KEGG   ENZYME: 3.4.23.25Help
Entry
EC 3.4.23.25                Enzyme                                 

Name
saccharopepsin;
yeast endopeptidase A;
Saccharomyces aspartic proteinase;
aspartic proteinase yscA;
proteinase A;
proteinase yscA;
yeast proteinase A;
Saccharomyces cerevisiae aspartic proteinase A;
yeast proteinase A;
PRA
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of proteins with broad specificity for peptide bonds. Cleaves -Leu-Leu!Val-Tyr bond in a synthetic substrate. Does not act on esters of Tyr or Arg
Comment
Located in the vacuole of the baker's yeast (Saccharomyces cerevisiae) cell. In peptidase family A1 (pepsin A family).
History
EC 3.4.23.25 created 1992 (EC 3.4.23.6 created 1992 (EC 3.4.23.6 created 1961 as EC 3.4.4.17, transferred 1972 to EC 3.4.23.6, modified 1981 [EC 3.4.23.7, EC 3.4.23.8, EC 3.4.23.9, EC 3.4.23.10, EC 3.4.99.1, EC 3.4.99.15 and EC 3.4.99.25 all created 1972 and incorporated 1978], part incorporated 1992)
Orthology
K01381  saccharopepsin
Genes
NAI: NECAME_00427 NECAME_02619 NECAME_06158 NECAME_15831
TSP: Tsp_11629
OVI: T265_01702 T265_09453 T265_09454 T265_11571 T265_11760 T265_11819 T265_13674 T265_13680 T265_13694
CSAT: 104735087
EUS: EUTSA_v10017686mg EUTSA_v10017850mg EUTSA_v10017857mg
BNA: 106345535 106364205 106389856 106435548
BOE: 106293064 106293878
RSZ: 108812392 108860360
CIT: 102618445 102619023 102623581
CIC: CICLE_v10025623mg CICLE_v10031639mg
TCC: 18587669 18589378
GRA: 105793727
GHI: 107895126 107938679
GAB: 108463355
DZI: 111316073
EGR: 104454535
GMX: 100784113 102670502
VUN: 114175540
CCAJ: 109791622 109806608
MTR: MTR_5g008110 MTR_5g044570
LJA: Lj3g3v0950710.1(Lj3g3v0950710.1)
LANG: 109334188 109336398
FVE: 101291658 101295182 101302869
RCN: 112165638 112165642 112192500
PPER: 18788058
PMUM: 103320692 103327300
MDM: 103438621
CMO: 103485161
CMAX: 111483445
CMOS: 111432642 111439774
CPEP: 111778386
RCU: 8265226 8282880
JCU: 105646088
POP: 18107996 7465018
QSU: 112013698 112020718 112022736 112034802 112037574
VVI: 100245570
SLY: 101244399 101249745 101249949
SPEN: 107028263
SOT: 102599987
CANN: 107857363 107862746 107876732
NTA: 107767344 107774576 107778643 107780195 107782290 107806399 107814374 107816390
NSY: 104221728 104221729
NTO: 104086645 104089299 104112533
NAU: 109218643 109233819
INI: 109149226 109149227 109149228 109149231
SIND: 105163422 105168270
OEU: 111377960
HAN: 110872390 110872391 110906976 110927509
LSV: 111897472 111911571 111912160
CCAV: 112528673
DCR: 108206034 108208402 108208435 108208480 108212598 108222371
BVG: 104887539 104889564 104897421
SOE: 110804227
CQI: 110706536 110730256 110731025
BDI: 104583273
EGU: 105034545 105060850
MUS: 103982469
DCT: 110093066 110094133 110100067 110100464 110100499 110100569 110101819 110102202 110110240 110113747 110114364
