KEGG   ENZYME: 3.4.22.34
Entry
EC 3.4.22.34                Enzyme                                 
Name
legumain;
asparaginyl endopeptidase;
citvac;
proteinase B (ambiguous);
hemoglobinase (ambiguous);
PRSC1 gene product (Homo sapiens);
vicilin peptidohydrolase;
bean endopeptidase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
Reaction(IUBMB)
Hydrolysis of proteins and small molecule substrates at -Asn!Xaa- bonds
Comment
Best known from legume seeds, the trematode Schistosoma mansoni and mammalian lysosomes. Not inhibited by compound E-64. Type example of peptidase family C13
History
EC 3.4.22.34 created 1992, modified 2000
Orthology
K01369  legumain
Genes
HSA5641(LGMN)
PTR453118(LGMN)
PPS100979480(LGMN)
GGO101150415(LGMN)
PON100173793(LGMN)
NLE100589580(LGMN)
MCC703734(LGMN)
MCF101867471(LGMN)
CSAB103229573(LGMN)
CATY105596590(LGMN)
PANU101021503(LGMN)
TGE112628457(LGMN)
RRO104679044(LGMN)
RBB108519101(LGMN)
TFN117071517(LGMN)
PTEH111538237(LGMN)
CJC100415145(LGMN)
SBQ101041065(LGMN)
CSYR103275558(LGMN)
MMUR105856740(LGMN)
LCAT123645195(LGMN)
OGA100953335(LGMN)
MMU19141(Lgmn)
MCAL110306821(Lgmn)
MPAH110324510(Lgmn)
RNO63865(Lgmn)
MCOC116080851(Lgmn)
CGE100752348(Lgmn)
MAUA101823798(Lgmn)
PLEU114706048(Lgmn)
MORG121434366(Lgmn)
AAMP119819177(Lgmn)
NGI103724596(Lgmn)
HGL101698288(Lgmn)
CPOC100718170(Lgmn)
CCAN109696677(Lgmn)
DORD105986147(Lgmn)
DSP122118712(Lgmn)
NCAR124976234
OCU100346565(LGMN)
OPI101534303(LGMN)
TUP102474276(LGMN)
CFA480232(LGMN)
VVP112909587(LGMN)
VLG121493012(LGMN)
AML100464092(LGMN)
UMR103670076(LGMN)
UAH113267343(LGMN)
UAR123798878(LGMN)
ELK111148711
LLV125104728
MPUF101683297(LGMN)
ORO101384948(LGMN)
EJU114205285(LGMN)
ZCA113909817(LGMN)
MLX118002628(LGMN)
FCA101098470(LGMN)
PYU121032215(LGMN)
PBG122469464(LGMN)
PTG102969813(LGMN)
PPAD109274478(LGMN)
AJU106980834(LGMN)
HHV120232097(LGMN)
BTA281281(LGMN)
BOM102279974(LGMN)
BBUB102411702(LGMN)
CHX102191183(LGMN)
OAS678680(LGMN)
ODA120874982(LGMN)
CCAD122455080(LGMN)
SSC100154477(LGMN)
CFR102509831(LGMN)
CBAI105079874(LGMN)
CDK105095852(LGMN)
VPC102544336(LGMN)
BACU103013176(LGMN)
LVE103083212(LGMN)
OOR101269340(LGMN)
DLE111176145(LGMN)
PCAD102994327(LGMN)
PSIU116748708(LGMN)
ECB100053265(LGMN)
EPZ103556526(LGMN)
EAI106825364(LGMN)
MYB102254818(LGMN)
MYD102768828(LGMN)
MMYO118659811(LGMN)
MLF102425900(LGMN)
MNA107531602(LGMN)
PKL118704253(LGMN)
HAI109376792(LGMN)
DRO112311858(LGMN)
SHON118976626(LGMN) 118984681
AJM119037886(LGMN) 119059121
PDIC114492513(LGMN)
PHAS123808120(LGMN)
MMF118640262(LGMN)
RFQ117023608(LGMN)
PALE102889046(LGMN)
PGIG120619626(LGMN)
PVP105300792(LGMN)
RAY107511241(LGMN)
MJV108409091(LGMN)
TOD119239452(LGMN)
SARA101549195(LGMN)
LAV100667671(LGMN)
TMU101343432
DNM101423287(LGMN)
MDO100016534(LGMN)
GAS123234044(LGMN)
SHR100923637(LGMN)
PCW110217718(LGMN)
OAA100079679(LGMN)
GGA423418(LGMN)
PCOC116228898(LGMN)
MGP100540998(LGMN)
CJO107315211(LGMN)
NMEL110402152(LGMN)
APLA101801019(LGMN)
