KEGG   ENZYME: 3.4.22.55
Entry
EC 3.4.22.55                Enzyme                                 
Name
caspase-2;
ICH-1;
NEDD-2;
caspase-2L;
caspase-2S;
neural precursor cell expressed developmentally down-regulated protein 2;
CASP-2;
NEDD2 protein
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
Reaction(IUBMB)
Strict requirement for an Asp residue at P1, with Asp316 being essential for proteolytic activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp!
Comment
Caspase-2 is an initiator caspase, as are caspase-8 (EC 3.4.22.61), caspase-9 (EC 3.4.22.62) and caspase-10 (EC 3.4.22.63) [6]. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation [6]. Two forms of caspase-2 with antagonistic effects exist: caspase-2L induces programmed cell death and caspase-2S suppresses cell death [2,3,5]. Caspase-2 is activated by caspase-3 (EC 3.4.22.56), or by a caspase-3-like protease. Activation involves cleavage of the N-terminal prodomain, followed by self-proteolysis between the large and small subunits of pro-caspase-2 and further proteolysis into smaller fragments [3]. Proteolysis occurs at Asp residues and the preferred substrate for this enzyme is a pentapeptide rather than a tetrapeptide [5]. Apart from itself, the enzyme can cleave golgin-16, which is present in the Golgi complex and has a cleavage site that is unique for caspase-2 [4,5]. alphaII-Spectrin, a component of the membrane cytoskeleton, is a substrate of the large isoform of pro-caspase-2 (caspase-2L) but not of the short isoform (caspase-2S). Belongs in peptidase family C14.
History
EC 3.4.22.55 created 2007
Orthology
K02186  caspase 2
Genes
HSA835(CASP2)
PTR463804(CASP2)
PPS100984572(CASP2)
GGO101128958(CASP2)
PON100454928(CASP2)
NLE100599260(CASP2)
MCC704339(CASP2)
MCF102128712(CASP2)
MTHB126951062
CSAB103227412(CASP2)
CATY105584645(CASP2)
PANU101006276(CASP2)
TGE112620420(CASP2)
RRO104674919(CASP2)
RBB108544234(CASP2)
TFN117072364(CASP2)
PTEH111521444(CASP2)
CJC100402493(CASP2)
SBQ101040888(CASP2)
CSYR103271043(CASP2)
MMUR105873292(CASP2)
LCAT123647584(CASP2)
OGA100963099(CASP2)
MMU12366(Casp2)
MCAL110296109(Casp2)
MPAH110316173(Casp2)
RNO64314(Casp2)
MCOC116098811(Casp2)
MUN110558418(Casp2)
CGE100689445(Casp2)
MAUA101832827(Casp2)
PLEU114698017(Casp2)
MORG121435560(Casp2)
MFOT126496292 126515102
AAMP119806861(Casp2)
NGI103730398(Casp2)
HGL101712106(Casp2)
CPOC100735399(Casp2)
CCAN109697479(Casp2)
DORD105989490(Casp2)
DSP122105905(Casp2)
NCAR124991564
OCU100101590(CASP2)
OPI101521745(CASP2)
TUP102498970(CASP2)
CFA482737(CASP2)
CLUD112650936(CASP2)
VVP112934814(CASP2)
VLG121488914(CASP2)
AML100474060(CASP2)
UMR103668980(CASP2)
UAH113265500(CASP2)
UAR123788834(CASP2)
ELK111152078
LLV125080608
MPUF101674782(CASP2)
ORO101384305(CASP2)
EJU114211737(CASP2)
ZCA113911860(CASP2)
MLX118021190(CASP2)
NSU110582867(CASP2)
