KEGG   ENZYME: 3.4.22.27
Entry
EC 3.4.22.27                Enzyme                                 

Name
cathepsin S
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
Reaction(IUBMB)
Similar to cathepsin L, but with much less activity on Z-Phe-Arg!NHMec, and more activity on the Z-Val-Val-Arg! compound
Comment
A lysosomal cysteine endopeptidase that is unusual amongst such enzymes for its stability to neutral pH. In peptidase family C1 (papain family)
History
EC 3.4.22.27 created 1992
Orthology
K01368  cathepsin S
Genes
HSA: 1520(CTSS)
PTR: 457277(CTSS)
PPS: 100975000(CTSS)
GGO: 101141942(CTSS)
PON: 100432810(CTSS)
NLE: 100579205(CTSS)
MCC: 708080(CTSS)
MCF: 102120796(CTSS)
CSAB: 103247206(CTSS)
RRO: 104681069(CTSS)
RBB: 108533262(CTSS)
CJC: 100409214(CTSS)
SBQ: 101044698(CTSS)
MMU: 13040(Ctss)
MCAL: 110290972(Ctss)
MPAH: 110320470(Ctss)
RNO: 50654(Ctss)
MUN: 110543431(Ctss)
CGE: 100751823(Ctss)
NGI: 103729103(Ctss)
HGL: 101697008(Ctss)
CCAN: 109681200(Ctss)
OCU: 100101598(CTSS)
TUP: 102469586(CTSS)
CFA: 403400(CTSS)
VVP: 112907699(CTSS)
AML: 100483259(CTSS)
UMR: 103667539(CTSS)
UAH: 113246210(CTSS)
ORO: 101370623(CTSS)
ELK: 111162017
FCA: 101083283(CTSS)
PTG: 102967913(CTSS)
PPAD: 109257065(CTSS)
AJU: 106979853(CTSS)
BTA: 327711(CTSS)
BOM: 102287237(CTSS)
BIU: 109555340(CTSS)
BBUB: 102408311(CTSS)
CHX: 102183747(CTSS)
OAS: 780472(CTSS)
SSC: 100153090(CTSS)
CFR: 102510939(CTSS)
BACU: 103007667(CTSS)
LVE: 103074342(CTSS)
OOR: 101269523(CTSS)
DLE: 111169766(CTSS)
PCAD: 102979785(CTSS)
ECB: 100054948(CTSS)
EPZ: 103547636(CTSS)
EAI: 106846535(CTSS)
MYB: 102259811(CTSS)
MYD: 102771016(CTSS)
MNA: 107539106(CTSS)
HAI: 109372254(CTSS)
DRO: 112313687(CTSS)
PALE: 102884940(CTSS)
RAY: 107498990(CTSS)
MJV: 108404026(CTSS)
LAV: 100674232(CTSS)
TMU: 101340786
MDO: 100017406(CTSS)
SHR: 100917184(CTSS)
PCW: 110220556(CTSS)
OAA: 100088270(CTSS)
GGA: 425657(CTSS)
MGP: 104914438(CTSS)
CJO: 107324540(CTSS)
NMEL: 110387850
APLA: 101794564(CTSS)
ACYG: 106049275(CTSS)
TGU: 100223082(CTSS)
LSR: 110476808
SCAN: 103824795
GFR: 102032358
FAB: 101815635(CTSS)
PHI: 102107924(CTSS)
PMAJ: 107214698
CCAE: 111939529
FPG: 101911722(CTSS)
FCH: 102055558(CTSS)
CLV: 102094330(CTSS)
EGZ: 104126881
ACUN: 113490571(CTSS)
AAM: 106495149(CTSS)
ASN: 102373459 102384087(CTSS)
AMJ: 102562033(CTSS) 109283982
PSS: 102458936
ACS: 100560943(ctss)
PVT: 110081451(CTSS)
PBI: 103053841(CTSS)
PMUR: 107292919(CTSS)
TSR: 106546304(CTSS)
PMUA: 114586295(CTSS) 114588654
GJA: 107120549(CTSS)
NPR: 108789799(CTSS) 108800693
DRE: 337572(ctss2.2) 393398(ctss1) 554157(ctss2.1)
IPU: 100305010(ctss) 108274831
NCC: 104957237
OLA: 100049247(ctss) 101165175
KMR: 108243190
AOCE: 111571630
MALB: 109968960
SASA: 100196462(cats) 106605328(CATS)
LCM: 102351684(CTSS) 102365039
LCQ: 111684259
TCA: 660428
BMAN: 114253569
TNL: 113498261
SHX: MS3_04774
BRP: 108871105
NTO: 104097067
SPAR: SPRG_10279
 » show all
Reference
1  [PMID:1182153]
  Authors
Turnsek T, Kregar I, Lebez D.
  Title
Acid sulphydryl protease from calf lymph nodes.
  Journal
Biochim Biophys Acta 403:514-20 (1975)
DOI:10.1016/0005-2744(75)90079-0
Reference
2  [PMID:2604727]
  Authors
Bromme D, Steinert A, Friebe S, Fittkau S, Wiederanders B, Kirschke H.
  Title
The specificity of bovine spleen cathepsin S. A comparison with rat liver cathepsins L and B.
  Journal
Biochem J 264:475-81 (1989)
DOI:10.1042/bj2640475
  Sequence
[bta:327711]
Reference
3  [PMID:2690828]
  Authors
Kirschke H, Wiederanders B, Bromme D, Rinne A.
  Title
Cathepsin S from bovine spleen. Purification, distribution, intracellular localization and action on proteins.
  Journal
Biochem J 264:467-73 (1989)
DOI:10.1042/bj2640467
Other DBs
ExplorEnz - The Enzyme Database: 3.4.22.27
IUBMB Enzyme Nomenclature: 3.4.22.27
ExPASy - ENZYME nomenclature database: 3.4.22.27
BRENDA, the Enzyme Database: 3.4.22.27
CAS: 71965-46-3

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