KEGG   ENZYME: 3.4.22.52
Entry
EC 3.4.22.52                Enzyme                                 
Name
calpain-1;
mu-calpain;
calcium-activated neutral protease I
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
Reaction(IUBMB)
Broad endopeptidase specificity
Comment
In peptidase family C2. Requires Ca2+ at micromolar concentrations for activity. Cytosolic in animal cells. The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 3.4.22.53, calpain-2.
History
EC 3.4.22.52 created 1981 as EC 3.4.22.17, transferred 2003 to EC 3.4.22.52
Orthology
K01367  calpain-1
Genes
HSA823(CAPN1)
PTR451317(CAPN1)
PPS100975624(CAPN1)
GGO101139860(CAPN1)
PON100174090(CAPN1)
NLE100605026(CAPN1)
HMH116468992(CAPN1)
MCC716618(CAPN1)
MCF101867512(CAPN1)
MTHB126935563
MNI105469562(CAPN1)
CSAB103230332(CAPN1)
CATY105577619(CAPN1)
PANU101025437(CAPN1)
TGE112605622(CAPN1)
MLEU105549135(CAPN1)
RRO104662820(CAPN1)
RBB108543285(CAPN1)
TFN117081573(CAPN1)
PTEH111522388(CAPN1)
CANG105512339(CAPN1)
CJC100411931(CAPN1)
SBQ101034774(CAPN1)
CIMI108310246(CAPN1)
CSYR103260399(CAPN1)
MMUR105878513(CAPN1)
LCAT123641381(CAPN1)
PCOQ105827335(CAPN1)
OGA100950762(CAPN1)
MMU12333(Capn1)
MCAL110285309(Capn1)
MPAH110316020(Capn1)
RNO29153(Capn1)
MCOC116103425(Capn1)
ANU117708552(Capn1)
MUN110549350(Capn1)
CGE100758636(Capn1)
MAUA101834701(Capn1)
PROB127228755(Capn1)
PLEU114682091(Capn1)
MORG121454081(Capn1)
MFOT126498550
AAMP119827467(Capn1)
NGI103724977(Capn1)
HGL101696511(Capn1)
CPOC100726550(Capn1)
CCAN109687155(Capn1)
DORD105989219(Capn1)
DSP122104935(Capn1)
PLOP125361658(Capn1)
NCAR124958508
MMMA107136010(Capn1)
OCU100009089
OPI101533134(CAPN1)
TUP102482492(CAPN1)
GVR103609904(CAPN1)
CFA483745(CAPN1)
CLUD112659212(CAPN1)
VVP112924271(CAPN1)
VLG121471842(CAPN1)
NPO129503235(CAPN1)
AML100468407(CAPN1)
UMR103679450(CAPN1)
UAH113244126(CAPN1)
UAR123778287(CAPN1)
ELK111149415
LLV125078527 125083453
MPUF101689283(CAPN1)
MNP132019080(CAPN1)
MLK131815210(CAPN1)
NVS122913101(CAPN1)
ORO101386731(CAPN1)
EJU114220301(CAPN1)
ZCA113914802(CAPN1)
MLX118016038(CAPN1)
NSU110576359(CAPN1)
LWW102743501(CAPN1)
FCA101096916(CAPN1)
PYU121023931(CAPN1)
PCOO112851928(CAPN1)
PBG122484002(CAPN1)
PVIV125176092(CAPN1)
LRUF124504804
PTG102955453(CAPN1)
PPAD109246719(CAPN1)
PUC125930886
AJU106971147
HHV120240133(CAPN1)
BTA281661(CAPN1)
BOM102283099(CAPN1)
BIU109554508(CAPN1)
BBUB102406040(CAPN1)
BBIS104987221(CAPN1)
CHX100861313(CAPN1)
OAS443130(CAPN1)
BTAX128069183(CAPN1)
ODA120874641(CAPN1)
CCAD122430944(CAPN1) 122435630
MBEZ129548783(CAPN1)
SSC397027(CAPN1)
CFR102517688(CAPN1)
CBAI105070674(CAPN1)
CDK105102612(CAPN1)
VPC102527808(CAPN1)
BACU103013016(CAPN1)
BMUS118899197(CAPN1)
LVE103069107(CAPN1)
OOR101287191(CAPN1)
DLE111183768(CAPN1)
PCAD102984504(CAPN1)