FCA101088318(CASP2)
PYU121028175(CASP2)
PBG122488449(CASP2)
LRUF124524191
PTG102948856(CASP2)
PPAD109269169(CASP2)
AJU106980767(CASP2)
HHV120239002(CASP2)
BTA531419(CASP2)
BOM102272786(CASP2)
BIU109557747(CASP2)
BBUB102407716(CASP2)
CHX102183569(CASP2)
OAS101115025(CASP2)
ODA120877702(CASP2)
CCAD122438770(CASP2)
SSC100521118(CASP2)
CFR102508934(CASP2)
CBAI105069548(CASP2)
CDK105105559(CASP2)
VPC102534115(CASP2)
BACU103017857(CASP2)
LVE103085195(CASP2)
OOR101271768(CASP2)
DLE111177325(CASP2)
PCAD102982974(CASP2)
PSIU116759648(CASP2)
ECB100050611(CASP2)
EPZ103562808(CASP2)
EAI106833854(CASP2)
MYB102264102(CASP2)
MYD102774985(CASP2)
MMYO118666310(CASP2)
MLF102430756(CASP2)
MNA107523761(CASP2)
PKL118714167(CASP2)
HAI109376369(CASP2)
DRO112316166(CASP2)
SHON118997005(CASP2)
AJM119060599(CASP2)
PDIC114507769(CASP2)
PHAS123831001(CASP2)
MMF118620397(CASP2)
RFQ117018233(CASP2)
PALE102895485(CASP2)
PGIG120600953(CASP2)
PVP105304116(CASP2)
RAY107516993(CASP2)
MJV108404389(CASP2)
TOD119248048(CASP2)
SARA101557433(CASP2)
LAV100661506(CASP2)
TMU101361957
DNM101434852(CASP2)
MDO100011923(CASP2)
GAS123249181(CASP2)
SHR100919881(CASP2)
PCW110216131(CASP2)
OAA100074924(CASP2)
GGA395857(CASP2)
PCOC116239978(CASP2)
MGP100544010(CASP2)
CJO107319105(CASP2)
NMEL110398088(CASP2)
APLA101794734(CASP2)
ACYG106048728(CASP2)
AFUL116502385(CASP2)
TGU100221143(CASP2)
LSR110480764(CASP2)
SCAN103827175(CASP2)
PMOA120506440(CASP2)
OTC121335940(CASP2)
PRUF121354699(CASP2)
GFR102043378(CASP2)
FAB101805629(CASP2)
PHI102108085(CASP2)
PMAJ107210261(CASP2)
CCAE111938007(CASP2)
CCW104687148(CASP2)
CBRC103617161(CASP2)
ETL114065685(CASP2)
ZAB102066161(CASP2)
ACHL103803479(CASP2)
FPG101915905(CASP2)
FCH102048179(CASP2)
CLV102095337(CASP2)
EGZ104126551(CASP2)
NNI104009575(CASP2)
PLET104617509(CASP2)
PCRI104033567(CASP2)
ACUN113482177(CASP2)
TALA104355497(CASP2)
PADL103920778(CASP2)
AFOR103905468(CASP2)
ACHC115343994(CASP2)
HALD104313373(CASP2)
CCRI104154467(CASP2)
CSTI104560146
EHS104502630(CASP2)
CMAC104480293(CASP2)
MUI104541760(CASP2)
FGA104069274(CASP2)
GSTE104254525(CASP2)
LDI104339704(CASP2)
MNB103770425(CASP2)
OHA104327124(CASP2)
NNT104404497(CASP2)
DPUB104299465(CASP2)
ACAR104529932(CASP2)
AVIT104277165
CVF104293293(CASP2)
AAM106497280(CASP2)
AROW112973008(CASP2)
NPD112951710(CASP2)
TGT104564902(CASP2)
DNE112990867(CASP2)
SCAM104150733(CASP2)
ASN102377638(CASP2)
AMJ102558644(CASP2)
CPOO109318987(CASP2)
GGN109304524(CASP2)
PSS102463164(CASP2)
CMY102929343(CASP2)
CPIC101938497(CASP2)
TST117885444(CASP2)
CABI116815538(CASP2)
MRV120375179(CASP2)
ACS100567806(casp2)
PVT110091477(CASP2)
SUND121920580(CASP2)
PBI103051794(CASP2)
PMUR107289968(CASP2)
CTIG120306071(CASP2)
TSR106546743(CASP2)
PGUT117661785(CASP2)
VKO123028058(CASP2)
PMUA114587363(CASP2)
ZVI118075180(CASP2)
GJA107115535(CASP2)
STOW125437119(CASP2)
XLA108697326 397817(casp2.L)