PEQ: 110027292 110030646
AOF: 109823111
ATR: 18444592
SCE: YPL154C(PEP4)
AGO: AGOS_ACR144W
ERC: Ecym_2396
KLA: KLLA0_D05929g
KMX: KLMA_70025(PEP4)
LTH: KLTH0D11264g
VPO: Kpol_1013p6 Kpol_1072p15
ZRO: ZYRO0F07392g
CGR: CAGL0M02211g
NCS: NCAS_0C01360(NCAS0C01360)
NDI: NDAI_0E02105(NDAI0E02105)
TPF: TPHA_0D01260(TPHA0D01260)
TBL: TBLA_0B03830(TBLA0B03830)
TDL: TDEL_0A06230(TDEL0A06230)
KAF: KAFR_0H02420(KAFR0H02420)
PPA: PAS_chr3_1087
DHA: DEHA2C08074g
PIC: PICST_73446(APR1)
PGU: PGUG_02232 PGUG_04145
SPAA: SPAPADRAFT_60314
LEL: LELG_01845
CAL: CAALFM_C207400CA(APR1)
CTP: CTRG_01724
COT: CORT_0B06330
CDU: CD36_21670
CTEN: CANTEDRAFT_112349
YLI: YALI0F27071g
CLU: CLUG_04124
CLUS: A9F13_04g04092
CAUR: CJI97_002630
SLB: AWJ20_3869(PEP4)
NCR: NCU02273(pep4)
NTE: NEUTE1DRAFT117869(NEUTE1DRAFT_117869)
SMP: SMAC_03712
PAN: PODANSg1740
TTT: THITE_2117251
MTM: MYCTH_2308737
CTHR: CTHT_0016370
MGR: MGG_00922
TMN: UCRPA7_2473
SSCK: SPSK_00526
FGR: FGSG_02918 FGSG_10782
FPU: FPSE_08829
FVR: FVEG_11453
FOX: FOXG_12714
NHE: NECHADRAFT_69103 NECHADRAFT_84965
TRE: TRIREDRAFT_77579
TRR: M419DRAFT_24696
MAW: MAC_01466
MAJ: MAA_04936
CMT: CCM_03813
PLJ: VFPFJ_01810 VFPFJ_09419
VAL: VDBG_03594 VDBG_04750
VDA: VDAG_00825 VDAG_04291
CFJ: CFIO01_00789 CFIO01_04238
ELA: UCREL1_3089
PFY: PFICI_01495 PFICI_12387
SSL: SS1G_11818
BFU: BCIN_02g08590(Bcap2)
MBE: MBM_06769
PSCO: LY89DRAFT_239290 LY89DRAFT_686337
GLZ: GLAREA_02737
ANI: AN2903.2
AFM: AFUA_3G11400
AOR: AO090003000693 AO090038000229
ANG: ANI_1_994024(An02g07210)
AFV: AFLA_031250 AFLA_126850
ACT: ACLA_039300
NFI: NFIA_065900
PCS: Pc13g09680
PDP: PDIP_29610
CIM: CIMG_03687
CPW: CPC735_005950
PBL: PAAG_01966
PBN: PADG_00634
URE: UREG_07448
ABE: ARB_02919
TVE: TRV_05606
AJE: HCAG_00037
PNO: SNOG_03312 SNOG_05528 SNOG_08913 SNOG_10798
PTE: PTT_14856
BZE: COCCADRAFT_37286 COCCADRAFT_8417
BSC: COCSADRAFT_343362 COCSADRAFT_34972
BOR: COCMIDRAFT_79427 COCMIDRAFT_97955
AALT: CC77DRAFT_481604
ZTR: MYCGRDRAFT_104895
PFJ: MYCFIDRAFT_89289
BCOM: BAUCODRAFT_34686
NPA: UCRNP2_3286
TML: GSTUM_00006237001
CNE: CNA05650
CNB: CNBA5450 CNBI1350
CGI: CGB_A5790C CGB_D1530C
TMS: TREMEDRAFT_39371
TVS: TRAVEDRAFT_114871 TRAVEDRAFT_144202 TRAVEDRAFT_160645 TRAVEDRAFT_34142 TRAVEDRAFT_47172 TRAVEDRAFT_59116
DSQ: DICSQDRAFT_110456 DICSQDRAFT_136845 DICSQDRAFT_150052 DICSQDRAFT_86757
PCO: PHACADRAFT_204793 PHACADRAFT_250062 PHACADRAFT_31478 PHACADRAFT_86559
SHS: STEHIDRAFT_167974 STEHIDRAFT_81180 STEHIDRAFT_95662
HIR: HETIRDRAFT_155322 HETIRDRAFT_34412 HETIRDRAFT_63493
PSQ: PUNSTDRAFT_141877 PUNSTDRAFT_65149 PUNSTDRAFT_97515
ADL: AURDEDRAFT_110432 AURDEDRAFT_113605
FME: FOMMEDRAFT_112639 FOMMEDRAFT_127575 FOMMEDRAFT_136736 FOMMEDRAFT_21888 FOMMEDRAFT_30151 FOMMEDRAFT_32032 FOMMEDRAFT_32033 FOMMEDRAFT_90897 FOMMEDRAFT_97647
