KEGG   ENZYME: 3.4.22.51
Entry
EC 3.4.22.51                Enzyme                                 
Name
cruzipain;
congopain;
cruzain;
evansain;
trypanopain
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
Reaction(IUBMB)
Broad endopeptidase specificity similar to that of cathepsin L
Comment
In peptidase family C1. Is located in the digestive vacuoles of the parasitic trypanosome and contributes to the nutrition of the organism by digestion of host proteins.
History
EC 3.4.22.51 created 2003
Orthology
K08571  cruzipain
Genes
TCR: 506529.550 507537.20 507603.260 507603.270 508595.40 509401.30 509429.320 509429.329 510889.261
Reference
1  [PMID:11472258]
  Authors
Jose Cazzulo J, Stoka V, Turk V
  Title
The major cysteine proteinase of Trypanosoma cruzi: a valid target for chemotherapy of Chagas disease.
  Journal
Curr Pharm Des 7:1143-56 (2001)
DOI:10.2174/1381612013397528
Other DBs
ExplorEnz - The Enzyme Database: 3.4.22.51
IUBMB Enzyme Nomenclature: 3.4.22.51
ExPASy - ENZYME nomenclature database: 3.4.22.51
BRENDA, the Enzyme Database: 3.4.22.51
CAS: 141588-22-9

  All links  
Gene (10)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (9)   
Protein sequence (58)   
   UniProt (5)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
   PDBSTR (47)   
DNA sequence (56)   
   RefSeq(nuc) (10)   
   GenBank (23)   
   EMBL (23)   
3D Structure (20)   
   PDB (20)   
Protein domain (9)   
   InterPro (9)   
All databases (153)   

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