KEGG ENZYME: 3.4.23.34

ENZYME: 3.4.23.34

Entry

EC 3.4.23.34                Enzyme

Name

cathepsin E;
slow-moving proteinase;
erythrocyte membrane aspartic proteinase;
SMP;
EMAP;
non-pepsin proteinase;
cathepsin D-like acid proteinase;
cathepsin E-like acid proteinase;
cathepsin D-type proteinase

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases

Reaction(IUBMB)

Similar to cathepsin D, but slightly broader specificity

Comment

Found in stomach, spleen, erythrocyte membrane; not lysosomal. Pro-cathepsin E is an 86 kDa disulfide-linked dimer; activation or reduction produces monomer. In peptidase family A1 (pepsin A family)

History

EC 3.4.23.34 created 1992

Orthology

K01382

cathepsin E

Genes

HSA:	1510(CTSE)

PTR:	457677(CTSE)

PPS:	100996015(CTSE)

GGO:	101124402(CTSE)

PON:	100452388(CTSE)

NLE:	100603573(CTSE)

HMH:	116457406(CTSE)

MCC:	696202(CTSE)

MCF:	102122689(CTSE)

MTHB:

126939097

MNI:	105484834(CTSE)

CSAB:

103230206(CTSE)

CATY:

105576555(CTSE)

PANU:

101000674(CTSE)

TGE:	112630667(CTSE)

MLEU:

105547028(CTSE)

RRO:	104661729(CTSE)

RBB:	108535115(CTSE)

TFN:	117075558(CTSE)

PTEH:

111522740(CTSE)

CANG:

105523007(CTSE)

CJC:	100413525(CTSE)

SBQ:	101046996(CTSE)

CIMI:

108302071(CTSE)

CSYR:

103256047(CTSE)

MMUR:

105869296(CTSE)

LCAT:

123627122(CTSE)

PCOQ:

105821191(CTSE)

OGA:	100951990(CTSE)

MMU:	13034(Ctse)

MCAL:

110297944(Ctse)

MPAH:

110322114(Ctse)

RNO:	25424(Ctse)

MCOC:

116098912(Ctse)

ANU:	117716318(Ctse)

CGE:	100757212(Ctse)

MAUA:

101824719(Ctse)

PROB:

127236431(Ctse)

PLEU:

114698041(Ctse)

MORG:

121446360(Ctse)

MFOT:

126505035

AAMP:

119827852(Ctse)

NGI:	103725942(Ctse)

HGL:	101699894(Ctse)

CPOC:

100135509(Ctse)

CCAN:

109697219(Ctse)

DORD:

105986454(Ctse)

DSP:	122109754(Ctse)

PLOP:

125359752(Ctse)

NCAR:

124961986

OCU:	100009063(CTSE)

OPI:	101529836(CTSE)

TUP:	102483572(CTSE)

GVR:	103596736(CTSE)

CFA:	488577(CTSE)

CLUD:

112643200(CTSE)

VVP:	112914539(CTSE)

VLG:	121471747(CTSE)

NPO:	129515251(CTSE)

AML:	100475014(CTSE)

UMR:	103671000(CTSE)

UAH:	113242470(CTSE)

UAR:	123785666(CTSE)

ELK:

111151129

LLV:

125086428

MPUF:

101675517(CTSE)

MNP:	132025673(CTSE)

NVS:	122918855(CTSE)

ORO:	101364641(CTSE)

EJU:	114222020(CTSE)

ZCA:	113933298(CTSE)

MLX:	118013666(CTSE)

NSU:	110577337(CTSE)

LWW:	102747303(CTSE)

FCA:	101088455(CTSE)

PYU:	121021633(CTSE)

PCOO:

112857896(CTSE)

PBG:	122476515(CTSE)

LRUF:

124509970

PTG:	102960694(CTSE)

PPAD:

109257566(CTSE)

PUC:

125925480

AJU:

106972890

HHV:	120228843(CTSE)

BOM:	106701532(CTSE)

OOR:	105748678(CTSE)

DLE:	111184605(CTSE)

PCAD:

112067583(CTSE)

PSIU:

116740615(CTSE)

NASI:

112403449(CTSE)

ECB:	100055161(CTSE)

EPZ:	103553838(CTSE)

EAI:	106823465(CTSE)

MYB:	102250825(CTSE)

MYD:	102753719(CTSE)

MMYO:

118673642(CTSE)

MLF:	102426302(CTSE)

MNA:	107539403(CTSE)

PKL:	118721390(CTSE)

EFUS:

103297485(CTSE)

HAI:	109386433(CTSE)

DRO:	112315908(CTSE)

SHON:

119001663(CTSE)

AJM:	119056851(CTSE)

PDIC:

114511999(CTSE)

PHAS:

123820623(CTSE)

MMF:	118637451(CTSE)

RFQ:	117014338(CTSE)

PALE:

102890366(CTSE)

PGIG:

120618005(CTSE)

PVP:	105300736(CTSE)

RAY:	107508871(CTSE)

MJV:	108390208(CTSE)

TOD:	119233746(CTSE)

SARA:

101543037(CTSE)

LAV:	100663037(CTSE)

TMU:

101345963

ETF:	101646648(CTSE)

DNM:	101428239(CTSE)

MDO:	100019361(CTSE)

GAS:

123255239

SHR:	100934264(CTSE)

AFZ:

127562637

PCW:	110219635(CTSE)

OAA:

100081153

GGA:	417848(CTSEAL) 771791(CTSE)

PCOC:

116226586 116237013(CTSE)

MGP:	100548063(CTSE) 100548118

CJO:	107310248 107324888(CTSE)

TPAI:

128073778 128088128(CTSE)

LMUT:

125684183(CTSE) 125700036

NMEL:

110388319(CTSE) 110392329

APLA:

101789387(CTSE) 101804173

ACYG:

106041279(CTSE) 106045567

CATA:

118246864 118255361(CTSE)

AFUL:

116498826(CTSE) 116501842

TGU:	100218931 100228499(CTSE)

LSR:	110473079(CTSE) 110477989

SCAN:

103813448 103822388(CTSE)

PMOA:

120497642(CTSE) 120499781

OTC:	121339446 121345607(CTSE)

PRUF:

121349772(CTSE) 121352500

GFR:	102041269 102043260(CTSE)

FAB:	101814202 101815239(CTSE)

OMA:	130248380 130263565(CTSE)

PHI:	102101700 102104842(CTSE)

PMAJ:

107205210 107214812(CTSE)

CCAE:

111932764 111939682(CTSE)

CCW:	104692361(CTSE) 104698380

CBRC:

103614888 103625402(CTSE)

ETL:	114062146 114066524(CTSE)

ZAB:	102065260 102068482(CTSE)

ACHL:

103797066 103804906(CTSE)

SVG:	106850998(CTSE) 106855233

MMEA:

130580271 130585760(CTSE)

HRT:	120752038 120762789(CTSE)

FPG:	101920453(CTSE) 101923255

FCH:	102049037 102051110(CTSE)

CLV:	102089416(CTSE) 102097331

EGZ:	104132915 104134468(CTSE)

NNI:	104010999 104013197(CTSE)

PCRI:

104028292 104035282(CTSE)

PLET:

104619697 104627629(CTSE)

EHS:	104508279(CTSE) 104510587

PCAO:

104049636 104052363(CTSE)

ACUN:

113488852(CTSE) 113491191

TALA:

104357104(CTSE) 104362117

PADL:

103919789(CTSE) 103919953

AFOR:

103893593(CTSE) 103893920

ACHC:

115335070(CTSE) 115336252

HALD:

104317214(CTSE) 104320136

HLE:	104828230 104839555(CTSE)