PSIU116757708(CAPN1)
NASI112402123(CAPN1)
ECB100051106(CAPN1)
EPZ103559156(CAPN1)
EAI106833590(CAPN1)
MYB102249013(CAPN1)
MYD102770312(CAPN1)
MMYO118665322(CAPN1)
MLF102430512
PKL118714933(CAPN1)
EFUS103302077(CAPN1)
MNA107533638(CAPN1)
DRO112317121(CAPN1)
SHON118991715(CAPN1)
AJM119050263(CAPN1)
PDIC114499495(CAPN1)
PHAS123829347(CAPN1)
MMF118627889(CAPN1)
PPAM129068584(CAPN1)
HAI109384300(CAPN1)
RFQ117030631(CAPN1)
PALE102891365(CAPN1)
PGIG120584867(CAPN1)
PVP105297886(CAPN1)
RAY107497519(CAPN1)
MJV108399216(CAPN1)
TOD119249985(CAPN1)
SARA101541032(CAPN1)
SETR126018055(CAPN1)
LAV100658150(CAPN1)
TMU101341766
ETF101659155(CAPN1)
DNM101447000(CAPN1)
MDO100030405(CAPN1)
GAS123251123(CAPN1)
SHR100927376(CAPN1)
AFZ127541787
PCW110195314(CAPN1) 110213557(CAPN11)
OAA100092537(CAPN11) 100680746(CAPN1)
GGA396240(CAPN11) 693249(CAPN1)
PCOC116229373(CAPN11) 116237750(CAPN1)
MGP100549763(CAPN11)
CJO107307079(CAPN1) 107311285(CAPN11)
TPAI128085411(CAPN11)
LMUT125689414(CAPN11)
NMEL110395367(CAPN11)
APLA101793085(CAPN11)
ACYG106048204(CAPN11) 106049805(CAPN1)
CATA118255178(CAPN11) 118261398(CAPN1)
AFUL116487825(CAPN11)
TGU100232236(CAPN11)
LSR110478839(CAPN1) 110481680(CAPN11)
SCAN103817882(CAPN11) 103824981(CAPN1)
PMOA120496887(CAPN11) 120504486(CAPN1)
OTC121335748(CAPN11) 121339668(CAPN1)
PRUF121358733(CAPN11) 121360157(CAPN1)
GFR102035321(CAPN11) 102043510(CAPN1)
FAB101816358(CAPN11) 101818353
OMA130251197(CAPN11) 130262735(CAPN1)
PHI102099356(CAPN11) 102102785(CAPN1)
PMAJ107202038(CAPN11)
CCAE111927556(CAPN11)
CCW104684409(CAPN11)
CBRC103621281(CAPN11) 103624406(CAPN1)
ETL114059349(CAPN11)
ZAB102068890(CAPN11)
ZLE135445800(CAPN11) 135460334(CAPN1)
ACHL103804587
SVG106854259(CAPN11) 106863566(CAPN1)
MMEA130576174(CAPN11) 130588003
HRT120747629(CAPN1) 120750165(CAPN11)
FPG101911941(CAPN1) 101913440(CAPN11)
FCH102045859(CAPN11) 102058565(CAPN1)
CLV102090692
EGZ104132723(CAPN11)
NNI104008776 104021518(CAPN11)
PCRI104036297
PLET104622448
EHS104507002(CAPN1)
PCAO104044755(CAPN1)
ACUN113478451(CAPN11)
TALA104362336(CAPN11)
PADL103922858(CAPN11)
AFOR103894552(CAPN1) 103902673(CAPN11)
ACHC115338336(CAPN1) 115350221(CAPN11)
HALD104320097
HLE104833773(CAPN1) 104840315(CAPN11)
AGEN126051602 126053403
GCL127014122 127029143
CCRI104161562
CSTI104563449(CAPN1)
CMAC104481933
MUI104540838
BREG104640836 104641952
FGA104074592
GSTE104256163(CAPN1)
LDI104344277
MNB103774687(CAPN1)
OHA104329293(CAPN11)
NNT104408211 104413019
SHAB115603498(CAPN1) 115613431(CAPN11)
DPUB104299944(CAPN11)
PGUU104464382
ACAR104522361 104522392
CPEA104394840 104396266(CAPN11)
AVIT104272733(CAPN1)
CVF104282327(CAPN11) 104290836(CAPN1)
RTD128901826(CAPN1) 128906946(CAPN11)
CUCA104057657(CAPN11) 104058082
TEO104378125
BRHI104494850
AAM106485511(CAPN11) 106494368(CAPN1)
