KEGG ENZYME: 3.4.23.25

ENZYME: 3.4.23.25

Entry

EC 3.4.23.25                Enzyme

Name

saccharopepsin;
yeast endopeptidase A;
Saccharomyces aspartic proteinase;
aspartic proteinase yscA (gene name);
proteinase A;
proteinase yscA (gene name);
yeast proteinase A;
Saccharomyces cerevisiae aspartic proteinase A;
PRA

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases

Reaction(IUBMB)

Hydrolysis of proteins with broad specificity for peptide bonds. Cleaves -Leu-Leu!Val-Tyr bond in a synthetic substrate. Does not act on esters of Tyr or Arg

Comment

Located in the vacuole of the baker's yeast (Saccharomyces cerevisiae) cell. In peptidase family A1 (pepsin A family).

History

EC 3.4.23.25 created 1992 (EC 3.4.23.6 created 1992 (EC 3.4.23.6 created 1961 as EC 3.4.4.17, transferred 1972 to EC 3.4.23.6, modified 1981 [EC 3.4.23.7, EC 3.4.23.8, EC 3.4.23.9, EC 3.4.23.10, EC 3.4.99.1, EC 3.4.99.15 and EC 3.4.99.25 all created 1972 and incorporated 1978], part incorporated 1992)

Orthology

K01381

saccharopepsin

Genes

BOD:

106627557

MQU:

129000973

PAME:

138695130

RSAN:

119375261

NAI:	NECAME_00427 NECAME_03271 NECAME_12064 NECAME_15831

TSP:

Tsp_11629

OVI:	T265_01702 T265_05073 T265_09454 T265_11571 T265_11819 T265_13674 T265_13680

BRP:

103840243

BNA:	106364205 106435548

BOE:

106293878

CIT:

102629074

CIC:	CICLE_v10003736mg

TCC:	18594864 18606949

GRA:	105764914 105783689

GHI:	107895126 107895127 107933472 107946863

GAB:	108463302 108478783

DZI:

111289306

GMX:

102670502

GSJ:

114393508

PDUL:

117626934 117638681 117638682 117638683

CMAX:

111480290 111483445

CMOS:

111437610 111447206 111447215

CPEP:

111803239 111810385

MEAN:

126682934

JCU:

105635054

TWL:

119985469

SLY:

101249745

SPEN:

107028263

SOT:

102599987

SSTN:

125842023 125842024

SDUL:

129888367

CANN:

107857364 107862746

LBB:	132612234 132612339 132612340 132612341

NTA:	107768307 107774576 107782290 107806399 107832511

NSY:	104212470 104221729

NTO:	104086645 104089299

NAU:

109218643

INI:	109149223 109149227 109149228

ITR:	116023310 116023679 116023680 116023683 116023684 116023685

EGT:	105957919 105963047 105966989 105967313 105967315 105967317 105967319 105967322

SSPL:

121766765 121766766 121770280 121771914

SMIL:

130987182 130987183

SHIS:

125206917 125209026 125210422 125210487

APAN:

127255486 127255489

PEBU:

140808245

ECAD:

122610503 122610504

LSV:

111898861

DCR:	108201695 108206682 108208402

CSIN:

114267628 114301929

RVL:	131310540 131336637 131336638

AEW:	130751566 130755462 130760606 130773227 130786413

BVG:	104897421 104897679

NNU:

104603908

TAES:

123148485 123161972 123164311 123166863 123170419

TUA:	125522891 125523719

SCE:	YPL154C(PEP4)

SEUB:

DI49_5311

SPAO:

SPAR_P01190

AGO:	AGOS_ACR143W AGOS_ACR144W AGOS_AGR407C

ERC:

Ecym_2396

KLA:	KLLA0_D05929g

KMX:	KLMA_70025(PEP4)

LTH:	KLTH0D11264g

VPO:	Kpol_1013p6 Kpol_1072p15

ZRO:	ZYRO0F07392g

CGR:	2891768(PEP4)

NCS:	NCAS_0C01360(NCAS0C01360)

NDI:	NDAI_0E02105(NDAI0E02105)

TPF:	TPHA_0D01260(TPHA0D01260)

TBL:	TBLA_0B03830(TBLA0B03830)

TGB:	HG536_0A07790

TDL:	TDEL_0A06230(TDEL0A06230)

KAF:	KAFR_0H02420(KAFR0H02420)

