

SMIL:

130987613

SHIS:

125197334

APAN:

127239644 127263718 127263719

HPUM:

140886944

PHUA:

140962890 140971464

PEBU:

140818039 140825834

HAN:	110886998 110896208

ECAD:

122594952

LSV:	111892539 111917749

CCAV:

112516574

DCR:

108199861

CSIN:

114304409 114310924

RVL:

131320011

AEW:	130757540 130789002

DLT:	127806092 127806095 127806096

BVG:

104883466

SOE:

110805191

CQI:	110682962 110715980

ATRI:

130816139

SLAF:

141605762

MOF:

131157459

NNU:

104600548

MING:

122083307

TSS:

122655718

PSOM:

113326749 113340013

OSA:

4347180

DOSA:

Os09g0442300

OBR:

102702127

OGL:

127784781

BDI:

100833741

ATS:

109751542

TDC:	119301562 119309424

TAES:

100037648 123051968 123111956 123121517

TUA:

125509313

LPER:

127301398

LRD:	124652793 124652893

SBI:

8062751

ZMA:

542451

MFLO:

136546317 136549890

SITA:

101765887

SVS:

117844542

PVIR:

120660798 120680138

PHAI:

112880300

PAUA:

133896756 133901311

TANG:

140778716

PDA:	103702035 103704943

EGU:	105036231 105041860

MUS:	135598802 135623116

ZOF:	121971521 121976133

DCT:	110106914 110109127 110110535

PEQ:	110018397 110018399 110026028

AOF:	109844564 109845680

MSIN:

131251718

ACAK:

137956006 137956166

NCOL:

116259100

ATR:

18439478

CJF:

131034057

SMO:	SELMODRAFT_228454 SELMODRAFT_439207

PPP:

112286849

TET:	TTHERM_00191270 TTHERM_00191280 TTHERM_00911100 TTHERM_01001420 TTHERM_01028740

AAF:	AURANDRAFT_34950 AURANDRAFT_3602

PIF:	PITG_13074

PSOJ:

PHYSODRAFT_361379

SPAR:

SPRG_12173

EHX:	EMIHUDRAFT_458272 EMIHUDRAFT_464692

GTT:	GUITHDRAFT_71985

» show all

Reference

1 [PMID:7043200]

Authors

Barrett AJ, Kirschke H.

Title

Cathepsin B, Cathepsin H, and cathepsin L.

Journal

Methods Enzymol 80 Pt C:535-61 (1981)
DOI:10.1016/s0076-6879(81)80043-2

Reference

2 [PMID:3663163]

Authors

Bromme D, Bescherer K, Kirschke H, Fittkau S.

Title

Enzyme-substrate interactions in the hydrolysis of peptides by cathepsins B and H from rat liver.

Journal

Biochem J 245:381-5 (1987)
DOI:10.1042/bj2450381

Reference

3 [PMID:2849458]

Authors

Fuchs R, Machleidt W, Gassen HG.

Title

Molecular cloning and sequencing of a cDNA coding for mature human kidney cathepsin H.

Journal

Biol Chem Hoppe Seyler 369:469-75 (1988)
DOI:10.1515/bchm3.1988.369.1.469

Sequence

[hsa:1512]

Other DBs

ExplorEnz - The Enzyme Database:

3.4.22.16

IUBMB Enzyme Nomenclature:

3.4.22.16

ExPASy - ENZYME nomenclature database:

3.4.22.16

BRENDA, the Enzyme Database:

3.4.22.16

CAS:	60748-73-4

All links

Gene (6654)   
   MGENES (138)   
   RefGene (6516)   
Protein sequence (371)   
   UniProt (279)   
   SWISS-PROT (9)   
   RefSeq(pep) (55)   
   PDBSTR (28)   
DNA sequence (169)   
   RefSeq(nuc) (93)   
   GenBank (61)   
   EMBL (15)   
3D Structure (5)   
   PDB (5)   
Protein domain (9)   
   InterPro (8)   
   PROSITE(DOC) (1)   
All databases (7208)   

Download RDF

DBGET integrated database retrieval system