ACYG106036483(LGMN)
AFUL116489919(LGMN)
TGU100220965(LGMN)
LSR110471370(LGMN)
SCAN103826466(LGMN)
PMOA120503758(LGMN)
OTC121333948(LGMN)
PRUF121356028(LGMN)
GFR102039394(LGMN)
FAB101806290(LGMN)
PHI102106609(LGMN)
PMAJ107206007(LGMN)
CCAE111929870(LGMN)
CCW104686131(LGMN)
ETL114067309(LGMN)
ZAB102065563(LGMN)
FPG101914771(LGMN)
FCH102057063(LGMN)
CLV102094176(LGMN)
EGZ104135339(LGMN)
NNI104022210(LGMN)
PLET104618949(LGMN)
ACUN113480710(LGMN)
TALA104366102(LGMN)
PADL103923923(LGMN)
ACHC115334228(LGMN)
AAM106482935(LGMN)
AROW112972731(LGMN)
NPD112953895(LGMN)
DNE112990515(LGMN)
ASN102373928(LGMN)
AMJ102570177(LGMN)
CPOO109321700(LGMN)
GGN109298511(LGMN)
PSS102451298(LGMN)
CMY102947732(LGMN)
CPIC101947250(LGMN)
TST117876730(LGMN)
CABI116823092(LGMN)
MRV120403771(LGMN)
ACS100567178(lgmn)
PVT110083625(LGMN)
SUND121919442(LGMN)
PBI103052653(LGMN)
PMUR107298068(LGMN)
TSR106546473(LGMN)
PGUT117665928(LGMN)
VKO123026670(LGMN)
PMUA114590795(LGMN)
ZVI118081031(LGMN)
GJA107123821(LGMN)
STOW125426657(LGMN)
XLA108699819(lgmn.S) 379601(lgmn.L)
XTR448252(lgmn)
NPR108788679(LGMN)
RTEM120920961(LGMN)
BBUF120981384(LGMN)
BGAR122921664(LGMN)
DRE100005129 100005175 100005220 100005266 100005356 406625(lgmn) 569153
SRX107705425 107732001 107739877
SANH107654963 107680193 107682791
SGH107553201 107565804 107574855 107578689 107602950
CCAR109080937 109085275 109100486 109100652
CAUA113046765 113056777 113076631 113092633 113112495
PPRM120467848(lgmn) 120487252
MAMB125255253 125255551 125255947 125264197 125277282(lgmn)
IPU108262994(lgmn) 108273608 108273609 108273610 108274367
PHYP113527241 113527621 113527635
SMEO124388481 124388482 124388489 124388495 124388506 124389380 124394193(lgmn)
TFD113649214 113649218 113649221 113652129 113652132 113652133 113652135 113652239 113655988(lgmn) 113656962 125146148
AMEX103039991 103043747 103046445
EEE113574748(lgmn) 113584551
TRU101076709(lgmn)
TNGGSTEN00035812G001
LCO104929778(lgmn)
CGOB115027782(lgmn)
ELY117267535(lgmn)
PLEP121953178(lgmn)
SLUC116057422(lgmn)
ECRA117935421(lgmn)
PFLV114546505(lgmn)
GAT120832477(lgmn)
PPUG119227524(lgmn)
MSAM119910240(lgmn)
CUD121526733(lgmn)
ALAT119005069(lgmn)
MZE101483614(lgmn)
ONL100697684(lgmn)
OAU116315231(lgmn)
OLA101163371(lgmn)
OML112148415(lgmn)
XMA102237395(lgmn)
XCO114134070(lgmn)
XHE116708863(lgmn)
PRET103458294(lgmn)
PFOR103131492(lgmn)
PLAI106936046(lgmn)
PMEI106904481(lgmn)
GAF122845818(lgmn)
CVG107094353(lgmn)
CTUL119776494(lgmn)
GMU124884851(lgmn)
NFU107391750(lgmn)
KMR108236324(lgmn)
ALIM106533809(lgmn)
NWH119427055(lgmn)
AOCE111579380(lgmn)
CSEM103381136(lgmn)
SSEN122783272(lgmn)
HHIP117756672(lgmn)
HSP118116851(lgmn)
LCF108886685(lgmn)
SDU111236086(lgmn)
SLAL111659502(lgmn)
XGL120795796(lgmn)
HCQ109517472(lgmn)
BPEC110171101(lgmn)
MALB109973394(lgmn)
BSPL114848393(lgmn)
SASA100306856(lgmn) 106589466
OTW112236405 112262155(lgmn)
OMY110498282 110505985
OGO124046780
ONE115118525(lgmn) 115125660