KNG:	KNAG_0J01710(KNAG0J01710)

ZMK:	HG535_0A06140

SLUD:

SCDLUD_002159

DHA:	DEHA2C08074g

PIC:	PICST_73446(APR1)

PGU:	PGUG_04145

SPAA:

SPAPADRAFT_60314

LEL:	PVL30_001818(APR1)

LBG:	92207768(LODBEIA_P25720) 92208826(LODBEIA_P36300)

CAL:	CAALFM_C207400CA(APR1)

CTP:	CTRG_01724

COT:	CORT_0B06330

CDU:	CD36_21670

CTEN:

18246484(APR1)

CLU:	CLUG_04124

CLUS:

A9F13_04g04092

CAUR:

CJI96_0000423

ASAU:

88171100(PUMCH_000031)

PPA:	PAS_chr3_1087

PKZ:	C5L36_0D00570

BNN:	FOA43_000478(APR1)

BBRX:

BRETT_003107(APR1)

OPA:	HPODL_03532

YLI:	2907949(YALI2_E00768g)

SLB:	AWJ20_3869(PEP4)

NCR:	NCU02273(pep4)

NTE:	NEUTE1DRAFT117869(NEUTE1DRAFT_117869)

SMP:	10808981(SMAC4_03712)

PAN:	PODANSg1740 PODANSg6547

PBEL:

QC761_509000(APR1)

PPSD:

QC762_509000(APR1)

PPSP:

QC763_509000(APR1)

PPSA:

QC764_509000(APR1)

TTT:	THITE_2117251

MTM:	MYCTH_2308737

CTHR:

CTHT_0016370

RTHE:

98124180(VTJ83DRAFT_3186)

MGR:

MGG_00922

PPEI:

PpBr36_08220

PGRI:

PgNI_08349

TMN:	UCRPA7_2473

SSCK:

SPSK_00526

FGR:	FGSG_02918 FGSG_10782

FPU:	FPSE_08829

FPOA:

FPOAC1_005268 FPOAC1_009504(PEP4)

FVN:	FVRRES_05810 FVRRES_07781 FVRRES_10144

FVR:	FVEG_11453 FVEG_12381

FOX:	FOXG_12714

NHE:	NECHADRAFT_69103 NECHADRAFT_84965

FFC:	NCS54_00662600

FKR:	NCS57_00702600

FMU:	J7337_009856(PEP4)

TRE:	TRIREDRAFT_77579

TRR:	M419DRAFT_24696

TATV:

25775525(TrAtP1_008316)

TASP:

36610077(PEP4)

MAW:	19245777(APR1)

MAJ:

MAA_04936

MBRN:

26242210(pep2)

PCHM:

VFPPC_07765

CMT:

CCM_03813

AMUS:

LMH87_004657

PLJ:	28883943(PLICBS_005233)

PTKZ:

JDV02_004131(APR1)

VAL:	VDBG_03594 VDBG_04750

VDA:	VDAG_00825 VDAG_04291

CFJ:	CFIO01_00789 CFIO01_04238

CHIG:

CH63R_01191

CDET:

87939932(CDEST_03429) 87945182(CDEST_08679)

SAPO:

SAPIO_CDS3865 SAPIO_CDS8239

ELA:	UCREL1_3089

PFY:	PFICI_01495 PFICI_12387

SSL:	SS1G_03576 SS1G_11366 SS1G_11818

BFU:	BCIN_02g08590(Bcap2) BCIN_08g00720(Bcap14) BCIN_08g04700

MBE:

MBM_06769

PSCO:

LY89DRAFT_239290 LY89DRAFT_686337

GLZ:	GLAREA_02737

ANI:	ANIA_02903

AFM:	AFUA_3G11400

ACT:	ACLA_039300

NFI:	NFIA_065900

AOR:	AO090003000693 AO090038000229

ANG:	An02g07210(pepE)

AFV:	AFLA_000995 AFLA_012491

ALUC:

AKAW2_10592S(PEP2)

ACHE:

ACHE_21120S(PEP2)

APUU:

APUU_30654S(PEP2)

PCS:	N7525_003211

PDP:	PDIP_29610

POU:	POX_b03158

TMF:	EYB26_000378

TRG:	TRUGW13939_03900

CIM:	CIMG_03687

CPW:	9694051(PEP2)

URE:	UREG_07448

ABE:

ARB_02919

TVE:

TRV_05606

PBL:	PAAG_01966

PBN:	PADG_00634

AJE:	HCAG_00037

BGH:	BDBG_06297

PNO:	SNOG_03312 SNOG_05528 SNOG_08913 SNOG_10798

PTE:	PTT_05144 PTT_14856

PTRR:

6339433(PtrM4_028580) 6349881(PtrM4_029530)

BZE:	COCCADRAFT_37286 COCCADRAFT_8417 COCCADRAFT_92376

BSC:	COCSADRAFT_287841 COCSADRAFT_343362 COCSADRAFT_34972

BOR:	COCMIDRAFT_79427 COCMIDRAFT_97955

AALT:

CC77DRAFT_481604 CC77DRAFT_696435

ADAC:

96084628(ACET3X_004306) 96087606(ACET3X_007284)

ARAB:

EKO05_0000473

ZTR:	MYCGRDRAFT_104895

PFJ:	MYCFIDRAFT_89289

FFU:	CLAFUR5_08972 CLAFUR5_09508 CLAFUR5_11777

CBET:

CB0940_10138

BCOM:

BAUCODRAFT_34686

NPA:	UCRNP2_3286

TML:	GSTUM_00006237001

CNE:	CNA05650 CNL05490

CNB:	CNBA5450 CNBI1350

CNG:	CNAG_00581 CNAG_05072

CGI:	CGB_A5790C CGB_D1530C CGB_F5270W

CDEU:

CNBG_1355 CNBG_4614

CDEC:

89988645(IAS62_001871)

CTEG:

91987004(I308_100146) 91988026(I308_101168)

CBAS:

91980754(I312_100706) 91981202(I312_101154)

CDEP:

91085183(L203_100969) 91086924(L203_102713) 91086925(L203_102714)

KMG:	30162579(I203_101132) 30164718(I203_108012) 30165819(I203_103300) 30165821(I203_103302) 30165822(I203_103303)

KNE:	92179475(IAR55_002216) 92181268(IAR55_004010) 92181269(IAR55_004011)

KDJ:	28966385(I303_102671) 28967619(I303_103901) 28970425(I303_107323) 28970436(I303_107332) 28970438(I303_107334)

KBI:	30205000(I302_101919) 30207070(I302_103965) 30211686(I302_108342) 30211688(I302_108340) 30211689(I302_108339) 30213003(I302_105319) 30213004(I302_105320)

KPIN:

30169099(I206_100595) 30169788(I206_103576) 30171474(I206_102750) 30173270(I206_106077) 30173280(I206_106087) 30173283(I206_106090)

KSH:	87954589(IL334_002458) 87956059(IL334_003928) 87959233(IL334_007103) 87959235(IL334_007105) 87959236(IL334_007106)

KER:	91100637(V865_001833) 91100638(V865_001834) 91100640(V865_001836) 91105745(V865_006944) 91106007(V865_007206) 91107260(V865_008459)

TMS:	TREMEDRAFT_39371

TASA:

A1Q1_05518 A1Q1_06820 A1Q1_06822 A1Q1_06831

CCAC:

CcaHIS019_0303870(APR1)

TVS:	TRAVEDRAFT_114871 TRAVEDRAFT_144202 TRAVEDRAFT_160645 TRAVEDRAFT_34142 TRAVEDRAFT_47172 TRAVEDRAFT_59116

DSQ:	DICSQDRAFT_110456 DICSQDRAFT_136845 DICSQDRAFT_150052 DICSQDRAFT_86757

PCO:	PHACADRAFT_204793 PHACADRAFT_250062 PHACADRAFT_31478 PHACADRAFT_86559

SHS:	STEHIDRAFT_167974 STEHIDRAFT_73338 STEHIDRAFT_81180 STEHIDRAFT_95662

HIR:	HETIRDRAFT_155322 HETIRDRAFT_34412 HETIRDRAFT_63493

PSQ:	PUNSTDRAFT_141877 PUNSTDRAFT_65063 PUNSTDRAFT_65149

ADL:	AURDEDRAFT_110432 AURDEDRAFT_113605 AURDEDRAFT_121248

FME:	FOMMEDRAFT_112639 FOMMEDRAFT_127575 FOMMEDRAFT_21888 FOMMEDRAFT_30151 FOMMEDRAFT_32033 FOMMEDRAFT_97647

GTR:	GLOTRDRAFT_101866 GLOTRDRAFT_114178 GLOTRDRAFT_131850 GLOTRDRAFT_70492

RSX:	RhiXN_04294

LBC:	LACBIDRAFT_250343 LACBIDRAFT_292883(PR_A5) LACBIDRAFT_292906(PR_A8) LACBIDRAFT_316878

CCI:	CC1G_00300 CC1G_00332

ABP:	AGABI1DRAFT113304(AGABI1DRAFT_113304) AGABI1DRAFT113487(AGABI1DRAFT_113487)