XTR100486813(casp2)
NPR108784894(CASP2)
RTEM120946867(CASP2)
BBUF121004327(CASP2)
BGAR122940296(CASP2)
DRE373118(casp2)
SRX107744674 107748817
SANH107685580 107699940(casp2)
SGH107569996(casp2) 107596737
CCAR109085235 109105725 109105733
CAUA113060139 113116229
PPRM120495040(casp2)
MAMB125244106(casp2)
IPU108268399(casp2)
PHYP113533689(casp2)
SMEO124385013(casp2)
TFD113644153(casp2)
AMEX103030250(casp2)
EEE113575293(casp2)
TRU101072588(casp2)
TNGGSTEN00015350G001
LCO104929017(casp2)
NCC104954509
CGOB115021650(casp2)
ELY117266305(casp2)
EFO125893125(casp2)
PLEP121945259(casp2)
SLUC116049656(casp2)
ECRA117946229(casp2)
ESP116674610 116691243(casp2)
PFLV114557483(casp2)
GAT120810840(casp2)
PPUG119197234(casp2)
MSAM119897458(casp2)
CUD121513407(casp2)
ALAT119006337(casp2)
MZE101470507(casp2)
ONL100703280(casp2)
OAU116323771(casp2)
OLA101171774(casp2)
OML112143669(casp2)
XMA102216745(casp2)
XCO114142068(casp2)
XHE116715507(casp2)
PRET103478021(casp2)
PFOR103136717(casp2)
PLAI106952586(casp2)
PMEI106916578(casp2)
GAF122831031(casp2)
CVG107082265(casp2)
CTUL119783113(casp2)
GMU124866040(casp2)
NFU107379433(casp2)
KMR108235415(casp2)
ALIM106520479(casp2)
NWH119409340(casp2)
AOCE111586367(casp2)
MCEP125017067(casp2)
CSEM103387931(casp2)
POV109633282(casp2)
SSEN122774915(casp2)
HHIP117776801(casp2)
HSP118113201(casp2)
LCF108887338
SDU111230073(casp2)
SLAL111669846(casp2)
XGL120783990(casp2)
HCQ109515309(casp2)
BPEC110163095(casp2)
MALB109966150(casp2)
BSPL114842940(casp2)
SASA106576719 106591706 106605831
STRU115176571(casp2) 115187894
OTW112225903(casp2) 112253770
OMY110509281 110537322(casp2)
OGO123998118 124006155
ONE115140808(casp2)
SALP111964847(casp2)
SNH120031202 120047724
CCLU121542975 121586223
ELS105019056(casp2)
SFM108924035(casp2)
PKI111833972(casp2)
AANG118213118(casp2)
LOC102696227
PSPA121325365(casp2)
ARUT117425205(casp2)
LCM102349624(CASP2)
BFO118409150 118424979 118425349 118430265 118430471 118432211
BBEL109463126 109464943 109469527 109472931 109484124 109486134 109486423 109487213
CIN100177955 100185724 100186877
SCLV120328281 120328394 120328429 120328437 120328561 120330725 120330783 120331055 120331321 120331427 120332053 120332057 120333296 120335043 120341081 120347096
BCOO119079878 119080014 119083223
FAS105264965
DAM107043402
SOY115885114
CSET123313332 123314254
AGB108915730
LDC111517097
HHAL106679793 106679794 106692455 106692462
TPAL117645803
DMK116919288
PVM113815986
PJA122243890 122243891 122244216 122244446 122245056 122245057 122256802 122257482 122257483 122257485 122260554 122263094 122266355
PCHN125028142 125029737 125032519 125038516 125038661 125041106 125041107 125041314
HAME121855528 121862919 121867711 121873881 121879450
PCLA123745763 123754306 123756154 123763565
PTRU123501256 123510132 123516621
HAZT108665303 108666522 108670568
LSM121114714
