Entry
Name
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
The recombinant enzyme cleaves synthetic substrates with Phe and Leu (better than Val) in P2, with high specificity constant (kcat/Km) comparable to that of cathepsin L
Comment
Cathepsin F is a lysosomal cysteine endopeptidase of family C1 (papain family), most active at pH 5.9. The enzyme is unstable at neutral pH values and is inhibited by compound E-64. Cathepsin F is expressed in most tissues of human, mouse and rat. Human gene locus: 11q13.1-13.3
History
EC 3.4.22.41 created 2000
Orthology
Genes
AJM : 119041930(CTSF) 119051369 119064887
PMUA : 114586314(CTSF) 114586315
SANH : 107660173 107680917
CCAR : 109101589 109101925
CAUA : 113057676 113113727
CGIB : 127971472 128027650
MASI : 127412720 127418034
ALIM : 106518961 106528385
SASA : 100195177(ctsw) 106612102(CATF)
STRU : 115168960 115205568
SALP : 111965961 111967249
CCLU : 121533542 121539902
PSPA : 121306296 121310116
ARUT : 117398711 117967865
LCM : 102345521 102362412(CTSW)
BBEL : 109463171 109483273
SCLV : 120338590 120347938
LPIC : 129264503 129264504
DSI : Dsimw501_GD19635(Dsim_GD19635)
DPL : KGM_200202 KGM_210899 KGM_214724B
BANY : 112054089 112054586
MCIX : 123668236 123668258
PMAC : 106714173 106716117
PRAP : 110996674 111000487
ZCE : 119828856 119837245 119837424 119839023
CCRC : 123694992 123706138
LSIN : 126967282 126976053
HAW : 110375351 110381927 110381955 110382264
TNL : 113493100 113493101 113493107 113493108 113496735
SLIU : 111352786 111352787 111352796 111356276
PXY : 105386458 105387640 105390473
PGW : 126370280 126374267 126374633 126374830
BTAB : 109029804 109030124 109031872 109034470 109035319 109035355 109039000 109039001 109039002 109039072 109039474 109040923 109041285 109042254 109043756
DCI : 103506565 103506566 103509189 103515186 103515421 103516702 103516704 103516808 103521260 103521261 103521262 113470521
DFR : 124489819 124494674 124498521 124499349
CEL : CELE_F41E6.6(tag-196)
CBR : CBG_01480(Cbr-tag-196)
NAI : NECAME_06602 NECAME_14862 NECAME_16641
LOA : LOAG_01434 LOAG_07188 LOAG_12683
TSP : Tsp_02382 Tsp_02383 Tsp_04256
LGI : LOTGIDRAFT_159961 LOTGIDRAFT_172186
CRG : 105333177 105344064 117684915
CVN : 111129848 111129849 111138065
CANU : 128176555 128188393
PMAX : 117320829 117323332
MMER : 123527709 123566447
OVI : T265_00017 T265_08812 T265_12204 T265_12428 T265_12429 T265_12430 T265_12431 T265_12432 T265_12433 T265_15994
ATH : AT2G21430 AT3G54940 AT4G16190 AT4G39090(RD19)
ALY : 9302904 9304225 9314075 9314621
CRB : 17878763 17880887 17885208 17888301
CSAT : 104716186 104718756 104720313 104720819 104723504 104729220 104732003 104781364 104791772
EUS : EUTSA_v10000210mg EUTSA_v10010475mg EUTSA_v10025494mg EUTSA_v10025521mg
BRP : 103835145 103841406 103842767 103860837 103864272 103870004 103873055
BNA : 106361486 106364060 106405314 106405911 106410239 106412144 106438869 106439875 106440299 106446592 106449741 106450303 111213433
BOE : 106301435 106304421 106310504 106311642 106336114 106342545
RSZ : 108822882 108834173 108842237 108843529 108848722 108852300 108860379
THJ : 104806912 104807756 104809980
CPAP : 110808204 110814564 110825991
CIT : 102608509 102609994 102620490
CIC : CICLE_v10001559mg CICLE_v10028670mg CICLE_v10031865mg
PVY : 116112383 116115359 116127483 116130079 116132355
MINC : 123202830 123213257 123227302 123228022 123229667
TCC : 18586508 18591475 18607719
GRA : 105762615 105771046 105778139 105783130 105793809 105795340