SALP112071076(lgmn)
SNH120022957(lgmn)
ELS105015924(lgmn)
PKI111856498
AANG118214254(lgmn)
LOC102683803(lgmn) 107078448
PSPA121324545 121329570
ARUT117413102 117413108 117417143 117963871
LCM102350037(LGMN)
CMK103185394(lgmn) 103188950
RTP109933280 109933282
BFO118406889 118424708
BBEL109471023 109480300
CIN100182585
SCLV120326786
SPU100889415
APLC110982893 110987149
SKO100376285
API100159991 100162169 100165598 100168946
DNX107161803 107164506 107164517
AGS114125009 114125012 114125014 114127879 114129740
RMD113555503 113558730 113559402 113559403
BTAB109033898
DCI103524489
CLEC106661504 106666612
HHAL106679841 106679842 106679851 106681316 106681318 106681603
NLU111045655 111046521
FOC113207765
TPAL117644527
ZNE110828600
CSEC111866360
FCD110844609
DPXDAPPUDRAFT_303947
DMK116936484
PVM113827864 113827865 113827866 113827868
PJA122267433 122267435 122267437 122267438
PCHN125041859 125041965 125041976 125041985
HAME121853168 121853176
PCLA123772889 123772890
PTRU123520049 123520050
EAF111718079
LSM121129902 121131760
ISCIscW_ISCW015983
DSV119440164 119440165 119440169 119440170 119440980 119441488 119441562 119442976
RSAN119386803 119386805 119386807 119386808 119388019
RMP119177858 119178106 119178165 119178389 119178653 119187251
TUT107360905 107365746 107372261
CSCU111618498 111618529
PTEP107448500
SDM118195235
CELCELE_T28H10.3(lgmn-1)
CBRCBG_23516
BMYBM_BM877(Bm877)
LOALOAG_02771
NAINECAME_14977
TSPTsp_00775 Tsp_03464
HROHELRODRAFT_185311
LGILOTGIDRAFT_115714
PCAN112570786
BGT106063735 106080232
GAE121371682
HRF124117809
HRJ124289441
CRG105319353
MYI110450417
PMAX117323002
MMER123545100
LAK106161828 106169358
SMMSmp_075800
OVIT265_04479 T265_05045 T265_05046 T265_05899 T265_08233 T265_08795 T265_08796 T265_09482 T265_09826 T265_09828 T265_09829 T265_09853 T265_09856 T265_10113 T265_10115 T265_10116 T265_10428 T265_10491 T265_10492 T265_10753 T265_10755 T265_10756 T265_10942 T265_10943 T265_10944 T265_11000 T265_11001 T265_11326 T265_11509 T265_11511 T265_11569 T265_11570 T265_11663 T265_11673 T265_11697 T265_11794 T265_11804 T265_11816 T265_11822 T265_11830 T265_11914 T265_11927 T265_11933 T265_11945 T265_11946 T265_12058 T265_12097 T265_14615 T265_14674 T265_14679 T265_14859 T265_15054 T265_15164 T265_15245 T265_15297 T265_15314 T265_15375 T265_15407 T265_15453 T265_15530 T265_15575 T265_15659 T265_15693 T265_15711 T265_15733 T265_15739
NVE5504044
EPA110252650
ATEN116300537
ADF107327341
AMIL114962334
SPIS111342829
DGT114522218
XEN124442203
HMG100207098
TADTRIADDRAFT_63455
ATHAT1G62710(BETA-VPE) AT2G25940(ALPHA-VPE) AT3G20210(DELTA-VPE) AT4G32940(GAMMA-VPE)
ALY9303291 9314976 9319303 9324070
CRB17879744 17888695 17891343 17894016
CSAT104703124 104703881 104714063 104714610 104716872 104721525 104729970 104746427 104752230 104752927 104765899 104785183
EUSEUTSA_v10001970mg EUTSA_v10020662mg EUTSA_v10023430mg EUTSA_v10025034mg
BRP103836684 103838040 103842166 103848303 103850260 103869347 117129893
