KEGG   ENZYME: 3.4.23.24Help
Entry
EC 3.4.23.24                Enzyme                                 

Name
candidapepsin;
Candida albicans aspartic proteinase;
Candida albicans carboxyl proteinase;
Candida albicans secretory acid proteinase;
Candida olea acid proteinase;
Candida aspartic proteinase;
Candida olea aspartic proteinase;
Candida albicans aspartic proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave Leu15-Tyr, Tyr16-Leu and Phe24-Phe of insulin B chain. Activates trypsinogen, and degrades keratin
Comment
This endopeptidase from the imperfect yeast Candida albicans is inhibited by pepstatin, but not by methyl 2-diazoacetamidohexanoate or 1,2-epoxy-3-(p-nitrophenoxy)propane. In peptidase family A1 (pepsin A family). Formerly included in EC 3.4.23.6
History
EC 3.4.23.24 created 1992 (EC 3.4.23.6 created 1992 (EC 3.4.23.6 created 1961 as EC 3.4.4.17, transferred 1972 to EC 3.4.23.6, modified 1981 [EC 3.4.23.7, EC 3.4.23.8, EC 3.4.23.9, EC 3.4.23.10, EC 3.4.99.1, EC 3.4.99.15 and EC 3.4.99.25 all created 1972 and incorporated 1978], part incorporated 1992)
Orthology
K06005  candidapepsin
Genes
PIC: PICST_63754
PGU: PGUG_03958
SPAA: SPAPADRAFT_51269
LEL: LELG_02104
CAL: CAALFM_C104870WA(SAP7) CAALFM_C302510CA(SAP8) CAALFM_C303870CA(SAP9) CAALFM_C305230WA(SAP3) CAALFM_C404470WA(SAP10) CAALFM_C602710CA(SAP6) CAALFM_C603030WA(SAP5) CAALFM_C603490CA(SAP1) CAALFM_C603500CA(SAP4) CAALFM_CR07800WA(SAP2)
CTP: CTRG_00096 CTRG_00264 CTRG_00700 CTRG_02113 CTRG_02432 CTRG_02621 CTRG_02698 CTRG_02710 CTRG_02711 CTRG_03508 CTRG_03750 CTRG_04491
COT: CORT_0B01090 CORT_0B03690 CORT_0B03810 CORT_0B03820 CORT_0B03830 CORT_0B03840 CORT_0B03850 CORT_0B03860 CORT_0B06860 CORT_0F03710 CORT_0G02040
CDU: CD36_04610(SAP7) CD36_33460(SAP2) CD36_44180(SAP10) CD36_63420(SAP6) CD36_63430(SAP1) CD36_82480(SAP8) CD36_83850(SAP9) CD36_85220(SAP3)
CTEN: CANTEDRAFT_101871 CANTEDRAFT_112537 CANTEDRAFT_113142 CANTEDRAFT_115143 CANTEDRAFT_118876
CLUS: A9F13_27g00198
CAUR: QG37_03391
 » show all
Taxonomy
Reference
1  [PMID:5729955]
  Authors
Remold H, Fasold H, Staib F.
  Title
Purification and characterization of a proteolytic enzyme from Candida albicans.
  Journal
Biochim Biophys Acta 167:399-406 (1968)
DOI:10.1016/0005-2744(68)90219-2
Reference
2  [PMID:7018586]
  Authors
Ruchel R.
  Title
Properties of a purified proteinase from the yeast Candida albicans.
  Journal
Biochim Biophys Acta 659:99-113 (1981)
DOI:10.1016/0005-2744(81)90274-6
Reference
3  [PMID:6203988]
  Authors
Negi M, Tsuboi R, Matsui T, Ogawa H.
  Title
Isolation and characterization of proteinase from Candida albicans: substrate specificity.
  Journal
J Invest Dermatol 83:32-6 (1984)
DOI:10.1111/1523-1747.ep12261656
Reference
4  [PMID:2646602]
  Authors
Lott TJ, Page LS, Boiron P, Benson J, Reiss E.
  Title
Nucleotide sequence of the Candida albicans aspartyl proteinase gene.
  Journal
Nucleic Acids Res 17:1779 (1989)
DOI:10.1093/nar/17.4.1779
Other DBs
ExplorEnz - The Enzyme Database: 3.4.23.24
IUBMB Enzyme Nomenclature: 3.4.23.24
ExPASy - ENZYME nomenclature database: 3.4.23.24
BRENDA, the Enzyme Database: 3.4.23.24
CAS: 69458-91-9

DBGET integrated database retrieval system