KEGG   ENZYME: 3.4.22.62
Entry
EC 3.4.22.62                Enzyme                                 
Name
caspase-9;
CASP-9;
ICE-like apoptotic protease 6;
ICE-LAP6;
apoptotic protease Mch-6;
apoptotic protease-activating factor 3;
APAF-3
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
Reaction(IUBMB)
Strict requirement for an Asp residue at position P1 and with a marked preference for His at position P2. It has a preferred cleavage sequence of Leu-Gly-His-Asp!Xaa
Comment
Caspase-9 is an initiator caspase, as are caspase -2 (EC 3.4.22.55), caspase-8 (EC 3.4.22.61) and caspase-10 (EC 3.4.22.63) [1]. Caspase-9 contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation [1]. An alternatively spliced version of caspase-9 also exists, caspase-9S, that inhibits apoptosis, similar to the situation found with caspase-2 [1]. Phosphorylation of caspase-9 from some species by Akt, a serine-threonine protein kinase, inhibits caspase activity in vitro and caspase activation in vivo [1]. The activity of caspase-9 is increased dramatically upon association with the apoptosome but the enzyme can be activated without proteolytic cleavage [2,3]. Procaspase-3 is the enzyme's physiological substrate [2]. Belongs in peptidase family C14.
History
EC 3.4.22.62 created 2007
Orthology
K04399  caspase 9
Genes
HSA842(CASP9)
PTR456457(CASP9)
PPS100992567(CASP9)
GGO101130414(CASP9)
PON100460459(CASP9)
NLE100597173(CASP9)
MCC694544(CASP9)
MCF102126830(CASP9)
CSAB103225550(CASP9)
CATY105599419(CASP9)
PANU101009907(CASP9)
TGE112628633(CASP9)
RRO104677696(CASP9)
RBB108524269(CASP9)
TFN117093253(CASP9)
PTEH111527287(CASP9)
CJC100409028(CASP9)
SBQ101051525(CASP9)
CSYR103260483(CASP9)
MMUR105870442(CASP9)
LCAT123635958(CASP9)
OGA100957904(CASP9)
MMU12371(Casp9)
MCAL110293440(Casp9)
MPAH110323338(Casp9)
RNO58918(Casp9)
MCOC116096967(Casp9)
MUN110545060(Casp9)
CGE100689370 103160479 113833881
MAUA101844218(Casp9)
PLEU114700859(Casp9)
MORG121448746(Casp9)
AAMP119817619(Casp9)
NGI103725336(Casp9)
HGL101702898(Casp9)
CPOC100714954(Casp9)
CCAN109692548(Casp9)
DORD105989961(Casp9)
DSP122099125(Casp9)
NCAR124966493
OCU100101592(CASP9)
OPI101526499(CASP9)
TUP102470940(CASP9)
CFA487432(CASP9)
VVP112929772(CASP9)
VLG121498045(CASP9)
AML100483760(CASP9)
UMR103666628(CASP9)
UAH113270476(CASP9)
UAR123777792(CASP9)
ELK111154673
LLV125098709
MPUF101681290(CASP9)
ORO101362812(CASP9)
EJU114213333(CASP9)
ZCA113909591(CASP9)
MLX118019979(CASP9)
FCA768260(CASP9)
PYU121021539(CASP9)
PBG122479964(CASP9)
PTG102967404(CASP9)
PPAD109274153(CASP9)
AJU106975594(CASP9)
HHV120229837(CASP9)
BTA100140945(CASP9)
BOM102268660(CASP9)
BIU109570433(CASP9)
BBUB102412012(CASP9)
CHX102174681(CASP9)
OAS101110953(CASP9)
ODA120880582(CASP9)
CCAD122452241(CASP9)
SSC100518913(CASP9)
CFR102519816(CASP9)
CBAI105070945(CASP9)
CDK105107056(CASP9)
VPC116282869
BACU103010071(CASP9)
LVE103086745(CASP9)
OOR101271677(CASP9)
DLE111187099(CASP9)
PCAD102989458(CASP9)
PSIU116757481(CASP9)
ECB100054331(CASP9)