BNA106356289 106363747 106364661 106368548 106368852 106377574 106379574 106393247 106398680 106399280 106401744 106408400 106413682 106428869
BOE106308848 106312010 106312995 106321575 106337497 106343242
RSZ108809443 108827899 108827900 108842821 108861855
THJ104803737 104803798 104817842 104823552
CPAP110807338 110817536
CIT102612763(VPE) 102623739
CICCICLE_v10008097mg CICLE_v10013934mg CICLE_v100139432m CICLE_v10013957mg CICLE_v10019686mg
PVY116105604 116106216 116107760 116123287
MINC123193850 123200721 123210274 123218103 123218194 123218231 123218821 123218822 123218918
TCC18588032 18595565 18606321
GRA105765113 105771433 105773196 105792105 105799357 105804025 105804681
GHI107886086 107889295 107891441 107897074 107901497 107929955 107931740 107953875
GAB108454010 108456312 108470311 108476942 108486442
DZI111274080 111285101 111290508 111299287
EGR104423281 104423282 104423283 104424218 104437823 104438342 104439968 104441879
GMX100784318 100788554 100791675 100807010 547555(PM40) 547700(VPE2) 547964(VPE)
GSJ114383716 114390342 114392623 114394179 114408805 114412131 114414805
PVUPHAVU_001G033500g PHAVU_003G217500g PHAVU_009G076100g
VRA106762174 106764744 106769123
VAR108322532 108331721 108334932 108338162
VUN114163155 114177634 114194621 114196266
CCAJ109789255 109804800 109805986 109808005 109812855
APRC113849561 113859483 113863937 113865927 113874911
MTRMTR_1g016780 MTR_3g104120 MTR_4g101730 MTR_7g032230 MTR_7g075310 MTR_7g079140
CAM101488586 101489581 101489898 101490235 101491855 101492543 101496833 101497152 101497484 101497749 101501913 101505224 101505549 101506305 101512602 101514688 101515346
LJALj0g3v0270939.1(Lj0g3v0270939.1) Lj0g3v0270939.2(Lj0g3v0270939.2) Lj1g3v1785750.1(Lj1g3v1785750.1) Lj2g3v1877640.1(Lj2g3v1877640.1) Lj2g3v1877640.2(Lj2g3v1877640.2) Lj5g3v0369970.1(Lj5g3v0369970.1)
ADU107461196 107487130 107488211 107494868 107494888 107494903 107495579
AIP107605552 107606332 107630361 107643026 107647457 107648431
AHF112697263 112697687 112698270 112706381 112721142 112749599 112755167 112755980 112759184 112764565 112800890 112803196 112805850
LANG109327911 109337103 109343833 109344379 109349992 109358681
FVE101290961 101292503 101302193 101302322 101302482 101303793 101307317
RCN112172694 112176024 112177932 112179139 112184811
PPER18769683 18775706 18782801 18783417 18791503
PMUM103320527 103327449 103337239 103339133
PAVI110744816 110753705 110761707 110765905
PDUL117616694 117622194 117628366 117634570
MDM103400695 103400696 103400697 103431519 103433087 103433678 103441005 103443359 103454774
PXB103929646 103936835 103951861 103960369 103960371 103960373 103967656
ZJU107410485 107410511 107420135 107435434
MNT112094636 21396998 21396999 21401960 21402472
CSV101216082 101221167
CMO103482645 103487795 103501567
BHJ120071736 120075472 120092847
MCHA111004600 111016825 111023347
CMAX111468940 111485183 111491963 111496569
