KEGG   ENZYME: 3.4.23.25
Entry
EC 3.4.23.25                Enzyme                                 
Name
saccharopepsin;
yeast endopeptidase A;
Saccharomyces aspartic proteinase;
aspartic proteinase yscA;
proteinase A;
proteinase yscA;
yeast proteinase A;
Saccharomyces cerevisiae aspartic proteinase A;
yeast proteinase A;
PRA
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
Reaction(IUBMB)
Hydrolysis of proteins with broad specificity for peptide bonds. Cleaves -Leu-Leu!Val-Tyr bond in a synthetic substrate. Does not act on esters of Tyr or Arg
Comment
Located in the vacuole of the baker's yeast (Saccharomyces cerevisiae) cell. In peptidase family A1 (pepsin A family).
History
EC 3.4.23.25 created 1992 (EC 3.4.23.6 created 1992 (EC 3.4.23.6 created 1961 as EC 3.4.4.17, transferred 1972 to EC 3.4.23.6, modified 1981 [EC 3.4.23.7, EC 3.4.23.8, EC 3.4.23.9, EC 3.4.23.10, EC 3.4.99.1, EC 3.4.99.15 and EC 3.4.99.25 all created 1972 and incorporated 1978], part incorporated 1992)
Orthology
K01381  saccharopepsin
Genes
BOD106627557
RSAN119375261
NAINECAME_00427 NECAME_03271 NECAME_12064 NECAME_15831
TSPTsp_11629
OVIT265_01702 T265_05073 T265_09454 T265_11571 T265_11819 T265_13674 T265_13680
BRP103840243
BNA106345535 106364205 106435548
BOE106293878
CIT102629074
CICCICLE_v10003736mg
TCC18594864 18606949
GRA105764914 105783689
GHI107895126 107895127 107918647 107933472 107946863
GAB108463302 108478783
DZI111289306
GMX102670502
GSJ114393508
PDUL117626934 117638681 117638682 117638683
CMAX111480290 111483445
CMOS111437610 111447206 111447215
CPEP111803239 111810385
JCU105635054
QSU112013698 112020718 112034802 112037574
TWL119985469
SLY101249745
SPEN107028263
SOT102599987
CANN107857364 107862746
NTA107768307 107774576 107782290 107806399 107832511
NSY104212470 104221729
NTO104086645 104089299
NAU109218643
INI109149227 109149228
ITR116023310 116023679 116023680 116023683 116023684 116023685
EGT105956891 105957919 105963047 105966989 105967313 105967315 105967317 105967319 105967322
SSPL121766765 121766766 121770280 121771914
ECAD122610503 122610504
LSV111898861
DCR108201695 108206682 108208402
CSIN114267628 114301929 114302900
BVG104897421 104897679
NNU104603908
TAES123148485 123161972 123164311 123166863 123170419
SCEYPL154C(PEP4)
SEUBDI49_5311
SPAOSPAR_P01190
AGOAGOS_ACR143W AGOS_ACR144W AGOS_AGR407C
ERCEcym_2396
KLAKLLA0_D05929g
KMXKLMA_70025(PEP4)
LTHKLTH0D11264g
VPOKpol_1013p6 Kpol_1072p15
ZROZYRO0F07392g
CGRCAGL0M02211g
NCSNCAS_0C01360(NCAS0C01360)
NDINDAI_0E02105(NDAI0E02105)
TPFTPHA_0D01260(TPHA0D01260)