AGEN:

126034397 126052105

GCL:	127026171 127026790

CCRI:

104158712 104166996(CTSE)

CSTI:

104559510(CTSE) 104563394

CMAC:

104476355 104482776(CTSE)

MUI:	104546268(CTSE) 104546523

BREG:

104634693(CTSE) 104636840

FGA:	104078964 104082284(CTSE)

GSTE:

104253533(CTSE) 104263294

LDI:	104340856 104343565(CTSE)

MNB:	103775751(CTSE) 103777806

OHA:	104326761 104338924(CTSE)

NNT:	104403415 104404306(CTSE)

SHAB:

115602365(CTSE) 115604680

DPUB:

104304783(CTSE) 104305539

PGUU:

104463627(CTSE) 104470968

ACAR:

104528006(CTSE) 104532132

CPEA:

104388640(CTSE) 104388806

AVIT:

104278738 104280682(CTSE)

CVF:	104288913 104289344(CTSE)

RTD:	128900284(CTSE) 128904079

CUCA:

104061887(CTSE) 104063965

TEO:	104372448(CTSE) 104382090

BRHI:

104490508(CTSE) 104499469

AAM:	106484553(CTSE) 106488475

AROW:

112964099 112971622(CTSE)

NPD:	112944636(CTSE) 112958853

TGT:	104566454(CTSE) 104570266

DNE:	112983336 112990348(CTSE)

SCAM:

104140686 104142395(CTSE)

ASN:	102380654 102384944(CTSE)

AMJ:	102566566(NOTS) 102567770(CTSE)

CPOO:

109315502 109317695(CTSE)

GGN:	109295252(CTSE) 109295724

PSS:	102461548 102463529(CTSE)

CMY:	102931323(CTSE) 102933016

CCAY:

125624957(CTSE) 125630200

DCC:	119846487(CTSE) 119856970

CPIC:

101933009(CTSE) 101941871

TST:	117876457(CTSE) 117877791

CABI:

116832075(CTSE) 116834455

MRV:	120387307 120404474(CTSE)

ACS:	100557309 100561705(ctse) 100561900

PVT:	110081416(CTSE)

SUND:

121928967(CTSE) 121931278

PBI:	103065297 103067272(CTSE)

PMUR:

107283823 107292374(CTSE)

CTIG:

120308438 120320051(CTSE)

TSR:	106539374(CTSE) 106540835

PGUT:

117655523 117664384(CTSE)

APRI:

131201978

PTEX:

113435697 113446101(CTSE)

NSS:	113412256 113418158(CTSE)

VKO:	123033306 123034217(CTSE)

PMUA:

114590067 114599920(CTSE) 114605772

PRAF:

128416127(CTSE) 128421636

ZVI:	118089386(CTSE) 118091055

HCG:	128323972(CTSE) 128327521

GJA:	107105702 107115330(CTSE)

STOW:

125433376(CTSE)

EMC:	129330675(CTSE) 129335331

XLA:	108712486 373572(ctse.L) 373573(ctse.S)

XTR:	100145572(ctse) 100493461

NPR:	108787647(CTSE) 108804543

RTEM:

120927148(CTSE) 120930385

BBUF:

120980617 120993317(CTSE)

BGAR:

122925799 122933450(CTSE)

MUO:	115477404 115482228(CTSE)

GSH:	117347862(CTSE) 117364069

DRE:	114367(nots)

SRX:

107725781

SANH:

107677818

SGH:

107569115

CCAR:

109062605

CAUA:

113066553

CGIB:

127956167

PTET:

122343045

OMC:	131538898(nots)

PPRM:

120480194

MAMB:

125246313(nots)

CIDE:

127511203

MASI:

127435341

TROS:

130547555(nots)

MANU:

129432324(nots)

IPU:	108279983(nots)

IFU:	128623500(nots)

PHYP:

113531975

SMEO:

124401120(nots)