CMOS111430261 111454335 111461846 111462747
CPEP111780111 111798094 111805689 111808778
RCU8272115 8275625
JCU105638176 105645980 105646245
HBR110631859 110636311 110644790 110665739 110667395
MESC110603677 110605250 110612704 110617985
POP18094383 7462273 7463725 7465529 7490837
PEU105121358 105122235 105131687 105132252
PALZ118028576 118030827 118036111 118040672 118045117
JRE109004943 109008852 109011344 109014534
QSU111986993 112000503 112005986 112015985 112015987 112022813 112028739
QLO115949623 115969922 115972077 115992888 115995247
TWL119987392 119997614 120004838 120007499 120007808
VVI100244137 100251259 100260773
VRI117905030 117912824 117921936
SLY101245974(VPE4) 101263441(VPE3) 101264958 101265153(VPE2) 101265263 101265459(VPE1) 101265567 101267042 101267916 101268492 778274(VPE5)
SPEN107007035 107027344 107027360 107027361 107027362 107027371 107027760 107028013 107028045 107028070 107028086 107028125 107028554
SOT102577844(VPE2) 102579989 102580313 102580646 102580986 102583556 102596720 102602967 102603642
CANN107850204 107860862 107866380 107867292 107874638
NTA107759462(NtVPE-2) 107763487 107772757(NtVPE-1b) 107779843 107795055(lenS) 107798049 107807347 107807348(pb3) 107807349 107809845 107809847(NtVPE-1a) 107820875 107822625 107824465(NtVPE-3) 107830109 107830563 107832849(lenE1)
NSY104214567 104214569 104215967 104221915 104229346 104231690 104231916 104240985
NTO104089255 104101855 104109122 104109158 104109159 104109160 104113214 108947365
NAU109206579 109216396 109232068 109236414 109239967 109239968 109240838
INI109153106 109170771 109179886
ITR116006644 116011332 116027535
SIND105155454 105164692 105175360
OEU111376116 111391141 111393200
EGT105961329 105967045 105972168 105975405 105977129
SSPL121752901 121768453 121781633 121789658 121805182 121809800
HAN110864271 110864273 110866033 110878023 110901898 110901906 110920649 110921684 110921695 110922574 110928271 110929854 110930588 110932507 110932508 110932509 110932511
ECAD122578307 122587567 122599004 122599014 122599504 122599829 122599868 122599921 122600884 122602999
LSV111877663 111877680 111892189 111903818 111903828 111903836 111904359 111906083
CCAV112499697 112521419 112527457 112527527 112529262 112529290 112529539 112529543 112529544
DCR108198311 108198312 108198313 108204253 108206347
CSIN114257876 114271969 114277704 114290778 114310631
BVG104886411 104886414 104886428 104886434 104886441 104892062 104907869
SOE110789235 110789263 110789264 110789265 110795232
CQI110681633 110684536 110684537 110702972 110704605 110705488 110705491 110705498 110729826 110729830 110732733
NNU104588207 104598590 104602279
MING122059921 122070705 122085974
TSS122655520 122666034
PSOM113279401 113300532 113300533 113304474 113306116 113319121 113319190 113347910 113349467 113359375
NCOL116252271 116252392 116256141 116265920 116267995
OSA107275984 4324683 4330133 4336523 4339804