AROW112960979(CAPN1) 112973405(CAPN11)
NPD112957522(CAPN11)
TGT104572642(CAPN11)
DNE112995258(CAPN1) 112997144(CAPN11)
SCAM104151698(CAPN11)
ASN102368421(CAPN11) 102375021(CAPN1)
AMJ102557663(CAPN11) 102561469(CAPN1)
CPOO109319857(CAPN11)
GGN109304336(CAPN11)
PSS102448184(CAPN11) 102458417(CAPN1)
CMY102939902(CAPN11) 102940343(CAPN1)
CCAY125633779(CAPN11) 125639557(CAPN1)
DCC119853228(CAPN11) 119858430(CAPN1)
CPIC101935497(CAPN1) 101953330(CAPN11)
TST117874582(CAPN11) 117880196(CAPN1)
CABI116819055(CAPN11) 116838779(CAPN1)
MRV120369426(CAPN1) 120400983(CAPN11)
ACS100551715 100560015(capn1) 100567116
ASAO132761299 132761300 132764284(CAPN1)
PVT110070204(CAPN1) 110074688(CAPN11)
SUND121915106(CAPN1) 121934501(CAPN11)
PBI103061442 103062813(CAPN1)
PMUR107294378(CAPN1) 107294458
CTIG120309615(CAPN11) 120318484(CAPN1)
TSR106543129(CAPN11) 106553714
PGUT117669752(CAPN1) 117671847(CAPN11)
APRI131186503(CAPN1) 131202284(CAPN11)
PTEX113433167(CAPN11) 113446716(CAPN1)
NSS113421006(CAPN11) 113427650(CAPN1)
VKO123031142(CAPN11) 123032712(CAPN1)
PMUA114586334(CAPN1) 114594533(CAPN11)
PRAF128403371(CAPN1) 128410982(CAPN11)
ZVI118075673(CAPN1) 118081772(CAPN11)
HCG128337469(CAPN1) 128348734(CAPN11)
GJA107111051(CAPN1) 107115263(CAPN11)
STOW125425756(CAPN11) 125443282(CAPN1)
EMC129328607(CAPN11) 129336645(CAPN1)
XLA380177(capn1.L) 398288(capn11.S) 398772(capn11.L) 447208(capn1.S)
XTR541454(capn11) 541455(capn1)
NPR108785269(CAPN1) 108802349
RTEM120917378(CAPN1) 120921949 120938079(CAPN11)
BBUF120980824(CAPN1) 120980825 120999823(CAPN11) 121009330
BGAR122920046 122920152(CAPN1) 122922491(CAPN11)
MUO115465329(CAPN11) 115480899(CAPN1)
GSH117356919(CAPN11) 117364650(CAPN1)
DRE393417(capn1a) 406768(capn1) 553353(si:ch211-202f3.3) 565106(capn1b) 565825(si:dkeyp-50d11.2)
SRX107722661 107723851 107728026 107732416 107734280 107755342 107757007 107758230
SANH107655377 107657473 107659327 107662629 107664433 107676389 107679188 107693804 107703864
SGH107549131 107554500 107559906 107560139 107560673 107565170 107569123 107570763 107586085
CCAR109047016 109052449 109052878 109052956 109062019 109100539 109106269
CAUA113038493 113039946 113060509 113065137 113092341 113096694 113105416 113105862 113112425 113117053
CGIB127942705 127961292 127969903 127976007(si:ch211-202f3.3) 127986600(si:dkeyp-50d11.2) 127988335 128017418 128025939 128031603
PTET122326832(si:dkeyp-50d11.2) 122327281(capn1b) 122327290 122348843(capn1) 122357007(capn1a) 122361693 122361695
LROH127152628(si:dkeyp-50d11.2) 127153352(capn1b) 127168278(capn1) 127175326(capn1a) 127179662 127179858
OMC131523225 131523295 131528458(si:dkeyp-50d11.2) 131531019(capn1b) 131544799(capn1) 131551992(capn1a)
PPRM120464116 120464117 120469908(capn1) 120471623 120479401(capn1a) 120494722(si:dkeyp-50d11.2) 120495253(capn1b)