EPZ103565016(CASP9)
EAI106828005(CASP9)
MYB102254877(CASP9)
MYD102759481(CASP9)
MMYO118677148(CASP9)
MLF102428235(CASP9)
MNA107531542(CASP9)
PKL118724633(CASP9)
HAI109381302(CASP9)
DRO112299456(CASP9)
SHON118986319(CASP9)
AJM119049966(CASP9)
PDIC114497767(CASP9)
PHAS123832288(CASP9)
MMF118626427(CASP9)
RFQ117027311(CASP9)
PALE102878565(CASP9)
PGIG120585783(CASP9)
PVP105294412(CASP9)
RAY107501830(CASP9)
TOD119235667(CASP9)
SARA101537803(CASP9)
LAV100656597(CASP9)
TMU101355103
DNM101432519(CASP9)
MDO100027338(CASP9)
GAS123240973(CASP9)
SHR100931481(CASP9)
PCW110198824(CASP9)
OAA100092345(CASP9)
GGA426970(CASP9)
PCOC116242603(CASP9)
MGP100550410(CASP9)
CJO107323418(CASP9)
NMEL110408509(CASP9)
APLA101795386(CASP9)
ACYG106040238(CASP9)
AFUL116497626(CASP9)
TGU100227981(CASP9)
LSR110472268(CASP9)
SCAN103824350(CASP9)
PMOA120499434(CASP9)
OTC121343962(CASP9)
PRUF121351369(CASP9)
GFR102039030(CASP9)
FAB101808292(CASP9)
PHI102108950(CASP9)
PMAJ107213687(CASP9)
CCAE111938513(CASP9)
CCW104697549(CASP9)
ETL114068717(CASP9)
ZAB102060592(CASP9)
FPG101914844(CASP9)
FCH102054465(CASP9)
CLV102093506(CASP9)
EGZ104133155(CASP9)
NNI104011166(CASP9)
PLET104627186(CASP9)
ACUN113487796(CASP9)
TALA104369295(CASP9)
PADL103918063(CASP9)
ACHC115343190(CASP9)
AAM106493414(CASP9)
AROW112966867(CASP9)
NPD112957495(CASP9)
DNE112988470(CASP9)
ASN102384999(CASP9)
AMJ102573968(CASP9)
CPOO109314378(CASP9)
GGN109293786(CASP9)
PSS102443524(CASP9)
CMY102939753(CASP9)
CPIC101944555(CASP9)
TST117867817(CASP9)
CABI116824353(CASP9)
MRV120387756(CASP9)
ACS100560103(casp9)
PVT110072690(CASP9)
SUND121936186(CASP9)
PBI103063403(CASP9)
PMUR107291376(CASP9)
TSR106547434(CASP9)
PGUT117669674(CASP9)
VKO123034748(CASP9)
PMUA114602391(CASP9)
ZVI118086144(CASP9)
GJA107124463(CASP9)
STOW125445630(CASP9)
XLA373560(casp9.S)
XTR100144708(casp9)
NPR108797190(CASP9)
RTEM120916261(CASP9)
BBUF120993957(CASP9)
DRE492763(casp9)
SRX107716147 107737696
SANH107673102 107687452
SGH107591141(casp9) 107593914
CCAR109048790 109103852
CAUA113065546 113068938(casp9)
PPRM120462747(casp9)
MAMB125259921(casp9)
IPU108276164(casp9)
PHYP113530268(casp9)
SMEO124399257(casp9)
TFD113641807(casp9)
AMEX103034324
EEE113576299(casp9)
TRU101075121(casp9)
TNGGSTEN00020648G001
LCO104939007(casp9)
NCC104954971
CGOB115011308(casp9)
ELY117258445(casp9)
PLEP121947010(casp9)
SLUC116040841(casp9)
ECRA117948337(casp9)
PFLV114558804(casp9)
GAT120829328(casp9)
PPUG119222143(casp9)
MSAM119905914 119915377 119915381
CUD121517291(casp9)
ALAT119023405(casp9)
MZE101487562(casp9)
ONL100700134(casp9)
OAU116332326(casp9)
OLA101157857(casp9)
OML112159047(casp9)
XMA102226741(casp9)
XCO114148510(casp9)
XHE116724932
PRET103467149(casp9)
PFOR103131123(casp9)
PLAI106963026(casp9)
PMEI106905173(casp9)
GAF122831022(casp9)
CVG107091512(casp9)
CTUL119788603(casp9)
GMU124870084(casp9)
NFU107386824 107390653
KMR108233046(casp9)
ALIM106513111(casp9)
NWH119417113(casp9)
AOCE111572548(casp9)
CSEM103385017(casp9)
POV109630724(casp9)