TBLTBLA_0B03830(TBLA0B03830)
TDLTDEL_0A06230(TDEL0A06230)
TGBHG536_0A07790
KAFKAFR_0H02420(KAFR0H02420)
KNGKNAG_0J01710(KNAG0J01710)
ZMKHG535_0A06140
PPAPAS_chr3_1087
DHADEHA2C08074g
PICPICST_73446(APR1)
PGUPGUG_04145
SPAASPAPADRAFT_60314
LELLELG_01845
CALCAALFM_C207400CA(APR1)
CTPCTRG_01724
COTCORT_0B06330
CDUCD36_21670
CTENCANTEDRAFT_112349
YLIYALI0F27071g
CLUCLUG_04124
CLUSA9F13_04g04092
CAURCJI97_002630
SLBAWJ20_3869(PEP4)
PKZC5L36_0D00570
BNNFOA43_000478(APR1)
BBRXBRETT_003107(APR1)
OPAHPODL_03532
NCRNCU02273(pep4)
NTENEUTE1DRAFT117869(NEUTE1DRAFT_117869)
SMPSMAC_03712
PANPODANSg1740 PODANSg6547
TTTTHITE_2117251
MTMMYCTH_2308737
CTHRCTHT_0016370
MGRMGG_00922
PPEIPpBr36_08220
TMNUCRPA7_2473
SSCKSPSK_00526
FGRFGSG_02918 FGSG_10782
FPUFPSE_08829
FVRFVEG_11453 FVEG_12381
FOXFOXG_12714
NHENECHADRAFT_69103 NECHADRAFT_84965
TRETRIREDRAFT_77579
TRRM419DRAFT_24696
MAWMAC_01466
MAJMAA_04936
CMTCCM_03813
PLJVFPFJ_01810
VALVDBG_03594 VDBG_04750
VDAVDAG_00825 VDAG_04291
CFJCFIO01_00789 CFIO01_04238
CHIGCH63R_01191
SAPOSAPIO_CDS3865 SAPIO_CDS8239
ELAUCREL1_3089
PFYPFICI_01495 PFICI_12387
SSLSS1G_03576 SS1G_11366 SS1G_11818
BFUBCIN_02g08590(Bcap2) BCIN_08g00720(Bcap14) BCIN_08g04700
MBEMBM_06769
PSCOLY89DRAFT_239290 LY89DRAFT_686337
GLZGLAREA_02737
ANIAN2903.2
AFMAFUA_3G11400
ACTACLA_039300
NFINFIA_065900
AORAO090003000693 AO090038000229
ANGANI_1_994024(An02g07210)
AFVAFLA_000995 AFLA_012491
ALUCAKAW2_10592S(PEP2)
ACHEACHE_21120S(PEP2)
APUUAPUU_30654S(PEP2)
PCSPc13g09680
PDPPDIP_29610
TMFPMAA_019280
TRGTRUGW13939_03900
CIMCIMG_03687
CPWCPC735_005950
UREUREG_07448
PBLPAAG_01966
PBNPADG_00634
ABEARB_02919
TVETRV_05606
AJEHCAG_00037
BGHBDBG_06297
PNOSNOG_03312 SNOG_05528 SNOG_08913 SNOG_10798
PTEPTT_05144 PTT_14856
BZECOCCADRAFT_37286 COCCADRAFT_8417 COCCADRAFT_92376
BSCCOCSADRAFT_287841 COCSADRAFT_343362 COCSADRAFT_34972
BORCOCMIDRAFT_79427 COCMIDRAFT_97955
AALTCC77DRAFT_481604 CC77DRAFT_696435
ZTRMYCGRDRAFT_104895
PFJMYCFIDRAFT_89289
FFUCLAFUR5_08972 CLAFUR5_09508 CLAFUR5_11777
BCOMBAUCODRAFT_34686
NPAUCRNP2_3286
TMLGSTUM_00006237001
CNECNA05650 CNL05490
CNBCNBA5450 CNBI1350
CNGCNAG_00581 CNAG_05072
CGICGB_A5790C CGB_D1530C CGB_F5270W
TMSTREMEDRAFT_39371
TASAA1Q1_05518 A1Q1_06820 A1Q1_06822 A1Q1_06831
PPLPOSPLDRAFT_96655
TVSTRAVEDRAFT_114871 TRAVEDRAFT_144202 TRAVEDRAFT_160645 TRAVEDRAFT_34142 TRAVEDRAFT_47172 TRAVEDRAFT_59116
DSQDICSQDRAFT_110456 DICSQDRAFT_136845 DICSQDRAFT_150052 DICSQDRAFT_86757
PCOPHACADRAFT_204793 PHACADRAFT_250062 PHACADRAFT_31478 PHACADRAFT_86559
SHSSTEHIDRAFT_167974 STEHIDRAFT_73338 STEHIDRAFT_81180 STEHIDRAFT_95662
