KEGG   ENZYME: 3.4.22.53
Entry
EC 3.4.22.53                Enzyme                                 
Name
calpain-2;
calcium-activated neutral protease II;
m-calpain;
milli-calpain
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
Reaction(IUBMB)
Broad endopeptidase specificity
Comment
Type example of peptidase family C2. Requires Ca2+ at millimolar concentrations for activity. Cytosolic in animal cells. The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 3.4.22.52, calpain-1.
History
EC 3.4.22.53 created 1981 as EC 3.4.22.17, transferred 2003 to EC 3.4.22.53
Orthology
K03853  calpain-2
Genes
HSA824(CAPN2)
PTR457765(CAPN2)
PPS100988890(CAPN2)
GGO101149206(CAPN2)
PON129047251(CAPN2)
PPYG129014371(CAPN2)
NLE100589114(CAPN2)
HMH116457885(CAPN2)
SSYN129458153(CAPN2)
MCC703047(CAPN2)
MCF102122692
MTHB126937478
MNI105478205(CAPN2)
CSAB103230023(CAPN2)
CATY105576962(CAPN2)
PANU101022030(CAPN2)
TGE112619114(CAPN2)
MLEU105554489(CAPN2)
RRO104677285(CAPN2)
RBB108528248(CAPN2)
TFN117075199(CAPN2)
PTEH111537094(CAPN2)
CANG105502824(CAPN2)
CJC100405215(CAPN2)
SBQ101035587(CAPN2)
CIMI108302703(CAPN2)
ANAN105722301(CAPN2)
CSYR103272581(CAPN2)
MMUR105863767
LCAT123627504(CAPN2)
PCOQ105810138(CAPN2)
OGA100946093(CAPN2)
MMU12334(Capn2)
MCAL110296563(Capn2)
MPAH110321506(Capn2)
RNO29154(Capn2)
MCOC116068107(Capn2)
ANU117721391(Capn2)
ASYL127697221(Capn2)
MUN110546658(Capn2)
CGE100771239(Capn2)
MAUA101833693(Capn2)
PROB127223719(Capn2)
PLEU114684418(Capn2)
MORG121435859(Capn2)
MFOT126502085
AAMP119799550(Capn2)
NGI103726266(Capn2)
HGL101720177(Capn2)
CPOC100725761(Capn2)
CCAN109677038(Capn2)
DORD105984946(Capn2)
DSP122109365(Capn2)
PLOP125360104(Capn2)
NCAR124961543
MMMA107140516(Capn2)
ITI101956753(Capn2)
OCU100009092(CAPN2)
OPI101532667(CAPN2)
TUP102481316(CAPN2)
GVR103607537(CAPN2)
CFA480118(CAPN2)
CLUD112648848(CAPN2)
VVP112923580(CAPN2)
VLG121485762(CAPN2)
NPO129509084(CAPN2)
AML100476150(CAPN2)
UMR103669131(CAPN2)
UAH113262899(CAPN2)
UAR123791973(CAPN2)
ELK111150685
LLV125085781
MPUF101675244(CAPN2)
MNP132025535(CAPN2)
MLK131814739(CAPN2)
NVS122918704(CAPN2)
ORO101364547(CAPN2)
EJU114215532(CAPN2)
ZCA113932475(CAPN2)
MLX118012992(CAPN2)
NSU110571384(CAPN2)
LWW102747421(CAPN2)
FCA101083231(CAPN2)
PYU121015188(CAPN2)
PBG122475955(CAPN2)
PVIV125159604(CAPN2)
LRUF124510321
LGF123585312(CAPN2)
AJU106983173
PPAD109258888(CAPN2)
PUC125925062
PLEZ122212404(CAPN2)
HHV120234148(CAPN2)
BTA281662(CAPN2)
BOM102276298(CAPN2)
BIU109570370(CAPN2)
BBUB102415122(CAPN2)
BBIS104997873
CHX102181227(CAPN2)
OAS100127211(CAPN2)
BTAX128061180(CAPN2)
CSUM138090405(CAPN2)
ODA120880362(CAPN2)
CCAD122452395(CAPN2)
MREE136170011(CAPN2)
OVR110128640(CAPN2)
MBEZ129551654(CAPN2)
SSC397393(CAPN2)
CFR102512386(CAPN2)
CBAI105083948(CAPN2)
CDK105099835(CAPN2)
VPC102524736(CAPN2)
BACU103007207(CAPN2) 103019749
BMUS118883081(CAPN2)
LVE103080579(CAPN2)
OOR101270285(CAPN2)
LALB132507824(CAPN2)
DLE111177507(CAPN2)
PCAD102976041(CAPN2)
PSIU116740338(CAPN2)
PPHC136120627(CAPN2)
NASI112403123(CAPN2)
ECB100055184(CAPN2)
EPZ103563904(CAPN2)
