Entry
Name
saccharopepsin;
yeast endopeptidase A;
Saccharomyces aspartic proteinase;
aspartic proteinase yscA (gene name);
proteinase A;
proteinase yscA (gene name);
yeast proteinase A;
Saccharomyces cerevisiae aspartic proteinase A;
PRA
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of proteins with broad specificity for peptide bonds. Cleaves -Leu-Leu!Val-Tyr bond in a synthetic substrate. Does not act on esters of Tyr or Arg
Comment
Located in the vacuole of the baker's yeast (Saccharomyces cerevisiae) cell. In peptidase family A1 (pepsin A family).
History
EC 3.4.23.25 created 1992 (EC 3.4.23.6 created 1992 (EC 3.4.23.6 created 1961 as EC 3.4.4.17, transferred 1972 to EC 3.4.23.6, modified 1981 [EC 3.4.23.7, EC 3.4.23.8, EC 3.4.23.9, EC 3.4.23.10, EC 3.4.99.1, EC 3.4.99.15 and EC 3.4.99.25 all created 1972 and incorporated 1978], part incorporated 1992)
Orthology
Genes
NAI : NECAME_00427 NECAME_03271 NECAME_12064 NECAME_15831
OVI : T265_01702 T265_05073 T265_09454 T265_11571 T265_11819 T265_13674 T265_13680
GHI : 107895126 107895127 107933472 107946863
PDUL : 117626934 117638681 117638682 117638683
CMAX : 111480290 111483445
CMOS : 111437610 111447206 111447215
CPEP : 111803239 111810385
SSTN : 125842023 125842024
CANN : 107857364 107862746
LBB : 132612234 132612339 132612340 132612341
NTA : 107768307 107774576 107782290 107806399 107832511
INI : 109149223 109149227 109149228
ITR : 116023310 116023679 116023680 116023683 116023684 116023685
EGT : 105957919 105963047 105966989 105967313 105967315 105967317 105967319 105967322
SSPL : 121766765 121766766 121770280 121771914
SMIL : 130987182 130987183
SHIS : 125206917 125209026 125210422 125210487
APAN : 127255486 127255489
ECAD : 122610503 122610504
DCR : 108201695 108206682 108208402
CSIN : 114267628 114301929
RVL : 131310540 131336637 131336638
AEW : 130751566 130755462 130760606 130773227 130786413
TAES : 123148485 123161972 123164311 123166863 123170419
AGO : AGOS_ACR143W AGOS_ACR144W AGOS_AGR407C
VPO : Kpol_1013p6 Kpol_1072p15
NCS : NCAS_0C01360(NCAS0C01360)
NDI : NDAI_0E02105(NDAI0E02105)
TPF : TPHA_0D01260(TPHA0D01260)
TBL : TBLA_0B03830(TBLA0B03830)
TDL : TDEL_0A06230(TDEL0A06230)
KAF : KAFR_0H02420(KAFR0H02420)
KNG : KNAG_0J01710(KNAG0J01710)
LBG : 92207768(LODBEIA_P25720) 92208826(LODBEIA_P36300)
CAL : CAALFM_C207400CA(APR1)
ASAU : 88171100(PUMCH_000031)
YLI : 2907949(YALI2_E00768g)
NTE : NEUTE1DRAFT117869(NEUTE1DRAFT_117869)
SMP : 10808981(SMAC4_03712)
PAN : PODANSg1740 PODANSg6547
RTHE : 98124180(VTJ83DRAFT_3186)
FGR : FGSG_02918 FGSG_10782
FPOA : FPOAC1_005268 FPOAC1_009504(PEP4)
FVN : FVRRES_05810 FVRRES_07781 FVRRES_10144
FVR : FVEG_11453 FVEG_12381
NHE : NECHADRAFT_69103 NECHADRAFT_84965
TATV : 25775525(TrAtP1_008316)
PLJ : 28883943(PLICBS_005233)
VAL : VDBG_03594 VDBG_04750
VDA : VDAG_00825 VDAG_04291
CFJ : CFIO01_00789 CFIO01_04238
CDET : 87939932(CDEST_03429) 87945182(CDEST_08679)
SAPO : SAPIO_CDS3865 SAPIO_CDS8239
PFY : PFICI_01495 PFICI_12387
SSL : SS1G_03576 SS1G_11366 SS1G_11818
BFU : BCIN_02g08590(Bcap2) BCIN_08g00720(Bcap14) BCIN_08g04700
PSCO : LY89DRAFT_239290 LY89DRAFT_686337
AOR : AO090003000693 AO090038000229
AFV : AFLA_000995 AFLA_012491
PNO : SNOG_03312 SNOG_05528 SNOG_08913 SNOG_10798
PTRR : 6339433(PtrM4_028580) 6349881(PtrM4_029530)
BZE : COCCADRAFT_37286 COCCADRAFT_8417 COCCADRAFT_92376
BSC : COCSADRAFT_287841 COCSADRAFT_343362 COCSADRAFT_34972
BOR : COCMIDRAFT_79427 COCMIDRAFT_97955
AALT : CC77DRAFT_481604 CC77DRAFT_696435
ADAC : 96084628(ACET3X_004306) 96087606(ACET3X_007284)
FFU : CLAFUR5_08972 CLAFUR5_09508 CLAFUR5_11777
CNG : CNAG_00581 CNAG_05072
