KEGG ENZYME: 3.4.22.53

ENZYME: 3.4.22.53

Entry

EC 3.4.22.53 Enzyme

Name

calpain-2;
calcium-activated neutral protease II;
m-calpain;
milli-calpain

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases

Reaction(IUBMB)

Broad endopeptidase specificity

Comment

Type example of peptidase family C2. Requires Ca2+ at millimolar concentrations for activity. Cytosolic in animal cells. The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 3.4.22.52, calpain-1.

History

EC 3.4.22.53 created 1981 as EC 3.4.22.17, transferred 2003 to EC 3.4.22.53

Orthology

K03853

calpain-2

Genes

HSA:	824(CAPN2)

PTR:	457765(CAPN2)

PPS:	100988890(CAPN2)

GGO:	101149206(CAPN2)

PON:	100445754(CAPN2)

NLE:	100589114(CAPN2)

MCC:	703047(CAPN2)

MCF:	102122692(CAPN2)

CSAB:

103230023(CAPN2)

RRO:	104677285(CAPN2)

RBB:	108528248(CAPN2)

CJC:	100405215(CAPN2)

SBQ:	101035587(CAPN2)

MMU:	12334(Capn2)

MCAL:

110296563(Capn2)

MPAH:

110321506(Capn2)

RNO:	29154(Capn2)

MUN:	110546658(Capn2)

CGE:	100771239(Capn2)

NGI:	103726266(Capn2)

HGL:	101720177(Capn2)

CCAN:

109677038(Capn2)

OCU:	100009092(CAPN2)

TUP:	102481316(CAPN2)

CFA:	480118(CAPN2)

VVP:	112923580(CAPN2)

AML:	100476150(CAPN2)

UMR:	103669131(CAPN2)

UAH:	113262899(CAPN2)

ORO:	101364547(CAPN2)

FCA:	101083231(CAPN2)

AJU:	106983173(CAPN2)

BTA:	281662(CAPN2)

BOM:	102276298(CAPN2)

BIU:	109570370(CAPN2)

BBUB:

102415122(CAPN2)

PHD:	102319895(CAPN2)

CHX:	102181227(CAPN2)

OAS:	100127211(CAPN2)

SSC:	397393(CAPN2)

CFR:	102512386(CAPN2)

CDK:	105099835(CAPN2)

BACU:

103000119 103007207(CAPN2) 103019749

LVE:	103080579(CAPN2)

OOR:	101270285(CAPN2)

DLE:	111177507(CAPN2)

PCAD:

102976041(CAPN2)

ECB:	100055184(CAPN2)

EPZ:	103563904(CAPN2)

EAI:	106829535(CAPN2)

MYB:	102240228(CAPN2)

MYD:	102769788(CAPN2)

MNA:	107543584(CAPN2)

HAI:	109381194(CAPN2)

RSS:

109437082

DRO:

112318759

PALE:

102897695(CAPN2)

RAY:

107498969

LAV:	100663804(CAPN2)

TMU:

101341399

MDO:	100018672(CAPN2)

SHR:

100922649

PCW:	110205536(CAPN2)

OAA:	100081577(CAPN2)

GGA:	395963(CAPN2)

MGP:	100546180(CAPN2)

CJO:	107311033(CAPN2)

NMEL:

110395702

APLA:

101799042

ACYG:

106031621(CAPN2)

TGU:	100225408 100229579(CAPN2)

LSR:

110483833

SCAN:

103819275(CAPN2)

GFR:	102045030(CAPN2)

FAB:	101809391(CAPN2)

PHI:	102111446(CAPN2)

PMAJ:

107202529(CAPN2)

CCAE:

111926249(CAPN2)

CCW:	104685555(CAPN2)

ETL:	114073709(CAPN2)

FPG:	101919959(CAPN2)

FCH:	102048431(CAPN2)

CLV:

102084552

EGZ:	104124542(CAPN2)

NNI:	104019299(CAPN2)