EAI106829535(CAPN2)
MYB102240228(CAPN2)
MYD102769788(CAPN2)
MMYO118678942(CAPN2)
MLF102438585
MDT132222451(CAPN2)
MYUM138999149(CAPN2)
PKL118727621(CAPN2)
EFUS103293526(CAPN2)
MNA107543584(CAPN2)
DRO112318759
SHON119003139
AJM119036522
PDIC114512462
PHAS123832759(CAPN2)
MMF118640556(CAPN2)
PPAM129072993(CAPN2)
HAI109381194(CAPN2)
RFQ117018599(CAPN2)
PALE102897695(CAPN2)
PGIG120619310(CAPN2)
PVP105292618(CAPN2)
RAY107498969(CAPN2)
MJV108400832(CAPN2)
TOD119244503(CAPN2)
SARA101557601(CAPN2)
SFUM130039425(CAPN2)
SETR126013535(CAPN2)
LAV100663804(CAPN2)
TMU101341399
ETF101648937(CAPN2)
DNM101424691(CAPN2)
MDO100018672(CAPN2)
GAS123244336(CAPN2)
SHR100922649(CAPN2)
AFZ127559523
PCW110205536(CAPN2)
TVP118846451(CAPN2)
PBRV138141764(CAPN2)
OAA100081577(CAPN2)
TACU119940722(CAPN2)
GGA395963(CAPN2)
PCOC116230900(CAPN2)
MGP100546180(CAPN2)
CJO107311033(CAPN2)
TPAI128076189(CAPN2)
LMUT125690047(CAPN2)
NMEL110395702
APLA101799042(CAPN2)
ACYG106031621
CATA118252991
AFUL116487638
TGU100225408
LSR110483833
SCAN103819275(CAPN2)
PMOA120505963(CAPN2)
OTC121346915(CAPN2)
PRUF121357014(CAPN2)
ATRC139587704(CAPN2)
GFR102045030(CAPN2)
FAB101809391(CAPN2)
OMA130250773(CAPN2)
PHI102111446(CAPN2)
PMAJ107202529(CAPN2)
CCAE111926249(CAPN2)
CCW104685555(CAPN2)
CBRC103612864(CAPN2)
ACOE138107701(CAPN2)
ETL114073709(CAPN2)
ZAB102073190(CAPN2)
ZLE135446046(CAPN2)
ACHL103797775
SVG106853912(CAPN2)
MMEA130583044(CAPN2)
HRT120750694(CAPN2)
SATI136359542(CAPN2)
CCIC134041972(CAPN2)
FPG101919959(CAPN2)
FCH102048431(CAPN2)
CCRI104159172(CAPN2)
NNT104408713
SHAB115613876
ACUN113477955(CAPN2)
TALA104365796
ACHC115349962(CAPN2)
HALD104317978(CAPN2)
HLE104838213(CAPN2)
AGEN126052620
HHAR128149890
GCL127015289
CSTI104550979(CAPN2)
LDI104350930
MNB103769082(CAPN2)
DPUB104300913(CAPN2)
PPUS135186653(CAPN2)
AVIT104268653
BRHI104489251(CAPN2)
EGZ104124542(CAPN2)
NNI104019299(CAPN2)
PCRI104030145
PCAO104045095
PADL103925056(CAPN2)
AFOR103894459(CAPN2)
FGA104081233(CAPN2)
GSTE104255472(CAPN2)
CBOY140649584(CAPN2)
CLV102084552
CNIC135987766
MUI104544144
PGUU104471956
PLET104620768
EHS104514071(CAPN2)
CMAC104483676(CAPN2)
CUCA104067050(CAPN2)
TEO104376259
BREG104630494(CAPN2)
OHA104332003(CAPN2)
ACAR104526948
CPEA104386198(CAPN2)
CVF104294692(CAPN2)
RTD128906890(CAPN2)
CRID134512660(CAPN2)
AAM106482724(CAPN2)
AROW112963405
NPD112954803(CAPN2)
TGT104570282(CAPN2)
DNE112980095(CAPN2)
SCAM104151845(CAPN2)
ASN102373508(CAPN2)
AMJ102560432(CAPN2)
CPOO109319765(CAPN2)
GGN109296890(CAPN2)
PSS102458713(CAPN2)
CMY102937008(CAPN2)
CCAY125633672
DCC119852740(CAPN2)
CPIC101940996(CAPN2)
TST117874491(CAPN2) 117888892
CABI116825598(CAPN2)
MRV120388744(CAPN12) 120400953(CAPN2)
ACS100561808(capn2)
ASAO132761385(CAPN2)
PVT110075406(CAPN2)
SUND121919237(CAPN2)
PBI103056946
PMUR107288074(CAPN2)
CTIG120307212(CAPN2)
TSR106549641(CAPN2)
PGUT117671750(CAPN2)
APRI131189346
PTEX113433240(CAPN2)
NSS113421716(CAPN2)
VKO123024724
PMUA114594632(CAPN2)
PRAF128411079 128418951(CAPN12)
ZVI118083208(CAPN2)
HCG128332565(CAPN12) 128350261
GJA107121636(CAPN2)
STOW125436868
