KEGG   ENZYME: 3.4.22.36Help
Entry
EC 3.4.22.36                Enzyme                                 

Name
caspase-1;
interleukin 1beta-converting enzyme;
protease VII;
protease A;
interleukin 1beta precursor proteinase;
interleukin 1 converting enzyme;
interleukin 1beta-converting endopeptidase;
interleukin-1beta convertase;
interleukin-1beta converting enzyme;
interleukin-1beta precursor proteinase;
prointerleukin 1beta protease;
precursor interleukin-1beta converting enzyme;
pro-interleukin 1beta proteinase;
ICE
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp!
Comment
From mammalian monocytes. This enzyme is part of the family of inflammatory caspases, which also includes caspase-4 (EC 3.4.22.57) and caspase-5 (EC 3.4.22.58) in humans and caspase-11 (EC 3.4.22.64), caspase-12, caspase-13 and caspase-14 in mice. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation [6,7]. Cleaves pro-interleukin-1beta (pro-IL-1beta) to form mature IL-1beta, a potent mediator of inflammation. Also activates the proinflammatory cytokine, IL-18, which is also known as interferon-gamma-inducing factor [6]. Inhibited by Ac-Tyr-Val-Ala-Asp-CHO. Caspase-11 plays a critical role in the activation of caspase-1 in mice, whereas caspase-4 enhances its activation in humans [7]. Belongs in peptidase family C14.
History
EC 3.4.22.36 created 1993, modified 1997, modified 2007
Orthology
K01370  caspase 1
Genes
HSA: 834(CASP1)
PTR: 101058924(CASP1)
PPS: 100985633(CARD17) 100985973 100986637(CARD16)
GGO: 101136563(CASP1)
PON: 100437679(CASP1)
NLE: 100588974(CASP1)
MCC: 706568(CASP1)
MCF: 102118885(CASP1)
CSAB: 103248363 103248365(CASP1) 103248933
RRO: 104659487 104665271(CASP1) 104665273 104665280
CJC: 100385618(CASP1)
SBQ: 101048062(CASP1) 101048706
MMU: 12362(Casp1)
RNO: 25166(Casp1)
CGE: 100759171(Casp1)
NGI: 103743236(Casp1)
HGL: 101725179(Casp1)
CCAN: 109694935(Casp1)
OCU: 100101588(CASP1)
TUP: 102490614(CASP1)
BTA: 514214(CASP1)
BIU: 109570010(CASP1)
PHD: 102340491
OAS: 101117013
SSC: 397319(CASP1)
CFR: 102514999
CDK: 105100418(CASP1)
BACU: 103013120
LVE: 103078860
OOR: 101289850(CASP1)
ECB: 100033888(CASP1)
EPZ: 103559838(CASP1)
EAI: 106837656(CASP1)
MYB: 102247565 102258149(CASP1)
MYD: 102769699
HAI: 109377701(CASP1)
RSS: 109435077(CASP1)
SHR: 100935043
OAA: 100078458
GGA: 395764(CASP1)
MGP: 100549639
CJO: 107322632
APLA: 101789899(CASP1)
ACYG: 106041090
FPG: 101914004
FCH: 102051371
CLV: 102097973
EGZ: 104131761
AAM: 106484675
ASN: 102373345 106722780(CARD18)
AMJ: 102575910(CASP1)
PSS: 102454294
CMY: 102948326
CPIC: 101951713
ACS: 100554079
PVT: 110084544
PBI: 103067193
GJA: 107112418
XLA: 378669(casp1.S) 397719(casp1.L)
XTR: 100491605(casp1)
NPR: 108790873
DRE: 57933(caspa)
IPU: 108267794(CASP1)
LCO: 104924732(Caspase-1)
NCC: 104959782
OLA: 101174762
PRET: 103474681
NFU: 107380030
CSEM: 103378482
BPEC: 110163616
SASA: 106612902
SFM: 108922456
LCM: 102363742
CMK: 103180499(caspase-1)
 » show all
Taxonomy
Reference
1  [PMID:1919001]
  Authors
Howard AD, Kostura MJ, Thornberry N, Ding GJ, Limjuco G, Weidner J, Salley JP, Hogquist KA, Chaplin DD, Mumford RA, et al.
  Title
IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDa IL-1 alpha.
  Journal
J Immunol 147:2964-9 (1991)
Reference
2  [PMID:1574116]
  Authors
Thornberry NA, Bull HG, Calaycay JR, Chapman KT, Howard AD, Kostura MJ, Miller DK, Molineaux SM, Weidner JR, Aunins J, et al.
  Title
A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes.
  Journal
Nature 356:768-74 (1992)
DOI:10.1038/356768a0
  Sequence
[hsa:834]
Reference
3  [PMID:7845238]
  Authors
Thornberry NA.
  Title
Interleukin-1 beta converting enzyme.
  Journal
Methods Enzymol 244:615-31 (1994)
Reference
4  [PMID:8861900]
  Authors
Alnemri ES, Livingston DJ, Nicholson DW, Salvesen G, Thornberry NA, Wong WW, Yuan J.
  Title
Human ICE/CED-3 protease nomenclature.
  Journal
Cell 87:171 (1996)
DOI:10.1016/S0092-8674(00)81334-3
Reference
5  [PMID:9054418]
  Authors
Margolin N, Raybuck SA, Wilson KP, Chen W, Fox T, Gu Y, Livingston DJ.
  Title
Substrate and inhibitor specificity of interleukin-1 beta-converting enzyme and related caspases.
  Journal
J Biol Chem 272:7223-8 (1997)
DOI:10.1074/jbc.272.11.7223
Reference
6  [PMID:15163405]
  Authors
Martinon F, Tschopp J.
  Title
Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases.
  Journal
Cell 117:561-74 (2004)
DOI:10.1016/j.cell.2004.05.004
Reference
7  [PMID:11104820]
  Authors
Chang HY, Yang X.
  Title
Proteases for cell suicide: functions and regulation of caspases.
  Journal
Microbiol Mol Biol Rev 64:821-46 (2000)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.22.36
IUBMB Enzyme Nomenclature: 3.4.22.36
ExPASy - ENZYME nomenclature database: 3.4.22.36
BRENDA, the Enzyme Database: 3.4.22.36
CAS: 122191-40-6

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