EC                Enzyme                                 

cathepsin K;
cathepsin O and cathepsin X (both misleading, having been used for other enzymes);
cathepsin O2
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg
Prominently expressed in mammalian osteoclasts, and believed to play a role in bone resorption. In peptidase family C1 (papain family)
EC created 1997
K01371  cathepsin K
HSA: 1513(CTSK)
PTR: 457278(CTSK)
PPS: 100974656(CTSK)
GGO: 101145486(CTSK)
PON: 100432447(CTSK)
NLE: 100580351(CTSK)
MCC: 574112(CTSK)
MCF: 102120416(CTSK)
CSAB: 103247207(CTSK)
RRO: 104681068(CTSK)
RBB: 108533261(CTSK)
CJC: 100410169(CTSK)
SBQ: 101045222(CTSK)
MMU: 13038(Ctsk)
MCAL: 110291053(Ctsk)
MPAH: 110320301(Ctsk)
RNO: 29175(Ctsk)
MUN: 110541001(Ctsk)
CGE: 100765407(Ctsk) 113833185
NGI: 103729102(Ctsk)
HGL: 101716993(Ctsk)
CCAN: 109681204(Ctsk)
OCU: 100009334(CTSK)
TUP: 102469152(CTSK)
CFA: 608843(CTSK)
VVP: 112907784(CTSK)
AML: 100483004(CTSK)
UMR: 103667534(CTSK)
UAH: 113246211(CTSK)
ORO: 101371209(CTSK)
FCA: 101093379(CTSK)
PTG: 102968588(CTSK)
PPAD: 109257023(CTSK)
AJU: 106979872(CTSK)
BTA: 513038(CTSK)
BOM: 102287709(CTSK)
BIU: 109555331(CTSK)
BBUB: 102407535(CTSK)
CHX: 102183473(CTSK)
OAS: 101108972(CTSK)
SSC: 397569(CTSK)
CFR: 102511322(CTSK)
CDK: 105103193(CTSK)
BACU: 103008252(CTSK)
LVE: 103075087(CTSK)
OOR: 101270188(CTSK)
DLE: 111169765(CTSK)
PCAD: 102980378(CTSK)
ECB: 100054991(CTSK)
EPZ: 103547638(CTSK)
EAI: 106846533(CTSK)
MYB: 102259503(CTSK)
MYD: 102771486(CTSK)
MNA: 107539127(CTSK)
HAI: 109372279(CTSK)
DRO: 112313792(CTSK)
PALE: 102885198(CTSK)
RAY: 107498992(CTSK)
MJV: 108408263(CTSK)
LAV: 100673950(CTSK)
TMU: 101349596
MDO: 100017449(CTSK)
SHR: 100917440(CTSK)
PCW: 110220566(CTSK)
OAA: 100088286(CTSK)
GGA: 395818(CTSK)
MGP: 104914440(CTSK)
APLA: 101794155(CTSK)
ACYG: 106049270(CTSK)
TGU: 101233119(CTSK)
LSR: 110476861(CTSK)
SCAN: 103824024(CTSK)
GFR: 102031691(CTSK)
PHI: 102102166(CTSK)
PMAJ: 107214633(CTSK)
CCAE: 111939475(CTSK)
FPG: 101919682(CTSK)
FCH: 102049655(CTSK)
CLV: 102096035(CTSK)
EGZ: 104132598
NNI: 104014432(CTSK)
AAM: 106495413(CTSK)
ASN: 112547876(CTSK)
AMJ: 109281035(CTSK)
ACS: 100561728(ctsk)
PVT: 110079243 110081453(CTSK)
PBI: 103053602(CTSK)
PMUR: 107292918(CTSK)
TSR: 106546306(CTSK) 106554193
PMUA: 114586294(CTSK)
GJA: 107120548(CTSK)
XTR: 100490139 100492634 448216(ctsk) 779889(ctsk)
DRE: 550475(ctsk)
IPU: 100528180(catk) 108274827(ctssa)
AMEX: 103044235
TRU: 101066261
LCO: 104923938
ONL: 102080361(ctsk) 109204084
XMA: 102230067
XCO: 114142267
PRET: 103477640
NFU: 107379225
KMR: 108243181
ALIM: 106524066
CSEM: 103388696
POV: 109633525
LCF: 108883173(ctsk) 108884675
BPEC: 110170731
SASA: 100195370(catk) 106580864
SALP: 111959001
ELS: 105009269(ctsk)
LCM: 102352136(CTSK)
RTP: 109919200
DME: Dmel_CG4847(CG4847)
CCAL: 108624475
ACEP: 105627376
VEM: 105558803
DQU: 106741339
CFO: 105252674
OBO: 105284231
PCF: 106790486
BMY: Bm1_13265
LAK: 106167228
EGL: EGR_02195
CRB: 17875720
CIT: 102620117
NAU: 109220629
ATR: 18442240
DFA: DFA_03112
 » show all
1  [PMID:7818555]
Inaoka T, Bilbe G, Ishibashi O, Tezuka K, Kumegawa M, Kokubo T.
Molecular cloning of human cDNA for cathepsin K: novel cysteine proteinase predominantly expressed in bone.
Biochem Biophys Res Commun 206:89-96 (1995)
2  [PMID:8647860]
Bossard MJ, Tomaszek TA, Thompson SK, Amegadzie BY, Hanning CR, Jones C, Kurdyla JT, McNulty DE, Drake FH, Gowen M, Levy MA.
Proteolytic activity of human osteoclast cathepsin K. Expression, purification, activation, and substrate identification.
J Biol Chem 271:12517-24 (1996)
3  [PMID:8670136]
Bromme D, Klaus JL, Okamoto K, Rasnick D, Palmer JT.
Peptidyl vinyl sulphones: a new class of potent and selective cysteine protease inhibitors: S2P2 specificity of human cathepsin O2 in comparison with cathepsins S and L.
Biochem J 315 ( Pt 1):85-9 (1996)
4  [PMID:9033588]
Zhao B, Janson CA, Amegadzie BY, D'Alessio K, Griffin C, Hanning CR, Jones C, Kurdyla J, McQueney M, Qiu X, Smith WW, Abdel-Meguid SS.
Crystal structure of human osteoclast cathepsin K complex with E-64.
Nat Struct Biol 4:109-11 (1997)
5  [PMID:9033587]
McGrath ME, Klaus JL, Barnes MG, Bromme D.
Crystal structure of human cathepsin K complexed with a potent inhibitor.
Nat Struct Biol 4:105-9 (1997)
Other DBs
ExplorEnz - The Enzyme Database:
IUBMB Enzyme Nomenclature:
ExPASy - ENZYME nomenclature database:
BRENDA, the Enzyme Database:
CAS: 94716-09-3

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