KEGG ENZYME: 3.4.22.40

ENZYME: 3.4.22.40

Entry

EC 3.4.22.40                Enzyme

Name

bleomycin hydrolase;
aminopeptidase C (Lactococcus lactis) [4]

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases

Reaction(IUBMB)

Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred [1]

Comment

The molecule is a homohexamer in which the monomers have a papain-like tertiary structure (in peptidase family C1). The active sites are on the walls of a central channel through the molecule, and access of substrate molecules to them is obstructed by this and by the C-terminus of each polypeptide chain [3]. Bleomycin can scarcely be the natural substrate, and there are reports of limited endopeptidase activity. Known from bacteria as well as eukaryotic organisms. Hydrolase H from chicken muscle has many similarities to bleomycin hydrolase, but hydrolyses Ph-CO-Arg-2-naphthylamine as well as aminopeptidase substrates [2].

History

EC 3.4.22.40 created 2000

Orthology

K01372

bleomycin hydrolase

Genes

HSA:

642(BLMH)

PTR:	454555(BLMH)

PPS:	100969716(BLMH)

GGO:	101132179(BLMH)

PON:	100458252(BLMH)

NLE:	100586005(BLMH)

HMH:	116474565(BLMH)

MCC:	712275(BLMH)

MCF:	102134260(BLMH)

MTHB:

126938245

MNI:	105476825(BLMH)

CSAB:

103242663(BLMH)

PANU:

101015328(BLMH)

TGE:	112609167(BLMH)

MLEU:

105547018(BLMH)

RRO:	104665982(BLMH)

RBB:	108517266(BLMH)

TFN:	117067643(BLMH)

PTEH:

111520783(BLMH)

CANG:

105510867(BLMH)

CJC:	100395816(BLMH)

SBQ:	101034854(BLMH)

CIMI:

108313605(BLMH)

CSYR:

103262426(BLMH)

MMUR:

105857970(BLMH)

LCAT:

123620238(BLMH)

PCOQ:

105820754(BLMH)

OGA:	100942653(BLMH)

MMU:	104184(Blmh)

MCAL:

110304415(Blmh)

MPAH:

110331198(Blmh)

RNO:	287552(Blmh)

MCOC:

116077143(Blmh)

ANU:	117710874(Blmh)

MUN:	110559451(Blmh)

CGE:	100754419(Blmh)

MAUA:

101834077(Blmh)

PROB:

127218887(Blmh)

PLEU:

114691459(Blmh) 114695678

MORG:

121457105(Blmh)

MFOT:

126492337

AAMP:

119812016(Blmh)

NGI:	103730487(Blmh)

HGL:	101706417(Blmh)

CPOC:

100717553(Blmh)

CCAN:

109695999(Blmh)

DORD:

105985844(Blmh)

DSP:	122118621(Blmh)

NCAR:

124981251

OCU:

100009580

OPI:	101524655(BLMH)

TUP:	102478767(BLMH)

GVR:	103599961(BLMH)

CFA:	480635(BLMH)

CLUD:

112677613(BLMH)

VVP:	112933091(BLMH)

VLG:	121473781(BLMH)

AML:	100481648(BLMH)

UMR:	103667396(BLMH)

UAH:	113269087(BLMH)

UAR:	123776888(BLMH)

ELK:

111151732

LLV:

125087400

MPUF:

101692876(BLMH)

NVS:	122906374(BLMH)

ORO:	101375650(BLMH)

EJU:	114213982(BLMH)

ZCA:	113908001(BLMH)

MLX:	118025247(BLMH)

NSU:	110592790(BLMH)

LWW:	102726788(BLMH)

FCA:	101090910(BLMH)

PYU:	121017268(BLMH)

PBG:	122486071(BLMH)

LRUF:

124512998

PTG:	102955199(BLMH)

PPAD:

109255188(BLMH)

PUC:

125927529

AJU:	106968720(BLMH)

HHV:	120246600(BLMH)

BTA:	504483(BLMH)

BOM:	102273666(BLMH)

BIU:	109574087(BLMH)

BBUB:

102404850(BLMH)

BBIS:

105003923(BLMH)

CHX:	102172384(BLMH)

OAS:	101111816(BLMH)

ODA:	120862242 120866246(BLMH)

CCAD:

122448019(BLMH)

SSC:	100521221(BLMH)

CFR:	102509179(BLMH)

CBAI:

105071541(BLMH)

CDK:	105088147(BLMH)

VPC:	102534062 102535868(BLMH)

BACU:

103008350(BLMH)

LVE:	103089598(BLMH)

OOR:	101288641(BLMH)

DLE:

111185781

PCAD:

102986991(BLMH)

PSIU:

116745620(BLMH)

NASI:

112394509(BLMH)

ECB:	100072223(BLMH)

EPZ:	103555362(BLMH)

EAI:	106822033(BLMH)

MYB:	102248365(BLMH)

MYD:	102770408(BLMH)

MMYO:

118671868(BLMH)

MLF:	102440520(BLMH)

MNA:	107528805(BLMH)

PKL:	118702515(BLMH)

HAI:	109386884(BLMH)

DRO:	112308419(BLMH)

SHON:

119003735(BLMH)

AJM:	119062044(BLMH)

PDIC:

114503106(BLMH) 114504888

PHAS:

123817713(BLMH) 123830110

MMF:	118634654(BLMH)

RFQ:	117013605(BLMH)

PALE:

102881345(BLMH)

PGIG:

120621007(BLMH)

PVP:	105291885(BLMH)

RAY:	107507749(BLMH)

MJV:	108405792(BLMH)

TOD:	119230588(BLMH)

SARA:

101546705(BLMH)

LAV:	100659455(BLMH)

TMU:

101345625

ETF:	101646370(BLMH)

DNM:	101440204(BLMH)

MDO:	100015608(BLMH)

GAS:	123244417(BLMH)

SHR:	100921705(BLMH)

AFZ:

127558874

PCW:	110192240(BLMH)

OAA:	100078861(BLMH)

GGA:	395996(BLMH)

PCOC:

116228029(BLMH)

MGP:	100541169(BLMH)

CJO:	107322595(BLMH)

NMEL:

110407963(BLMH)

APLA:

101789672(BLMH)

ACYG:

106045773(BLMH)

AFUL:

116497286(BLMH)

TGU:	100228177(BLMH)

LSR:	110467702(BLMH)

SCAN:

103820309(BLMH)

PMOA:

120507781(BLMH)

OTC:	121345834(BLMH)

PRUF:

121361719(BLMH)

GFR:	102042474(BLMH)

FAB:	101820091(BLMH)

PHI:	102109841(BLMH)

PMAJ:

107212921(BLMH)

CCAE:

111937784(BLMH)

CCW:	104691183(BLMH)

CBRC:

103613428(BLMH)

ETL:	114061223(BLMH)

ZAB:	102060886(BLMH)

ACHL:

103802546(BLMH)

SVG:	106853409(BLMH)

FPG:	101913334(BLMH)

FCH:	102056437(BLMH)

CLV:	102098401(BLMH)

EGZ:	104121867(BLMH)

NNI:	104012209(BLMH)

PLET:

104613832(BLMH)

PCRI:

104036269(BLMH)

PCAO:

104044811(BLMH)

ACUN:

113487161(BLMH)

TALA:

104369181(BLMH)

PADL:

103920817(BLMH)

AFOR:

103898115(BLMH)

ACHC:

115347444(BLMH)

HALD:

104324332(BLMH)

HLE:	104835774(BLMH)

AGEN:

126039532

GCL:

127024502

CCRI:

104166903(BLMH)

CSTI:

104560383(BLMH)

EHS:	104507115(BLMH)

CMAC:

104476407(BLMH)

MUI:	104541415(BLMH)

FGA:	104072732(BLMH)

GSTE:

104257861(BLMH)

LDI:	104347404(BLMH)

MNB:	103776921(BLMH)

OHA:	104327171(BLMH)

NNT:	104402241(BLMH)

SHAB:

115601918(BLMH)

DPUB:

104302871(BLMH)

PGUU:

104471216(BLMH)

ACAR:

104524275(BLMH)

CPEA:

104384830(BLMH)

AVIT:

104279078(BLMH)

CVF:	104282146(BLMH)

CUCA:

104057179(BLMH)

TEO:	104374404(BLMH)

BRHI:

104494839(BLMH)

AAM:	106493735(BLMH)

AROW:

112960714(BLMH)

NPD:	112954629(BLMH)

TGT:	104576799(BLMH)

DNE:	112983972(BLMH)

SCAM:

104142850(BLMH)

ASN:	102371516(BLMH)

AMJ:	102567319(BLMH)

CPOO:

109317228(BLMH)

GGN:	109293360(BLMH)

PSS:	102462350 102462832(BLMH)