RKG130080215 130080302 130083183(capn1a) 130083230(capn1) 130095293(si:dkeyp-50d11.2)
MAMB125252746(si:dkeyp-50d11.2) 125263730(capn1b) 125265358(capn1) 125269037 125269039(si:ch211-202f3.3) 125276706(capn1a)
CIDE127498406 127498407 127503143(si:dkeyp-50d11.2) 127515870 127520138 127524775
MASI127412196 127413958 127430555 127438535 127438756 127453368
TROS130548322(capn1b) 130555445(capn1) 130559785(si:ch211-202f3.3) 130569748(si:dkeyp-50d11.2)
TDW130407563(si:dkeyp-50d11.2) 130428658(capn1) 130429402(capn1b) 130431460(capn1a) 130436764(si:ch211-202f3.3)
MANU129415665(capn1a) 129417785(si:ch211-202f3.3) 129423590(si:dkeyp-50d11.2) 129437261(capn1) 129452864
IPU108259403(capn1b) 108267277(capn1) 108270103 108278958(si:dkeyp-50d11.2)
IFU128602566 128610341(capn1) 128612326 128622317(si:dkeyp-50d11.2)
PHYP113538997 113540004 113541709 113547580
SMEO124379880(capn1b) 124387228(capn1) 124389812 124398377(si:dkeyp-50d11.2)
TFD113657080 113659445 113662087(si:dkeyp-50d11.2) 113663003(capn1)
TVC132838528(capn1b) 132845464 132848938(capn1) 132852557 132859799(si:dkeyp-50d11.2)
TRN134312431(capn1) 134314953(capn1a) 134325693 134330165(si:dkeyp-50d11.2) 134334751
AMEX103021914 103023637 103024720 103042634 111196138
CMAO118801737(capn1) 118801767 118804576 118804658 118810903(capn1a) 118820023(si:dkeyp-50d11.2)
EEE113574132 113577729 113581470 113585150 113585580
CHAR105895689 105900400(si:dkeyp-50d11.2) 105902954(capn1) 105909413 105909415 116223611 122129547(capn1a)
TRU101063922 101070832 101072522 101075956 101080097 115247065
TFS130523209(capn1) 130533558 130537546 130540093 130540094
TNGGSTEN00014283G001 GSTEN00030801G001
LCO104918347 104932304 104934901 104939929 104939931
NCC104942481 104966646
TBEN117486632 117486640 117486643 117486661 117486706 117490139 117490140 117497617(capn1b) 117497989(capn1) 117499889(capn1a)
CGOB115018781 115020111 115024059 115027649 115027655
PGEO117442465 117458007 117459872(capn1a) 117463801(capn1)
GACU117534434 117553001(capn1a) 117555502(capn1) 117558516 117558532 117562483
EMAC134858873 134863798(capn1b) 134872154 134872647(capn1) 134881361 134881449
ELY117246401(capn1) 117248263 117261239 117267601 117268334
EFO125883482(capn1) 125885995 125895050 125898646 125898647 125900413 125903525
PLEP121952757 121953760 121954410(capn1a) 121961803(capn1)
SLUC116049143 116051586 116053240(capn1)
ECRA117934628(capn1) 117960008(capn1a)
ESP116669923 116704838 116706951(capn1)
PFLV114545493 114563646 114572187
GAT120820505 120821247(capn1) 120821752 120824591 120832531 120832532
PPUG119214658(capn1a) 119215001 119217603(capn1b) 119223501(capn1) 119227499
AFB129092325 129093021(capn1) 129095696(capn1b) 129103564 129114076
