KEGG   ENZYME: 3.4.22.60
Entry
EC 3.4.22.60                Enzyme                                 
Name
caspase-7;
CASP-7;
ICE-like apoptotic protease 3;
ICE-LAP3;
apoptotic protease Mch-3;
Mch3;
CMH-1
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
Reaction(IUBMB)
Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Asp-Glu-Val-Asp!
Comment
Caspase-7 is an effector/executioner caspase, as are caspase-3 (EC 3.4.22.56) and caspase-6 (EC 3.4.22.59) [1]. These caspases are responsible for the proteolysis of the majority of cellular polypeptides [e.g. poly(ADP-ribose) polymerase (PARP)], which leads to the apoptotic phenotype [2]. Although a hydrophobic residue at P5 of caspase-2 (EC 3.4.22.55) and caspase-3 leads to more efficient hydrolysis, the amino-acid residue at this location in caspase-7 has no effect [3]. Caspase-7 is activated by the initiator caspases [caspase-8 (EC 3.4.22.61), caspase-9 (EC 3.4.22.62) and caspase-10 (EC 3.4.22.63)]. Removal of the N-terminal prodomain occurs before cleavage in the linker region between the large and small subunits [4]. Belongs in peptidase family C14.
History
EC 3.4.22.60 created 2007
Orthology
K04397  caspase 7
Genes
HSA840(CASP7)
PTR450745(CASP7)
PPS100985952(CASP7)
GGO101147760(CASP7)
PON100435918(CASP7)
MCC697633(CASP7)
MCF102127213(CASP7)
CSAB103216537(CASP7)
CATY105577913(CASP7)
PANU100999117(CASP7)
TGE112631724(CASP7)
RRO104662231(CASP7)
RBB108542466(CASP7)
TFN117066706(CASP7)
PTEH111538909(CASP7)
CJC100386577(CASP7)
SBQ101036039(CASP7)
CSYR103252552(CASP7)
MMUR105875340(CASP7)
OGA100942180(CASP7)
MMU12369(Casp7)
MCAL110285885(Casp7)
MPAH110328167(Casp7)
RNO64026(Casp7)
MCOC116104023(Casp7) 116104574
MUN110545113(Casp7)
CGE100766857(Casp7)
PLEU114697063(Casp7)
NGI103731752(Casp7)
HGL101709568(Casp7)
CPOC100715159(Casp7)
CCAN109688558(Casp7)
DORD105986773(Casp7)
DSP122115995(Casp7)
NCAR124985521
OCU100101591(CASP7)
OPI101528295(CASP7)
TUP102470949(CASP7)
CFA486896(CASP7)
VVP112916200(CASP7)
VLG121485514(CASP7)
AML100471992(CASP7)
UMR103657312(CASP7)
UAH113251949(CASP7)
UAR123795973(CASP7)
ELK111145267
LLV125084583
MPUF101683818(CASP7)
ORO101363955(CASP7)
EJU114223033(CASP7)
ZCA113923463(CASP7)
MLX118026509(CASP7)
FCA768262(CASP7)
PYU121037247(CASP7)
PBG122493262(CASP7)
PTG102951959(CASP7)
PPAD109272923(CASP7)
AJU106974123(CASP7)
HHV120235365(CASP7)
BTA526279(CASP7)
BOM102271384(CASP7)
BIU109553157(CASP7)
BBUB102397231(CASP7)
CHX100861343(CASP7)
OAS101122741(CASP7)
ODA120873906(CASP7)
CCAD122446263(CASP7)
SSC100156777(CASP7)
CFR102509752(CASP7)
CBAI105080743(CASP7)
CDK105091687(CASP7)
VPC102536869(CASP7)
BACU103013605(CASP7)
LVE103083104(CASP7)
OOR101287199(CASP7)
DLE111172296(CASP7)
PCAD102974187(CASP7)
PSIU116742039(CASP7)
ECB100068258(CASP7)
EPZ103540204(CASP7)
EAI106848104(CASP7)
MYB102243767(CASP7)
MYD102768516(CASP7)
MMYO118669734(CASP7)
MLF102430193(CASP7)
MNA107536472(CASP7)
PKL118719495(CASP7)
HAI109384919(CASP7)
DRO112300184(CASP7)
SHON118999405(CASP7)
AJM119040063(CASP7) 119055055
PDIC114497398(CASP7)
PHAS123828762(CASP7)
MMF118632454(CASP7)
RFQ117036398(CASP7)
PALE102879606(CASP7)
PGIG120609077(CASP7)
PVP105291475(CASP7)
RAY107511708(CASP7)
MJV108384433(CASP7)
TOD119233843(CASP7) 119233844
