KEGG   ENZYME: 3.4.22.16
Entry
EC 3.4.22.16                Enzyme                                 

Name
cathepsin H;
cathepsin B3;
benzoylarginine-naphthylamide (BANA) hydrolase (obsolete);
cathepsin Ba;
aleurain;
N-benzoylarginine-beta-naphthylamide hydrolase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
Reaction(IUBMB)
Hydrolysis of proteins, acting as an aminopeptidase (notably, cleaving Arg! bonds) as well as an endopeptidase
Comment
Present in lysosomes of mammalian cells. In peptidase family C1 (papain family)
History
EC 3.4.22.16 created 1981, modified 1989
Orthology
K01366  cathepsin H
Genes
HSA: 1512(CTSH)
PTR: 740462(CTSH)
PPS: 100994578(CTSH)
GGO: 101144312(CTSH)
PON: 100460934(CTSH)
NLE: 100584322(CTSH)
MCC: 711437(CTSH)
MCF: 102115935(CTSH)
CSAB: 103245241(CTSH)
RRO: 104675185(CTSH)
RBB: 108538647(CTSH)
CJC: 100413104(CTSH)
SBQ: 101038067(CTSH)
MMU: 13036(Ctsh)
MCAL: 110302403(Ctsh)
MPAH: 110327865(Ctsh)
RNO: 25425(Ctsh)
MUN: 110549493(Ctsh)
CGE: 100756691(Ctsh)
NGI: 103726016(Ctsh)
HGL: 101700582(Ctsh)
CCAN: 109697210(Ctsh)
OCU: 100101597(CTSH)
TUP: 102483972(CTSH)
CFA: 479065(CTSH)
VVP: 112920972(CTSH)
AML: 100481013(CTSH)
UMR: 103660296(CTSH)
UAH: 113263792(CTSH)
ORO: 101362840(CTSH)
ELK: 111152563
FCA: 101092687(CTSH)
PTG: 102969753(CTSH)
PPAD: 109273576(CTSH)
AJU: 106988474(CTSH)
BTA: 510524(CTSH)
BOM: 102281958(CTSH)
BIU: 109575407(CTSH)
BBUB: 102413180(CTSH)
CHX: 102170638(CTSH)
OAS: 101108427(CTSH)
SSC: 396969(CTSH)
CFR: 102524291(CTSH)
CDK: 105092231(CTSH)
BACU: 103019787(CTSH)
LVE: 103084230(CTSH)
OOR: 101287575(CTSH)
DLE: 111164745(CTSH)
PCAD: 102974243(CTSH)
ECB: 100059835(CTSH) 111775628 111775633
EPZ: 103559011(CTSH)
EAI: 106840814(CTSH)
MYB: 102242799(CTSH)
MYD: 102754763(CTSH)
MNA: 107525553(CTSH)
HAI: 109381379(CTSH)
DRO: 112305948(CTSH)
PALE: 102897634(CTSH)
RAY: 107500384(CTSH)
MJV: 108400192(CTSH)
LAV: 100662496(CTSH)
TMU: 101361718
MDO: 100014210(CTSH)
SHR: 100926518(CTSH)
PCW: 110193663(CTSH)
OAA: 100681064(CTSH)
GGA: 770109(CTSH)
MGP: 100551376(CTSH)
CJO: 107318952(CTSH)
NMEL: 110403678(CTSH)
APLA: 101804912(CTSH)
ACYG: 106048660(CTSH)
TGU: 115496729(CTSH)
LSR: 110476644(CTSH)
SCAN: 103816275(CTSH)
GFR: 102036092(CTSH)
FAB: 101811077(CTSH)
PHI: 102108387(CTSH)
PMAJ: 107209076(CTSH)
CCAE: 111933844
CCW: 104684052(CTSH)
ETL: 114069603(CTSH)
FPG: 101922144(CTSH)
FCH: 102057998(CTSH)
CLV: 102087477(CTSH)
EGZ: 104122478(CTSH)
NNI: 104017190(CTSH)
ACUN: 113483959(CTSH)
PADL: 103914793(CTSH)
AAM: 106487037(CTSH)
ASN: 102384797(CTSH)
AMJ: 102564481(CTSH)
PSS: 102458148(CTSH)
CMY: 102938471(CTSH)
CPIC: 101936196(CTSH)
ACS: 100561600(ctsh)
PVT: 110091401(CTSH)
PBI: 103061128
PMUR: 107283909(CTSH)
PMUA: 114584529(CTSH)
GJA: 107125357(CTSH)
DRE: 324818(ctsh)
SRX: 107715232(ctsh)
SANH: 107690365 107691125 107691144
SGH: 107551467(ctsh) 107556249
CCAR: 109056799 109076347
IPU: 100305012(ctsh)
PHYP: 113537355(ctsh)
AMEX: 103043563(ctsh)
EEE: 113573981(ctsh)
TRU: 101078766(ctsh)
TNG: GSTEN00035643G001
LCO: 104917829(ctsh) 104940230
NCC: 104951771 104964027
MZE: 101468200(ctsh) 101475779
ONL: 100702144 100708413(ctsh)
OLA: 111947539(ctsh)
XMA: 102227764(ctsh)
XCO: 114159939(ctsh)
PRET: 103466621(ctsh)
CVG: 107099914(ctsh)
NFU: 107388794(ctsh)
KMR: 108230028(ctsh) 108237393
ALIM: 106514343(ctsh) 106518967
AOCE: 111580156 111587586
CSEM: 103379443(ctsh)
LCF: 108875435 108877025
SDU: 111220923 111228545
SLAL: 111659106 111666932
MALB: 109967274(ctsh)
SASA: 106561173(CATH) 106562440(CATH)
OTW: 112218593 112247294 112247472
SALP: 111962429
ELS: 105025674(ctsh)
SFM: 108931675(ctsh)
PKI: 111843502(ctsh)
LCM: 102358878(CTSH)
CMK: 103186362(ctsh)
RTP: 109934550(ctsh)
BFO: BRAFLDRAFT_57270
CIN: 100184721
