Acting on peptide bonds (peptidases);
Strict requirement for Asp at the P1 position and has a preferred cleavage sequence of (Ile/Leu/Val/Phe)-Gly-His-Asp!
This murine enzyme is part of the family of inflammatory caspases, which also includes caspase-1 (EC 184.108.40.206), caspase-4 (EC 220.127.116.11) and caspase-5 (EC 18.104.22.168) in humans and caspase-12, caspase-13 and caspase-14 in mice. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation. Like caspase-5, but unlike caspase-4, this enzyme can be induced by lipopolysaccharide . This enzyme not only activates caspase-1, which is required for the maturation of proinflammatory cytokines such as interleukin-1beta (IL-1beta) and IL-18, but it also activates caspase-3 (EC 22.214.171.124), which leads to cellular apoptosis under pathological conditions [1,2]. Belongs in peptidase family C14.