SSEN122777636(casp9)
HHIP117764610(casp9)
HSP118111023(casp9)
LCF108882570(casp9)
SDU111236985(casp9)
SLAL111651602(casp9)
XGL120787755(casp9)
HCQ109511699(casp9)
BPEC110167143(casp9)
MALB109967174(casp9)
BSPL114859219(casp9)
SASA106567147 106572551(casp9)
OTW112216271 112221816(casp9)
OMY100136676 110533029
OGO124045997(casp9)
ONE115102458(casp9)
SALP111976406 111976415(casp9)
SNH120059174 120060666
ELS105028691(casp9)
SFM108939364(casp9)
PKI111855646 111855651 111855875
AANG118207855(casp9)
LOC102691575(casp9)
PSPA121329059 121329093
ARUT117425431 117426078 117968643 117972138
LCM102362720(CASP9)
CMK103187647
RTP109927787(casp9)
BFO118430470 118430560
BBEL109464119 109469526 109478152 109478980 109479656 109485199 109487109
SPU100892193 115924698 586121 592436
APLC110979123 110979155
SKO100376094
MGEN117227888
PFUC122522064
CCIN107266595
SOY115884630
OTU111427185
SLIU111347867
DCI103511907
TPAL117646417
CSEC111871800
PCHN125041105
PTRU123518246
HAZT108681847
PTEP107444889 107448186
SDM118179813 118204201
GAE121369009 121373560 121386529 121387980
HRF124111246 124123771 124123773 124123777 124129978 124133461 124137665 124139128 124140738
HRJ124258755 124260912 124271901 124277139 124279295 124283703 124283714
CRG105318727 105325340 105325343 105332032 105338802 105340308 105343974 117681496 117685537
MYI110446169 110446170 110466239
PMAX117314749 117329172 117333353 117333425 117336099
MMER123526212 123526469 123527692 123541996 123548470 123563303 123565749
OSN115223936 115224053 115231131
LAK106168207 106168747 106170245 106171849
NVE5512986
EPA110241763
ATEN116297532 116297533 116301778
AMIL114960022 114973117
DGT114518280
XEN124443874 124443875 124454245
HMG101235218
AQU100633941
 » show all
Reference
1  [PMID:11104820]
  Authors
Chang HY, Yang X.
  Title
Proteases for cell suicide: functions and regulation of caspases.
  Journal
Microbiol Mol Biol Rev 64:821-46 (2000)
DOI:10.1128/mmbr.64.4.821-846.2000
Reference
2  [PMID:16630893]
  Authors
Yin Q, Park HH, Chung JY, Lin SC, Lo YC, da Graca LS, Jiang X, Wu H.
  Title
Caspase-9 holoenzyme is a specific and optimal procaspase-3 processing machine.
  Journal
Mol Cell 22:259-68 (2006)
DOI:10.1016/j.molcel.2006.03.030
Reference
3  [PMID:12620239]
  Authors
Boatright KM, Renatus M, Scott FL, Sperandio S, Shin H, Pedersen IM, Ricci JE, Edris WA, Sutherlin DP, Green DR, Salvesen GS.
  Title
A unified model for apical caspase activation.
  Journal
Mol Cell 11:529-41 (2003)
DOI:10.1016/S1097-2765(03)00051-0
Reference
4
  Authors
Salvesen, G.S. and Boatright, K.M.
  Title
Caspase-9.
  Journal
In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.), Handbook of Proteolytic Enzymes, 2nd ed., Elsevier, London, 2004, p. 1296-1298.
Other DBs
ExplorEnz - The Enzyme Database: 3.4.22.62
IUBMB Enzyme Nomenclature: 3.4.22.62
ExPASy - ENZYME nomenclature database: 3.4.22.62
BRENDA, the Enzyme Database: 3.4.22.62
CAS: 180189-96-2

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