EMC129330026(CAPN2) 129342991 129343726
XLA100127267(XB5844015.L) 108716477(capn8.5.L) 108717697(capn2.S) 399075(capn2.L)
XTR100379861(capn8.5) 100494922 100495980 448035(capn2)
NPR108786661 108787073(CAPN2)
RTEM120913392 120937867
ACAT141107755 141140828(CAPN2)
BBUF120977198 120999612(CAPN2)
BGAR122934009(CAPN2)
DTC141051967 141060116(CAPN2)
PWL138259658(CAPN12) 138295492
MUO115465480(CAPN2) 115481010
GSH117356530
DRE337730(capn8) 445091(capn2l) 541374(capn2a) 563053(capn2b)
SRX107722658 107722663 107722669 107724584 107734257 107755343 107755344 107755345 107755925
SANH107655329 107655374 107655376 107655378 107659324 107659328 107676365 107679193
SGH107549147 107565171 107565172 107565180 107566058 107569122 107571859 107577564 107586086
CCAR109046473(capn2l) 109047015(capn2b) 109057483 109062020 109070306 109076939 109100541(capn2a) 109111554
CAUA113039948 113039949 113039950 113039951 113065066 113065067 113065139 113065999 113092354 113112426
CGIB127942702 127943373 127943374 127956591 127970457 127988414 127988415 127988417 128025938
PTET122327143 122327282(capn2b) 122327288 122327868 122327869 122328220(capn2l) 122356702(capn2a)
LROH127153354(capn2b) 127159477(capn2l) 127159478 127159480 127175321(capn2a)
GRF141325177(capn2a) 141339041(capn8) 141339156 141339307(capn2b) 141339309(capn2l)
OMC131530830(capn8) 131531102(capn2l) 131531156 131551993(capn2a)
PPRM120479402(capn2a) 120495254(capn8) 120495255(capn2b) 120495447(capn2l)
RKG130083184(capn2a) 130103527(capn2l) 130103528(capn8)
MAMB125263723(capn2l) 125263724(capn8) 125263725 125263726 125263728 125263731(capn2b) 125276707(capn2a)
CIDE127520139 127520684 127521576 127521577 127524777
CERY137020441(capn2a) 137027817(capn2b) 137027820 137029203 137029204 137029205 137029208 137029209(capn2l)
MASI127412206 127413959 127438536 127438537 127438758 127438759
TROS130548323(capn2b) 130548655 130548689 130548690(capn2l) 130550965
TDW130429403(capn2b) 130429719 130429728 130430172(capn2l) 130431461(capn2a)
MANU129415666(capn2a) 129452865(capn2b) 129453082 129453423(capn2l) 129453424 129453425 129453426 129453427 129453428 129453429 129453430 129453432 129453433 129453436 129453438 141359517 141359519
PDAB135741001(capn2b) 135741004(capn2l) 135741005 135741006 135741008 135741009 135741010 135741131 135741132 135786616(capn2a)
IPU108259404 108259406 108259420
IFU128602567 128602877 128602878
PHYP113547581
SMEO124379814 124380107(capn8)
TFD113656951 113657035 113657038 113657047 113657081 113657082
TVC132838552 132839063(capn8)
CGAR128518526(capn8) 128518527 128518529 128518556
NGRA132874911(capn8) 132874912
TRN134308116 134314954(capn2a) 134334283 134334752 134334783
AMEX103024279(capn8) 103026146(capn2b) 107197131(capn2a)
CMAO118804562 118804578 118804588 118804589 118804595 118804599 118804628 118810905(capn2a)
EEE113577726 113581471 113581475
CHAR105896912 105910532 116219353 122129548 122129552 122129555 122132274
SPIL134061589 134061715(capn8) 134064510 134064515 134100748
TRU101064754 101076184 101076595
TFS130527429 130533559 130533560
