KEGG   ENZYME: 3.4.22.35Help
Entry
EC 3.4.22.35                Enzyme                                 

Name
histolysain;
histolysin;
histolysin;
Entamoeba histolytica cysteine proteinase;
amebapain;
Entamoeba histolytica cysteine protease;
Entamoeba histolytica neutral thiol proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of proteins, including basement membrane collagen and azocasein. Preferential cleavage: Arg-Arg! in small molecule substrates including Z-Arg-Arg!NHMec
Comment
From the protozoan, Entamoeba histolytica. In peptidase family C1 (papain family)
History
EC 3.4.22.35 created 1992
Orthology
K08570  histolysain
Genes
EHI: EHI_010850 EHI_033710(206.t00005) EHI_039610(358.t00002) EHI_050570(10.t00046) EHI_074180(242.t00001) EHI_151400(2.t00042) EHI_151440(2.t00055) EHI_168240(191.t00018)
EDI: EDI_113060 EDI_113090 EDI_156850 EDI_171580 EDI_310810
Taxonomy
Reference
1  [PMID:2860002]
  Authors
Lushbaugh WB, Hofbauer AF, Pittman FE.
  Title
Entamoeba histolytica: purification of cathepsin B.
  Journal
Exp Parasitol 59:328-36 (1985)
Reference
2  [PMID:2898937]
  Authors
Luaces AL, Barrett AJ.
  Title
Affinity purification and biochemical characterization of histolysin, the major cysteine proteinase of Entamoeba histolytica.
  Journal
Biochem J 250:903-9 (1988)
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.4.22.35
IUBMB Enzyme Nomenclature: 3.4.22.35
ExPASy - ENZYME nomenclature database: 3.4.22.35
BRENDA, the Enzyme Database: 3.4.22.35
CAS: 92228-52-9

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