Entry |
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Name |
cathepsin V;
Cathepsin L2;
cathepsin U
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Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
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Reaction(IUBMB) |
The recombinant enzyme hydrolyses proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec)
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Comment |
Cathepsin V is a human lysosomal cysteine endopeptidase of family C1 (papain family) that is maximally active at pH 5.7 and unstable at neutral pH. Compound E-64, leupeptin and chicken cystatin are inhibitors. Human cathepsin V shows expression restricted to thymus, testis, corneal epithelium and some colon and breast carcinomas. Human gene locus: 9q22.2
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History |
EC 3.4.22.43 created 2000
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Orthology |
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Genes |
» show all
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Reference |
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Authors |
Bromme D, Li Z, Barnes M, Mehler E |
Title |
Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization. |
Journal |
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Sequence |
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Reference |
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Authors |
Adachi W, Kawamoto S, Ohno I, Nishida K, Kinoshita S, Matsubara K, Okubo K |
Title |
Isolation and characterization of human cathepsin V: a major proteinase in corneal epithelium. |
Journal |
Invest Ophthalmol Vis Sci 39:1789-96 (1998) |
Sequence |
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Reference |
|
Authors |
Santamaria I, Velasco G, Cazorla M, Fueyo A, Campo E, Lopez-Otin C. |
Title |
Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas. |
Journal |
Cancer Res 58:1624-30 (1998) |
Sequence |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 3.4.22.43 |
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