EC                Enzyme                                 

calpain p94;
muscle calpain;
calpain 3;
calcium-activated neutral proteinase 3;
muscle-specific calcium-activated neutral protease 3;
calpain L3
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
Broad endopeptidase activity
This Ca2+-dependent enzyme is found in skeletal muscle and is genetically linked to limb girdle muscular dystrophy type 2A [1,4]. The enzyme is activated by autoproteolytic cleavage of insertion sequence 1 (IS1), which allows substrates and inhibitors gain access to the active site [4]. Substrates include the protein itself [3,4] and connectin/titin [2,5]. Belongs in peptidase family C2.
EC created 2007
K08573  calpain-3
HSA: 825(CAPN3)
PPS: 100984344(CAPN3)
PON: 100449804(CAPN3)
MCC: 707913(CAPN3)
MCF: 102115794(CAPN3)
CSAB: 103245772(CAPN3)
CATY: 105574217(CAPN3)
PANU: 101003739(CAPN3)
RRO: 104665262(CAPN3)
RBB: 108521152(CAPN3)
TFN: 117070804(CAPN3)
PTEH: 111529157
SBQ: 101035050(CAPN3)
MMUR: 105872501(CAPN3)
MMU: 12335(Capn3)
MCAL: 110309710(Capn3)
MPAH: 110318292(Capn3)
RNO: 29155(Capn3)
MCOC: 116090761(Capn3)
CGE: 100758723(Capn3)
PLEU: 114681123(Capn3)
NGI: 103744953(Capn3)
HGL: 101707543(Capn3)
CCAN: 109690734(Capn3)
OCU: 100008726(CAPN3)
OPI: 101533222(CAPN3)
TUP: 102468105(CAPN3)
CFA: 100856545(CAPN3)
VVP: 112919983(CAPN3)
VLG: 121485770(CAPN3)
AML: 100478387(CAPN3)
UMR: 103673424(CAPN3)
UAH: 113241990(CAPN3)
ORO: 101384331(CAPN3)
ELK: 111160918
MPUF: 101675191(CAPN3)
EJU: 114201673(CAPN3)
MLX: 118003460(CAPN3)
FCA: 101081304(CAPN3)
PYU: 121041570(CAPN3)
PBG: 122467655(CAPN3)
PTG: 102962051(CAPN3)
PPAD: 109263103(CAPN3)
AJU: 106968505(CAPN3)
HHV: 120232213(CAPN3)
BTA: 281663(CAPN3)
BOM: 102284625(CAPN3)
BIU: 109564987(CAPN3)
BBUB: 102393431(CAPN3)
CHX: 102189762(CAPN3)
OAS: 443038(CAPN3)
ODA: 120853162(CAPN3)
CCAD: 122443440(CAPN3)
SSC: 397349(CAPN3)
CFR: 102518250(CAPN3)
CBAI: 105076938(CAPN3)
CDK: 105101740(CAPN3)
LVE: 103088026(CAPN3)
OOR: 101289409(CAPN3)
DLE: 111181696(CAPN3)
PCAD: 102985687(CAPN3)
ECB: 100056798(CAPN3)
EPZ: 103549943(CAPN3)
EAI: 106841338(CAPN3)
MYB: 102245181(CAPN3)
MYD: 102768421(CAPN3)
MMYO: 118650353(CAPN3)
MNA: 107536546(CAPN3)
PKL: 118722897(CAPN3)
DRO: 112311921(CAPN3)
AJM: 119061279(CAPN3)
MMF: 118641423(CAPN3)
PALE: 102886269(CAPN3)
PGIG: 120622749(CAPN3)
RAY: 107510930(CAPN3)
MJV: 108386637(CAPN3)
TOD: 119238530(CAPN3)
LAV: 100667912(CAPN3)
TMU: 101356561
MDO: 100010062(CAPN3)
SHR: 100916328(CAPN3)
PCW: 110223679(CAPN3)
OAA: 100084116(CAPN3)
GGA: 423233(CAPN3)
MGP: 100546035(CAPN3)
CJO: 107314753(CAPN3)
NMEL: 110401942(CAPN3)
APLA: 101792647(CAPN3)
ACYG: 106042918(CAPN3)
TGU: 100225837(CAPN3)
LSR: 110472120(CAPN3)
SCAN: 103826645(CAPN3)
PMOA: 120500534(CAPN3)
OTC: 121335792(CAPN3)
PRUF: 121349554(CAPN3)
GFR: 102042342(CAPN3)
FAB: 101814350(CAPN3)
PHI: 102107172(CAPN3)
PMAJ: 107205589(CAPN3)
CCAE: 111930233(CAPN3)
CCW: 104698659(CAPN3)
ETL: 114056480(CAPN3)
FPG: 101924532(CAPN3)
FCH: 102055944(CAPN3)
CLV: 102094715(CAPN3)
EGZ: 104127554(CAPN3)
NNI: 104020344(CAPN3)
ACUN: 113480542(CAPN3)
PADL: 103912804(CAPN3)
AROW: 112964040(CAPN3)
