KEGG   ENZYME: 3.4.23.3Help
Entry
EC 3.4.23.3                 Enzyme                                 

Name
gastricsin;
pepsin C;
pig parapepsin II;
parapepsin II
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
BRITE hierarchy
Reaction(IUBMB)
More restricted specificity than pepsin A, but shows preferential cleavage at Tyr! bonds. High activity on hemoglobin
Comment
Formed from progastricsin, apparently in the gastric juice of most vertebrates. In addition to the fundus, progastricsin is also secreted in antrum and proximal duodenum. Seminal plasma contains a zymogen that is immunologically identical with progastricsin [6]. In peptidase family A1 (pepsin A family).
History
EC 3.4.23.3 created 1965 as EC 3.4.4.22, transferred 1972 to EC 3.4.23.3, modified 1986
Orthology
K01377  gastricsin
Genes
HSA: 5225(PGC)
PTR: 107975138(PGC) 469410
PPS: 100974556(PGC)
GGO: 101127433 101129549(PGC)
PON: 100271706(PGC)
NLE: 100583614(PGC)
MCC: 695713(PGC)
MCF: 102124827(PGC)
CSAB: 103221511(PGC)
RRO: 104667302(PGC)
RBB: 108533509(PGC)
CJC: 100404738(PGC)
SBQ: 101046472(PGC)
MMU: 109820(Pgc)
RNO: 24864(Pgc)
CGE: 100770180(Pgc)
NGI: 103725818(Pgc)
HGL: 101713573(Pgc)
CCAN: 109682091(Pgc) 109690302
OCU: 100009323(PGC)
TUP: 102468155(PGC) 102471668
CFA: 403552(PGB) 611675
ORO: 101370826(PGC) 101377876
FCA: 101100053(PGC) 111556254
BTA: 514502(PGC)
BOM: 102288190(PGC)
BIU: 109577457(PGC)
PHD: 102341255(PGC)
CHX: 102189914(PGC)
OAS: 101106633(PGC)
SSC: 100521201(PGC) 100620249
CFR: 102523783(PGC)
CDK: 105086751(PGC)
BACU: 103010186(PGC)
LVE: 103070634(PGC)
OOR: 101276675(PGC)
ECB: 100066460(PGC)
EPZ: 103563497(PGC)
EAI: 106824587(PGC) 106828552
MYB: 102255177(PGC) 102261843
MYD: 102755151(PGC) 102772869
HAI: 109373549 109382920(PGC)
RSS: 109446812 109450719(PGC)
PALE: 102877967(PGC) 102881919
LAV: 100665648(PGC) 100675371
GGA: 395690(PGC) 428272(GASTL)
APLA: 101792780 101794692(PGC)
ACYG: 106045837(PGC) 106045861
GFR: 102041764(PGC)
FAB: 101807666(PGC)
CCW: 104692528(PGC)
CLV: 102091578(PGC)
CMY: 102930064(Gastricsin) 102941343(Gastricsin) 102941576(Gastricsin)
PVT: 110081367 110081374(PGC)
LCO: 104940478(pgc)
LCF: 108875170(pgc)
LCM: 102354616(PGC)
BMY: Bm1_34740
 » show all
Taxonomy
Reference
1
  Authors
Ryle, A.P.
  Title
The porcine pepsins and pepsinogens.
  Journal
Methods Enzymol 19:316-336 (1970)
Reference
2
  Authors
Tang, J.
  Title
Gastricsin and pepsin.
  Journal
Methods Enzymol 19:406-421 (1970)
Reference
3  [PMID:6795036]
  Authors
Foltmann B.
  Title
Gastric proteinases--structure, function, evolution and mechanism of action.
  Journal
Essays Biochem 17:52-84 (1981)
Reference
4  [PMID:6816595]
  Authors
Foltmann B, Jensen AL.
  Title
Human progastricsin. Analysis of intermediates during activation into gastricsin and determination of the amino acid sequence of the propart.
  Journal
Eur J Biochem 128:63-70 (1982)
DOI:10.1111/j.1432-1033.1982.tb06931.x
  Sequence
[hsa:5225]
Reference
5  [PMID:6800788]
  Authors
Martin P, Trieu-Cuot P, Collin JC, Ribadeau Dumas B.
  Title
Purification and characterization of bovine gastricsin.
  Journal
Eur J Biochem 122:31-9 (1982)
DOI:10.1111/j.1432-1033.1982.tb05844.x
Reference
6  [PMID:6432332]
  Authors
Reid WA, Vongsorasak L, Svasti J, Valler MJ, Kay J.
  Title
Identification of the acid proteinase in human seminal fluid as a gastricsin originating in the prostate.
  Journal
Cell Tissue Res 236:597-600 (1984)
Reference
7  [PMID:3335549]
  Authors
Hayano T, Sogawa K, Ichihara Y, Fujii-Kuriyama Y, Takahashi K.
  Title
Primary structure of human pepsinogen C gene.
  Journal
J Biol Chem 263:1382-5 (1988)
  Sequence
[hsa:5225]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.23.3
IUBMB Enzyme Nomenclature: 3.4.23.3
ExPASy - ENZYME nomenclature database: 3.4.23.3
BRENDA, the Enzyme Database: 3.4.23.3
CAS: 9012-71-9

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