Entry
Name
caspase-7;
CASP-7;
ICE-like apoptotic protease 3;
ICE-LAP3;
apoptotic protease Mch-3;
Mch3;
CMH-1
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Asp-Glu-Val-Asp!
Comment
Caspase-7 is an effector/executioner caspase, as are caspase-3 (EC
3.4.22.56 ) and caspase-6 (EC
3.4.22.59 ) [1]. These caspases are responsible for the proteolysis of the majority of cellular polypeptides [e.g. poly(ADP-ribose) polymerase (PARP)], which leads to the apoptotic phenotype [2]. Although a hydrophobic residue at P5 of caspase-2 (EC
3.4.22.55 ) and caspase-3 leads to more efficient hydrolysis, the amino-acid residue at this location in caspase-7 has no effect [3]. Caspase-7 is activated by the initiator caspases [caspase-8 (EC
3.4.22.61 ), caspase-9 (EC
3.4.22.62 ) and caspase-10 (EC
3.4.22.63 )]. Removal of the N-terminal prodomain occurs before cleavage in the linker region between the large and small subunits [4]. Belongs in peptidase family C14.
History
EC 3.4.22.60 created 2007
Orthology
Genes
MCOC : 116104023(Casp7) 116104574
AJM : 119040063(CASP7) 119055055
TOD : 119233843(CASP7) 119233844
GAS : 123238175(CASP7) 123254583
OAA : 100082745(CASP7) 114817891
APLA : 101799962(CASP7) 101800944
ACYG : 106031898(CASP7) 106048888
AFUL : 116491407(CASP7) 116499313
ACUN : 113481788(CASP7) 113490234
TALA : 104361444(CASP7) 104362344
ACHC : 115347960(CASP7) 115349915
CPOO : 109324255(CASP7) 109324644
GGN : 109286694 109287627(CASP7)
PSS : 102455743 102458724(CASP7)
CMY : 102931635 102934687(PLEKHS1) 114018624(CASP7)
CPIC : 101936900(CASP7) 101949026
TST : 117872876 117880658(CASP7)
CABI : 116820740 116821743(CASP7)
MRV : 120399323 120409074(CASP7)
PVT : 110071974(CASP7) 110084328
SUND : 121925218(CASP7) 121934729
PBI : 103054928(CASP7) 103066503
PMUR : 107286243 107291550(CASP7)
TSR : 106545868(CASP7) 106555302
PGUT : 117677061 117678719(CASP7)
VKO : 123027053 123027901(CASP7)
STOW : 125437375(CASP7) 125441779
XLA : 100037079(casp7.S) 108711587(XB5812047.L) 108712725 397819(casp7.L)
XTR : 549053(casp7) 733553
NPR : 108792468 108793513(CASP7)
RTEM : 120933073 120946831(CASP7)
BBUF : 120987211 121003754(CASP7)
BGAR : 122929475 122940313(CASP7)
DRE : 100331324(casp21) 553634(casp7) 798445
SRX : 107705510 107707870 107740219 107746199 107755536(casp7) 107758576 107758655
SANH : 107658598 107658599 107662725 107684033 107689250 107689777 107701921 107702451(casp7)
SGH : 107558111 107558112 107566160 107578309 107579886 107581558 107584640 107602036 107602063
CCAR : 109050440 109061445 109061475 109064749 109076849 109079949 109099653(casp7) 109099719
CAUA : 113054568 113054569 113054872 113063759 113076928 113102528 113110248 113110500 113111581
PPRM : 120474601(casp7) 120491456(casp21)
MAMB : 125253569(casp21) 125255638(casp7)
PHYP : 113527344(casp7) 113543971
TFD : 113638889 113638890 113638891 113643355 113643356
TRU : 101068895(casp7) 101074856
TNG : GSTEN00015090G001 GSTEN00025416G001 GSTEN00034975G001
LCO : 104927890(casp7) 104937898
CGOB : 115016952 115024673(casp7)
ELY : 117247638(casp7) 117269417
SLUC : 116041859 116041861 116061247(casp7)
ECRA : 117936824(casp7) 117959744
PFLV : 114548038(casp7) 114571494
GAT : 120813523 120819358(casp7) 120831648
PPUG : 119212792(casp7) 119226884
MSAM : 119914744 119916041(casp7) 119919358
MZE : 101466737 101468707 101473187(casp7)
ONL : 100705447 100705706 100708873(casp7)
OAU : 116321289 116321418 116329808(casp7)
OLA : 101156378 101161677(casp7)
OML : 112154505(casp7) 112162928(casp17)
XMA : 102218392 102230553(casp7)
XCO : 114150095 114152207(casp7)
XHE : 116723800 116726736(casp7)
PRET : 103473137 103481281(casp7)
PFOR : 103153213 103153381(casp7)
PLAI : 106948312(casp7) 106963693
PMEI : 106907578(casp7) 106931868
GAF : 122819312(casp17) 122823254(casp7)
CVG : 107094701(casp7) 107096398
CTUL : 119777624 119780490(casp7)
GMU : 124872805 124875343(casp7)
KMR : 108242539 108246368(casp7)
ALIM : 106513803 106516949(casp7)
NWH : 119423641(casp7) 119424442(casp17)
CSEM : 103381449(casp7) 103389354
POV : 109644782(casp7) 109648155