TFD:	113645810(nots)

AMEX:

103036771

CMAO:

118812424(nots)

EEE:

113573545

CHAR:

105892403(nots)

TRU:	777958(nts)

TFS:	130519271(nots)

TNG:	GSTEN00004063G001

LCO:

104935800

NCC:

104947164

CGOB:

115005988 115005990

ELY:	117249457(nots)

EFO:	125883124(nots)

PLEP:

121961372(nots)

SLUC:

116052020(nots)

ESP:

116672897

PFLV:

114550096

GAT:	120815261(nots)

PPUG:

119210951(nots)

AFB:	129112426(nots)

CLUM:

117726321(nots)

MSAM:

119895273(nots)

SCHU:

122870954(nots)

CUD:	121505784(nots)

ALAT:

119032520(nots)

MZE:

101475107

ONL:

100700379

OAU:	116318224(nots)

OLA:

101159061

OML:	112155171(nots)

XMA:

102238257

XCO:

114160681

XHE:

116737075

PRET:

103459337

PFOR:

103154275

PLAI:

106961768

PMEI:

106917304

GAF:	122826528(nots)

CVG:

107089060

CTUL:

119796575(nots)

GMU:	124883378(nots)

NFU:

107387581

KMR:	108250475(nots)

ALIM:

106532841

NWH:	119428105(nots)

AOCE:

111569281

MCEP:

125000247(notS)

CSEM:

103383134 103384628

POV:	109644666 109647025

SSEN:

122761390 122767242

HHIP:

117757039(nots)

HSP:	118101601(nots)

LCF:

108901352

SDU:

111224749

SLAL:

111664974

XGL:	120802483(nots)

HCQ:

109532693

SSCV:

125991976

BPEC:

110161516

MALB:

109967703

BSPL:

114862529(nots)

SASA:

106576650

STRU:

115189933 115189939

OTW:	112238804 121844344

OMY:	110499710 118938828

OGO:

124019765

OKI:	109879517 109884573

OKE:	118383310(nots)

SNH:	120032108(nots)

CCLU:

121553548(nots)

ELS:

105023104

SFM:

108936584

PKI:	111843136 111851189

AANG:

118219028(nots)

LOC:	102685181(ctse) 102693226

PSPA:

121299842 121299843 121299844 121317969(nots) 121319148

ARUT:

117396772 117415061(nots) 117419715 117435600

PSEX:

120536437 120539087(nots)

LCM:	102345230(CTSE) 102354975

CMK:	103185314(nots)

RTP:	109925993 109929492

CPLA:

122559769 122563101

LERI:

129706423 129708909

DER:

6555650

DSI:	Dsimw501_GD29212(Dsim_GD29212)

DPO:

6902149

CNS:	116340310 116348307

CSEC:

111873772

PPOI:

119093579

NAI:	NECAME_03267

OSN:

115230038

OVI:	T265_01716 T265_11831

CSL:	COCSUDRAFT_55151 COCSUDRAFT_62232 COCSUDRAFT_66898

CTEN:

CANTEDRAFT_113597

YLI:	YALI0D02024g

SLB:	AWJ20_1217(PEP4)

CTHR:

CTHT_0013610

NHE:	NECHADRAFT_101400

CMT:

CCM_00473

PFY:	PFICI_13644

ALUC:

AKAW2_12041S

TMF:	EYB26_002286

PNO:	SNOG_05297

FFU:	CLAFUR5_06056

CNE:	CNC04480 CNF01040

CNB:	CNBC2690 CNBF3670

CNG:	CNAG_05869 CNAG_07520

CGI:	CGB_C6590C

CCAC:

CcaHIS019_0107290(CcaverHIS019_0107290) CcaHIS019_0500840(CcaverHIS019_0500840) CcaHIS019_0500910(CcaverHIS019_0500910) CcaHIS019_0601270(CcaverHIS019_0601270)