SKO: 100370397
AQU: 100636464 100636590
ATH: AT3G45310 AT5G60360(ALP)
ALY: 9302454 9313468
CRB: 17876993 17887285
CSAT: 104710996 104726627 104737757 104756683 104762144 104790787
EUS: EUTSA_v10002588mg EUTSA_v10013934mg
BRP: 103837111 103845456 103851512 103856563 103856569
BNA: 106364017 106371600 106385145 106385833 106386886 106401153 106419550 106419694 106430471 106431716
BOE: 106319139 106327677 106329729
RSZ: 108818372 108820664 108846542
THJ: 104814838
CPAP: 110817702
CIT: 102578016
CIC: CICLE_v10008748mg
TCC: 18588277
GRA: 105768892 105772929 105782653
GHI: 107893361 107901061 107907097 107951073 107958837
GAB: 108463952 108465689 108473592
DZI: 111285718 111299188 111303055
EGR: 104436410 104436411 104436414 104436415 104436417 104439003 104439006
GMX: 100170694 100787165 547734
GSJ: 114367678 114387650 114393883
PVU: PHAVU_003G130600g PHAVU_009G227100g
VRA: 106762644 106769487
VAR: 108330571 108337148
VUN: 114163167 114179052
CCAJ: 109808138 109815285
MTR: MTR_4g125300
CAM: 101510518
LJA: Lj4g3v2203610.1(Lj4g3v2203610.1)
ADU: 107457839 107479122
AIP: 107630460 107643670
LANG: 109347727 109356310
FVE: 101297079
RCN: 112188415
PPER: 18770752
PMUM: 103340590
PAVI: 110749196
MDM: 103400937 103451125 103453996
PXB: 103929718 103950268
ZJU: 107423924
CSV: 101209045
CMO: 103492370
MCHA: 111016585
CMAX: 111467145 111485029
CMOS: 111440035 111461492
CPEP: 111780306 111793834
RCU: 8281173
JCU: 105637967
HBR: 110631569 110635086
MESC: 110603794 110612147
POP: 18100334
PEU: 105140741
JRE: 109008520
QSU: 111993009 112023279
VVI: 100244107
SLY: 101252200 101252505(Cyp-3)
SPEN: 107024548 107026034
SOT: 102578939 102579266 107059966
CANN: 107877862(cyp-3)
NTA: 107775429 107779938 107784768(NTCP-23) 107818105 107823208(CYS)
NSY: 104224819 104246478
NTO: 104089405 104107336
NAU: 109225599 109225621
INI: 109193112
SIND: 105161928 105173682
OEU: 111368619 111385176
HAN: 110886998 110896208
LSV: 111892539 111917749
CCAV: 112516574
DCR: 108199861
BVG: 104883466
SOE: 110805191
CQI: 110682962 110715980
NNU: 104600548
PSOM: 113326749 113340013
OSA: 4347180
DOSA: Os09t0442300-01(Os09g0442300)
OBR: 102702127
BDI: 100833741
ATS: 109751542(LOC109751542)
SBI: 8062751
ZMA: 542451(ccp2)
SITA: 101765887
PDA: 103702035 103704943
EGU: 105036231 105041860
MUS: 103991149 103998167
DCT: 110106914 110109127 110110535
PEQ: 110018397 110018399 110026028
AOF: 109844564 109845680
ATR: 18439478
SMO: SELMODRAFT_228454 SELMODRAFT_439207
PPP: 112286849
TET: TTHERM_00191270 TTHERM_00191280 TTHERM_00911100 TTHERM_01001420 TTHERM_01028740
AAF: AURANDRAFT_34950 AURANDRAFT_3602
PIF: PITG_13074
PSOJ: PHYSODRAFT_361379
SPAR: SPRG_12173
EHX: EMIHUDRAFT_458272 EMIHUDRAFT_464692
GTT: GUITHDRAFT_71985
 » show all
Reference
1  [PMID:7043200]
  Authors
Barrett AJ, Kirschke H.
  Title
Cathepsin B, Cathepsin H, and cathepsin L.
  Journal
Methods Enzymol 80 Pt C:535-61 (1981)
DOI:10.1016/s0076-6879(81)80043-2
Reference
2  [PMID:3663163]
  Authors
Bromme D, Bescherer K, Kirschke H, Fittkau S.
  Title
Enzyme-substrate interactions in the hydrolysis of peptides by cathepsins B and H from rat liver.
  Journal
Biochem J 245:381-5 (1987)
DOI:10.1042/bj2450381
Reference
3  [PMID:2849458]
  Authors
Fuchs R, Machleidt W, Gassen HG.
  Title
Molecular cloning and sequencing of a cDNA coding for mature human kidney cathepsin H.
  Journal
Biol Chem Hoppe Seyler 369:469-75 (1988)
DOI:10.1515/bchm3.1988.369.1.469
  Sequence
[hsa:1512]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.22.16
IUBMB Enzyme Nomenclature: 3.4.22.16
ExPASy - ENZYME nomenclature database: 3.4.22.16
BRENDA, the Enzyme Database: 3.4.22.16
CAS: 60748-73-4

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