SSEN : 122758623 122759030(casp7)
LCF : 108895937 108895947 108898722(casp7)
SDU : 111219886(casp7) 111224299
SLAL : 111664455 111669656(casp7)
BPEC : 110154157(casp7) 110161916
MALB : 109951188 109963005(casp7)
SASA : 106568012 106578356(casp7)
OTW : 112224061(casp7) 112230827
OMY : 110498822(casp7) 110516770
ONE : 115101020 115121027 115143950(casp7)
SALP : 111961772 111963622 111976969(casp7)
SNH : 120021869 120026227 120060921(casp7)
ELS : 105015185 105026234(casp7)
SFM : 108923620 108940466(casp7)
PKI : 111836049(casp7) 111837755
AANG : 118220445(casp7) 118231433
LOC : 102691279(casp7) 102693931
PSPA : 121302301 121303085 121320517 121322130 121326143(casp7)
ARUT : 117397812 117414465 117417933 117420466 117968959
LCM : 102357990(CASP7) 102367521
CMK : 103172118(casp7) 103172119
RTP : 109923449 109929106(casp7)
BFO : 118407807 118411406 118411417 118415634 118419156 118430457 118432249
BBEL : 109468013 109470881 109481307 109481366
CIN : 100175569 100175572 100176782 100177694 100178691 100185209 494382
SCLV : 120331606 120332051 120332231 120333241 120334940 120342079 120347763
APLC : 110978834 110978835 110981895
SKO : 100371155 100373033 100373106 100374591 100374606 100376925 102803581 102806744
DME : Dmel_CG14902(Decay) Dmel_CG7788(Drice)
DSI : Dsimw501_GD20281(Dsim_GD20281) Dsimw501_GD21467(Dsim_GD21467)
DYA : Dyak_GE23886 Dyak_GE26146
DPO : Dpse_GA13340 Dpse_GA20588
DWI : 26529862 6646969 6647739 6647740 6647741
DGR : 6566647 6567727 6567728 6567811
DMO : Dmoj_GI10391 Dmoj_GI22043 Dmoj_GI22869
DAZ : 108609625 108609645 108621217 108621386
DNV : 108659226 108660325 115562691 115562909
DHE : 111594818 111596107 111598807 111599126
CCAT : 101449231 101454266 101459760 105664451
BOD : 106614590 106615177 106615221
MDE : 101889252(caspase-1) 101896713
SCAC : 106087832 106093599
LCQ : 111681534 111691111 111691144
AGA : AgaP_AGAP000830(CASPS7) AgaP_AGAP004920(CASPS6) AgaP_AGAP004921(CASPS5) AgaP_AGAP004922(CASPS11) AgaP_AGAP009832(CASPS8) AgaP_AGAP010826(CASPS13) AgaP_AGAP011949(CASPS1) AgaP_AGAP011951(CASPS4) AgaP_AGAP012544(CASPS14) AgaP_AGAP012945
ACOZ : 120947599 120950965 120951392 120951393 120957130 120957642 120959057
AARA : 120895331 120895342 120895798 120896274 120896275 120896277 120900367 120900925 120901230 120903002 120905765
AAG : 5564196 5564917 5575873 5578111 5578112
AALB : 109399676 109400467 109427925 109427926 109427949 109428244 109428267 109431512 115253749 115253750 115256800 115256801 115256802 115266369 115271029
CQU : CpipJ_CPIJ000671 CpipJ_CPIJ008093 CpipJ_CPIJ008252 CpipJ_CPIJ008253 CpipJ_CPIJ009056 CpipJ_CPIJ009057
CPII : 120414726 120414730 120416829 120416833 120422391 120424151 120428316
ACER : 107995721 107998622 108003290
ALAB : 122715062 122720329 122720916
BBIF : 117208725 117214724
BVK : 117232171 117232191 117232386
BVAN : 117157820 117164750
BTER : 100645000 100646875
BPYO : 122567095 122573404 122573547
MGEN : 117219775 117223909 117227399 117228331
NMEA : 116424466 116427803 116431717
CGIG : 122395435 122400486
SOC : 105193867 105194248 105198123 105201885 113005913
MPHA : 105832229 105836709 105837700
ACEP : 105623746 105626959
PBAR : 105423294 105431912
VEM : 105559272 105567937 105568970
HST : 105181481 105184990 105185893
CFO : 105250225 105250735 105252365
LHU : 105671932 105674282 105675143
PGC : 109852283 109856752 109858528
PCF : 106784538 106784872 106790912 106790913 106791068
PFUC : 122521067 122523332
VPS : 122628040 122628391 122629991 122637479
NVI : 100115867 100680489 103315801
TPRE : 106651222 106656095
CGLO : 123262229 123270872
AGIF : 122848118 122855699
CCIN : 107265269 107272788
DPA : 109539488 109541949 109544766 109544773
SOY : 115885196 115886458 115886459
ATD : 109595512 109600499 109603613 109607706
CSET : 123309282 123313484 123318717 123322388
AGB : 108908184 108908189 108908304 108917125
LDC : 111509868 111510887 111516283 111517301
NVL : 108556664 108562135 108565953 108569306
APLN : 108733855 108742126
PPYR : 116176570 116180475