SARA101536946(CASP7)
LAV100670890(CASP7)
TMU101346298
DNM101429170(CASP7)
MDO100027500(CASP7)
GAS123238175(CASP7) 123254583
SHR100927801(CASP7)
PCW110209601(CASP7)
OAA100082745(CASP7) 114817891
GGA423901(CASP7)
PCOC116231613(CASP7)
MGP100546410(CASP7)
CJO107316128(CASP7)
NMEL110400168(CASP7)
APLA101799962(CASP7) 101800944
ACYG106031898(CASP7) 106048888
AFUL116491407(CASP7) 116499313
TGU100218002(CASP7)
LSR110468271(CASP7)
SCAN103813818(CASP7)
PMOA120502211(CASP7)
OTC121341938(CASP7)
PRUF121350321(CASP7)
GFR102032484(CASP7)
FAB101807080(CASP7)
PHI102112480(CASP7)
PMAJ107207062(CASP7)
CCAE111931322(CASP7)
CCW104695187(CASP7)
ETL114066978(CASP7)
ZAB102061989(CASP7)
FPG101911113(CASP7)
FCH102047023(CASP7)
CLV102084230(CASP7)
EGZ104123620(CASP7)
NNI104022338(CASP7)
ACUN113481788(CASP7) 113490234
TALA104361444(CASP7) 104362344
PADL103918570(CASP7)
ACHC115347960(CASP7) 115349915
AAM106483734(CASP7)
AROW112968031(CASP7)
NPD112957190(CASP7)
DNE112993680(CASP7)
ASN102375360(CASP7)
AMJ102566884(CASP7)
CPOO109324255(CASP7) 109324644
GGN109286694 109287627(CASP7)
PSS102455743 102458724(CASP7)
CMY102931635 102934687(PLEKHS1) 114018624(CASP7)
CPIC101936900(CASP7) 101949026
TST117872876 117880658(CASP7)
CABI116820740 116821743(CASP7)
MRV120399323 120409074(CASP7)
ACS100563813(casp7)
PVT110071974(CASP7) 110084328
SUND121925218(CASP7) 121934729
PBI103054928(CASP7) 103066503
PMUR107286243 107291550(CASP7)
TSR106545868(CASP7) 106555302
PGUT117677061 117678719(CASP7)
VKO123027053 123027901(CASP7)
PMUA114597474(CASP7)
ZVI118093559(CASP7)
GJA107117397 107122431
STOW125437375(CASP7) 125441779
XLA100037079(casp7.S) 108711587(XB5812047.L) 108712725 397819(casp7.L)
XTR549053(casp7) 733553
NPR108792468 108793513(CASP7)
RTEM120933073 120946831(CASP7)
BBUF120987211 121003754(CASP7)
BGAR122929475 122940313(CASP7)
DRE100331324(casp21) 553634(casp7) 798445
SRX107705510 107707870 107740219 107746199 107755536(casp7) 107758576 107758655
SANH107658598 107658599 107662725 107684033 107689250 107689777 107701921 107702451(casp7)
SGH107558111 107558112 107566160 107578309 107579886 107581558 107584640 107602036 107602063
CCAR109050440 109061445 109061475 109064749 109076849 109079949 109099653(casp7) 109099719
CAUA113054568 113054569 113054872 113063759 113076928 113102528 113110248 113110500 113111581
PPRM120474601(casp7) 120491456(casp21)
MAMB125253569(casp21) 125255638(casp7)
IPU108273727(casp7)
PHYP113527344(casp7) 113543971
SMEO124388868(casp7)
TFD113638889 113638890 113638891 113643355 113643356
AMEX103041716(casp7)
EEE113586620(casp7)
TRU101068895(casp7) 101074856
TNGGSTEN00015090G001 GSTEN00025416G001 GSTEN00034975G001
LCO104927890(casp7) 104937898
NCC104942136(casp7)
CGOB115016952 115024673(casp7)
ELY117247638(casp7) 117269417
PLEP121958571(casp7)
SLUC116041859 116041861 116061247(casp7)
ECRA117936824(casp7) 117959744
PFLV114548038(casp7) 114571494
GAT120813523 120819358(casp7) 120831648
PPUG119212792(casp7) 119226884
MSAM119914744 119916041(casp7) 119919358
CUD121528758(casp7)
MZE101466737 101468707 101473187(casp7)
ONL100705447 100705706 100708873(casp7)
OAU116321289 116321418 116329808(casp7)
OLA101156378 101161677(casp7)
OML112154505(casp7) 112162928(casp17)
