KEGG   ENZYME: 3.4.22.63
Entry
EC 3.4.22.63                Enzyme                                 
Name
caspase-10;
FLICE2;
Mch4;
CASP-10;
ICE-like apoptotic protease 4;
apoptotic protease Mch-4;
FAS-associated death domain protein interleukin-1beta-converting enzyme 2
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
Reaction(IUBMB)
Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Leu-Gln-Thr-Asp!Gly
Comment
Caspase-10 is an initiator caspase, as are caspase-2 (EC 3.4.22.55), caspase-8 (EC 3.4.22.61) and caspase-9 (EC 3.4.22.62) [1]. Like caspase-8, caspase-10 contains two tandem death effector domains (DEDs) in its N-terminal prodomain, and these play a role in procaspase activation [1]. The enzyme has many overlapping substrates in common with caspase-8, such as RIP (the cleavage of which impairs NF-kappaB survival signalling and starts the cell-death process) and PAK2 (associated with some of the morphological features of apoptosis, such as cell rounding and apoptotic body formation) [2]. Bid, a Bcl2 protein, can be cleaved by caspase-3 (EC 3.4.22.56), caspase-8 and caspase-10 at Lys-Gln-Thr-Asp! to yield the pro-apoptotic p15 fragment. The p15 fragment is N-myristoylated and enhances the release of cytochrome c from mitochondria (which, in turn, initiatiates the intrinsic apoptosis pathway). Bid can be further cleaved by caspase-10 and granzyme B but not by caspase-3 or caspase-8 at Ile-Glu-Thr-Asp! to yield a p13 fragment that is not N-myristoylated [2]. Belongs in peptidase family C14.
History
EC 3.4.22.63 created 2007
Orthology
K04400  caspase 10
Genes
HSA843(CASP10)
PTR459873(CASP10)
PPS100972863(CASP10)
GGO101131419(CASP10)
PON100174433(CASP10)
NLE100585413(CASP10)
MCC701295(CASP10)
MCF102144792(CASP10)
CSAB103217635(CASP10)
CATY105580202(CASP10)
PANU101011831(CASP10)
TGE112636361(CASP10)
RRO104671862(CASP10)
RBB108532107(CASP10)
TFN117095222(CASP10)
PTEH111547163(CASP10)
CJC100394139(CASP10)
SBQ101028043(CASP10)
CSYR103273364(CASP10)
MMUR105856963(CASP10)
LCAT123643896(CASP10)
OGA100965785(CASP10)
HGL101712620(Casp10)
CPOC100717714(Casp10)
NCAR124980755
OCU100101580(CASP10)
OPI101520873(CASP10)
TUP102496563(CASP10)
CFA488472(CASP10)
CLUD112656355(CASP10)
VVP112922875(CASP10)
VLG121480767(CASP10)
AML100475128(CASP10)
UMR103659739(CASP10)
UAH113250594(CASP10)
UAR123798198(CASP10)
ELK111141157
LLV125094997
MPUF101685031(CASP10)
ORO101366538(CASP10)
EJU114223391(CASP10)
ZCA113920561(CASP10)
MLX118012154(CASP10)
FCA101085995(CASP10)
PYU121030907(CASP10)
PBG122481640(CASP10)
PTG102962753(CASP10)
PPAD109260756(CASP10)
AJU106987987(CASP10)
HHV120220687(CASP10)
BTA100848685
BBUB102394793
OAS101103049(CASP10)
ODA120854625
SSC100154896(CASP10)
CFR102514092(CASP10)
CBAI105082301(CASP10)
CDK105099180(CASP10)
VPC102540480(CASP10)
BACU103001347(CASP10)
LVE103076785(CASP10)
OOR101282021(CASP10)
DLE111171725(CASP10)
PCAD102989304(CASP10)
PSIU116756541(CASP10)
ECB100068201(CASP10)
EPZ103566002(CASP10)
EAI106823486(CASP10)
MYB102253536(CASP10)
MYD102763065(CASP10)
MMYO118661389(CASP10)
MLF102434278 102439064(CASP10)
MNA107533942(CASP10)
PKL118708994(CASP10)
HAI109379185(CASP10)
DRO112308028(CASP10)
SHON118985243(CASP10)
AJM119065494(CASP10)
PDIC114494329(CASP10)