NPD: 112942521(CAPN3)
DNE: 112980626(CAPN3)
ASN: 102379878(CAPN3)
AMJ: 102577345(CAPN3)
CPOO: 109321300(CAPN3)
GGN: 109298795(CAPN3)
PSS: 102450185(CAPN3)
CMY: 102936637(CAPN3)
CPIC: 101952809(CAPN3)
TST: 117876784(CAPN3)
CABI: 116825465(CAPN3)
ACS: 100559629(capn3)
PVT: 110079031(CAPN3)
PBI: 103066997(CAPN3)
PMUR: 107295757(CAPN3)
TSR: 106547747(CAPN3)
PGUT: 117665635(CAPN3)
PMUA: 114594341(CAPN3)
ZVI: 118083644(CAPN3)
GJA: 107117895(CAPN3)
XLA: 100125665(capn3.L) 108700461
XTR: 100497532(capn3)
NPR: 108797818(CAPN3)
DRE: 447832(capn3a)
SANH: 107664429(capn3)
SGH: 107586853
IPU: 108269768
PHYP: 113538734
EEE: 113587020
TRU: 101077986(capn3)
LCO: 104936553
CGOB: 115027228(capn3)
ELY: 117267460(capn3a)
PLEP: 121953730(capn3a)
SLUC: 116057697(capn3a)
ECRA: 117936309(capn3a)
PFLV: 114546330(capn3)
GAT: 120833187(capn3a)
PPUG: 119227420(capn3a)
MSAM: 119909908(capn3a)
CUD: 121526230(capn3a)
MZE: 101466182(capn3)
ONL: 100691885(capn3)
OAU: 116318066(capn3a)
OLA: 101157263
OML: 112144429(capn3a)
XMA: 102221680(capn3)
XCO: 114134598(capn3)
XHE: 116708429(capn3)
PRET: 103458212(capn3)
CVG: 107096801(capn3)
CTUL: 119779718(capn3a)
NFU: 107391866(capn3)
KMR: 108234555(capn3a)
ALIM: 106524302(capn3)
AOCE: 111587838
CSEM: 103381555
POV: 109644862
LCF: 108876634(capn3)
SDU: 111225368(capn3)
SLAL: 111646798(capn3)
XGL: 120795487(capn3a)
HCQ: 109517476(capn3)
BPEC: 110157545(capn3)
MALB: 109962461(capn3)
SASA: 106568467(capn3) 106611143
OTW: 112249945(capn3b)
OMY: 110498417 110505915(capn3a)
SNH: 120035919(capn3a)
ELS: 105015896(capn3)
SFM: 108924080
PKI: 111859952(capn3)
AANG: 118223800(capn3a) 118229185
LOC: 102695785(capn3)
PSPA: 121324768
ARUT: 117422311(capn3a)
LCM: 102358118(CAPN3)
BFO: 118430052
BBEL: 109472173
CIN: 100185355
SCLV: 120327282
NLU: 120353930
HAME: 121860621
EAF: 111705561
BGT: 106078254
GAE: 121378117
 » show all
1  [PMID:2555341]
Sorimachi H, Imajoh-Ohmi S, Emori Y, Kawasaki H, Ohno S, Minami Y, Suzuki K.
Molecular cloning of a novel mammalian calcium-dependent protease distinct from both m- and mu-types. Specific expression of the mRNA in skeletal muscle.
J Biol Chem 264:20106-11 (1989)
[hsa:825] [rno:29155]
2  [PMID:8537379]
Sorimachi H, Kinbara K, Kimura S, Takahashi M, Ishiura S, Sasagawa N, Sorimachi N, Shimada H, Tagawa K, Maruyama K, et al.
Muscle-specific calpain, p94, responsible for limb girdle muscular dystrophy type 2A, associates with connectin through IS2, a p94-specific sequence.
J Biol Chem 270:31158-62 (1995)
3  [PMID:12482600]
Rey MA, Davies PL.
The protease core of the muscle-specific calpain, p94, undergoes Ca2+-dependent intramolecular autolysis.
FEBS Lett 532:401-6 (2002)
4  [PMID:16533054]
Garcia Diaz BE, Gauthier S, Davies PL.
Ca2+ dependency of calpain 3 (p94) activation.
Biochemistry 45:3714-22 (2006)
5  [PMID:16627476]
Ono Y, Torii F, Ojima K, Doi N, Yoshioka K, Kawabata Y, Labeit D, Labeit S, Suzuki K, Abe K, Maeda T, Sorimachi H.
Suppressed disassembly of autolyzing p94/CAPN3 by N2A connectin/titin in a genetic reporter system.
J Biol Chem 281:18519-31 (2006)
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