XMA102218392 102230553(casp7)
XCO114150095 114152207(casp7)
XHE116723800 116726736(casp7)
PRET103473137 103481281(casp7)
PFOR103153213 103153381(casp7)
PLAI106948312(casp7) 106963693
PMEI106907578(casp7) 106931868
GAF122819312(casp17) 122823254(casp7)
CVG107094701(casp7) 107096398
CTUL119777624 119780490(casp7)
GMU124872805 124875343(casp7)
NFU107387877(casp7)
KMR108242539 108246368(casp7)
ALIM106513803 106516949(casp7)
NWH119423641(casp7) 119424442(casp17)
AOCE111567292(casp7)
CSEM103381449(casp7) 103389354
POV109644782(casp7) 109648155
SSEN122758623 122759030(casp7)
HHIP117752570(casp7)
LCF108895937 108895947 108898722(casp7)
SDU111219886(casp7) 111224299
SLAL111664455 111669656(casp7)
XGL120793897(casp7)
HCQ109523912
BPEC110154157(casp7) 110161916
MALB109951188 109963005(casp7)
SASA106568012 106578356(casp7)
OTW112224061(casp7) 112230827
OMY110498822(casp7) 110516770
OGO124039943(casp7)
ONE115101020 115121027 115143950(casp7)
SALP111961772 111963622 111976969(casp7)
SNH120021869 120026227 120060921(casp7)
ELS105015185 105026234(casp7)
SFM108923620 108940466(casp7)
PKI111836049(casp7) 111837755
AANG118220445(casp7) 118231433
LOC102691279(casp7) 102693931
PSPA121302301 121303085 121320517 121322130 121326143(casp7)
ARUT117397812 117414465 117417933 117420466 117968959
LCM102357990(CASP7) 102367521
CMK103172118(casp7) 103172119
RTP109923449 109929106(casp7)
BFO118407807 118411406 118411417 118415634 118419156 118430457 118432249
BBEL109468013 109470881 109481307 109481366
CIN100175569 100175572 100176782 100177694 100178691 100185209 494382
SCLV120331606 120332051 120332231 120333241 120334940 120342079 120347763
SPU115918952 115921557
APLC110978834 110978835 110981895
SKO100371155 100373033 100373106 100374591 100374606 100376925 102803581 102806744
DMEDmel_CG14902(Decay) Dmel_CG7788(Drice)
DER26526264 6552618
DSE6612746
DSIDsimw501_GD20281(Dsim_GD20281) Dsimw501_GD21467(Dsim_GD21467)
DYADyak_GE23886 Dyak_GE26146
DAN6501437
DSR110176449 110191011
DPODpse_GA13340 Dpse_GA20588
DPE6588648 6598605
DMN108156639 108157734
DWI26529862 6646969 6647739 6647740 6647741
DGR6566647 6567727 6567728 6567811
DMODmoj_GI10391 Dmoj_GI22043 Dmoj_GI22869
DAZ108609625 108609645 108621217 108621386
DNV108659226 108660325 115562691 115562909
DHE111594818 111596107 111598807 111599126
DVI6631267
CCAT101449231 101454266 101459760 105664451
BOD106614590 106615177 106615221
MDE101889252(caspase-1) 101896713
SCAC106087832 106093599
LCQ111681534 111691111 111691144
AGAAgaP_AGAP000830(CASPS7) AgaP_AGAP004920(CASPS6) AgaP_AGAP004921(CASPS5) AgaP_AGAP004922(CASPS11) AgaP_AGAP009832(CASPS8) AgaP_AGAP010826(CASPS13) AgaP_AGAP011949(CASPS1) AgaP_AGAP011951(CASPS4) AgaP_AGAP012544(CASPS14) AgaP_AGAP012945
ACOZ120947599 120950965 120951392 120951393 120957130 120957642 120959057
AARA120895331 120895342 120895798 120896274 120896275 120896277 120900367 120900925 120901230 120903002 120905765
AAG5564196 5564917 5575873 5578111 5578112
AALB109399676 109400467 109427925 109427926 109427949 109428244 109428267 109431512 115253749 115253750 115256800 115256801 115256802 115266369 115271029
CQUCpipJ_CPIJ000671 CpipJ_CPIJ008093 CpipJ_CPIJ008252 CpipJ_CPIJ008253 CpipJ_CPIJ009056 CpipJ_CPIJ009057
