KEGG   ENZYME: 3.4.22.48Help
Entry
EC 3.4.22.48                Enzyme                                 

Name
staphopain;
staphylopain
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Broad endopeptidase action on proteins including elastin, but rather limited hydrolysis of small-molecule substrates. Assays are conveniently made with hemoglobin, casein or Z-Phe-Arg-NHMec as substrate
Comment
Known from species of Staphylococcus. Type example of peptidase family C47.
History
EC 3.4.22.48 created 2003
Orthology
K08258  staphopain A
Genes
SAU: SA1725
SAV: SAV1909
SAW: SAHV_1894
SAH: SaurJH1_1998
SAJ: SaurJH9_1964
SAM: MW1850
SAS: SAS1832
SAR: SAR2001
SAC: SACOL1970(sspB2)
SAX: USA300HOU_1910
SAE: NWMN_1847(sspB)
SAD: SAAV_1975(sspB2) SAAV_c10(scpA)
SUE: SAOV_2011
SUK: SAA6008_01930(sspB2)
SUQ: HMPREF0772_11233(sspP)
SUZ: MS7_1944(sspP)
SUW: SATW20_19040(scpA)
SUG: SAPIG2003
SUF: SARLGA251_17940(scpA)
SAUA: SAAG_02428
SAUE: RSAU_001796(sspA)
SAUS: SA40_1750(scpA)
SAUU: SA957_1834(scpA)
SAUG: SA268_1906(scpA)
SAUZ: SAZ172_1921(scpA)
SAUV: SAI7S6_1014490(sspP)
SAUW: SAI5S5_1014430(sspP)
SAUX: SAI6T6_1014450(sspP)
SAUY: SAI8T7_1014470(sspP)
SAUF: X998_1964(scpA)
SAB: SAB1845
SAUB: C248_1984
SAUC: CA347_1997(sspP)
SAUR: SABB_02334(sspP)
SAUI: AZ30_10175
SAUD: CH52_09380
SEP: SE0184
SER: SERP2390(sspB)
SEPP: SEB_00115
SEPS: DP17_1276(sspP)
SPAS: STP1_1663
SHU: SHYC_10000(sspP)
SAGQ: EP23_12145
 » show all
Taxonomy
Reference
1
  Authors
Hofmann, B., Hecht, H.J., Kiess, M. and Schomburg, D.
  Title
Crystal structure of a thiol proteinase from Staphylococcus aureus V8 in the E-64 inhibitor complex.
  Journal
Acta Crystallogr Sect A (Suppl) 49:102 (1993)
Reference
2
  Authors
Potempa, J., Dubin, A. and Travis, J.
  Title
Staphylopain.
  Journal
In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.), Handbook of Proteolytic Enzymes, Handbook of Proteolytic Enzymes, London, 1998, p. 669-671.
Reference
3  [PMID:11767947]
  Authors
Dubin G, Chmiel D, Mak P, Rakwalska M, Rzychon M, Dubin A.
  Title
Molecular cloning and biochemical characterisation of proteases from Staphylococcus epidermidis.
  Journal
Biol Chem 382:1575-82 (2001)
DOI:10.1515/BC.2001.192
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.4.22.48
IUBMB Enzyme Nomenclature: 3.4.22.48
ExPASy - ENZYME nomenclature database: 3.4.22.48
BRENDA, the Enzyme Database: 3.4.22.48
CAS: 347841-89-8

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