PPL:	POSPLDRAFT_104081 POSPLDRAFT_104985

TVS:	TRAVEDRAFT_124687 TRAVEDRAFT_37373 TRAVEDRAFT_40186 TRAVEDRAFT_43716 TRAVEDRAFT_54018

DSQ:	DICSQDRAFT_49340 DICSQDRAFT_52871 DICSQDRAFT_89467

PCO:	PHACADRAFT_197031 PHACADRAFT_203593 PHACADRAFT_247956 PHACADRAFT_248326 PHACADRAFT_80588 PHACADRAFT_83207

SHS:	STEHIDRAFT_117825 STEHIDRAFT_146264 STEHIDRAFT_96294

HIR:	HETIRDRAFT_99524

PSQ:	PUNSTDRAFT_116452 PUNSTDRAFT_63287

ADL:	AURDEDRAFT_114231 AURDEDRAFT_169434 AURDEDRAFT_170430 AURDEDRAFT_186499 AURDEDRAFT_63677

RSX:	RhiXN_08361

LBC:	LACBIDRAFT_254624 LACBIDRAFT_310997(LbPR_A3)

MRR:	Moror_14679

E1B28_000213 E1B28_000766

CPUT:

CONPUDRAFT_151723

SLA:	SERLADRAFT_418893

PGR:	PGTG_06539

PTRC:

PtA15_4A360 PtA15_8A639 PtA15_9A326

PSTR:

Pst134EA_015483 Pst134EA_015493

MLR:	MELLADRAFT_123288 MELLADRAFT_65252

PTM:	GSPATT00010671001 GSPATT00012501001 GSPATT00016271001 GSPATT00019552001

SMIN:

v1.2.003841.t1(symbB.v1.2.003841.t1) v1.2.015387.t1(symbB.v1.2.015387.t1) v1.2.018093.t1(symbB.v1.2.018093.t1) v1.2.018143.t1(symbB.v1.2.018143.t1) v1.2.018682.t1(symbB.v1.2.018682.t1) v1.2.018682.t2(symbB.v1.2.018682.t2) v1.2.022081.t1(symbB.v1.2.022081.t1) v1.2.024260.t1(symbB.v1.2.024260.t1) v1.2.037886.t1(symbB.v1.2.037886.t1)

PIF:	PITG_04975

PSOJ:

PHYSODRAFT_324695

SPAR:

SPRG_05634 SPRG_15475

» show all

Reference

1 [PMID:3741628]

Authors

Lapresle C, Puizdar V, Porchon-Bertolotto C, Joukoff E, Turk V.

Title

Structural differences between rabbit cathepsin E and cathepsin D.

Journal

Biol Chem Hoppe Seyler 367:523-6 (1986)
DOI:10.1515/bchm3.1986.367.1.523

Reference

2 [PMID:3058036]

Authors

Yonezawa S, Fujii K, Maejima Y, Tamoto K, Mori Y, Muto N.

Title

Further studies on rat cathepsin E: subcellular localization and existence of the active subunit form.

Journal

Arch Biochem Biophys 267:176-83 (1988)
DOI:10.1016/0003-9861(88)90021-5

Reference

3 [PMID:3058118]

Authors

Jupp RA, Richards AD, Kay J, Dunn BM, Wyckoff JB, Samloff IM, Yamamoto K.

Title

Identification of the aspartic proteinases from human erythrocyte membranes and gastric mucosa (slow-moving proteinase) as catalytically equivalent to cathepsin E.

Journal

Biochem J 254:895-8 (1988)
DOI:10.1042/bj2540895

Reference

4 [PMID:2674141]

Authors

Azuma T, Pals G, Mohandas TK, Couvreur JM, Taggart RT

Title

Human gastric cathepsin E. Predicted sequence, localization to chromosome 1, and sequence homology with other aspartic proteinases.

Journal

J Biol Chem 264:16748-53 (1989)

Sequence

[hsa:1510]