CLUM117725453(zgc:136872) 117730292(capn1b) 117743049 117744466 117747843(capn1)
PSWI130191938 130205654 130207628 130212112(capn1)
MSAM119895757 119899878 119909865 119910299 119910300 119910301 119913377(capn1) 119917655
SCHU122861757 122869720(capn1) 122872851 122884012
CUD121504906(capn1) 121508228 121511413 121519223 121519348 121526517 121526592
ALAT119004677 119004958 119004959 119004960 119019727 119027102(capn1) 119031765 119034165
MZE101467615 101467885 101468863 101486012 112429759 112430029
ONL100691068 100696988 100701772 100705917 102077767 102077964 102078968 109203919
OAU116311103 116313244 116313245 116314133 116314147 116314341(capn1) 116317687 116318561 116330628 116330629 116333975
OLA101155642 101157105 101163842 111947154
OML112143352 112150453 112156162(capn1) 112162007(capn1a)
CSAI133418693 133420741(capn1) 133445772 133459623 133460170 133462170 133462354 133463923
XMA102217715 102219604 102226708 102232073
XCO114134372 114138433 114144099 114157275
XHE116708692 116709144 116713623 116720100 116725464 116725465 116733499
PRET103460682 103472760 103475916 103477211
PFOR103130122 103134144 103145921 103154184 103154186
PLAI106935684 106937324 106943754 106959256 106961192
PMEI106904866 106904867 106910171 106929419 106931775
GAF122820130(capn1) 122829987 122842934 122845740 122845742
PPRL129356397 129359619 129374849 129379432(capn1)
CVG107082646 107086239 107102261 107103873
CTUL119778526 119785525(capn1b) 119787455(capn1) 119797784
GMU124859312(capn1a) 124868861 124875985 124875986 124880692(capn1)
NFU107375568 107377026 107393886
KMR108234076(capn1a) 108247006 108248456(capn1) 108251140(capn1b)
ALIM106510975 106515920 106528973 106536235
NWH119408762(capn1) 119411369 119422750
AOCE111562577 111568896 111575356 111585234 111588653
MCEP125018834(capn1a) 125019929(capn1) 125020749 125021136 125024190 125024213
CSEM103383277 103386024 103387546 103394997
POV109627978 109632311 109635880 109647408
SSEN122766463(capn1) 122771467(capn1b) 122779801 122779816 122781449
HHIP117756127 117756184 117756185 117763874 117774803 117776079 117779098 117779099
HSP118102443(capn1) 118116387 118116972 118119433 118122368
PPLT128430131(capn1) 128437467 128450816 128450817 128453897 128457370
SMAU118283771(capn1a) 118284011(capn1) 118285906 118300443 118312230
LCF108877119 108882288 108883663 108893145 108893472 108894122 108894126 108897989
SDU111217029 111220564 111225630 111235646 111237566
SLAL111647234 111647455 111651024 111668118 111669491
XGL120795618 120795730 120796298 120797166(capn1) 120799962 120802854
HCQ109506946 109516161 109530237
SSCV125978325 125981321 125993645
SBIA133493938 133494821(capn1) 133509565(capn1a)
PEE133397627(capn1) 133397975 133409416 133412464(zgc:136872)