DOSAOs01t0559600-01(Os01g0559600) Os02t0644000-01(Os02g0644000) Os04t0537900-01(Os04g0537900) Os05t0593900-01(Os05g0593900) Os06t0105100-00(Os06g0105100)
OBR102701172 102702520 102703575 102710946
BDI100821265 100823658 100833696 100835846
ATS109740567 109746962 109752674 109752680 109761353 109765815 109765816 109773848 109775604
TDC119268210 119270757 119270758 119276104 119278967 119278968 119301743 119309783 119317276 119322374 119355891 119355897 119355899 119365031 119365038 119365039
TAES100127067 123046146 123046148 123054028 123054035 123061314 123063693 123063694 123069944 123072843 123072845 123078394 123081003 123081004 123103902 123112133 123121688 123127856 123137786 123144950 123145936 123189913 123189920 123189922 542914
TUA125509513 125513896 125529901 125539188 125539195 125539197 125543799 125546345
SBI8066566 8078601 8078883 8083326
ZMA100192667 100286140 542001 542077 542609
SITA101754691 101758135 101758290 101773432
SVS117847121 117857491 117863887 117864224
PVIR120641369 120656618 120673239 120681774 120700431 120709565 120710771
PHAI112884215 112888357 112892345 112898465 112899492
PDA103712950
EGU105037223 105054041
MUS103970333 103981750 103982804 103990024 103992712 103994243 104000506
DCT110093855 110099701 110110623
PEQ110029498 110029499
AOF109820171 109840805
ATR18429267 18429268 18443673
SMOSELMODRAFT_126781 SELMODRAFT_137569 SELMODRAFT_445464 SELMODRAFT_75074
PPP112273608 112276780 112285791 112291620
CRECHLRE_12g483550v5
CSLCOCSUDRAFT_64138
CVRCHLNCDRAFT_24292
APROF751_1333
FFUCLAFUR5_04817
SREPTSG_01549
TETTTHERM_00066890 TTHERM_00066900 TTHERM_00415590 TTHERM_00415600
PTMGSPATT00009342001 GSPATT00019832001
SMINv1.2.032754.t1(symbB.v1.2.032754.t1)
AAFAURANDRAFT_54735
PIFPITG_02821
PSOJPHYSODRAFT_537874
SPARSPRG_06015
EHXEMIHUDRAFT_455379(AEP1)
GTTGUITHDRAFT_96965
NGRNAEGRDRAFT_1734
TVATVAG_035520 TVAG_050390 TVAG_060430 TVAG_068410 TVAG_185540 TVAG_277470 TVAG_305110 TVAG_328450 TVAG_385340 TVAG_426660
 » show all
Reference
1
  Authors
Hara-Nishimura, I.
  Title
Asparaginyl endopeptidase.
  Journal
In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.), Handbook of Proteolytic Enzymes, Academic Press, London, 1998, p. 746-749.
Reference
2
  Authors
Dalton, J.P. and Brindley, P.J.
  Title
Schistosome legumain.
  Journal
In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.), Handbook of Proteolytic Enzymes, Academic Press, London, 1998, p. 749-754.
Reference
3  [PMID:9891971]
  Authors
Chen JM, Rawlings ND, Stevens RA, Barrett AJ.
  Title
Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases.
  Journal
FEBS Lett 441:361-5 (1998)
DOI:10.1016/S0014-5793(98)01574-9
  Sequence
[mmu:19141]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.22.34
IUBMB Enzyme Nomenclature: 3.4.22.34
ExPASy - ENZYME nomenclature database: 3.4.22.34
BRENDA, the Enzyme Database: 3.4.22.34
CAS: 149371-18-6

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