CPII120414726 120414730 120416829 120416833 120422391 120424151 120428316
CNS116340652 116352091
AME100576484 412235
ACER107995721 107998622 108003290
ALAB122715062 122720329 122720916
BIM100743099 100746075
BBIF117208725 117214724
BVK117232171 117232191 117232386
BVAN117157820 117164750
BTER100645000 100646875
BPYO122567095 122573404 122573547
CCAL108625912
OBB114872021 114872480
MGEN117219775 117223909 117227399 117228331
NMEA116424466 116427803 116431717
CGIG122395435 122400486
SOC105193867 105194248 105198123 105201885 113005913
MPHA105832229 105836709 105837700
AEC105144642 105150894
ACEP105623746 105626959
PBAR105423294 105431912
VEM105559272 105567937 105568970
HST105181481 105184990 105185893
DQU106742148 106748001
CFO105250225 105250735 105252365
FEX115236258 115236718
LHU105671932 105674282 105675143
PGC109852283 109856752 109858528
OBO105278081 105278819
PCF106784538 106784872 106790912 106790913 106791068
PFUC122521067 122523332
VPS122628040 122628391 122629991 122637479
NVI100115867 100680489 103315801
CSOL105364891
TPRE106651222 106656095
MDL103572120 103578638
CGLO123262229 123270872
FAS105270368 105271107
DAM107043794
AGIF122848118 122855699
CCIN107265269 107272788
TCA655845
DPA109539488 109541949 109544766 109544773
SOY115885196 115886458 115886459
ATD109595512 109600499 109603613 109607706
CSET123309282 123313484 123318717 123322388
AGB108908184 108908189 108908304 108917125
LDC111509868 111510887 111516283 111517301
NVL108556664 108562135 108565953 108569306
APLN108733855 108742126
PPYR116176570 116180475
OTU111417231 111417440 111419159 111422164 111427097
BMOR692604(Caspase1) 692735(ICE)
BMAN114243240 114249132
MSEX115443475 115448329 115451794 119191711
DPLKGM_213029
BANY112054726 112058547
PMAC106718543
PPOT106099858 106109364
PXU106128394
PRAP110991328 110994624 110999004
ZCE119834942 119837516
HAW110371527 110371551
TNL113501324 113504388 113504517 113504518 113506916 113507749
SLIU111351893 111351894
OFU114361608 114364360 114366116 114366123 114366520
PXY105385382 105394672(caspase-1)
API100160647 100161906 100162302
DNX107162114 107168420
RMD113550549
BTAB109039243
DCI103507569
HHAL106680747
NLU111044000
PHUPhum_PHUM221390 Phum_PHUM536790
FOC113202699 113210200 113211468
ZNE110836372 110837449 110837734 110841540
CSEC111866127 111872158 111873682
FCD110843035 110861905
DPXDAPPUDRAFT_15026 DAPPUDRAFT_307426 DAPPUDRAFT_309162 DAPPUDRAFT_309167 DAPPUDRAFT_314077 DAPPUDRAFT_314078
DMK116919294 116919296 116931192
PVM113805238 113805778 113823293
PJA122254193 122265261
PCHN125025457 125038775 125038776
HAME121867139
PTRU123499123
HAZT108670557 108682707
EAF111699590 111699915 111710697 111710710 111713158
LSM121116019 121121326
ISCIscW_ISCW003039 IscW_ISCW013172 IscW_ISCW022545
DSV119433223 119437252
RSAN119391161 119404888 119404889 119405422
RMP119161026 119179024 119180863
VDE111255217
VJA111271978
TUT107359700
DPTE113798234
DFR124497214 124500011
CSCU111612965 111621489
PTEP107449048 107449050 107449060 107450427
HROHELRODRAFT_157123 HELRODRAFT_87042 HELRODRAFT_96017
LGILOTGIDRAFT_105903 LOTGIDRAFT_106792 LOTGIDRAFT_133150 LOTGIDRAFT_134426 LOTGIDRAFT_154123 LOTGIDRAFT_209997 LOTGIDRAFT_210703 LOTGIDRAFT_228982 LOTGIDRAFT_228989 LOTGIDRAFT_73381 LOTGIDRAFT_74313