PTAO133472538 133472597 133472712(capn1) 133473202 133485739 133487881(zgc:136872)
BPEC110155378 110157214 110170755
MALB109961588 109971454 109971825 109973686
BSPL114844951(capn1) 114857480 114870535
SJO128370889 128372451 128374969 128375510 128378205 128383934(capn1)
SASA106563699 106565008 106578020(CAN1) 106589958 106592837 106608991(CAN1) 106611380 106611381
STRU115155639 115161930 115161931 115161932 115172948 115194504 115198469 115201754 115204450 115208448
OTW112214584 112224715 112231173(si:dkeyp-50d11.2) 112236242(capn1a) 112255810 112256945 112259847 112266445(capn1b)
OMY100136223(capn1) 110492801 110493821 110499567 110505911 110505912 110510127(si:dkeyp-50d11.2) 110531583
OGO124002437 124006952(si:dkeyp-50d11.2) 124008520 124014338 124046749 124046750 124048057
ONE115101443 115120433 115120435 115133377 115137941 115142698
OKI109873796 109879243 109880976 109884540 109890671 109896910 109904613 109906394
OKE118368033 118376417 118378562 118379536 118384987(si:dkeyp-50d11.2) 118389063 118392135 127906023
SALP111952551 111960900 111964347 112069495
SNH120021440 120022988 120022989 120029354 120030363 120046057(capn1a) 120049771 120059734 120064847
CCLU121542097(si:dkeyp-50d11.2) 121544225 121544245 121555340 121565383 121571353 121572326 121580075 123483154 123484544
ELS105008817 105009069 105023100 105028005 105030042 105030135
SFM108921654 108927110 108933741 108934318
PKI111851624 111852307 111852380 111857887 111860100
AANG118217792(capn1a) 118220681 118221077 118234986(si:dkeyp-50d11.2)
LOC102683266
PSPA121306282 121312284 121315709 121316791 121317117 121317118
ARUT117402957 117410781 117410849(zgc:136872) 117411200 117429789 117430547 117962701 117968954
PSEX120516974 120525717 120525719 120533753
LCM102347136(CAPN1) 102363773(CAPN11)
CMK103177926 121852245
CPLA122543979
HOC132830166 132836287
LERI129697548
PMRN116939633 116939783 116947819
LRJ133341336 133342422 133347252 133347268
NPT124223179 124223180 124223181
NFB124185358 124186482
NLO107218468 107219811 107219812 107226751
NVG124307157 124308890 124308892
AGB108917355
LSIN126965281
DCI103521221
HHAL106677274
MQU128988432 128989011
IEL124170937
TCF131888460
BGT106062960 106063383
GAE121381496
HRJ124292435 124292548
OSN115229049
LLON135500905
NGRNAEGRDRAFT_35326
 » show all
Reference
1  [PMID:12014988]
  Authors
Dutt P, Spriggs CN, Davies PL, Jia Z, Elce JS
  Title
Origins of the difference in Ca2+ requirement for activation of mu- and m-calpain.
  Journal
Biochem J 367:263-9 (2002)
DOI:10.1042/BJ20020485
Other DBs
ExplorEnz - The Enzyme Database: 3.4.22.52
IUBMB Enzyme Nomenclature: 3.4.22.52
ExPASy - ENZYME nomenclature database: 3.4.22.52
BRENDA, the Enzyme Database: 3.4.22.52
CAS: 78990-62-2

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