CMY:	102937945(BLMH)

CPIC:

101931127(BLMH)

TST:	117867573(BLMH)

CABI:

116829762(BLMH)

MRV:	120387491(BLMH)

ACS:	100564025(blmh)

PVT:	110084273(BLMH)

SUND:

121917088(BLMH)

PBI:	103065214(BLMH)

PMUR:

107298999(BLMH)

CTIG:

120296833 120297102

PGUT:

117658186(BLMH)

VKO:	123023348(BLMH)

PMUA:

114585586(BLMH)

ZVI:	118097045(BLMH)

GJA:	107119546(BLMH)

STOW:

125446045(BLMH)

XLA:	108707946(blmh.L) 734349(blmh.S)

XTR:	448747(blmh)

NPR:	108794441(BLMH)

RTEM:

120927718(BLMH)

BBUF:

120994664(BLMH)

BGAR:

122932423(BLMH)

DRE:	336541(blmh)

SRX:	107743628 107756769

SANH:

107669757 107685090

SGH:	107548589 107589715

CCAR:

109088447

CAUA:

113058535 113114848

CGIB:

127973004 128029519

PPRM:

120472453(blmh)

MAMB:

125248304(blmh)

CIDE:

127495303

MASI:

127422393 127429479

IPU:	108277823(blmh)

PHYP:

113533078(blmh)

SMEO:

124395024(blmh)

TFD:	113642011(blmh)

AMEX:

103039033(blmh)

EEE:	113574712(blmh)

TRU:	101064322(blmh)

TNG:	GSTEN00008392G001

LCO:	104925422(blmh)

NCC:	104964477(blmh)

CGOB:

115018286(blmh)

ELY:	117259379(blmh)

EFO:	125889233(blmh)

PLEP:

121943379(blmh)

SLUC:

116046550(blmh)

ECRA:

117942503(blmh)

ESP:	116687092(blmh)

PFLV:

114550397(blmh)

GAT:	120823017(blmh)

PPUG:

119217991(blmh)

MSAM:

119883225(blmh)

CUD:	121516011(blmh)

ALAT:

119010977(blmh)

MZE:	101466499(blmh)

ONL:	100707585(blmh)

OAU:	116331795(blmh)

OLA:	101174209(blmh)

OML:	112149027(blmh)

XMA:	102223824(blmh)

XCO:	114133331(blmh)

XHE:	116707708(blmh)

PRET:

103474802(blmh)

PFOR:

103148119(blmh)

PLAI:

106935092(blmh)

PMEI:

106933841(blmh)

GAF:	122832303(blmh)

CVG:	107098221(blmh)

CTUL:

119786927(blmh)

GMU:	124884591(blmh)

NFU:	107373652(blmh)

KMR:	108249710(blmh)

ALIM:

106527603(blmh)

AOCE:

111588566(blmh)

MCEP:

125013960(blmh)

CSEM:

103377743(blmh)

POV:	109634639(blmh)

SSEN:

122773371(blmh)

HHIP:

117772332(blmh)

HSP:	118106536(blmh)

LCF:

108898807

SDU:	111233421(blmh)

SLAL:

111656451(blmh)

XGL:	120792308(blmh)

HCQ:	109525436(blmh)

SSCV:

125971995

BPEC:

110159414(blmh)

MALB:

109952217(blmh)

BSPL:

114867619(blmh)

SASA:

106580795(blmh) 106612652

STRU:

115163112(blmh) 115206061

OTW:	112265178 112266826

OMY:	110503658 110507537

OGO:	123992967 124004759

ONE:	115136988 115141603

SALP:

111949477 111960488

SNH:	120018346 120028813

CCLU:

121563418 121567473

ELS:	105024097(blmh)

SFM:	108921280(blmh)

PKI:	111842700(blmh)

AANG:

118236290(blmh)

LOC:	102696089(blmh)

PSPA:

121308609(blmh) 121327498

ARUT:

117429588 117430219

PSEX:

120531604(blmh)

LCM:	102354437(BLMH)

CMK:	103183348(blmh)

RTP:	109936271(blmh)

CPLA:

122564006(blmh)

BFO:

118425710

BBEL:

109466987

SPU:	115918829 752414

APLC:

110980695

AJC:

117122144

SKO:

100366618

DME:	Dmel_CG13423(CG13423) Dmel_CG1440(CG1440)

DER:	6547530 6549706

DSE:	6610078 6619806

DSI:	Dsimw501_GD11522(Dsim_GD11522) Dsimw501_GD16898(Dsim_GD16898)

DYA:	Dyak_GE12121 Dyak_GE15781

DAN:

6505026

DSR:	110175945 110182913

DPO:	4804638 4814434

DPE:	6593235 6598214

DMN:	108160582 108162426 117185785

DWI:	6638419 6641502

DGR:	6560659 6564920

DMO:	Dmoj_GI15765 Dmoj_GI20946

DAZ:

108619644

DNV:	108654155 108656693

DHE:	111595496 111600225

DVI:

6631870

CCAT:

101463351

BOD:

106625244

RZE:	108373435 108377820

MDE:

101896232

SCAC:

106087831

LCQ:

111691121

LSQ:

119605978

HIS:

119653717

AGA:	AgaP_AGAP001341

ACOZ:

120947555

AARA:

120908643

ASTE:

118506540

AAG:

5569945

AALB:

109408449

CQU:	CpipJ_CPIJ007788

CPII:

120430876 120431718

CNS:

116348795

BCOO:

119076407 119083405

AME:

724901

ACER:

107992831

ALAB:

122711914

BIM:

100745080

BBIF:

117204172

BVK:

117235680

BVAN:

117159612

BTER:

100642561

BPYO:

122567111

CCAL:

108631462

OBB:

114873348

MGEN:

117229456

NMEA:

116427542

CGIG:

122396095 122396176

SOC:

105196208

MPHA:

105829475

AEC:

105149781

ACEP:

105619266

PBAR:

105423767

VEM:

105561330

HST:

105184936

DQU:

106747224

CFO:

105254839

FEX:

115237537

LHU:

105678265

PGC:

109862004

OBO:

105274528

PCF:

106784904

PFUC:

122521386

VPS:

122637504

NVI:

100117484

CSOL:

105361977

TPRE:

106658740

MDL:

103576510

CGLO:

123270252

FAS:

105264009

DAM:

107048446

AGIF:

122855474

CINS:

118063679

LHT:

122498282

CCIN:

107274278

TCA:

660395

DPA:

109542947

SOY:

115876025

ATD:

109597813

CSET:

123320021

AGB:	108905919 108915338 111691288

LDC:

111504129

NVL:

108558323

APLN:

108737953

PPYR:

116161744

OTU:

111416712

BMOR:

101743988

BMAN:

114252832

MSEX:

115453323

DPL:	KGM_207070

BANY:

112057167 112057851

NIQ:

126775444

PMAC:

106714551

PPOT:

106107648

PXU:

106117923

PRAP:

110993230

PBX:

123713380

PNAP:

125060372

ZCE:

119835192

CCRC:

123700194

HAW:

110380461

HZE:

124639585

TNL:

113502864

SLIU:

111360274

OFU:

114362402

PXY:

105382656

CFEL:

113378759

API:	100162995 100163837

DNX:	107165906 107167158

AGS:	114131357 114132801

RMD:	113558079 113558080 113560407

BTAB:

109038490

DCI:

103521940

PHU:	Phum_PHUM316230

FOC:

113209534

TPAL:

117642818

ZNE:

110837928

CSEC:

111862828

SGRE:

126284400

DPX:	DAPPUDRAFT_300309

DMK:

116919259

DPZ:

124313021

PVM:	113820688 113820697

PJA:

122256249

PCHN:

125037749

HAME:

121857716

PCLA:

123745348

PTRU:

123499267

ESN:

127008960

HAZT:

108678899

EAF:

111697180

LSM:

121116401

PPOI:

119093832 119093903 119112150

ISC:	IscW_ISCW001472

DSV:

119446498

RSAN:

119376983 119389685

RMP:

119180213

CSCU:

111622899

PTEP:

107446795

SDM:

118183031

CRG:

105319386

PMAX:

117340001

MCAF:

127710557

MMER:

123534318

DPOL:

127854001

OBI:

106869468

OSN:

115226075

LAK:

106151611

NVE:

5519611

EPA:

110232742

ATEN:

116295917

ADF:

107349437

AMIL:

114961201

PDAM:

113675573

SPIS:

111340473

DGT:

114523755

TAD:	TRIADDRAFT_28626

AQU:

100637582

QSU:

112032687

GSL:	Gasu_01320

SCE:	YNL239W(LAP3)

SEUB:

DI49_4508

SPAO:

SPAR_N00890

AGO:	AGOS_ABL204W

ERC:

Ecym_6487

VPO:	Kpol_1015p10

ZRO:	ZYRO0F15620g

CGR:	CAGL0J07568g

NCS:	NCAS_0G03590(NCAS0G03590)

NDI:	NDAI_0F03900(NDAI0F03900)

TPF:	TPHA_0P01800(TPHA0P01800)

TBL:	TBLA_0B00120(TBLA0B00120)

TGB:	HG536_0D00230

TDL:	TDEL_0E00400(TDEL0E00400)

KAF:	KAFR_0A08050(KAFR0A08050)

KNG:	KNAG_0F00760(KNAG0F00760)

ZMK:	HG535_0D00280

PIC:	PICST_58854

PGU:	PGUG_01006

SPAA:

SPAPADRAFT_137654

CAL:	CAALFM_CR04480CA(LAP3)

CTP:	CTRG_00394

COT:	CORT_0A10310

CDU:	CD36_29830

CTEN:

CANTEDRAFT_116142

YLI:	YALI0F05940g YALI0F17974g

CLU:	CLUG_00029 CLUG_01084

CLUS:

A9F13_09g01375 A9F13_19g00759

CAUR:

CJI97_000889 CJI97_003033

SLB:	AWJ20_3438(LAP3)

PKZ:	C5L36_0C08730 C5L36_0E01270

BNN:	FOA43_002361 FOA43_004609

BBRX:

BRETT_001803 BRETT_005152

OPA:	HPODL_03714 HPODL_03865

SLUD:

SCDLUD_003041

NCR:

NCU08333

NTE:	NEUTE1DRAFT125878(NEUTE1DRAFT_125878)

SMP:	SMAC_01602

MGR:

MGG_02695

PPEI:

PpBr36_09734

TMN:	UCRPA7_2847

FGR:	FGSG_08736

FPU:	FPSE_07720

FVR:	FVEG_01921

FOX:	FOXG_03058

NHE:	NECHADRAFT_35505

TRE:	TRIREDRAFT_65735

TRR:	M419DRAFT_101325

MAW:

MAC_08380

MAJ:

MAA_00781

CMT:

CCM_03797

PLJ:	VFPFJ_00252

VAL:	VDBG_01804

VDA:	VDAG_01750

CFJ:	CFIO01_05064

CLUP:

CLUP02_08519

CHIG:

CH63R_07635

SAPO:

SAPIO_CDS1939

ELA:	UCREL1_7248

PFY:	PFICI_10529

SSL:	SS1G_03526

BFU:	BCIN_08g01120(Bclap3)

MBE:

MBM_07492

PSCO:

LY89DRAFT_690427

GLZ:	GLAREA_03285

ANI:

AN6399.2

AOR:	AO090005000599

ANG:	ANI_1_216014(An01g01720)

AFV:	AFLA_003408

ALUC:

AKAW2_20363A

APUU:

APUU_51385A

PDP:	PDIP_46820

TMF:	PMAA_016000

TRG:	TRUGW13939_11694

PBL:	PAAG_03464

PBN:	PADG_06359

AJE:	HCAG_08620

BGH:	BDBG_05791

PNO:	SNOG_06146

PTE:

PTT_06632

BZE:	COCCADRAFT_1550

BSC:	COCSADRAFT_32930

BOR:	COCMIDRAFT_105949

AALT:

CC77DRAFT_1020375

ZTR:	MYCGRDRAFT_41275

PFJ:	MYCFIDRAFT_58247

FFU:	CLAFUR5_11897

BCOM:

BAUCODRAFT_566432

NPA:	UCRNP2_8839

TML:	GSTUM_00003999001

TMS:	TREMEDRAFT_73057

TASA:

A1Q1_00262

TVS:	TRAVEDRAFT_161451

DSQ:	DICSQDRAFT_143946 DICSQDRAFT_166325

PCO:	PHACADRAFT_174941

SHS:	STEHIDRAFT_141376

HIR:	HETIRDRAFT_61505

PSQ:	PUNSTDRAFT_62183

ADL:	AURDEDRAFT_129391 AURDEDRAFT_178787

FME:	FOMMEDRAFT_108627 FOMMEDRAFT_85586

GTR:	GLOTRDRAFT_45763 GLOTRDRAFT_58931

LBC:	LACBIDRAFT_183606 LACBIDRAFT_312916

CCI:	CC1G_03271

ABP:	AGABI1DRAFT116802(AGABI1DRAFT_116802)

ABV:	AGABI2DRAFT192278(AGABI2DRAFT_192278)

PCUB:

JR316_0001896

MPR:	MPER_08810

MRR:	Moror_17290

SCM:	SCHCO_02632766(SCHCODRAFT_02632766)

CPUT:

CONPUDRAFT_101840

SLA:	SERLADRAFT_348280

WSE:	WALSEDRAFT_33007

WIC:	J056_004001

UMA:	UMAG_01232

PFP:	PFL1_02310

PGR:	PGTG_14638

MLR:	MELLADRAFT_123252 MELLADRAFT_123253 MELLADRAFT_48972 MELLADRAFT_88407

MBR:	MONBRDRAFT_35515

SRE:	PTSG_10848

SPAR:

SPRG_08808 SPRG_12809 SPRG_17535

BBA:	Bd1649(pepC)

BBAT:

Bdt_1638(pepC)

BBAC:

EP01_04445

BDC:	DOE51_12355

BEX:

A11Q_1024

BCK:	BCO26_0876

BAG:

Bcoa_0301

BCOA:

BF29_3405

VIL:	CFK37_10060

SEDD:

ERJ70_05110

STEA:

C0679_15005

PUK:	PU629_09600

LMO:	lmo2338(pepC)

LMN:	LM5578_2536(pepC)

LMY:	LM5923_2486(pepC)

LMT:	LMRG_01505

LMOC:

LMOSLCC5850_2342(pepC)

LMOE:

BN418_2763

LMOB:

BN419_2772

LMOD:

LMON_2350(pepC)

LMOW:

AX10_05665

LMOQ:

LM6179_3055(pepC)

LMR:	LMR479A_2457(pepC)

LMOM:

IJ09_13210

LMF:	LMOf2365_2308

LMC:	Lm4b_02302(pepC)

LMOG:

BN389_23050(pepC)

LMP:

MUO_11665

LMOL:

LMOL312_2293(pepC)

LMOZ:

LM1816_19540(pepC)

LMOX:

AX24_09480

LMH:	LMHCC_0267

LMQ:	LMM7_2376(pepC)

LML:	lmo4a_2335(pepC)

LMG:	LMKG_02828

LMS:

LMLG_0937

LMJ:	LMOG_03180

LMW:	LMOSLCC2755_2342(pepC)

LMX:	LMOSLCC2372_2400(pepC)

LMZ:	LMOSLCC2482_2340(pepC)

LMON:

LMOSLCC2376_2233(pepC)

LMOS:

LMOSLCC7179_2252(pepC)

LMOO:

LMOSLCC2378_2342(pepC)

LMOY:

LMOSLCC2479_2398(pepC)

LMOT:

LMOSLCC2540_2373(pepC)

LMOA:

LMOATCC19117_2337(pepC)

LMOK:

CQ02_11790

LMV:	Y193_04115(pepC)

LIN:

pepC

LWE:

lwe2290

LSG:	lse_2254(pepC)

LIV:	LIV_2260(pepC)

LII:	JL52_11860

LIW:	AX25_12045

LIA:	JL58_12040

LIO:	JL53_12530

LGZ:	NCTC10812_02253(pepC)

LMAR:

LAX80_011175(pepC)

AFX:	JZ786_02100

ACUR:

JZ785_17515

ADAU:

NZD86_01335

AFAS:

NZD89_01065

ACYC:

JI721_11130

LLA:	L130687(pepC)

LLK:	LLKF_2071(pepC)

LLT:	CVCAS_1818(pepC)

LLS:	lilo_1882(pepC)

LLD:	P620_10595(pepC)

LLX:	NCDO2118_1998(pepC)

LLJ:	LG36_1833(pepC)

LLM:	llmg_2069(pepC)

LLC:

LACR_2073

LLR:

llh_2670

LLN:	LLNZ_10650

LLI:	uc509_1839(pepC)

LLW:	kw2_1935(pepC)

LGR:

LCGT_1619

LGV:

LCGL_1641

LPK:	LACPI_2049(pepC)

LRN:	CMV25_03745

LACT:

D7I46_07420(pepC)

LACK:

FLP15_12570(pepC)

LTI:	JW886_08830(pepC)

LCAR:

BHS00_01185

LPAA:

BHS01_09695

LPET:

lgb_01692(pepC)

LFO:	LMK00_09535(pepC)

SPY:	SPy_1651(pepC)

SPZ:	M5005_Spy1356(pepC)

SPYM:

M1GAS476_1434(pepC)

SPYA:

A20_1399c(pepC)

SPM:	spyM18_1662(pepC)

SPG:	SpyM3_1391(pepC)

SPS:

SPs0471

SPH:	MGAS10270_Spy1473(pepC)

SPI:	MGAS10750_Spy1465(pepC)

SPJ:	MGAS2096_Spy1378(pepC)

SPK:	MGAS9429_Spy1352(pepC)

SPF:	SpyM50435(pepC)

SPA:	M6_Spy1402

SPB:	M28_Spy1397(pepC)

STG:	MGAS15252_1252(pepC)

STX:	MGAS1882_1313(pepC)

SOZ:	Spy49_1280c(pepC)

STZ:	SPYALAB49_001398(pepC)

SPYH:

L897_06795

SPYO:

STAB901_06815

SPN:	SP_0281(pepC)

SPD:	SPD_0261(pepC)

SPR:	spr0258(pepC)

SPW:	SPCG_0292(pepC)

SJJ:

SPJ_0289

SNV:	SPNINV200_02630(pepC)

SPX:

SPG_0264

SNT:

SPT_0326

SND:

MYY_0360

SPNN:

T308_01375

SNE:	SPN23F02690(pepC)

SPV:

SPH_0397

SNC:	HMPREF0837_10596

SNM:	SP70585_0340

SPP:

SPP_0330

SNI:	INV104_02380(pepC)

SPNG:

HMPREF1038_00336(pepC)

SNB:	SP670_0353

SNP:

SPAP_0328

SNX:	SPNOXC02990(pepC)

SNU:	SPNA45_01757(pepC)

SPNE:

SPN034156_13550(pepC)

SPNU:

SPN034183_03050(pepC)

SPNM:

SPN994038_02930(pepC)

SPNO:

SPN994039_02940(pepC)

SAG:	SAG0297(pepC)

SAN:

pepC

SAK:	SAK_0369(pepC)

SGC:	A964_0305(pepC)

SAGL:

GBS222_0059(pepC)

SAGM:

BSA_3730

SAGI:

MSA_3630

SAGR:

SAIL_3680

SAGP:

V193_00395

SAGC:

DN94_00395

SAGT:

GBSCOH1_0280

SAGE:

EN72_01835

SAGG:

EN73_01770

SAGN:

W903_0353

SAGJ:

ID870_07860(pepC)

SMU:	SMU_466(pepC)

SMC:	SmuNN2025_1502(pepC)

SMUT:

SMUGS5_02010

SMJ:	SMULJ23_1521(pepC)

SMUA:

SMUFR_0400(pepC)

STC:	str0229(pepC)

STL:	stu0229(pepC)

STE:

STER_0276

STN:

STND_0227

STU:	STH8232_0323(pepC)

STW:

Y1U_C0218

STHE:

T303_02345

STHS:

AVT04_03675

SSA:	SSA_1861(pepC)

SSB:	SSUBM407_1594(pepC)

SSU:	SSU05_1709

SSV:	SSU98_1721

SSI:	SSU1520(pepC)

SSS:	SSUSC84_1546(pepC)

SSF:	SSUA7_1541

SSW:	SSGZ1_1540

SUP:

YYK_07280

SSUS:

NJAUSS_1580

SST:	SSUST3_1554

SSUY:

YB51_7660

SSK:	SSUD12_1686

SSQ:	SSUD9_1718

SUI:	SSUJS14_1679

SUO:	SSU12_1656

SRP:	SSUST1_1598

SSUT:

TL13_1514(pepC)

SSUI:

T15_1776(pepC)

SGO:	SGO_0585(pepC)

SEZ:	Sez_1572(pepC)

SEQ:

SZO_03940

SEZO:

SeseC_02106

SEQU:

Q426_00990

SEU:

SEQ_1791

SUB:	SUB1408(pepC)

SDS:	SDEG_1712(pepC)

SDG:	SDE12394_08570

SDA:	GGS_1545(pepC)

SDC:	SDSE_1809(pepC)

SDQ:	SDSE167_1773(pepC)

SGA:	GALLO_0478

SGG:	SGGBAA2069_c04140(pepC)

SGT:	SGGB_0452(pepC)

SMB:	smi_0268(pepC)

SOR:	SOR_0218(pepC)

STK:	STP_1254(pepC)

STB:	SGPB_0379(pepC)

SCP:	HMPREF0833_12000(pepC)

SCF:	Spaf_0212(pepC)

SSR:	SALIVB_0252(pepC)

STF:	Ssal_01946(pepC)

STJ:	SALIVA_0230(pepC)

STRS:

SSAL8618_01495

SSAH:

HSISS4_00181(pepC)

STD:	SPPN_02145

SMN:	SMA_0442(pepC)

SIF:	Sinf_0388(pepC)

SIE:	SCIM_0356(pepC)

SIB:	SIR_1349(pepC)

SIU:	SII_1334(pepC)

SANG:

SAIN_0350(pepC)

SANC:

SANR_0397(pepC)

SANS:

DK43_08280

SCG:	SCI_0418(pepC)

SCON:

SCRE_0398(pepC)

SCOS:

SCR2_0398(pepC)

SOI:	I872_01660

SLU:

KE3_0464

SIG:	N596_09590

SIP:	N597_01555

STV:	V470_00990

SPAT:

A0O21_07290

STRA:

ATM98_09070

STRN:

SNAG_0285(pepC)

SSOB:

DK181_01670(pepC)

SRQ:	SR187_7705

SEQI:

A6J79_04130(pepC)

SKI:	D7D50_00600(pepC)

SPEI:

EHW89_01825

SRAT:

FY406_05580(pepC)

SGW:	D7D53_07850(pepC)

STRG:

SRT_16500(pepC)

SVB:	NCTC12167_00266(pepC)

SMEN:

SAMEA4412692_1425(pepC)

SCAI:

NCTC12191_01103(pepC)

SPSU:

NCTC13786_01625(pepC)

SCHJ:

DDV21_009220(pepC)

SPOC:

NCTC10925_01532(pepC)

SPAB:

KQ224_03900(pepC)

SLAT:

J4854_02575(pepC)

SAUP:

NCTC3168_00271(pepC)

SURN:

NCTC13766_00447(pepC)

SACO:

SAME_00473(pepC_2)

SVF:	NCTC3166_00502(pepC)

SOS:	INT76_04310(pepC)

STOY:

STYK_02290(pepC)

FPEN:

KIW23_03725(pepC)

LJO:	LJ_0395 LJ_0716 LJ_0719

LJF:	FI9785_254(pepG) FI9785_256(pepG) FI9785_413(pepC) FI9785_589 FI9785_590 FI9785_591 FI9785_592 FI9785_694(pepE)

LJH:	LJP_0182 LJP_0184c LJP_0372c LJP_0528c LJP_0531c LJP_0649

LJN:	T285_01000 T285_01010 T285_01875 T285_02755 T285_02770 T285_03450

LAC:	LBA0195(pepG) LBA0204(pepE) LBA0343 LBA0911

LAD:	LA14_0190 LA14_0199 LA14_0340 LA14_0932

LAF:	SD55_0187(pepG) SD55_0196(pepE) SD55_0339 SD55_0932

LDB:	Ldb1730(pepC)

LBU:	LBUL_0241 LBUL_0242 LBUL_1604

LDE:	LDBND_0244(pepG) LDBND_0245(pepW) LDBND_1615

LDL:	LBU_0223 LBU_0224 LBU_1473

LGA:	LGAS_0179 LGAS_0181 LGAS_0334 LGAS_0730

LHE:	lhv_0212 lhv_0221 lhv_0363 lhv_0983

LHL:	LBHH_0198 LBHH_0201 LBHH_0324 LBHH_1202

LHR:	R0052_01120 R0052_01165 R0052_01850 R0052_07070

LHV:	lhe_0914(pepCE) lhe_1868(pepE) lhe_1877(pepE2)

LHH:	LBH_0167 LBH_0170 LBH_0289 LBH_0810

LHD:	HUO_01960 HUO_02010 HUO_02710 HUO_07190

LCR:	LCRIS_00198(pepC1) LCRIS_00207(pepC2) LCRIS_00344(pepC3) LCRIS_00964(pepC4)

LAM:	LA2_01125 LA2_01170 LA2_01775 LA2_04750

LAI:	LAC30SC_00930 LAC30SC_00985 LAC30SC_01695 LAC30SC_04565

LAY:	LAB52_01010 LAB52_01065 LAB52_01665 LAB52_04535

LKE:	WANG_0043 WANG_0752(pepC4) WANG_1817 WANG_1827

LAW:	LACWKB8_1340 LACWKB8_1523

LAE:	LBAT_0229 LBAT_0411

LGL:	AO203_01210 AO203_01920 AO203_01950 AO203_07480

LJE:	BUE77_01410 BUE77_01420 BUE77_02100

LAMY:

B1745_00910 B1745_00955 B1745_01515 B1745_07355

LPW:	LpgJCM5343_01800(pepC) LpgJCM5343_01830(pepC) LpgJCM5343_03300(pepC) LpgJCM5343_05120(pepC) LpgJCM5343_06840(pepC)

LKL:	DKL58_06800(pepC) DKL58_07835

LAPI:

DKL56_05740(pepC) DKL56_06680

LHS:	DLD54_06470(pepC) DLD54_07250

LTA:	H1A07_00945 H1A07_00980 H1A07_01870(pepC) H1A07_02700 H1A07_02715 H1A07_03315

LUU:	H4B44_01140 H4B44_01310 H4B44_02080(pepC)

LPAI:

GYM71_07490(pepC) GYM71_08735

LID:	GYK47_06215

LIQ:	KBW87_00940 KBW87_00965 KBW87_01705(pepC) KBW87_05515

LCA:	LSEI_2328 LSEI_2329

LCZ:	LCAZH_2302 LCAZH_2303

LCS:	LCBD_2514(blmH) LCBD_2515

LCE:	LC2W_2497 LC2W_2498

LCW:	BN194_24670(pepC) BN194_24680(pepC_2)

LCL:	LOCK919_2565 LOCK919_2566

LPQ:	AF91_11575 AF91_11580

LPI:	LBPG_02255 LBPG_03092

LPAP:

LBPC_2258 LBPC_2259

LCB:	LCABL_25130(pepC1) LCABL_25140(pepC2)

LCX:	LCA12A_1852 LCA12A_1853

LRH:	LGG_02345(pepC1) LGG_02346(pepC2)

LRG:	LRHM_2255 LRHM_2256

LRL:	LC705_02337(pepC1) LC705_02338(pepC2)

LRA:	LRHK_2347(pepE) LRHK_2348

LRO:	LOCK900_2307 LOCK900_2308

LRC:	LOCK908_2402 LOCK908_2403

LCHI:

KG086_10315 KG086_10320

LZE:	KG087_11165 KG087_11170

LPL:	lp_0601(pepC1) lp_3673(pepC2)

LPJ:	JDM1_0540(pepC1) JDM1_2938(pepC2)

LPT:	zj316_0210(pepC2)

LPS:	LPST_C0501(pepC1) LPST_C3000(pepC2)

LPR:	LBP_cg0482 LBP_cg2937

LPZ:	Lp16_0520 Lp16_2827

LPB:	SH83_02615 SH83_15245

LPX:	ASU28_04060 ASU28_14460

LPG:	BB562_13740 BB562_16285

LARG:

LPA65_02590 LPA65_15330

LRE:	Lreu_0297 Lreu_1881

LRF:	LAR_0285 LAR_1763

LRU:	HMPREF0538_21095(pepE) HMPREF0538_21502(pepC)

LRT:	LRI_0150 LRI_1642

LRR:	N134_01570 N134_09945

LFE:

LAF_0252

LFR:

LC40_0190

LFF:

LBFF_0273

LMU:	LBLM1_00065 LBLM1_09645

LOR:	AYI71_00195 AYI71_08005 AYI71_15430

LVA:	LV515_01470 LV515_09090

LFN:	LF145_01575 LF145_08500

LPON:

LP475_01650 LP475_08310

LGAS:

LG045_07685

LPAS:

KZE55_02335 KZE55_09675

LPOR:

PRK60_07865 PRK60_09035

LNG:	BSQ50_00735 BSQ50_02115

LHW:	BSQ49_02740

LMAL:

LM596_01140 LM596_02900

LSN:	LSA_04460(pepC) LSA_13430(pepE)

LLE:	AYR59_00140 AYR59_01640

LFV:	LF543_00725 LF543_06635

FIX:	M8332_01575 M8332_06745

FCLI:

M3M38_02835 M3M38_04510

FHIN:

M3M39_07095

FMT:	M3M35_04715 M3M35_06315

FCP:	M3M37_04500 M3M37_06360

LBH:	Lbuc_1479 Lbuc_2248

LBN:	LBUCD034_1533 LBUCD034_2347(pepC)

LPAR:

FAM21731_01149 FAM21731_01972

LCU:	PL11_004455 PL11_007580

LKF:	DNL43_04365 DNL43_11520

LHIL:

G8J22_01811(pepC) G8J22_02630(pepE_1)

LLAO:

LHL71_00130 LHL71_04860

LBR:	LVIS_0572 LVIS_2296

LBK:	LVISKB_0583 LVISKB_2372

LKO:	ABN16_01935 ABN16_05770

LZY:	LZ3411_0597 LZ3411_2440

LSUA:

H3M12_03150 H3M12_06005

LJI:	ELX58_03680 ELX58_07070 ELX58_07735 ELX58_07740

LSL:	LSL_1253(pepC)

LSI:	HN6_01029(pepC)

LSJ:	LSJ_1233(pepC)

LRM:	LRC_03930 LRC_16600

LAGL:

BEN83_00550

LACA:

LAC1533_0523 LAC1533_1708

LANI:

FAX13_01985

LMUR:

CPS94_06945

LSW:	GTO87_00675 GTO87_01585

LBT:	AYR52_01610

LCY:	LC20004_05275 LC20004_12355

LHO:	LOOC260_104470 LOOC260_122570

LOL:	LACOL_1446

LNN:	F0161_09380

LKU:	APS55_01055 APS55_02815 APS55_02820

ABOM:

D7I45_00440 D7I45_00445 D7I45_05235

AAPI:

MOO46_00020 MOO46_05680 MOO46_05685

LPD:	AYR62_08375 AYR62_14100

LMAE:

FGL90_04770 FGL90_07260

PPE:

PEPE_1507

PPEN:

T256_07445

PCE:	PECL_1859(pepE) PECL_371

PDM:	ADU72_1174 ADU72_1554

PACI:

A4V11_04940

PIO:	PI20285_07310 PI20285_09555

LROS:

LROSL1_0768 LROSL1_2391

LGN:	ABM34_05150 ABM34_09490

LHI:	JP39_02380 JP39_12040

LCT:	BI355_0048 BI355_0497

LALW:

BTM29_00445 BTM29_02680

LALI:

LA20249_08080 LA20249_10950

LFM:	LF20184_00090 LF20184_09800 LF20184_12365

LZH:	D1B17_00230 D1B17_02840

LFT:	FG051_09640 FG051_12470

CPAB:

G6534_07945 G6534_10470

LSA:	LCA_1686(pepC1N) LCA_1687(pepC1C) LCA_1688(pepC2)

LCV:	FBA2_01785 FBA2_01790

LGM:	LG542_07585 LG542_07590

LAH:	LA20533_01980

LBM:	DS830_00790 DS830_07690

BOG:	MOO47_01835

BFP:	MOO45_01540

LHB:	D1010_11575 D1010_11580

LDX:	LH506_04680

OOE:	OEOE_0024 OEOE_0461

OEN:	DSM07_05605 DSM07_07820

OSI:	DLJ48_05050

LME:

LEUM_1760

LMM:

MI1_07620

LMK:

LMES_1527

LKI:

LKI_07375

LEC:	LGMK_04780

LCN:	C270_01545

LGS:	LEGAS_0424(pepC)

LGE:	C269_02080

LSU:	A6B45_08415

LPSE:

FGL85_04340

WJO:	FOL01_0407

WPA:	CO680_06155

WCF:	C6P13_08305

WHE:	EFA59_01925

WVR:	IE337_03935

WEI:	EQG49_05310

LBE:	MOO44_02305 MOO44_03465 MOO44_03470

EFA:	EF0302(pepC)

EFL:

EF62_0691

EFI:	OG1RF_10245(pepC)

EFD:	EFD32_0241(pepC)

EFS:	EFS1_0243(pepC)

EFN:	DENG_00287(pepC)

EFQ:

DR75_2350

ENE:

ENT_26260

EFC:	EFAU004_02214

EFAU:

EFAU085_02268

EFU:	HMPREF0351_12197(pepC) HMPREF0351_13050(pepC2)

EFM:

M7W_2206

EFT:	M395_10290

EHR:

EHR_07645

ECAS:

ECBG_00008

EMU:

EMQU_0684

EDU:

LIU_11940

EGA:	AL523_08325

ESS:	ATZ33_10175

ETH:	CK496_09450

EGV:	EGCR1_01355

EAV:	EH197_10295

ESG:	EsVE80_05940(pepC)

ELAC:

I4Q40_10360

ECEC:

NCTC12421_01118(pepC)

ERAF:

J9537_03215

EIE:	ENLAB_24570(pepC)

EDS:	PML78_04760

MPS:

MPTP_1783

MPX:

MPD5_0283

THL:	TEH_09450(pepC) TEH_25330

TEY:	GLW17_03680 GLW17_06925

TOO:	C7K38_01305 C7K38_04500

TKR:	C7K43_10645 C7K43_12925

VTE:	BHY08_03890 BHY08_09885

VPI:	BW732_03310 BW732_06985

VCP:	H9L18_04655

VHY:	G7082_01360

VFV:	K5K99_12575

VLU:	M2919_07235

AUR:	HMPREF9243_0702

AUN:	AWM73_06080

ASAN:

AWM72_04640

ACG:	AWM71_06050

CRN:	CAR_c19130(pepC)

CAW:	Q783_08765

CARC:

NY10_847

CVD:	LHA31_09570

MARR:

BKP56_05055

JDA:	BW727_101316(pepC)

JEM:	LZ578_04555

DPM:	FNV33_01930

GAD:	K8O88_06680

CLO:	HMPREF0868_0823 HMPREF0868_1340

FSA:	C5Q98_06835

RUK:	A4V00_07105

RBP:	B6259_02965

EHA:	Ethha_0171

FPRA:

CG447_01880

FDU:	GXM22_06990

CAPR:

EQM14_13765

CAML:

H6X83_10845

CLF:	GJQ69_07505

SINT:

K5I26_04690

ERE:	EUBREC_0748

LBW:	C3V36_05890

PBQ:	C3V37_04420 C3V37_04425

FMS:	M1R53_00685 M1R53_00690

HAS:	Halsa_1202

HPK:	Hprae_1104

HALS:

D7D81_14965

IFN:	GM661_12075

APR:

Apre_0140

AVG:	I6H45_08220

AOB:	I6H46_02225

AMEI:

LV469_07310

PMIC:

NW74_01985 NW74_02865

SPOA:

EQM13_01935 EQM13_09740

KPAR:

JL105_01030

ECOU:

M1R54_03240 M1R54_03245

MED:

MELS_1325

MHW:	ACT01_10225

MMAX:

LCQ47_11980

AFN:	Acfer_1040

AIN:

Acin_1435

ERH:	ERH_0462(pepC)

ERS:	K210_00255

ERI:	EEI45_07495

BULL:

JOS54_04715

MANS:

FRW55_03355

MNH:	FG904_02210

MSTR:

EGN60_01715

MAMP:

MAMA39_04500 MAMA39_04510

MTUY:

H3143_02150 H3143_02155

MTAU:

JS510_02860

MMIR:

HLA87_02140

MMIO:

HLA92_01990 HLA92_01995

MPHE:

HGG69_00350 HGG69_00355

MPHN:

HGG64_02285

MCR:	MCFN_00255

MCM:	MCAL160_0988(pepC)

MFR:	MFE_04450(pepC)

MFM:	MfeM64YM_0552(pepC)

MFP:

MBIO_0472

MARG:

MARG145_0367(pepC)

MANI:

DP067_02305

MPHI:

EG856_02745

MMAU:

NCTC10168_00488(pepC)

MMEL:

NCTC10153_00345(pepC)

MCAV:

NPA07_02870

MEQI:

NPA09_02565

ABRA:

BN85307460

APAL:

BN85406150(pepC)

AAXA:

NCTC10138_00831(pepC)

MANR:

MPAN_012180(pepC)

MGA:	MGA_0100(pepC_1) MGA_0101(pepC_2)

MGH:	MGAH_0100(pepC_1) MGAH_0101(pepC_2)

MGF:	MGF_2888(pepC_2) MGF_2898(pepC_1)

MGN:	HFMG06NCA_3326(pepC_1) HFMG06NCA_3334(pepC_2)

MGS:	HFMG95NCA_3342(pepC_1) HFMG95NCA_3350(pepC_2)

MGT:	HFMG01NYA_3404(pepC_1) HFMG01NYA_3412(pepC_2)

MGV:	HFMG94VAA_3415(pepC_1) HFMG94VAA_3423(pepC_2)

MGW:	HFMG01WIA_3264(pepC_1) HFMG01WIA_3272(pepC_2)

MGAC:

HFMG06CAA_3465(pepC_1) HFMG06CAA_3473(pepC_2)

MGAN:

HFMG08NCA_3292(pepC_1) HFMG08NCA_3300(pepC_2)

MGNC:

HFMG96NCA_3512(pepC_1) HFMG96NCA_3520(pepC_2)

MGZ:	GCW_02520(pepC_1) GCW_02525(pepC_2)

MAT:	MARTH_orf878(pepC)

MHO:	MHO_0350(pepC)

MHOM:

MLBD4_00185(pepC)

MCAN:

MCAN360_0482(pepC)

MPHO:

DA803_01755

MHYV:

MHSN_03050

MCLO:

DK849_00885

MPHC:

DMC14_000020 DMC14_000515

MANE:

DP065_01250 DP065_01260

MSAI:

NCTC10113_01268(pepC)

MOB:	NCTC10112_00252(pepC)

MPE:	MYPE9890(MYPE9890) MYPE9900(MYPE9900)

MIW:	EER00_03035 EER00_03040

TBM:	BK010_03250

TBZ:	BK011_03730

CKP:	ckrop_0521(pepC2) ckrop_0522(pepC1)

CPU:	CPFRC_01605

CPL:	Cp3995_0312(pepC1)

CPG:	CP316_01655 CP316_01660

CPP:	CpP54B96_0314(pepC1)

CPK:	CP1002_01605

CPQ:	CPC231_01605

CPX:	CPI19_01605

CPZ:	CpPAT10_0316a(pepC2)

COR:	Cp267_0323(pepG) Cp267_0324(pepC1)

COP:	CP31_01875 CP31_01880

COD:	Cp106_0303(pepC1)

COS:	Cp4202_0308(pepC1)

COI:	CPCIP5297_01660 CPCIP5297_01665

COE:	CP258_01660 CP258_01665

COU:	CP162_01695 CP162_01700

CPSE:

CPTA_00841 CPTA_00842

CPSU:

CPTB_00690 CPTB_00691

CPSF:

CPTC_00352 CPTC_00353

CUL:	CULC22_00358(bleo1) CULC22_00359(bleo2)

CUC:	CULC809_00354(bleo1) CULC809_00355(bleo2)

CUE:	CULC0102_0400 CULC0102_0401

CUN:	Cul210932_0373(pepG) Cul210932_0374(pepC)

CUS:	CulFRC11_0355(pepG) CulFRC11_0356(pepC)

CUQ:	Cul210931_0360(pepG) Cul210931_0361(pepC)

CUZ:	Cul05146_0385(pepG) Cul05146_0386(pepC)

CUJ:	CUL131002_0357(pepG) CUL131002_0358(pepC)

CVA:	CVAR_2268 CVAR_2269

CTER:

A606_09190 A606_09195

CGY:	CGLY_04155 CGLY_04160

CAX:	CATYP_08895

CPRE:

Csp1_07000(pepC_1) Csp1_07010(pepC_2)

CKF:	I6I12_02530 I6I12_02535

CGLU:

I6J20_03650 I6J20_03655

CSIL:

CBE74_02020

CTUB:

I6I74_03625 I6I74_03630

CACC:

CACC_10240(pepC2)

CBQ:	AL705_04745

SHY:

SHJG_2511

SHO:	SHJGH_2275

SRW:	TUE45_01410(pepC)

SGS:	AVL59_01275

SBRO:

GQF42_23570

SCYG:

S1361_05490(pepC)

PSIC:

J4E96_13920

MVD:	AWU67_08280

FRP:	AX769_19440

LVI:	G7068_05490

ARM:

ART_4144

ARE:	AL755_06685

ARI:	UM93_11200

RSA:	RSal33209_2730

ALX:	LVQ62_16260

PRA:	PALO_02070

CGRN:

4412665_01843(pepE)

PFR:	PFREUD_06380(pepC) PFREUD_11360(pepC)

PFRE:

RM25_0598 RM25_1055

PACD:

EGX94_12870

PAUS:

NCTC13651_01291(pepC)

PBO:	PACID_25010 PACID_33490

AACI:

ASQ49_05485 ASQ49_09515

ACIJ:

JS278_00167(pepC) JS278_01008(pepE_2)

AJI:	C0Z10_00510 C0Z10_03400

MIK:	FOE78_15830

MICG:

GJV80_09855

NAQU:

ENKNEFLB_00660(pepC)

NPS:	KRR39_07890

KFL:

Kfla_1242

KQI:	F1D05_26020

ATL:	Athai_34390

ASER:

Asera_40390

SNA:

Snas_3912

ASG:	FB03_07815

ACTT:

DDD63_10715

AMY:	ADJ76_04275

SOO:	FBF35_04050

ACQ:	AM609_13390

AOS:	AXE84_04405

ARD:	AXF14_04285

ACTO:

C3V41_09125

ANE:	ATCC27039_22200

AVC:	NCTC10951_02146(pepE)

AWE:	JG540_09880

WIK:	H8R18_04105

FVG:	I6G91_00290 I6G91_02380

BLO:	BL0173(pepC1) BL0321(pepC2)

BLJ:	BLD_1079(pepC1) BLD_1534(pepC2)

BLN:	Blon_0356 Blon_2423

BLON:

BLIJ_0363 BLIJ_2494

BLF:	BLIF_0271 BLIF_0272 BLIF_1896

BLL:	BLJ_0335 BLJ_1941

BLB:	BBMN68_1084(pepC1) BBMN68_1467(pepC2)

BLM:	BLLJ_0291 BLLJ_1828

BLK:	BLNIAS_00063 BLNIAS_02382

BLG:	BIL_06180 BIL_15890

BLZ:	BLGT_01915 BLGT_09800

BLX:	GS08_01760 GS08_10060

BAD:	BAD_0272(pepC2) BAD_0964(pepC1)

BADL:

BADO_0280 BADO_1021

BADO:

BBMN23_0300 BBMN23_1105

BLA:	BLA_0320(pepC) BLA_0418(pepC)

BLC:	Balac_0336 Balac_0441

BLT:	Balat_0336 Balat_0441

BBB:	BIF_00088 BIF_00833

BBC:	BLC1_0322 BLC1_0421

BNM:	BALAC2494_00675 BALAC2494_00794

BLV:	BalV_0325 BalV_0423

BLW:	W7Y_0338 W7Y_0443

BLS:	W91_0350 W91_0457

BANI:

Bl12_0314 Bl12_0409

BANL:

BLAC_01685 BLAC_02210

BNI:	BANAN_01740 BANAN_02300

BANM:

EN10_01705 EN10_02240

BDE:	BDP_0380(pepC2) BDP_1343

BDN:	BBDE_0362 BBDE_1281

BBP:	BBPR_0613(pepC) BBPR_1612

BBI:	BBIF_0637(pepC1) BBIF_1556(pepC2)

BBF:	BBB_0597(pepC) BBB_1591(pepC)

BBV:	HMPREF9228_1766 HMPREF9228_1767 HMPREF9228_1919

BBRU:

Bbr_1699(pepC1) Bbr_1700(pepC2) Bbr_1818(pepC3)

BBRE:

B12L_1628 B12L_1765

BBRV:

B689b_1727 B689b_1859

BBRJ:

B7017_1894 B7017_2040

BBRC:

B7019_1867 B7019_2004

BBRN:

B2258_1717 B2258_1718 B2258_1841

BBRS:

BS27_1689(pepC1) BS27_1690(pepC2)

BBRD:

BBBR_1699

BAST:

BAST_1409

BTP:	D805_1497 D805_1657

BCOR:

BCOR_1223

BKA:	AH68_01545 AH68_05565 AH68_06515

BKS:	BBKW_0289 BBKW_1200

BCAT:

BBCT_0253 BBCT_1075

BPSP:

AH67_01815 AH67_07185

BII:	BINDI_1149

BANG:

BBAG_0298 BBAG_0699

BPSC:

BBPC_0282 BBPC_0920

BSCA:

BBSC_0454 BBSC_2365

BACT:

AB656_06765

BCHO:

BcFMB_00765 BcFMB_04075

BGX:	ESN35_09260

BLEM:

BL8807_00545 BL8807_05965

BEU:	BE0216_05735 BE0216_11045

BSUE:

BS3272_00945

GVG:	HMPREF0421_20285 HMPREF0421_20340

GVA:	HMPREF0424_0217 HMPREF0424_1255

GVH:	HMPREF9231_1214 HMPREF9231_1272

GPT:	K9E43_02595 K9E43_04035

GSW:	K9E37_02690 K9E37_04205

SIJ:	SCIP_0240 SCIP_0317

PDO:	PSDT_0441 PSDT_1264

AEQ:

AEQU_2111

AHAT:

ADCFC_23970

CBAC:

JI75_05630

APV:	Apar_0899 Apar_0900

OLS:	Olsu_1084 Olsu_1085

OLO:	ADJ70_10185 ADJ70_10220

PCAT:

Pcatena_12840(pepC)

ATB:	J4859_07275 J4859_07280

TIO:	INP52_06445 INP52_06450

LCAL:

ATTO_08400(pepC) ATTO_13420

CGO:	Corgl_1107

CSTC:

LK434_02845

CCZ:	CCALI_02317

FGI:	OP10G_4043

NPY:	NPRO_17500

MFF:	MFFC18_24750(pepC)

MCAD:

Pan265_05620(pepC)

TPA:

TP_0112

TPW:	TPANIC_0112(pepC)

TPP:	TPASS_0112(pepC)

TPU:	TPADAL_0112(pepC)

TPH:	TPChic_0112

TPO:	TPAMA_0112(pepC)

TPC:	TPECDC2_0112(pepC)

TPG:	TPEGAU_0112(pepC)

TPM:	TPESAMD_0112(pepC)

TPB:	TPFB_0112(pepC)

TPL:	TPCCA_0112(pepC)

TRM:	JO41_01310

TPHG:

FUT81_07985

TRZ:	GWP43_05305

TRC:	DYE49_04160 DYE49_04165

TMED:

DWB79_08110

SGP:	SpiGrapes_0858

THYD:

TTHT_0919(pepC)

SMF:

Smon_1289

SNS:	VC03_01030 VC03_02685

PPIO:

CE91St28_24240(pepC)

BTH:

BT_1161

BTHO:

Btheta7330_02732(pepC_2)

BFR:

BF2010

BFS:	BF9343_1980

BFG:	BF638R_2135

BHL:	Bache_2624

BXY:

BXY_07430

BOA:	Bovatus_00501(pepE_1)

BCEL:

BcellWH2_00619(pepE_1)

BCAC:

CGC64_11590

BCAE:

A4V03_07180

BIS:	DXK01_018330

BUN:	Bun01g_24570

BEG:	INE88_03453(pepE_2)

BSTE:

K6V31_01570

BFE:	K6V30_17770

BNO:	K8P02_08620

BHUM:

JXR92_011125

BFC:	BacF7301_16950

BSAL:

K6V25_14515

BVU:

BVU_3228

BSA:	Bacsa_0806

BDO:	EL88_09325

BDH:	GV66_17345

PCOP:

I6J50_08835

PGI:	PG_1605(pepC)

PGN:

PGN_0508

PGT:	PGTDC60_0696(pepC)

PAH:	Poras_1447

PCRE:

NCTC12858_01591(pepC)

PCAG:

NCTC12856_02100(pepE_2)

PEND:

LA319_04025

PORP:

J4862_04110

DYS:	G7050_13440

PPN:	Palpr_2216

PDI:

BDI_2287

PARC:

CI960_17620

PMER:

INE87_03491(pepE_2)

PGOL:

K6V26_28105

PJO:	LK449_12845

PFAI:

NXY11_26625

PARY:

A4V02_11715

DUN:	FDZ78_14345

BVS:	BARVI_08690

COPR:

Cop2CBH44_30320

OSP:	Odosp_1312 Odosp_2172

BUY:	D8S85_08235 D8S85_10870 D8S85_18145

BVIR:

I6J59_18315

PRU:	PRU_0548(pepC)

PMZ:	HMPREF0659_A6065

PDN:	HMPREF9137_1730

PIT:	PIN17_A1076

PDT:	Prede_0955

PRO:	HMPREF0669_00090

PFUS:

ADJ77_01100

POC:	NCTC13071_00048(pepC)

PNI:	J5A59_05500

PMUF:

J4864_08820

PHIS:

J5A62_01920

PCOI:

LK433_04460

PHER:

prwr041_03180

PVF:	J5A55_01610

PBY:	L6471_10765

PSCJ:

J4856_10425

PEO:	AS203_08920

PBUC:

LK429_06400

ALQ:	C7Y71_007510

PCLR:

PC1C4_06590

AFD:

Alfi_1645

ASH:

AL1_17240

ALD:	GFH31_12690

ACOU:

A5CBH24_21470 A5CBH24_22440

ADA:	A5CPEGH6_02740

AIT:	AI2BBH_00160

BLQ:	L21SP5_01437(pepC_1) L21SP5_02101

DORI:

FH5T_14480

DRC:	G0Q07_06440

MCOS:

GM418_02980 GM418_13125 GM418_15965

MBAS:

ALGA_0766 ALGA_2401 ALGA_3062 ALGA_3130

CPI:	Cpin_0714 Cpin_6206

CBAE:

COR50_05375 COR50_20955

CHIT:

FW415_04465

CHIH:

GWR21_10775 GWR21_19185

COY:	HF329_25470

CFIL:

MYF79_03580

CHF:	KTO58_24090

NSO:	NIASO_02975

NIA:	A8C56_09305

ARB:	A9P82_00890

ARK:	D6B99_05925 D6B99_11135

AGI:	FSB73_18905

ARAC:

E0W69_000755 E0W69_001205

ATEE:

K9M52_16085 K9M52_17495

FLN:

FLA_6015

PGO:	FSB84_10075

SGN:	SGRA_2848(pepC)

PHE:

Phep_3630

PEP:	AQ505_03410 AQ505_20675

PCM:	AY601_0831

PSTY:

BFS30_02015 BFS30_08130

PGS:	CPT03_01975 CPT03_15210

PEK:	FFJ24_022500

PROE:

H9L23_22755

PRK:	H9N25_20765

PSN:	Pedsa_2728

SHG:	Sph21_5158

SHT:	KO02_03090

SPHN:

BV902_02540 BV902_04700

SMIZ:

4412673_00444(pepC)

SPSC:

E2P86_02295

SPHZ:

E3D81_01625

SPHE:

GFH32_02015

SPDR:

G6053_01540 G6053_03490

SDJ:	NCTC13534_00450(pepC)

STHA:

NCTC11429_00908(pepC_1) NCTC11429_01288(pepC_2)

SSPI:

I6J01_11025

SMUI:

I6J00_20185

SSIY:

JVX97_02090 JVX97_28490

SFAE:

MUK51_15825

SCN:	Solca_1159

MUH:	HYN43_015575

MMAB:

HQ865_12575

MJJ:	PQO05_04045

OLI:	FKG96_23360

SBX:	CA265_21780

RHOZ:

GXP67_12390

FLM:

MY04_2411

FLL:	EI427_13520

FYA:	KMW28_04190

FKA:	KM029_15975

FPS:	FP2369(pepC)

FPC:	FPSM_02498

FPY:	FPG101_12515

FPO:	FPG3_11895

FPQ:	IB65_11975

FPV:	IA03_11750

FPW:	IA04_11635

FPK:	IA06_11710

FPSZ:

AMR72_11535

FJO:

Fjoh_1152

FJG:	BB050_01452(pepC)

FBR:	FBFL15_1467(pepC)

FCO:	FCOL_08095

FGL:	EM308_02755

FAT:	DVK85_04840

FKI:	FK004_02735 FK004_11090

FPAL:

HYN49_11920

FMG:	HYN48_10770

FALB:

HYN59_03355

FCR:	HYN56_05910

FSE:	DI487_00055

FSN:	GS03_02483

FAK:	FUA48_05100

FFL:	HYN86_05300

FEN:	J0383_10395

FCV:	AWN65_00490

FOE:	JJC03_05920

FSD:	LXD69_12730

FLO:	K1I41_02490

FCC:	LOS86_08410

FCB:	LOS89_05620

FPB:	NLJ00_06235

FEH:	LZF87_04225 LZF87_13175

FAZ:	M0M57_13870

FBI:	L0669_05975

FCS:	TRV642_1129

FPLU:

NLG42_05530

COC:

Coch_1729

CCM:	Ccan_19720

COL:	AM608_01120

CHG:	AXF12_09790

CAPN:

CBG49_12930

CGH:	CGC50_13030 CGC50_13035

CLK:	CGC53_08325

CSPU:

CGC55_12890

CCYN:

CGC48_09410

CAPH:

CGC49_08330

CSTO:

CGC58_02715

CAPQ:

CGC52_08375

CAPF:

FOC45_02160

CAPO:

HW278_10915

CAT:	CA2559_10538

CLY:	Celly_1041

CLH:	IX49_05030

COMN:

PBN93_05105

KDI:	Krodi_2158

DOK:	MED134_14006

DDO:

I597_1595

DOD:	DCS32_00945

ASL:	Aeqsu_2588

AIC:	JK629_11305

MYR:	MYRA21_0892 MYRA21_2980

MPW:	MPR_1800 MPR_3418

MOD:	AS202_04085 AS202_14525

MYZ:	BK054_03965 BK054_14175

MOA:	I6I89_18105

MALS:

NWE55_08545

TDI:	AUW17_02680

TJE:	TJEJU_3650

TMP:	F9Y86_03710

TOV:	PG911_12655

TRT:	PG912_10065

TPAC:

PG913_09815

LUT:	Lupro_03865

LUL:	LPB138_00485

FOP:	FNB79_12390

SEON:

BWZ22_06645

FEK:	C1H87_23025

AUE:	C5O00_11580

KOS:	KORDIASMS9_04145(pepC)

KAN:	IMCC3317_11960

OCI:	FEZ18_13725

MGEL:

G5B37_01195

ALTI:

ALE3EI_2450

MARX:

INR76_09680

SINH:

LS482_19495

ZSP:	MQE36_12895

BIA:	GMA17_05355

FBU:	UJ101_00844(pepC)

RAN:	Riean_0287

RAI:

RA0C_0495

RAR:

RIA_1999

RAG:

B739_1791

RAE:

G148_1341

RAT:

M949_2167

WVI:	Weevi_1363

ORH:	Ornrh_1332

ORI:	Q785_03280

EAO:

BD94_2507

EMN:	M876_09575

EEN:	BBD30_14245

ELB:	VO54_00206(pepE_1)

EMG:	BBD33_10460

EGO:	BBD34_01640

EGM:	AYC65_05460

ELZ:	FCS00_18615

ELT:	FGE20_09810

CHZ:

CHSO_3515

CGN:	OK18_00135

CIH:	ATE47_09610

CHH:	A0O34_16335

CIO:	CEQ15_10890

CHRY:

CEY12_07255

CPIP:

CJF12_01355

CHRS:

EAG08_04640

CARH:

EGY05_14135

CSHA:

EG350_07470

CNK:	EG343_06070

CJT:	EG359_07290

CIL:	EG358_15290

CCAU:

EG346_14540

CBEN:

EG339_21910

CGLE:

NCTC11432_01781(pepE_2)

CLAC:

EG342_22320

CBP:	EB354_04520

CNP:	M0D58_05595

CCAO:

H5J24_05720

CRHI:

KB553_06975

CORZ:

MTP08_08935

CDAE:

MUU74_11195

CCAB:

PFY12_03925

CTUR:

LNP04_17945

EBV:	F0358_01395 F0358_03235

EFAL:

FH779_13735 FH779_15895

ESTE:

HNV03_08940 HNV03_13020

BCAD:

DBX24_08355

APIB:

G8C43_01980

FBO:	J9309_02355

FTE:	Fluta_1569

FLU:	CHH17_18830

OHO:	Oweho_0435 Oweho_1142

CHYD:

H4K34_15735

SHYR:

LA303_07380 LA303_10305

IAL:

IALB_1605

MRO:

MROS_0944

ASAC:

ATHSA_1780

CABY:

Cabys_4188 Cabys_488

» show all

Reference

1 [PMID:8639621]

Authors

Bromme D, Rossi AB, Smeekens SP, Anderson DC, Payan DG

Title

Human bleomycin hydrolase: molecular cloning, sequencing, functional expression, and enzymatic characterization.

Journal

Biochemistry 35:6706-14 (1996)
DOI:10.1021/bi960092y

Sequence

[hsa:642]

Reference

2 [PMID:9151954]

Authors

Adachi H, Tsujimoto M, Fukasawa M, Sato Y, Arai H, Inoue K, Nishimura T.

Title

cDNA cloning and expression of chicken aminopeptidase H, possessing endopeptidase as well as aminopeptidase activity.

Journal

Eur J Biochem 245:283-8 (1997)
DOI:10.1111/j.1432-1033.1997.t01-1-00283.x

Sequence

[gga:395996]

Reference

3 [PMID:9546396]

Authors

Zheng W, Johnston SA, Joshua-Tor L.

Title

The unusual active site of Gal6/bleomycin hydrolase can act as a carboxypeptidase, aminopeptidase, and peptide ligase.

Journal

Cell 93:103-9 (1998)
DOI:10.1016/S0092-8674(00)81150-2

Sequence

[sce:YNL239W]

Reference

4 [PMID:9546047]

Authors

Mistou MY, Gripon JC.

Title

Catalytic properties of the cysteine aminopeptidase PepC, a bacterial bleomycin hydrolase.

Journal

Biochim Biophys Acta 1383:63-70 (1998)
DOI:10.1016/S0167-4838(97)00185-4

Sequence

[lla:L130687]

Other DBs

ExplorEnz - The Enzyme Database:

3.4.22.40

IUBMB Enzyme Nomenclature:

3.4.22.40

ExPASy - ENZYME nomenclature database:

3.4.22.40

BRENDA, the Enzyme Database:

3.4.22.40

CAS:	53096-17-6

DBGET integrated database retrieval system