KEGG   ENZYME: 3.4.22.43
Entry
EC 3.4.22.43                Enzyme                                 
Name
cathepsin V;
Cathepsin L2;
cathepsin U
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
Reaction(IUBMB)
The recombinant enzyme hydrolyses proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec)
Comment
Cathepsin V is a human lysosomal cysteine endopeptidase of family C1 (papain family) that is maximally active at pH 5.7 and unstable at neutral pH. Compound E-64, leupeptin and chicken cystatin are inhibitors. Human cathepsin V shows expression restricted to thymus, testis, corneal epithelium and some colon and breast carcinomas. Human gene locus: 9q22.2
History
EC 3.4.22.43 created 2000
Orthology
K01375  cathepsin V
Genes
HSA1515(CTSV)
PTR107976728(CTSV)
PPS100974568(CTSV)
GGO101143768(CTSV)
PON100439744(CTSV)
PPYG129044178(CTSV)
NLE100586899(CTSV)
HMH116475293(CTSV)
SSYN129479144(CTSV)
MCC710850(CTSV)
MCF102134104(CTSV)
MTHB126937929
MNI105498915(CTSV)
CSAB103219808(CTSV)
CATY105579323(CTSV)
PANU101024395(CTSV)
TGE112607992(CTSV)
MLEU105536595(CTSV)
RRO104659881(CTSV)
RBB108529277(CTSV)
TFN117098294(CTSV)
PTEH111531260(CTSV)
CANG105501514(CTSV)
CJC100411470(CTSV)
SBQ101031643(CTSV)
CIMI108316998(CTSV)
ANAN105723754(CTSV)
GAS123253951
TVP118853187
PSEX120534456
CPLA122565185
HOC132828998 132829185 132829187
CSET123316310
DVV126884025
PCLA123751089 123767845
DSV119444730 119454161
HRJ124278407
MCAF127721774
MMER123548727
 » show all
Reference
1  [PMID:10029531]
  Authors
Bromme D, Li Z, Barnes M, Mehler E
  Title
Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization.
  Journal
Biochemistry 38:2377-85 (1999)
DOI:10.1021/bi982175f
  Sequence
[hsa:1515]
Reference
2  [PMID:9727401]
  Authors
Adachi W, Kawamoto S, Ohno I, Nishida K, Kinoshita S, Matsubara K, Okubo K
  Title
Isolation and characterization of human cathepsin V: a major proteinase in corneal epithelium.
  Journal
Invest Ophthalmol Vis Sci 39:1789-96 (1998)
  Sequence
[hsa:1515]
Reference
3  [PMID:9563472]
  Authors
Santamaria I, Velasco G, Cazorla M, Fueyo A, Campo E, Lopez-Otin C.
  Title
Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas.
  Journal
Cancer Res 58:1624-30 (1998)
  Sequence
[hsa:1515]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.22.43
IUBMB Enzyme Nomenclature: 3.4.22.43
ExPASy - ENZYME nomenclature database: 3.4.22.43
BRENDA, the Enzyme Database: 3.4.22.43
CAS: 223670-00-6

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