KEGG   ENZYME: 3.4.22.27
Entry
EC 3.4.22.27                Enzyme                                 
Name
cathepsin S
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
Reaction(IUBMB)
Similar to cathepsin L, but with much less activity on Z-Phe-Arg!NHMec, and more activity on the Z-Val-Val-Arg! compound
Comment
A lysosomal cysteine endopeptidase that is unusual amongst such enzymes for its stability to neutral pH. In peptidase family C1 (papain family)
History
EC 3.4.22.27 created 1992
Orthology
K01368  cathepsin S
Genes
HSA1520(CTSS)
PTR457277(CTSS)
PPS100975000(CTSS)
GGO101141942(CTSS)
PON100432810(CTSS)
NLE100579205(CTSS)
MCC708080(CTSS)
MCF102120796(CTSS)
MTHB126932352
CSAB103247206(CTSS)
CATY105590202(CTSS)
PANU101021545(CTSS)
TGE112620366(CTSS)
RRO104681069(CTSS)
RBB108533262(CTSS)
TFN117075084(CTSS)
PTEH111543624(CTSS)
CJC100409214(CTSS)
SBQ101044698(CTSS)
CSYR103251385(CTSS)
MMUR105873003(CTSS)
LCAT123633923(CTSS)
OGA100950667(CTSS)
MMU13040(Ctss)
MCAL110290972(Ctss)
MPAH110320470(Ctss)
RNO50654(Ctss)
MCOC116093415(Ctss)
MUN110543431(Ctss)
CGE100751823(Ctss)
MAUA101842997(Ctss)
PLEU114682396(Ctss)
MORG121437918 121450702
MFOT126490028
AAMP119801374(Ctss)
NGI103729103(Ctss)
HGL101697008(Ctss)
CPOC100722492(Ctss)
CCAN109681200(Ctss)
DORD105984724(Ctss)
DSP122109432(Ctss)
NCAR124959416
OCU100101598(CTSS)
OPI101532461(CTSS)
TUP102469586(CTSS)
CFA403400(CTSS)
CLUD112663998(CTSS)
VVP112907699(CTSS)
VLG121492130(CTSS)
AML100483259(CTSS)
UMR103667539(CTSS)
UAH113246210(CTSS)
UAR123787738(CTSS)
ELK111162017
LLV125096876
MPUF101683261(CTSS)
ORO101370623(CTSS)
EJU114197270(CTSS)
ZCA113912803(CTSS)
MLX118000310(CTSS)
NSU110578526(CTSS)
FCA101083283(CTSS)
PYU121021050(CTSS)
PBG122481131(CTSS)
LRUF124514705
PTG102967913(CTSS)
PPAD109257065(CTSS)
AJU106979853(CTSS)
HHV120241248(CTSS)
BTA327711(CTSS)
BOM102287237(CTSS)
BIU109555340(CTSS)
BBUB102408311(CTSS)
CHX102183747(CTSS)
OAS780472(CTSS)
ODA120855927(CTSS)
CCAD122434353(CTSS)
SSC100153090(CTSS)
CFR102510939(CTSS)
CBAI105071741(CTSS)
VPC102544736(CTSS)
BACU103007667(CTSS)
LVE103074342(CTSS)
OOR101269523(CTSS)
DLE111169766(CTSS)
PCAD102979785(CTSS)
PSIU116738968(CTSS)
ECB100054948(CTSS)
EPZ103547636(CTSS)
EAI106846535(CTSS)
MYB102259811(CTSS)
MYD102771016(CTSS)
MMYO118672753(CTSS)
MLF102439661(CTSS)
MNA107539106(CTSS)
PKL118727473(CTSS)
HAI109372254(CTSS)
DRO112313687(CTSS)
AJM119034681(CTSS)
PDIC114489220(CTSS)
PHAS123804406(CTSS)
MMF118637207 118637209 118637210
RFQ117015222(CTSS)
PALE102884940(CTSS)
PGIG120585211(CTSS)
PVP105303820(CTSS)
RAY107498990(CTSS)
MJV108404026(CTSS)
TOD119236327(CTSS)
SARA101543601(CTSS)
LAV100674232(CTSS)
TMU101340786
DNM101441455(CTSS)
MDO100017406(CTSS)
GAS123247280(CTSS)
SHR100917184(CTSS)
PCW110220556(CTSS)
OAA100088270(CTSS)
GGA425657(CTSS)
PCOC116238445(CTSS)
MGP104914438(CTSS)
CJO107324540(CTSS)
NMEL110387850
APLA101794564(CTSS)
ACYG106049275(CTSS)
AFUL116499813(CTSS)
TGU100223082(CTSS)
LSR110476808
SCAN103824795