GHI : 107887300 107908812 107910208 107913542 107915798 107920206 107934535 107941581 107953848 121222312
GAB : 108461150 108476419 108483373 108484892 108487218
DZI : 111282439 111297097 111308832 111312770 111315324
EGR : 104418867 104423542 104448798 104453361
GMX : 100778716 100779565 100791283 100791503 100812198 547893 547978(CP3)
GSJ : 114369184 114374150 114377973 114383215 114393993 114401242 114408606 114414618
PVU : PHAVU_001G009900g PHAVU_007G099600g PHAVU_009G013600g PHAVU_011G041600g
VRA : 106754659 106762220 106765046 106771338
VAR : 108325138 108338501 108339526 108343009
VUN : 114163210 114169942 114190430 114193091
CCAJ : 109798502 109798506 109810631 109815496 109815499 109816643
APRC : 113846930 113864463 113864660 113873068
MTR : 11414263 11439660 11443223 11444338 25484917 25492783
TPRA : 123886845 123918363 123919959
CAM : 101490203 101500737 101501911
PSAT : 127091491 127097212 127101749
LJA : Lj0g3v0259509.1(Lj0g3v0259509.1) Lj1g3v2140860.1(Lj1g3v2140860.1) Lj3g3v0129310.1(Lj3g3v0129310.1) Lj3g3v0129320.1(Lj3g3v0129320.1) Lj3g3v3375960.1(Lj3g3v3375960.1) Lj3g3v3375970.1(Lj3g3v3375970.1)
ADU : 107460057 107468005 107476641 107493029
AIP : 107610026 107619390 107628854 107645286
AHF : 112696347 112705601 112736920 112754345 112764128 112776516 112789162
LANG : 109327490 109347683 109355475 109358491 109359410
PCIN : 129284800 129292696 129297286 129300019 129318048 129320895
FVE : 101294030 101294426 101310260
RCN : 112169736 112171688 112172589
PPER : 18767142 18784700 18788408
PMUM : 103321308 103332313 103335715
PAVI : 110765545 110768529 110771529
PDUL : 117614355 117619296 117636823
MDM : 103426367 103445116 103450429 114826424 114827547
MSYL : 126584157 126604174 126624740 126629711 126633198
PXB : 103928316 103942739 103962063 103962084 103965628 103965630
ZJU : 107412702 107413362 107420476 107426701 107435460
CSAV : 115701384 115705088 115724523
CSV : 101203809 101204401 101210316 101217613
CMO : 103488015 103489441 103490359 103499710
BHJ : 120075550 120077607 120081702 120088522
MCHA : 111014075 111015466
CMAX : 111469766 111482910 111484259 111496246 111499563
CMOS : 111440857 111448673 111451872 111454190 111458402
CPEP : 111776760 111793673 111795726 111797038 111798412
RCU : 8261722 8275806 8284340
JCU : 105630111 105633872 105641112
HBR : 110652793 110657020 110658609 110668145
MESC : 110605958 110613657 110625015 110626869
POP : 7456351 7461242 7463461 7479706 7493938
PEU : 105125550 105128811 105134462 105140151 105141984
PALZ : 118039712 118052757 118058945 118059823 118062085
JRE : 108991364 109003280 109005735 109008275
CILL : 122274279 122288525 122309723 122313269 122316636
CAVE : 132187129 132189580 132190232
QSU : 111995640 111996440 112003888 112027045
QLO : 115955780 115968249 115974428
TWL : 119989660 120002275 120009932
VVI : 100233020 100233049(CYSP) 100244387 100245344 100248853 100250475
VRI : 117905858 117905859 117906932 117911312 117912379 117928429
SLY : 101258107 101266086 544144
SPEN : 107003445 107009246 107017618
SOT : 102581491 102585555 102604809
SSTN : 125844004 125850148 125855058
CANN : 107840461 107851229 107866938
LBB : 132599214 132614980 132625666 132629146
NTA : 107760226 107770604 107787047(cpr2) 107795478 107799707 107807655
NSY : 104226053 104234172 104236913
NTO : 104097384 104104816 104109786
NAU : 109224677 109224858 109228034
INI : 109149683(In15) 109161861 109170434 109190370
ITR : 116022037 116023155 116028677 116029565