ACUN:

113477955(CAPN2)

PADL:

103925056(CAPN2)

AAM:	106482724(CAPN2)

ASN:	102373508(CAPN2)

AMJ:	102560432(CAPN2)

PSS:	102458713(CAPN2)

CMY:	102937008(CAPN2)

CPIC:

101940996(CAPN2)

ACS:	100561808(capn2)

PVT:	110075406(CAPN2)

PBI:

103056946

PMUR:

107288074(CAPN2) 107301241

GJA:	107121636(CAPN2)

XLA:	100127267 108716477 108717697(capn2.2.S) 399075(capn2.2.L)

XTR:	448035(capn2.2)

NPR:	108786661 108787073(CAPN2)

DRE:	541374(capn2a) 563053(capn2b)

SRX:	107722658 107722663 107722669 107724584 107734257 107755343 107755344 107755345 107755925

SANH:

107655329 107655374 107655376 107655378 107659324 107659328 107676365 107679193

SGH:	107549147 107565171 107565172 107565180 107566058 107569122 107571859 107577564 107586086

CCAR:

109046872 109046967 109046972 109047015 109070306 109076939 109081032 109100541 109106274

IPU:	108259404 108259406(CAPN2) 108259420

PHYP:

113547581

AMEX:

103024279 103026146 107197131

EEE:	113577726 113581471 113581475

TRU:	101064754 101076184 101076595

TNG:	GSTEN00008927G001 GSTEN00011212G001 GSTEN00030802G001 GSTEN00030804G001

LCO:	104918327 104918337 104934896 104934897 104934898

NCC:	104962953 104963449 104963450

MZE:	101466554 101468385

OLA:	101162579 101165172

XMA:	102227133 102234145

XCO:	114138434 114138435 114144102 114162076

PRET:

103473154 103474658 103477212 103477213

NFU:	107375570 107380268 107393875

KMR:	108234077 108234124 108240958 108251143 108251144

AOCE:

111568891 111568893 111568895 111583663 111585239

CSEM:

103378451 103383278 103383281 103387544 103387545

POV:	109630641 109647469 109647544

LCF:	108877132 108877133 108882260 108882289

SDU:	111220638 111220639 111237555 111237556 111237557

HCQ:	109516162 109527604

BPEC:

110153505 110156974 110156975 110166012

MALB:

109960723 109971792 109971799 109971826

SASA:

106565007 106565009 106578756 106578800 106578801 106584767 106589959 106589985 106589986

OTW:	112223208 112266430 112266436

SALP:

111960924 111960936 112075055 112076663 112076664

ELS:	105028009 105028010 105031125

SFM:	108927097 108927098 108927128 108933713 108933714

PKI:	111835677 111841738 111852308 111852340 111852381 111852382

LCM:	102347065(CAPN2)

CMK:	103177931 103180786

» show all

Reference

1 [PMID:10639123]

Authors

Strobl S, Fernandez-Catalan C, Braun M, Huber R, Masumoto H, Nakagawa K, Irie A, Sorimachi H, Bourenkow G, Bartunik H, Suzuki K, Bode W.

Title

The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium.

Journal

Proc Natl Acad Sci U S A 97:588-92 (2000)
DOI:10.1073/pnas.97.2.588

Sequence

[hsa:824]

Reference

2 [PMID:12014988]

Authors

Dutt P, Spriggs CN, Davies PL, Jia Z, Elce JS.

Title

Origins of the difference in Ca2+ requirement for activation of mu- and m-calpain.

Journal

Biochem J 367:263-9 (2002)
DOI:10.1042/BJ20020485

Other DBs

ExplorEnz - The Enzyme Database:

3.4.22.53

IUBMB Enzyme Nomenclature:

3.4.22.53

ExPASy - ENZYME nomenclature database:

3.4.22.53

BRENDA, the Enzyme Database:

3.4.22.53

CAS:	702693-80-9

DBGET integrated database retrieval system