EC                Enzyme                                 

calcium-activated neutral protease II;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
Broad endopeptidase specificity
Type example of peptidase family C2. Requires Ca2+ at millimolar concentrations for activity. Cytosolic in animal cells. The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC, calpain-1.
EC created 1981 as EC, transferred 2003 to EC
K03853  calpain-2
HSA: 824(CAPN2)
PTR: 457765(CAPN2)
PPS: 100988890(CAPN2)
GGO: 101149206(CAPN2)
PON: 100445754(CAPN2)
NLE: 100589114(CAPN2)
MCC: 703047(CAPN2)
MCF: 102122692(CAPN2)
CSAB: 103230023(CAPN2)
CATY: 105576962(CAPN2)
PANU: 101022030(CAPN2)
RRO: 104677285(CAPN2)
RBB: 108528248(CAPN2)
TFN: 117075199(CAPN2)
PTEH: 111537094(CAPN2)
CJC: 100405215(CAPN2)
SBQ: 101035587(CAPN2)
MMUR: 105863767
MMU: 12334(Capn2)
MCAL: 110296563(Capn2)
MPAH: 110321506(Capn2)
RNO: 29154(Capn2)
MCOC: 116068107(Capn2)
MUN: 110546658(Capn2)
CGE: 100771239(Capn2)
PLEU: 114684418(Capn2)
NGI: 103726266(Capn2)
HGL: 101720177(Capn2)
CCAN: 109677038(Capn2)
OCU: 100009092(CAPN2)
TUP: 102481316(CAPN2)
CFA: 480118(CAPN2)
VVP: 112923580(CAPN2)
VLG: 121485762(CAPN2)
AML: 100476150(CAPN2)
UMR: 103669131(CAPN2)
UAH: 113262899(CAPN2)
ORO: 101364547(CAPN2)
ELK: 111150685
MPUF: 101675244(CAPN2)
EJU: 114215532(CAPN2)
MLX: 118012992(CAPN2)
FCA: 101083231(CAPN2)
PYU: 121015188(CAPN2)
PBG: 122475955(CAPN2)
PPAD: 109258888(CAPN2)
AJU: 106983173(CAPN2)
HHV: 120234148(CAPN2)
BTA: 281662(CAPN2)
BOM: 102276298(CAPN2)
BIU: 109570370(CAPN2)
BBUB: 102415122(CAPN2)
CHX: 102181227(CAPN2)
OAS: 100127211(CAPN2)
ODA: 120880362(CAPN2)
CCAD: 122452395(CAPN2)
SSC: 397393(CAPN2)
CFR: 102512386(CAPN2)
CBAI: 105083948(CAPN2)
CDK: 105099835(CAPN2)
BACU: 103007207(CAPN2) 103019749
LVE: 103080579(CAPN2)
OOR: 101270285(CAPN2)
DLE: 111177507(CAPN2)
PCAD: 102976041(CAPN2)
ECB: 100055184(CAPN2)
EPZ: 103563904(CAPN2)
EAI: 106829535(CAPN2)
MYB: 102240228(CAPN2)
MYD: 102769788(CAPN2)
MMYO: 118678942(CAPN2)
MNA: 107543584(CAPN2)
HAI: 109381194(CAPN2)
DRO: 112318759
SHON: 119003139
AJM: 119036522(CAPN2)
MMF: 118640556(CAPN2)
PALE: 102897695(CAPN2)
PGIG: 120619310(CAPN2)
RAY: 107498969
MJV: 108400832(CAPN2)
TOD: 119244503(CAPN2)
LAV: 100663804(CAPN2)
TMU: 101341399
MDO: 100018672(CAPN2)
SHR: 100922649(CAPN2)
PCW: 110205536(CAPN2)
OAA: 100081577(CAPN2)
GGA: 395963(CAPN2)
PCOC: 116230900(CAPN2)
MGP: 100546180(CAPN2)
CJO: 107311033(CAPN2)
NMEL: 110395702
APLA: 101799042
ACYG: 106031621(CAPN2)
TGU: 100225408
LSR: 110483833
SCAN: 103819275(CAPN2)
PMOA: 120505963(CAPN2)
GFR: 102045030(CAPN2)
FAB: 101809391(CAPN2)
PHI: 102111446(CAPN2)
PMAJ: 107202529(CAPN2)
CCAE: 111926249(CAPN2)
CCW: 104685555(CAPN2)
ETL: 114073709(CAPN2)
FPG: 101919959(CAPN2)
FCH: 102048431(CAPN2)
CLV: 102084552
EGZ: 104124542(CAPN2)
NNI: 104019299(CAPN2)
ACUN: 113477955(CAPN2)
PADL: 103925056(CAPN2)
AAM: 106482724(CAPN2)
AROW: 112963405
NPD: 112954803(CAPN2)
DNE: 112980095(CAPN2)
ASN: 102373508(CAPN2)
AMJ: 102560432(CAPN2)
CPOO: 109319765(CAPN2)
GGN: 109296890(CAPN2)
PSS: 102458713(CAPN2)
CMY: 102937008(CAPN2)
CPIC: 101940996(CAPN2)
TST: 117874491(CAPN2) 117888892
CABI: 116825598(CAPN2)
ACS: 100561808(capn2)
PVT: 110075406(CAPN2)
PBI: 103056946
PMUR: 107288074(CAPN2)
TSR: 106549641(CAPN2)
PGUT: 117671750
PMUA: 114594632(CAPN2)
ZVI: 118083208(CAPN2)
GJA: 107121636(CAPN2)
XLA: 100127267(XB5844015.L) 108716477(capn8.5.L) 108717697(capn2.S) 399075(capn2.L)
XTR: 100379861(capn8.5) 100494922 100495980 448035(capn2)
NPR: 108786661 108787073(CAPN2)
DRE: 337730(capn8) 445091(capn2l) 541374(capn2a) 563053(capn2b)
PHYP: 113547581
PLEP: 121942132
ECRA: 117960009
MSAM: 119899880(capn2l) 119899881(capn8) 119899882 119917657
OAU: 116317696 116317707(capn8) 116317874(capn2l) 116318507
ALIM: 106515918(capn11) 106536239
XGL: 120796274 120796275 120800453(capn2l) 120800454(capn8) 120800455(capn2b)
LCM: 102347065(CAPN2)
CMK: 103177931
RTP: 109927474
 » show all
1  [PMID:10639123]
Strobl S, Fernandez-Catalan C, Braun M, Huber R, Masumoto H, Nakagawa K, Irie A, Sorimachi H, Bourenkow G, Bartunik H, Suzuki K, Bode W.
The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium.
Proc Natl Acad Sci U S A 97:588-92 (2000)
2  [PMID:12014988]
Dutt P, Spriggs CN, Davies PL, Jia Z, Elce JS
Origins of the difference in Ca2+ requirement for activation of mu- and m-calpain.
Biochem J 367:263-9 (2002)
Other DBs
ExplorEnz - The Enzyme Database:
IUBMB Enzyme Nomenclature:
ExPASy - ENZYME nomenclature database:
BRENDA, the Enzyme Database:
CAS: 702693-80-9

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