PMOA120502604(CTSS)
OTC121335620(CTSS)
PRUF121353497
GFR102032358
FAB101815635(CTSS)
PHI102107924(CTSS)
PMAJ107214698
CCAE111939529
CBRC103619621(CTSS)
ETL114072354 114072744
ACHL103808852(CTSS)
FPG101911722(CTSS)
FCH102055558(CTSS)
CLV102094330(CTSS)
EGZ104126881
NNI104014433 104014434
PLET104615368
PCRI104025589(CTSS) 104037773
ACUN113490571(CTSS)
TALA104366166 122152486 122152489 122152527
PADL103919476 103919480
AFOR103900497 103900498
ACHC115345557 115345558
HALD104315201 104315202
CCRI104168031 104168032
CSTI104562030(CTSS)
CMAC104476793 104476794
MUI104534231 104538170
FGA104081458 104081459
GSTE104256108 104264334(CTSS)
LDI104347091(CTSS)
MNB103780570(CTSS)
OHA104338084(CTSS)
NNT104409361(CTSS)
PGUU104459482(CTSS)
ACAR104518069(CTSS)
CVF104285441 104285443
AAM106495149(CTSS)
AROW112972481 112972517
NPD112953003(CTSS)
TGT104573262(CTSS)
DNE112990058 112990083
SCAM104139547 104149055
ASN102373459 102384087(CTSS)
AMJ102562033(CTSS) 109283982
PSS102458936
CMY102947704 102947924 119564251
CPIC101931018 101934688 101940635 101944372 101944639 101949655
TST117869840
CABI116817621 116817622 116817623 116817624
MRV120390630 120390631 120390632 120390633
ACS100560943(ctss)
PVT110081451(CTSS)
SUND121916254(CTSS)
PBI103053841(CTSS)
PMUR107292919(CTSS)
CTIG120317009(CTSS)
TSR106546304(CTSS)
PGUT117670137(CTSS)
VKO123032984(CTSS)
PMUA114586295(CTSS) 114588654
ZVI118076374(CTSS)
GJA107120549(CTSS)
STOW125438579
XLA100036949(ctsh.L) 108699062 108699063 108699333 108699334 108699410 108700331 108700332 108700335 108700336 380516(ctss.L) 398927 443661(XB5914295.S) 443722 446505(ctss.S)
XTR100124852 100494325 100498084 100498238 105945585 105948322 116406662 116406764 448203(ctss) 496647(ctss.2) 496748(ctsh) 594890
NPR108789799(CTSS) 108800693
RTEM120920090 120920158 120920159 120920357
BBUF120982070 120982478
BGAR122923217 122923219
DRE337572(ctss2.2) 393398(ctss1) 554157(ctss2.1)
SRX107714774 107741752 107741753 107741774
SANH107663319 107663331 107689850 107689852 107689853 107691368
SGH107571626 107587832 107587833 107597985 107597987
CCAR109051923 109056426 109058805 109089990 109096260 109099830
CAUA113059153 113059154 113062485 113116109 113116110 113116111 113116112 113116113 113119713 113119760
PPRM120475234(ctss1) 120484669(ctss2.1) 120484670
MAMB125243015(ctss2.1) 125243016 125275994(ctss1)
IPU100305010(ctss2.1) 108274831
PHYP113525243 113533916
SMEO124383789
TFD113634015 113642169 113644583 113647392(ctss1) 125145725
AMEX103044830 103045424
EEE113575272 113590155
TRU101066490 101073909
TNGGSTEN00011685G001
LCO104923937 104931628 104931629
NCC104957237
CGOB115015608 115021677
ELY117263943 117265981(ctss2.1)
EFO125892608 125904820
PLEP121945417
SLUC116047397 116049093
ECRA117946034(ctss2.1)
ESP116677005 116690788
PFLV114556853 114556913 114567831
GAT120810481(ctss2.1)
PPUG119197582(ctss2.1) 119219161
MSAM119882210 119897015(ctss2.1) 119906692(ctss1)
CUD121513325 121523314