TNGGSTEN00008927G001 GSTEN00030802G001 GSTEN00030804G001
LCO104918327 104918337 104934896 104934897 104934898
NCC104963449 104963450
TBEN117499311 117499313 117499673(capn8) 117499674
PGEO117441997 117459873 117459874
GACU117535626 117553009 117553016
EMAC134858433(capn8) 134858435 134862697 134862887 134863186
ELY117248470 117248471 117255565 117255600 117255876
EFO125885996(capn8) 125885997 125885998 125903649 125903650
PLEP121942132
SLUC116034148 116049140 116049141 116049166 116049190 116051494 116058023 116058030 116058374 116058375 116058502 118496042
ECRA117960009
ESP116704839
PFLV114556645 114556646 114556744 114557816 114557817 114557979 114557980 114563664 114563675 114566584 114572526
GAT120824594 120824596
PPUG119214540 119214541 119217601(capn2l) 119217602(capn2b)
AFB129092103 129092104 129095536 129095538 129095695
CLUM117729021 117743953 117743954
PSWI130191238 130191246 130206983 130207436
CANA137780110 137780111 137801993 137801994 137801995
CVE137866671 137866673 137866703(capn2l) 137882927 137882980
MSAM119899880(capn2l) 119899881(capn8) 119899882 119917657
SCHU122872848(capn8) 122872850 122884013
CUD121508149 121508172 121510754 121510929
SPUL138588182 138588979 138594452 138595237
LMIX132975131 132975132 132993622 132993654
ALAT119019705(capn2l) 119019734(capn8) 119019742(capn2b) 119033589 119034167
ASTR137600544 137600545 137600546 137603665 137603667
MZE101466554 101468385
ONL100706186 100709493 102083160
OAU116317696 116317707(capn8) 116317874(capn2l) 116318507
OLA101162579 101164919 101165172
OML112143530 112162134 112162135
CSAI133445752 133445763 133463976 133464168
XMA102227133 102234145
XCO114138434 114138435 114144102
XHE116713621 116713624 116720104
PRET103473154 103477212 103477213
PFOR103130124 103134145 103134146
PLAI106959257 106959267 106961194
PMEI106929428 106929429 106931777
GAF122829988 122842935 122842936
PPRL129356041 129359660(capn8) 129359661
CVG107082647 107082675 107102256 107102257
CTUL119785494 119785503 119797741 119797749
GMU124858622 124868214
NFU107375570 107393875
KMR108234077 108234124 108251143 108251144(capn2b)
ALIM106515918(capn11) 106536239
NWH119411348 119411359 119422313
AOCE111568891 111568893 111568895 111585239 111585240
EJA138195508 138195509 138208769 138209706
BFRE138616095 138616096 138634836 138634890
MCEP125004579(capn8) 125004580(capn2l) 125004581(capn2b) 125019146 125019147
CSEM103383278 103383281 103387544 103387545
POV109630641 109632323 109647469 109647544
SSEN122762072 122771004 122781965 122781966
SSOE131466793 131467261
HHIP117763891(capn2l) 117763907(capn8) 117763923 117775632 117776037 117776080
HSP118119322 118119434 118119503 118119505 118120876
PPLT128437470 128453113 128453899(capn8)
SMAU118283772 118283773 118312232 118312235(capn2l) 118312236(capn2b)
LCF108877132 108877133(capn8) 108882289
SDU111220638 111220639 111237555 111237556 111237557
SLAL111649592 111658604 111669521 111669522
XGL120796274 120796275 120800453(capn2l) 120800454(capn8) 120800455(capn2b)
HCQ109516162 109527604
SSCV125968492 125978751
SBIA133505698 133509944