OTU : 111417231 111417440 111419159 111422164 111427097
BMOR : 692604(Caspase1) 692735(ICE)
BMAN : 114243240 114249132
MSEX : 115443475 115448329 115451794 119191711
BANY : 112054726 112058547
PPOT : 106099858 106109364
PRAP : 110991328 110994624 110999004
TNL : 113501324 113504388 113504517 113504518 113506916 113507749
SLIU : 111351893 111351894
OFU : 114361608 114364360 114366116 114366123 114366520
PXY : 105385382 105394672(caspase-1)
API : 100160647 100161906 100162302
PHU : Phum_PHUM221390 Phum_PHUM536790
FOC : 113202699 113210200 113211468
ZNE : 110836372 110837449 110837734 110841540
CSEC : 111866127 111872158 111873682
DPX : DAPPUDRAFT_15026 DAPPUDRAFT_307426 DAPPUDRAFT_309162 DAPPUDRAFT_309167 DAPPUDRAFT_314077 DAPPUDRAFT_314078
DMK : 116919294 116919296 116931192
PVM : 113805238 113805778 113823293
PCHN : 125025457 125038775 125038776
HAZT : 108670557 108682707
EAF : 111699590 111699915 111710697 111710710 111713158
ISC : IscW_ISCW003039 IscW_ISCW013172 IscW_ISCW022545
RSAN : 119391161 119404888 119404889 119405422
RMP : 119161026 119179024 119180863
CSCU : 111612965 111621489
PTEP : 107449048 107449050 107449060 107450427
HRO : HELRODRAFT_157123 HELRODRAFT_87042 HELRODRAFT_96017
LGI : LOTGIDRAFT_105903 LOTGIDRAFT_106792 LOTGIDRAFT_133150 LOTGIDRAFT_134426 LOTGIDRAFT_154123 LOTGIDRAFT_209997 LOTGIDRAFT_210703 LOTGIDRAFT_228982 LOTGIDRAFT_228989 LOTGIDRAFT_73381 LOTGIDRAFT_74313
PCAN : 112568690 112568719 112568728 112568743
BGT : 106054370 106054379 106060605 106073003 106075649 106077776 106078266 106078855
GAE : 121378490 121379720 121380083 121381619 121390503 121390783
HRF : 124112819 124120464 124124428 124124435 124124743 124124744 124132608 124132704 124132705 124138238 124149294 124149295 124149342 124149343 124149345 124149346 124149349 124149352 124149355 124151583
HRJ : 124277140 124277141 124277144 124277152 124277154 124277156 124277157 124280306 124283934 124283944 124283953 124291479
CRG : 105322178 105322179 105322180 105325186 105328531 105328899 105336650 105340742 105342048 105342049 105346972 105348272 109617035 109617112
MYI : 110445959 110445960 110446693 110450209 110458747 110462768 110463353 110464686 110466240 110467369 110467497
PMAX : 117317718 117322653 117322837 117323380 117323554 117323556 117323762 117324476 117325054 117332246 117334389 117336709 117343240 117343665
MMER : 123543143 123546363 123546364 123548934 123553921 123563302 123563866 123564308 123564393 123564573 123566401
OBI : 106867126 106870008 106871720 106872234 106872243 106872370 106872943 106872944 106872945 106872946 106872949 106876459 106877589 106877590 106877591 106878727 106879492 106883553 106883554
OSN : 115209813 115211860 115212182 115213902 115222146 115222351 115222361 115224717 115224718 115224719 115224800 115226491 115226492 115226515 115227788 115227791 115229979 115231030 115231058 115231059 115231467
LAK : 106152130 106159365 106161486 106165948 106166789 106168208 106169949 106170891 106170892 106172310 106172685 106172686 106172687 106174578 106174579 106176896 106180484 112042632
PDAM : 113664248 113676717
DGT : 114516655 114521785 114523052 114523154 114523840 114537594 114537596 114540174 114541744
XEN : 124449030 124452399 124452400 124452521 124453694
HMG : 100198668(casp7) 100201678 100204696 100205422 100210019 100210729
» show all
Taxonomy
Reference
Authors
Chang HY, Yang X.
Title
Proteases for cell suicide: functions and regulation of caspases.
Journal
Reference
2
Authors
Nicholson, D. and Thornberry, N.A.
Title
Caspase-3 and caspase-7.
Journal
In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.), Handbook of Proteolytic Enzymes, 2nd ed., Elsevier, London, 2004, p. 1298-1302.
Reference
Authors
Fang B, Boross PI, Tozser J, Weber IT.
Title
Structural and kinetic analysis of caspase-3 reveals role for s5 binding site in substrate recognition.
Journal
Reference
Authors
Denault JB, Salvesen GS.
Title
Human caspase-7 activity and regulation by its N-terminal peptide.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 3.4.22.60