CGI : CGB_A5790C CGB_D1530C CGB_F5270W
CDEU : CNBG_1355 CNBG_4614
CDEC : 89988645(IAS62_001871)
CTEG : 91987004(I308_100146) 91988026(I308_101168)
CBAS : 91980754(I312_100706) 91981202(I312_101154)
CDEP : 91085183(L203_100969) 91086924(L203_102713) 91086925(L203_102714)
KMG : 30162579(I203_101132) 30164718(I203_108012) 30165819(I203_103300) 30165821(I203_103302) 30165822(I203_103303)
KNE : 92179475(IAR55_002216) 92181268(IAR55_004010) 92181269(IAR55_004011)
KDJ : 28966385(I303_102671) 28967619(I303_103901) 28970425(I303_107323) 28970436(I303_107332) 28970438(I303_107334)
KBI : 30205000(I302_101919) 30207070(I302_103965) 30211686(I302_108342) 30211688(I302_108340) 30211689(I302_108339) 30213003(I302_105319) 30213004(I302_105320)
KPIN : 30169099(I206_100595) 30169788(I206_103576) 30171474(I206_102750) 30173270(I206_106077) 30173280(I206_106087) 30173283(I206_106090)
KSH : 87954589(IL334_002458) 87956059(IL334_003928) 87959233(IL334_007103) 87959235(IL334_007105) 87959236(IL334_007106)
KER : 91100637(V865_001833) 91100638(V865_001834) 91100640(V865_001836) 91105745(V865_006944) 91106007(V865_007206) 91107260(V865_008459)
TASA : A1Q1_05518 A1Q1_06820 A1Q1_06822 A1Q1_06831
CCAC : CcaHIS019_0303870(APR1)
TVS : TRAVEDRAFT_114871 TRAVEDRAFT_144202 TRAVEDRAFT_160645 TRAVEDRAFT_34142 TRAVEDRAFT_47172 TRAVEDRAFT_59116
DSQ : DICSQDRAFT_110456 DICSQDRAFT_136845 DICSQDRAFT_150052 DICSQDRAFT_86757
PCO : PHACADRAFT_204793 PHACADRAFT_250062 PHACADRAFT_31478 PHACADRAFT_86559
SHS : STEHIDRAFT_167974 STEHIDRAFT_73338 STEHIDRAFT_81180 STEHIDRAFT_95662
HIR : HETIRDRAFT_155322 HETIRDRAFT_34412 HETIRDRAFT_63493
PSQ : PUNSTDRAFT_141877 PUNSTDRAFT_65063 PUNSTDRAFT_65149
ADL : AURDEDRAFT_110432 AURDEDRAFT_113605 AURDEDRAFT_121248
FME : FOMMEDRAFT_112639 FOMMEDRAFT_127575 FOMMEDRAFT_21888 FOMMEDRAFT_30151 FOMMEDRAFT_32033 FOMMEDRAFT_97647
GTR : GLOTRDRAFT_101866 GLOTRDRAFT_114178 GLOTRDRAFT_131850 GLOTRDRAFT_70492
LBC : LACBIDRAFT_250343 LACBIDRAFT_292883(PR_A5) LACBIDRAFT_292906(PR_A8) LACBIDRAFT_316878
CCI : CC1G_00300 CC1G_00332
ABP : AGABI1DRAFT113304(AGABI1DRAFT_113304) AGABI1DRAFT113487(AGABI1DRAFT_113487)
ABV : AGABI2DRAFT191864(AGABI2DRAFT_191864) AGABI2DRAFT192052(AGABI2DRAFT_192052)
MRR : Moror_7340 Moror_7383
SCM : SCHCO_02307907(SCHCODRAFT_02307907) SCHCO_02508594(SCHCODRAFT_02508594) SCHCO_02538183(SCHCODRAFT_02538183) SCHCO_02622148(SCHCODRAFT_02622148) SCHCO_02703034(SCHCODRAFT_02703034)
CPUT : CONPUDRAFT_125712 CONPUDRAFT_125715 CONPUDRAFT_130472 CONPUDRAFT_142107 CONPUDRAFT_166168 CONPUDRAFT_57516 CONPUDRAFT_84820
PFP : PFL1_02785 PFL1_06442
SGRA : EX895_001290 EX895_005742
PGR : PGTG_02033 PGTG_02559 PGTG_10570
PTRC : PtA15_10A46 PtA15_5A821
PSTR : Pst134EA_018968 Pst134EA_027834
TET : TTHERM_00011710 TTHERM_000440508 TTHERM_000440509 TTHERM_00191200 TTHERM_00437390 TTHERM_00600720 TTHERM_00678540 TTHERM_01128610
PSOJ : PHYSODRAFT_352787 PHYSODRAFT_386834
GTT : GUITHDRAFT_104110 GUITHDRAFT_122682
» show all
Taxonomy
Reference
1
Authors
Hata T, Hayashi R, Dot E.
Title
Purification of yeast proteinases. Part III. Isolation and physicochemical properties of yeast proteinase A and C.
Journal
Agric Biol Chem 31:357-367 (1967)
Reference
Authors
Meussdoerffer F, Tortora P, Holzer H.
Title
Purification and properties of proteinase A from yeast.
Journal
J Biol Chem 255:12087-93 (1980)
Reference
Authors
Ammerer G, Hunter CP, Rothman JH, Saari GC, Valls LA, Stevens TH
Title
PEP4 gene of Saccharomyces cerevisiae encodes proteinase A, a vacuolar enzyme required for processing of vacuolar precursors.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 3.4.23.25