PEE133403937 133410220 133410221
PTAO133476952 133485740 133485741
BPEC110156974 110156975 110166012
ENY140350952 140351565 140365137 140375899
MALB109960723 109971792 109971799 109971826
BSPL114857498 114857509(capn2b) 114870532 114870586 114870587
SJO128357669 128373143 128373144 128375865 128378195
SSCO133976931 133992285 133992369 134000275
GMH115539934 115539935 115559787
SASA106565007 106565009 106578800 106578801 106584767 106589959 106589985
STRU115155631 115155640 115201755 115201756 115208449 115208455
OTW112223208 112223950 112236240 112266430(capn8) 112266436
OMY100135837 100136224(capn2) 110491224 110491235 110493820(capn8)
OGO124002438 124003579(capn8) 124039071 124048054 124048056
ONE115107157 115122462 115126231 115142697 115142699
OKI109879240 109880977 109890699 109890707 116355398
OKE118376416 118379311 118379869 118389064 118389067(capn8)
OMM135505262 135505264 135539481
OCLA139367880 139367881 139369375 139370607 139377011
SALP111960924 111960936
SNH120022367(capn8) 120029335 120045314 120045401 120064858
CCLU121555339 121572329 121572330(capn8) 121580572 121580650 123484545
ELS105028009 105028010 105031125
OEP134008523 134008524(capn8) 134022287
SFM108927097 108927098 108927128 108933713 108933714
PKI111835677 111841738 111852308 111852340 111852381 111852382
AANG118212877 118212878 118217793(capn2a) 118218445 118218446(capn8) 118220682 118220959
AROT135239032 135245073(capn8) 135245074(capn2a) 135245220 135245571 135249567
CCOG133115141(capn8) 133116027 133116505 133118029 133118365 133118366
LOC102683469 102686084 102686287
PSPA121315710 121315712 121316792 121316797 121316798
ARUT117402852 117403231 117403377 117410845 117410846 117411201
PSEX120516279(capn8) 120516295(capn2l) 120516636 120516907
LCM102347065(CAPN2)
CMK103177931
HOC132819701 132830514
LERI129699624
HAKA140730337 140733023
PMRN116943157
AGIF122847603 122849323
TPAL117639677
PVUL126817811
GAE121379756 121386152 121386313
HRF124115873 124136697 124145344
HRJ124274220 124291720
HASI137256212 137256542 137276711
HCRA139459127 139464408 139470348
CVN111110708 111127234
OED125666590
AIRR138329990
MMER123566327
RPHI132718623 132745282
DPOL127877971
MAEA128228716
OSN115209388
LJP135482163
 » show all
Reference
1  [PMID:10639123]
  Authors
Strobl S, Fernandez-Catalan C, Braun M, Huber R, Masumoto H, Nakagawa K, Irie A, Sorimachi H, Bourenkow G, Bartunik H, Suzuki K, Bode W.
  Title
The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium.
  Journal
Proc Natl Acad Sci U S A 97:588-92 (2000)
DOI:10.1073/pnas.97.2.588
  Sequence
[hsa:824]
Reference
2  [PMID:12014988]
  Authors
Dutt P, Spriggs CN, Davies PL, Jia Z, Elce JS
  Title
Origins of the difference in Ca2+ requirement for activation of mu- and m-calpain.
  Journal
Biochem J 367:263-9 (2002)
DOI:10.1042/BJ20020485
Other DBs
ExplorEnz - The Enzyme Database: 3.4.22.53
IUBMB Enzyme Nomenclature: 3.4.22.53
ExPASy - ENZYME nomenclature database: 3.4.22.53
BRENDA, the Enzyme Database: 3.4.22.53
CAS: 702693-80-9

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