GTR: GLOTRDRAFT_101866 GLOTRDRAFT_114178 GLOTRDRAFT_131850 GLOTRDRAFT_70492
LBC: LACBIDRAFT_250343 LACBIDRAFT_292883(PR_A5) LACBIDRAFT_292906(PR_A8) LACBIDRAFT_316878
MRR: Moror_7340 Moror_7383
CCI: CC1G_00300 CC1G_00332 CC1G_11688 CC1G_12113
SCM: SCHCODRAFT_235968 SCHCODRAFT_48367 SCHCODRAFT_56138 SCHCODRAFT_67036 SCHCODRAFT_71897 SCHCODRAFT_82617
ABP: AGABI1DRAFT113304(AGABI1DRAFT_113304) AGABI1DRAFT113487(AGABI1DRAFT_113487)
ABV: AGABI2DRAFT191864(AGABI2DRAFT_191864) AGABI2DRAFT192052(AGABI2DRAFT_192052)
CPUT: CONPUDRAFT_125712 CONPUDRAFT_130472 CONPUDRAFT_142107 CONPUDRAFT_166168 CONPUDRAFT_57516 CONPUDRAFT_84820 CONPUDRAFT_93826
SLA: SERLADRAFT_361378 SERLADRAFT_461213
WSE: WALSEDRAFT_33836
WIC: J056_001023
UMA: UMAG_04926
PFP: PFL1_02785 PFL1_06442
MGL: MGL_3195
PGR: PGTG_02033 PGTG_02559
MLR: MELLADRAFT_123279 MELLADRAFT_42703
ACAN: ACA1_280510
PFD: PFDG_02912
PFH: PFHG_00463
PYO: PY17X_1036800(PY06899)
PVX: PVX_086040
PCY: PCYB_134860
TET: TTHERM_000046379 TTHERM_00011710 TTHERM_000440508 TTHERM_000440509 TTHERM_00191200 TTHERM_00437390 TTHERM_00600720 TTHERM_00624160 TTHERM_00678540 TTHERM_01128610
PTM: GSPATT00014220001 GSPATT00031042001
SMIN: v1.2.015207.t1(symbB.v1.2.015207.t1)
FCY: FRACYDRAFT_268878
AAF: AURANDRAFT_4422
PIF: PITG_09387
PSOJ: PHYSODRAFT_352787
SPAR: SPRG_10505
GTT: GUITHDRAFT_102922 GUITHDRAFT_104110 GUITHDRAFT_122682 GUITHDRAFT_161360
PTV: AA957_28630
PAZO: AYR47_23165
 » show all
Taxonomy
Reference
1
  Authors
Hata, T., Hayashi, R. and Dot, E.
  Title
Purification of yeast proteinases. Part III. Isolation and physicochemical properties of yeast proteinase A and C.
  Journal
Agric Biol Chem 31:357-367 (1967)
Reference
2  [PMID:7002931]
  Authors
Meussdoerffer F, Tortora P, Holzer H.
  Title
Purification and properties of proteinase A from yeast.
  Journal
J Biol Chem 255:12087-93 (1980)
Reference
3  [PMID:3023936]
  Authors
Ammerer G, Hunter CP, Rothman JH, Saari GC, Valls LA, Stevens TH.
  Title
PEP4 gene of Saccharomyces cerevisiae encodes proteinase A, a vacuolar enzyme required for processing of vacuolar precursors.
  Journal
Mol Cell Biol 6:2490-9 (1986)
DOI:10.1128/MCB.6.7.2490
  Sequence
[sce:YPL154C]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.23.25
IUBMB Enzyme Nomenclature: 3.4.23.25
ExPASy - ENZYME nomenclature database: 3.4.23.25
BRENDA, the Enzyme Database: 3.4.23.25
CAS: 37228-80-1

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Gene (4462)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (367)   
   KEGG MGENES (67)   
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Protein sequence (38)   
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DNA sequence (17)   
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3D Structure (11)   
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