ABV:	AGABI2DRAFT191864(AGABI2DRAFT_191864) AGABI2DRAFT192052(AGABI2DRAFT_192052)

PCUB:

JR316_0004792

MRR:	Moror_7340 Moror_7383

E1B28_004332

SCM:	SCHCO_02307907(SCHCODRAFT_02307907) SCHCO_02508594(SCHCODRAFT_02508594) SCHCO_02538183(SCHCODRAFT_02538183) SCHCO_02622148(SCHCODRAFT_02622148) SCHCO_02703034(SCHCODRAFT_02703034)

CPUT:

CONPUDRAFT_125712 CONPUDRAFT_125715 CONPUDRAFT_130472 CONPUDRAFT_142107 CONPUDRAFT_166168 CONPUDRAFT_57516 CONPUDRAFT_84820

SLA:	SERLADRAFT_461213

WSE:	WALSEDRAFT_33836

WIC:	J056_001023

UMA:	UMAG_04926

PFP:	PFL1_02785 PFL1_06442

SGRA:

EX895_001290 EX895_005742

MGL:

MGL_3195

MRT:

MRET_2166

MSYM:

MSY001_2800

PGR:	PGTG_02033 PGTG_02559 PGTG_10570

PTRC:

PtA15_10A46 PtA15_5A821

PSTR:

Pst134EA_018968 Pst134EA_027834

MLR:	MELLADRAFT_42703

RIE:	OCT59_022372

TET:	TTHERM_00011710 TTHERM_000440508 TTHERM_000440509 TTHERM_00191200 TTHERM_00437390 TTHERM_00600720 TTHERM_00678540 TTHERM_01128610

PTM:	GSPATT00031042001

FCY:	FRACYDRAFT_268878

AAF:	AURANDRAFT_4422

PIF:	PITG_09387

PSOJ:

PHYSODRAFT_352787 PHYSODRAFT_386834

SPAR:

SPRG_10505

GTT:	GUITHDRAFT_104110 GUITHDRAFT_122682

PTV:	AA957_28630

PAZO:

AYR47_23165

PANR:

A7J50_3082

» show all

Reference

Authors

Hata T, Hayashi R, Dot E.

Title

Purification of yeast proteinases. Part III. Isolation and physicochemical properties of yeast proteinase A and C.

Journal

Agric Biol Chem 31:357-367 (1967)

Reference

2 [PMID:7002931]

Authors

Meussdoerffer F, Tortora P, Holzer H.

Title

Purification and properties of proteinase A from yeast.

Journal

J Biol Chem 255:12087-93 (1980)

Reference

3 [PMID:3023936]

Authors

Ammerer G, Hunter CP, Rothman JH, Saari GC, Valls LA, Stevens TH

Title

PEP4 gene of Saccharomyces cerevisiae encodes proteinase A, a vacuolar enzyme required for processing of vacuolar precursors.

Journal

Mol Cell Biol 6:2490-9 (1986)
DOI:10.1128/MCB.6.7.2490

Sequence

[sce:YPL154C]

Other DBs

ExplorEnz - The Enzyme Database:

3.4.23.25

IUBMB Enzyme Nomenclature:

3.4.23.25

ExPASy - ENZYME nomenclature database:

3.4.23.25

BRENDA, the Enzyme Database:

3.4.23.25

CAS:	37228-80-1

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Gene (4085)   
   MGENES (58)   
   RefGene (4027)   
Protein sequence (403)   
   UniProt (356)   
   SWISS-PROT (5)   
   RefSeq(pep) (27)   
   PDBSTR (15)   
DNA sequence (129)   
   RefSeq(nuc) (53)   
   GenBank (40)   
   EMBL (36)   
3D Structure (11)   
   PDB (11)   
Protein domain (6)   
   InterPro (5)   
   PROSITE(DOC) (1)   
All databases (4634)   

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