HIRHETIRDRAFT_106390 HETIRDRAFT_155322 HETIRDRAFT_34412 HETIRDRAFT_63493
PSQPUNSTDRAFT_141877 PUNSTDRAFT_65063 PUNSTDRAFT_65149
ADLAURDEDRAFT_110432 AURDEDRAFT_113605 AURDEDRAFT_114018 AURDEDRAFT_121248
FMEFOMMEDRAFT_112639 FOMMEDRAFT_127575 FOMMEDRAFT_21888 FOMMEDRAFT_30151 FOMMEDRAFT_32033 FOMMEDRAFT_97647
GTRGLOTRDRAFT_101866 GLOTRDRAFT_114178 GLOTRDRAFT_131850 GLOTRDRAFT_70492
LBCLACBIDRAFT_250343 LACBIDRAFT_292883(PR_A5) LACBIDRAFT_292906(PR_A8) LACBIDRAFT_316878
MRRMoror_7340 Moror_7383
MOREE1B28_004332
CCICC1G_00300 CC1G_00332 CC1G_12113
SCMSCHCODRAFT_235968 SCHCODRAFT_56138 SCHCODRAFT_71700 SCHCODRAFT_71897 SCHCODRAFT_82617
ABPAGABI1DRAFT113304(AGABI1DRAFT_113304) AGABI1DRAFT113487(AGABI1DRAFT_113487)
ABVAGABI2DRAFT191864(AGABI2DRAFT_191864) AGABI2DRAFT192052(AGABI2DRAFT_192052)
CPUTCONPUDRAFT_125712 CONPUDRAFT_125715 CONPUDRAFT_130472 CONPUDRAFT_142107 CONPUDRAFT_166168 CONPUDRAFT_57516 CONPUDRAFT_84820
SLASERLADRAFT_461213
WSEWALSEDRAFT_33836
WICJ056_001023
UMAUMAG_04926
PFPPFL1_02785 PFL1_06442
MGLMGL_3195
MRTMRET_2166
MSYMMSY001_2800
PGRPGTG_02033 PGTG_02559 PGTG_10570
MLRMELLADRAFT_42703
TETTTHERM_000046379 TTHERM_00011710 TTHERM_000440508 TTHERM_000440509 TTHERM_00191200 TTHERM_00437390 TTHERM_00600720 TTHERM_00678540 TTHERM_01128610
PTMGSPATT00031042001
SMINv1.2.015207.t1(symbB.v1.2.015207.t1)
FCYFRACYDRAFT_268878
AAFAURANDRAFT_4422
PIFPITG_09387
PSOJPHYSODRAFT_352787 PHYSODRAFT_386834
SPARSPRG_10505
GTTGUITHDRAFT_104110 GUITHDRAFT_122682
PTVAA957_28630
PAZOAYR47_23165
PANRA7J50_3082
MMEMarme_3794
 » show all
Reference
1
  Authors
Hata, T., Hayashi, R. and Dot, E.
  Title
Purification of yeast proteinases. Part III. Isolation and physicochemical properties of yeast proteinase A and C.
  Journal
Agric Biol Chem 31:357-367 (1967)
Reference
2  [PMID:7002931]
  Authors
Meussdoerffer F, Tortora P, Holzer H.
  Title
Purification and properties of proteinase A from yeast.
  Journal
J Biol Chem 255:12087-93 (1980)
Reference
3  [PMID:3023936]
  Authors
Ammerer G, Hunter CP, Rothman JH, Saari GC, Valls LA, Stevens TH
  Title
PEP4 gene of Saccharomyces cerevisiae encodes proteinase A, a vacuolar enzyme required for processing of vacuolar precursors.
  Journal
Mol Cell Biol 6:2490-9 (1986)
DOI:10.1128/MCB.6.7.2490
  Sequence
[sce:YPL154C]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.23.25
IUBMB Enzyme Nomenclature: 3.4.23.25
ExPASy - ENZYME nomenclature database: 3.4.23.25
BRENDA, the Enzyme Database: 3.4.23.25
CAS: 37228-80-1

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