SIND : 105166101 105169681 105172913 105174184
OEU : 111375518 111378038 111380660 111388469 111388470 111394575 111410084
EGT : 105952039 105955404 105957681 105968695
SSPL : 121747784 121750680 121753288 121759281
SMIL : 130986611 131005474 131014804
APAN : 127243945 127252557 127256852
HAN : 110865540 110873074 110886044 110916173 110938200 110941314
ECAD : 122578491 122586495 122590066 122593418
LSV : 111879689 111881598 111912452 111913201 111919079
CCAV : 112501428 112508738 112514450 112516505 112524175
DCR : 108218962 108219867 108220706 108225089
CSIN : 114263065 114268788 114299140 114302861
RVL : 131300288 131325166 131330958
AEW : 130758537 130759038 130760137 130775877 130776087 130776734 130785264 130785791
BVG : 104888961 104902417 104904299
SOE : 110789554 110798765 110801396
CQI : 110692368 110705143 110718912 110721068 110723312 110724732
ATRI : 130811529 130815666 130824226
MOF : 131156464 131163109 131165432
NNU : 104587380 104605516 104607556
MING : 122057292 122077789 122083539
TSS : 122650833 122657932 122661022
PSOM : 113288742 113295340 113308099 113349808 113357708
OSA : 4329339 4335455 4343231
DOSA : Os02t0469600-01(Os02g0469600) Os04t0311400-01(Os04g0311400) Os07t0480900-01(Os07g0480900)
OBR : 102716776 102717914 102719354
OGL : 127762996 127770679 127780613
BDI : 100822914 100834449 100836576
ATS : 109734944 109740709 109764551
TDC : 119302647 119311326 119353971 119354865 119363214 119363995
TAES : 123044439 123052302 123104585 123112857 123188105 123188961 606331
TUA : 125510145 125536522 125537854
LPER : 127316416 127330230 127334213
LRD : 124655094 124661331 124670687 124679331 124679419
SITA : 101766321 101776544 101778290
SVS : 117846551 117851145 117863708
PVIR : 120640514 120655703 120658464 120682031 120687961 120701393
PHAI : 112882935 112887320 112900096
PDA : 103695678 103695876 103696984 103700159 103717420
EGU : 105036083 105042933 105061301
MUS : 103978532 103987551 103988663 103989280
ZOF : 121981567 121982178 121985444 121986064 121992723 121996684 121996685 122002632 122006873 122021214
PEQ : 110021884 110034983 110036884
NCOL : 116247875 116260779 116260944
SMO : SELMODRAFT_109056 SELMODRAFT_110288 SELMODRAFT_266583 SELMODRAFT_91274 SELMODRAFT_93661
DDI : DDB_G0290957(cprA) DDB_G0291191
ACAN : ACA1_244230 ACA1_277940 ACA1_296310
TET : TTHERM_00016590 TTHERM_01248970 TTHERM_01276400
SMIN : v1.2.007447.t1(symbB.v1.2.007447.t1)
AAF : AURANDRAFT_18666(CYP1) AURANDRAFT_21107 AURANDRAFT_22129 AURANDRAFT_22962 AURANDRAFT_26549 AURANDRAFT_53321
NGR : NAEGRDRAFT_30199 NAEGRDRAFT_69856 NAEGRDRAFT_71941 NAEGRDRAFT_82965
» show all
Taxonomy
Reference
Authors
Santamaria I, Velasco G, Pendas AM, Paz A, Lopez-Otin C.
Title
Molecular cloning and structural and functional characterization of human cathepsin F, a new cysteine proteinase of the papain family with a long propeptide domain.
Journal
Sequence
Reference
Authors
Nagler DK, Sulea T, Menard R.
Title
Full-length cDNA of human cathepsin F predicts the presence of a cystatin domain at the N-terminus of the cysteine protease zymogen.
Journal
Sequence
Reference
Authors
Wex T, Levy B, Wex H, Bromme D.
Title
Human cathepsins F and W: A new subgroup of cathepsins.
Journal
Sequence
Reference
Authors
Wang B, Shi GP, Yao PM, Li Z, Chapman HA, Bromme D
Title
Human cathepsin F. Molecular cloning, functional expression, tissue localization, and enzymatic characterization.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 3.4.22.41