KEGG   ENZYME: 3.4.22.38
Entry
EC 3.4.22.38                Enzyme                                 

Name
cathepsin K;
cathepsin O and cathepsin X (both misleading, having been used for other enzymes);
cathepsin O2
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
Reaction(IUBMB)
Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg
Comment
Prominently expressed in mammalian osteoclasts, and believed to play a role in bone resorption. In peptidase family C1 (papain family)
History
EC 3.4.22.38 created 1997
Orthology
K01371  cathepsin K
Genes
HSA: 1513(CTSK)
PTR: 457278(CTSK)
PPS: 100974656(CTSK)
GGO: 101145486(CTSK)
PON: 100432447(CTSK)
NLE: 100580351(CTSK)
MCC: 574112(CTSK)
MCF: 102120416(CTSK)
CSAB: 103247207(CTSK)
RRO: 104681068(CTSK)
RBB: 108533261(CTSK)
CJC: 100410169(CTSK)
SBQ: 101045222(CTSK)
MMU: 13038(Ctsk)
MCAL: 110291053(Ctsk)
MPAH: 110320301(Ctsk)
RNO: 29175(Ctsk)
MUN: 110541001(Ctsk)
CGE: 100765407(Ctsk) 113833185
NGI: 103729102(Ctsk)
HGL: 101716993(Ctsk)
CCAN: 109681204(Ctsk)
OCU: 100009334(CTSK)
TUP: 102469152(CTSK)
CFA: 608843(CTSK)
VVP: 112907784(CTSK)
AML: 100483004(CTSK)
UMR: 103667534(CTSK)
UAH: 113246211(CTSK)
ORO: 101371209(CTSK)
ELK: 111161944
FCA: 101093379(CTSK)
PTG: 102968588(CTSK)
PPAD: 109257023(CTSK)
AJU: 106979872(CTSK)
BTA: 513038(CTSK)
BOM: 102287709(CTSK)
BIU: 109555331(CTSK)
BBUB: 102407535(CTSK)
CHX: 102183473(CTSK)
OAS: 101108972(CTSK)
SSC: 397569(CTSK)
CFR: 102511322(CTSK)
CDK: 105103193(CTSK)
BACU: 103008252(CTSK)
LVE: 103075087(CTSK)
OOR: 101270188(CTSK)
DLE: 111169765(CTSK)
PCAD: 102980378(CTSK)
ECB: 100054991(CTSK)
EPZ: 103547638(CTSK)
EAI: 106846533(CTSK)
MYB: 102259503(CTSK)
MYD: 102771486(CTSK)
MNA: 107539127(CTSK)
HAI: 109372279(CTSK)
DRO: 112313792(CTSK)
PALE: 102885198(CTSK)
RAY: 107498992(CTSK)
MJV: 108408263(CTSK)
LAV: 100673950(CTSK)
TMU: 101349596
MDO: 100017449(CTSK)
SHR: 100917440(CTSK)
PCW: 110220566(CTSK)
OAA: 100088286(CTSK)
GGA: 395818(CTSK)
MGP: 104914440(CTSK)
APLA: 101794155(CTSK)
ACYG: 106049270(CTSK)
TGU: 101233119(CTSK)
LSR: 110476861(CTSK)
SCAN: 103824024(CTSK)
GFR: 102031691(CTSK)
PHI: 102102166(CTSK)
PMAJ: 107214633(CTSK)
CCAE: 111939475(CTSK)
FPG: 101919682(CTSK)
FCH: 102049655(CTSK)
CLV: 102096035(CTSK)
NNI: 104014432(CTSK)
AAM: 106495413(CTSK)
ASN: 112547876(CTSK)
AMJ: 109281035(CTSK)
ACS: 100561728(ctsk)
PVT: 110081453(CTSK)
PBI: 103053602(CTSK)
PMUR: 107292918(CTSK)
TSR: 106554193
PMUA: 114586294(CTSK)
GJA: 107120548(CTSK)
XTR: 100490139 100492634 448216(ctsk) 779889(ctsk)
DRE: 550475(ctsk)
IPU: 100528180(catk) 108274827(ctssa)
AMEX: 103044235
TRU: 101066261
LCO: 104923938
ONL: 102080361(ctsk) 109204084
XMA: 102230067
XCO: 114142267
PRET: 103477640
NFU: 107379225
KMR: 108243181
ALIM: 106524066
CSEM: 103388696
POV: 109633525
LCF: 108883173(ctsk) 108884675
HCQ: 109512208
BPEC: 110170731
SASA: 100195370(catk) 106580864
SALP: 111959001
ELS: 105009269(ctsk)
LCM: 102352136(CTSK)
RTP: 109919200
DME: Dmel_CG4847(CG4847)
BIM: 100748409
CCAL: 108624475
AEC: 105146908
ACEP: 105627376
DQU: 106741339
CFO: 105252674
OBO: 105284231
PCF: 106790486
FCD: 110852181
DPTE: 113792611
PTEP: 107450796
LAK: 106167228
EGL: EGR_02195
NAU: 109220629
DFA: DFA_03112
TPV: TP02_0140
SLI: Slin_5291
ZPR: ZPR_4593
WIN: WPG_0559
 » show all
Reference
1  [PMID:7818555]
  Authors
Inaoka T, Bilbe G, Ishibashi O, Tezuka K, Kumegawa M, Kokubo T.
  Title
Molecular cloning of human cDNA for cathepsin K: novel cysteine proteinase predominantly expressed in bone.
  Journal
Biochem Biophys Res Commun 206:89-96 (1995)
DOI:10.1006/bbrc.1995.1013
  Sequence
[hsa:1513]
Reference
2  [PMID:8647860]
  Authors
Bossard MJ, Tomaszek TA, Thompson SK, Amegadzie BY, Hanning CR, Jones C, Kurdyla JT, McNulty DE, Drake FH, Gowen M, Levy MA.
  Title
Proteolytic activity of human osteoclast cathepsin K. Expression, purification, activation, and substrate identification.
  Journal
J Biol Chem 271:12517-24 (1996)
DOI:10.1074/jbc.271.21.12517
Reference
3  [PMID:8670136]
  Authors
Bromme D, Klaus JL, Okamoto K, Rasnick D, Palmer JT.
  Title
Peptidyl vinyl sulphones: a new class of potent and selective cysteine protease inhibitors: S2P2 specificity of human cathepsin O2 in comparison with cathepsins S and L.
  Journal
Biochem J 315 ( Pt 1):85-9 (1996)
DOI:10.1042/bj3150085
Reference
4  [PMID:9033588]
  Authors
Zhao B, Janson CA, Amegadzie BY, D'Alessio K, Griffin C, Hanning CR, Jones C, Kurdyla J, McQueney M, Qiu X, Smith WW, Abdel-Meguid SS.
  Title
Crystal structure of human osteoclast cathepsin K complex with E-64.
  Journal
Nat Struct Biol 4:109-11 (1997)
DOI:10.1038/nsb0297-109
Reference
5  [PMID:9033587]
  Authors
McGrath ME, Klaus JL, Barnes MG, Bromme D.
  Title
Crystal structure of human cathepsin K complexed with a potent inhibitor.
  Journal
Nat Struct Biol 4:105-9 (1997)
DOI:10.1038/nsb0297-105
  Sequence
[hsa:1513]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.22.38
IUBMB Enzyme Nomenclature: 3.4.22.38
ExPASy - ENZYME nomenclature database: 3.4.22.38
BRENDA, the Enzyme Database: 3.4.22.38
CAS: 94716-09-3

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