PCAN112568690 112568719 112568728 112568743
BGT106054370 106054379 106060605 106073003 106075649 106077776 106078266 106078855
GAE121378490 121379720 121380083 121381619 121390503 121390783
HRF124112819 124120464 124124428 124124435 124124743 124124744 124132608 124132704 124132705 124138238 124149294 124149295 124149342 124149343 124149345 124149346 124149349 124149352 124149355 124151583
HRJ124277140 124277141 124277144 124277152 124277154 124277156 124277157 124280306 124283934 124283944 124283953 124291479
CRG105322178 105322179 105322180 105325186 105328531 105328899 105336650 105340742 105342048 105342049 105346972 105348272 109617035 109617112
MYI110445959 110445960 110446693 110450209 110458747 110462768 110463353 110464686 110466240 110467369 110467497
PMAX117317718 117322653 117322837 117323380 117323554 117323556 117323762 117324476 117325054 117332246 117334389 117336709 117343240 117343665
MMER123543143 123546363 123546364 123548934 123553921 123563302 123563866 123564308 123564393 123564573 123566401
OBI106867126 106870008 106871720 106872234 106872243 106872370 106872943 106872944 106872945 106872946 106872949 106876459 106877589 106877590 106877591 106878727 106879492 106883553 106883554
OSN115209813 115211860 115212182 115213902 115222146 115222351 115222361 115224717 115224718 115224719 115224800 115226491 115226492 115226515 115227788 115227791 115229979 115231030 115231058 115231059 115231467
LAK106152130 106159365 106161486 106165948 106166789 106168208 106169949 106170891 106170892 106172310 106172685 106172686 106172687 106174578 106174579 106176896 106180484 112042632
SMMSmp_172010
OVIT265_08003
EGLEGR_05059
EPA110236584 110236893
ATEN116303938
PDAM113664248 113676717
DGT114516655 114521785 114523052 114523154 114523840 114537594 114537596 114540174 114541744
XEN124449030 124452399 124452400 124452521 124453694
HMG100198668(casp7) 100201678 100204696 100205422 100210019 100210729
TADTRIADDRAFT_50539
 » show all
Reference
1  [PMID:11104820]
  Authors
Chang HY, Yang X.
  Title
Proteases for cell suicide: functions and regulation of caspases.
  Journal
Microbiol Mol Biol Rev 64:821-46 (2000)
DOI:10.1128/mmbr.64.4.821-846.2000
Reference
2
  Authors
Nicholson, D. and Thornberry, N.A.
  Title
Caspase-3 and caspase-7.
  Journal
In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.), Handbook of Proteolytic Enzymes, 2nd ed., Elsevier, London, 2004, p. 1298-1302.
Reference
3  [PMID:16781734]
  Authors
Fang B, Boross PI, Tozser J, Weber IT.
  Title
Structural and kinetic analysis of caspase-3 reveals role for s5 binding site in substrate recognition.
  Journal
J Mol Biol 360:654-66 (2006)
DOI:10.1016/j.jmb.2006.05.041
Reference
4  [PMID:12824163]
  Authors
Denault JB, Salvesen GS.
  Title
Human caspase-7 activity and regulation by its N-terminal peptide.
  Journal
J Biol Chem 278:34042-50 (2003)
DOI:10.1074/jbc.M305110200
Other DBs
ExplorEnz - The Enzyme Database: 3.4.22.60
IUBMB Enzyme Nomenclature: 3.4.22.60
ExPASy - ENZYME nomenclature database: 3.4.22.60
BRENDA, the Enzyme Database: 3.4.22.60
CAS: 189258-14-8

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