Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases

The recombinant enzyme hydrolyses proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec)

Cathepsin V is a human lysosomal cysteine endopeptidase of family C1 (papain family) that is maximally active at pH 5.7 and unstable at neutral pH. Compound E-64, leupeptin and chicken cystatin are inhibitors. Human cathepsin V shows expression restricted to thymus, testis, corneal epithelium and some colon and breast carcinomas. Human gene locus: 9q22.2

EC 3.4.22.43 created 2000

1  [PMID:10029531]

Bromme D, Li Z, Barnes M, Mehler E.

Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization.

Biochemistry 38:2377-85 (1999)
DOI:10.1021/bi982175f

[hsa:1515]

2  [PMID:9727401]

Adachi W, Kawamoto S, Ohno I, Nishida K, Kinoshita S, Matsubara K, Okubo K.

Isolation and characterization of human cathepsin V: a major proteinase in corneal epithelium.

Invest Ophthalmol Vis Sci 39:1789-96 (1998)

[hsa:1515]

3  [PMID:9563472]

Santamaria I, Velasco G, Cazorla M, Fueyo A, Campo E, Lopez-Otin C.

Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas.

Cancer Res 58:1624-30 (1998)

[hsa:1515]