PPOI119092901
DSV119445431
RSAN119390615 119390616 119398843
RMP119163741
VDE111249789
VJA111263318
LOALOAG_03664
HROHELRODRAFT_177179
LGILOTGIDRAFT_236948
PCAN112556116 112556538 112556707 112557443
BGT106055445 106061941 106067681
GAE121372701 121373401 121390165 121390245 121390246 121390247 121390352 121390424 121390558 121390663
HRF124110783 124112468 124117145 124117732 124123912 124131199 124137147
HRJ124254802 124257484 124261785 124265586 124269445 124278193 124279710 124281642 124286221
CRG105318726 105319473 105320022 105322339 105325341 105336315 105347532 117681574 117685088 117685130 117685157 117685551 117685688 117685692 117685846 117685890 117686000 117686111 117686190 117686957 117687343 117688244 117690840 117691394 117691848
MYI110449061 110461055
PMAX117314630 117314633 117314695 117314821 117315454 117323289 117327753 117327805 117345248
MMER123527379 123527584 123543142 123561121
OBI106869844 106878642
OSN115209565 115221437
LAK106156302 106157002 106162784 106178017 106178332
SMMSmp_032000
OVIT265_00765
EGLEGR_04133 EGR_04138
NVE5511249
ADF107345198
AMIL114961896
SPIS111329232 111336048
XEN124437949
TAES123139565
 » show all
Reference
1  [PMID:7958843]
  Authors
Kumar S, Kinoshita M, Noda M, Copeland NG, Jenkins NA
  Title
Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme.
  Journal
Genes Dev 8:1613-26 (1994)
DOI:10.1101/gad.8.14.1613
  Sequence
[mmu:12366]
Reference
2  [PMID:8087842]
  Authors
Wang L, Miura M, Bergeron L, Zhu H, Yuan J.
  Title
Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death.
  Journal
Cell 78:739-50 (1994)
DOI:10.1016/S0092-8674(94)90422-7
  Sequence
[hsa:835]
Reference
3  [PMID:9261102]
  Authors
Li H, Bergeron L, Cryns V, Pasternack MS, Zhu H, Shi L, Greenberg A, Yuan J.
  Title
Activation of caspase-2 in apoptosis.
  Journal
J Biol Chem 272:21010-7 (1997)
DOI:10.1074/jbc.272.34.21010
Reference
4  [PMID:10791974]
  Authors
Mancini M, Machamer CE, Roy S, Nicholson DW, Thornberry NA, Casciola-Rosen LA, Rosen A.
  Title
Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis.
  Journal
J Cell Biol 149:603-12 (2000)
DOI:10.1083/jcb.149.3.603
  Sequence
[hsa:2802]
Reference
5  [PMID:15865942]
  Authors
Zhivotovsky B, Orrenius S.
  Title
Caspase-2 function in response to DNA damage.
  Journal
Biochem Biophys Res Commun 331:859-67 (2005)
DOI:10.1016/j.bbrc.2005.03.191
Reference
6  [PMID:11104820]
  Authors
Chang HY, Yang X.
  Title
Proteases for cell suicide: functions and regulation of caspases.
  Journal
Microbiol Mol Biol Rev 64:821-46 (2000)
DOI:10.1128/mmbr.64.4.821-846.2000
Other DBs
ExplorEnz - The Enzyme Database: 3.4.22.55
IUBMB Enzyme Nomenclature: 3.4.22.55
ExPASy - ENZYME nomenclature database: 3.4.22.55
BRENDA, the Enzyme Database: 3.4.22.55
CAS: 182372-14-1

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