PHAS123824433(CASP10)
MMF118625231(CASP10)
RFQ117026299(CASP10)
PALE102877929(CASP10)
PGIG120587527(CASP10)
PVP105298128(CASP10)
RAY107503159(CASP10)
MJV108404750(CASP10)
TOD119256100(CASP10) 119260153
LAV100663859
TMU101341837
DNM101433860(CASP10)
MDO100016987(CASP10)
GAS123241894(CASP10)
SHR100930260(CASP10)
PCW110197140(CASP10)
OAA100092695
GGA424081(CASP10)
PCOC116233976(CASP10)
MGP100550034(CASP10)
CJO107316521(CASP10)
NMEL110400691
APLA101799731
ACYG106040000(CASP10)
AFUL116490833
TGU100220453
LSR110484588(CASP10)
SCAN103814509(CASP10)
PMOA120499262(CASP10)
OTC121335317(CASP10)
PRUF121356473
GFR102044879(CASP10)
FAB101815409(CASP10)
PHI102103849(CASP10)
PMAJ107207334(CASP10)
CCAE111931987(CASP10)
CCW104693775
CBRC103612146
ZAB102073289(CASP10)
FPG101918719(CASP10)
FCH102057122(CASP10)
CLV102085114(CASP10)
EGZ104130512(CASP10)
NNI104010195(CASP10)
PLET104623374(CASP10)
PCRI104026021(CASP10)
ACUN113482525
TALA104359794
PADL103923449(CASP10)
ACHC115343323(CASP10)
HALD104322667(CASP10)
CCRI104163888(CASP10)
EHS104507514
FGA104082183
GSTE104255506(CASP10)
LDI104346355(CASP10)
MNB103775951(CASP10)
AAM106492410
AROW112976366
NPD112956252
DNE112987710(CASP10)
ASN102380890(CASP10)
AMJ102573990(CASP10)
CPOO109322724
GGN109301899(CASP10)
PSS102463731
CMY102931579
CPIC101941379
TST117885051
CABI116836064
MRV120375092
ACS100564281(casp10)
PVT110089021
SUND121934703(CASP10)
PBI103052358
PMUR107296977(CASP10)
TSR106547531(CASP10)
PGUT117673283
VKO123024246(CASP10)
PMUA114584652
ZVI118095885
GJA107122423
XLA397820(casp10.S) 398762(casp10.L)
XTR548432(casp10)
NPR108795087
RTEM120943729(CASP10)
BBUF121007625
BGAR122944468
SRX107752597
AMEX103035342
EEE113574035
MALB109958095
SASA106600207
AANG118222447(casp10)
ARUT117408574 117426544
BBEL109462052 109464410 109465186 109475257 109479913
HHAL106684022
PJA122244006 122244008 122244009 122261469 122261470
PCHN125037021 125037022 125037023 125037225
SDM118205802
LGILOTGIDRAFT_53303
GAE121379957 121385161 121387653
HRF124125871
HRJ124273712
CRG105339898
PMAX117315065 117315066
MMER123548935
OSN115223204
ADF107335801
AMIL114951335
 » show all
Reference
1  [PMID:11104820]
  Authors
Chang HY, Yang X.
  Title
Proteases for cell suicide: functions and regulation of caspases.
  Journal
Microbiol Mol Biol Rev 64:821-46 (2000)
DOI:10.1128/mmbr.64.4.821-846.2000
Reference
2  [PMID:16186808]
  Authors
Fischer U, Stroh C, Schulze-Osthoff K.
  Title
Unique and overlapping substrate specificities of caspase-8 and caspase-10.
  Journal
Oncogene 25:152-9 (2006)
DOI:10.1038/sj.onc.1209015
Reference
3  [PMID:12884866]
  Authors
Shikama Y, Yamada M, Miyashita T.
  Title
Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases.
  Journal
Eur J Immunol 33:1998-2006 (2003)
DOI:10.1002/eji.200324013
Reference
4  [PMID:15209560]
  Authors
Boatright KM, Deis C, Denault JB, Sutherlin DP, Salvesen GS.
  Title
Activation of caspases-8 and -10 by FLIP(L).
  Journal
Biochem J 382:651-7 (2004)
DOI:10.1042/BJ20040809
Other DBs
ExplorEnz - The Enzyme Database: 3.4.22.63
IUBMB Enzyme Nomenclature: 3.4.22.63
ExPASy - ENZYME nomenclature database: 3.4.22.63
BRENDA, the Enzyme Database: 3.4.22.63
CAS: 189088-85-5

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