KEGG ENZYME: 3.4.22.43

ENZYME: 3.4.22.43

Entry

EC 3.4.22.43                Enzyme

Name

cathepsin V;
Cathepsin L2;
cathepsin U

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases

Reaction(IUBMB)

The recombinant enzyme hydrolyses proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec)

Comment

Cathepsin V is a human lysosomal cysteine endopeptidase of family C1 (papain family) that is maximally active at pH 5.7 and unstable at neutral pH. Compound E-64, leupeptin and chicken cystatin are inhibitors. Human cathepsin V shows expression restricted to thymus, testis, corneal epithelium and some colon and breast carcinomas. Human gene locus: 9q22.2

History

EC 3.4.22.43 created 2000

Orthology

K01375

cathepsin V

Genes

HSA:	1515(CTSV)

PTR:	107976728(CTSV)

PPS:	100974568(CTSV)

GGO:	101143768(CTSV)

PON:	100439744(CTSV)

PPYG:

129044178(CTSV)

NLE:	100586899(CTSV)

HMH:	116475293(CTSV)

SSYN:

129479144(CTSV)

MCC:	710850(CTSV)

MCF:	102134104(CTSV)

MTHB:

126937929

MNI:	105498915(CTSV)

CSAB:

103219808(CTSV)

CATY:

105579323(CTSV)

PANU:

101024395(CTSV)

TGE:	112607992(CTSV)

MLEU:

105536595(CTSV)

RRO:	104659881(CTSV)

RBB:	108529277(CTSV)

TFN:	117098294(CTSV)

PTEH:

111531260(CTSV)

CANG:

105501514(CTSV)

CJC:	100411470(CTSV)

SBQ:	101031643(CTSV)

CIMI:

108316998(CTSV)

ANAN:

105723754(CTSV)

GAS:

123253951

TVP:

118853187

PBRV:

138161000

PSEX:

120534456

CPLA:

122565185

HOC:	132828998 132829185 132829187

CSET:

123316310

DVV:

126884025

DSV:	119444730 119454161

HRJ:

124278407

MCAF:

127721774

MMER:

123548727

» show all

Reference

1 [PMID:10029531]

Authors

Bromme D, Li Z, Barnes M, Mehler E

Title

Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization.

Journal

Biochemistry 38:2377-85 (1999)
DOI:10.1021/bi982175f

Sequence

[hsa:1515]

Reference

2 [PMID:9727401]

Authors

Adachi W, Kawamoto S, Ohno I, Nishida K, Kinoshita S, Matsubara K, Okubo K

Title

Isolation and characterization of human cathepsin V: a major proteinase in corneal epithelium.

Journal

Invest Ophthalmol Vis Sci 39:1789-96 (1998)

Sequence

[hsa:1515]

Reference

3 [PMID:9563472]

Authors

Santamaria I, Velasco G, Cazorla M, Fueyo A, Campo E, Lopez-Otin C.

Title

Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas.

Journal

Cancer Res 58:1624-30 (1998)

Sequence

[hsa:1515]

Other DBs

ExplorEnz - The Enzyme Database:

3.4.22.43

IUBMB Enzyme Nomenclature:

3.4.22.43

ExPASy - ENZYME nomenclature database:

3.4.22.43

BRENDA, the Enzyme Database:

3.4.22.43

CAS:	223670-00-6

All links

Protein sequence (32)   
   UniProt (10)   
   SWISS-PROT (2)   
   RefSeq(pep) (4)   
   PDBSTR (16)   
DNA sequence (10)   
   RefSeq(nuc) (5)   
   GenBank (5)   
3D Structure (4)   
   PDB (4)   
Protein domain (8)   
   InterPro (8)   
All databases (54)   

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