ALAT119005463 119005464 119016604
MZE101485929 105940410
ONL100690368 100690911 100695758 100705431
OAU116333435 116333436
OLA100049247(ctss) 101165175
OML112136685(ctss2.1) 112137547
XMA102230330 102235885
XCO114142240 114156396
XHE116717363 116731587
PRET103472454 103477641
PFOR103156712
PLAI106949136
PMEI106920372
GAF122831313(ctss2.1)
CVG107086772 107088360
CTUL119781874(ctss2.1) 119784819
GMU124865441(ctss2.1)
NFU107379223 107394690
KMR108243190(ctss2.1)
ALIM106518088 106524065
NWH119409270(ctss2.1)
AOCE111571630
MCEP125016156(ctss2.1) 125020405
CSEM103388697 103394262 103394264
POV109633509 109638767 109638800
SSEN122774431(ctss2.1) 122786334
HHIP117770319 117776444(ctss2.1)
HSP118113996(ctss2.1) 118125133
LCF108883175(ctss2.1) 108898158
SDU111222413 111222981
SLAL111659220 111669221
XGL120784605(ctss2.1) 120786191(ctss1) 120786192
HCQ109512113 109514600
BPEC110162666 110162667 110162671 110168875 110168941
MALB109968960
BSPL114843549(ctss2.1)
SASA100196462(cats) 106605328(CATS)
STRU115176789 115178898
OTW112222947(ctss2.1) 112229276
OMY100136261 110487241
OGO123997753 124006231
ONE115103957 115141062
SALP111958812 112081015
SNH120022490 120031296 120048417
CCLU121543126 121566614
ELS105031242 105031251 114829684
SFM108930364 108930365 108930367 108930412 108930417 108941877 108941910 114909387
PKI111838382 111838421
AANG118220535 118233653 118233655 118233657
LOC102686501 102694713 107075469
PSPA121307010 121309884
ARUT117395491 117395567 117965122 117965129 117965168 117971317
LCM102351684(CTSS) 102365039
RZE108371693
LCQ111684259
LSQ119615829
CNS116343293
BCOO119070995 119085401
TCA660428
CSET123316307
AGB108903191 108903193 108909798 108914557 108915519
LDC111506937
TPAL117651242
DPXDAPPUDRAFT_216612 DAPPUDRAFT_315499 DAPPUDRAFT_315500
DMK116926832
VDE111251592
DFR124497903
HRF124126641 124126648 124135997
SMMSmp_187140
NTO104097067
EGT105971619
NCOL116244932
PTMGSPATT00038477001
SPARSPRG_10279
 » show all
Reference
1  [PMID:1182153]
  Authors
Turnsek T, Kregar I, Lebez D.
  Title
Acid sulphydryl protease from calf lymph nodes.
  Journal
Biochim Biophys Acta 403:514-20 (1975)
DOI:10.1016/0005-2744(75)90079-0
Reference
2  [PMID:2604727]
  Authors
Bromme D, Steinert A, Friebe S, Fittkau S, Wiederanders B, Kirschke H
  Title
The specificity of bovine spleen cathepsin S. A comparison with rat liver cathepsins L and B.
  Journal
Biochem J 264:475-81 (1989)
DOI:10.1042/bj2640475
  Sequence
[bta:327711]
Reference
3  [PMID:2690828]
  Authors
Kirschke H, Wiederanders B, Bromme D, Rinne A.
  Title
Cathepsin S from bovine spleen. Purification, distribution, intracellular localization and action on proteins.
  Journal
Biochem J 264:467-73 (1989)
DOI:10.1042/bj2640467
Other DBs
ExplorEnz - The Enzyme Database: 3.4.22.27
IUBMB Enzyme Nomenclature: 3.4.22.27
ExPASy - ENZYME nomenclature database: 3.4.22.27
BRENDA, the Enzyme Database: 3.4.22.27
CAS: 71965-46-3

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